Cinacalcet_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cinacalcet perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cinacalcet_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TSC22D2 TSC22 domain family, member 2 0.0798237
ZNF292 zinc finger protein 292 0.0687914
PEG10 paternally expressed 10 0.0663608
ACSL3 acyl-CoA synthetase long-chain family member 3 0.061224
ITGAV integrin, alpha V 0.056148
ZFAND3 zinc finger, AN1-type domain 3 0.0480709
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0461052
SPAG9 sperm associated antigen 9 0.0431689
CDC73 cell division cycle 73 0.0422013
WDR43 WD repeat domain 43 0.0418784
KMT2E lysine (K)-specific methyltransferase 2E 0.0411686
RHEB Ras homolog enriched in brain 0.041151
PDGFC platelet derived growth factor C 0.0405225
ENAH enabled homolog (Drosophila) 0.0400463
CRY1 cryptochrome circadian clock 1 0.0393899
TRA2A transformer 2 alpha homolog (Drosophila) 0.0389502
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0388812
PUM1 pumilio RNA-binding family member 1 0.0380626
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0352704
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0348395
PDS5B PDS5 cohesin associated factor B 0.0342175
PLPP1 phospholipid phosphatase 1 0.0336626
RLF rearranged L-myc fusion 0.0307876
RBM39 RNA binding motif protein 39 0.0291436
ZNF217 zinc finger protein 217 0.0284069
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0282847
NCOR1 nuclear receptor corepressor 1 0.0279779
MB21D2 Mab-21 domain containing 2 0.0278361
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 0.0274527
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0270168
FBXO11 F-box protein 11 0.0266362
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0263437
RPL3 ribosomal protein L3 0.0260811
CAMTA1 calmodulin binding transcription activator 1 0.0258055
PCBP2 poly(rC) binding protein 2 0.0254701
STRN3 striatin, calmodulin binding protein 3 0.0252279
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0252255
NCKAP1 NCK-associated protein 1 0.0251691
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0249138
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0248361
MEMO1 mediator of cell motility 1 0.0244109
FUBP1 far upstream element (FUSE) binding protein 1 0.0242872
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0242028
KMT2C lysine (K)-specific methyltransferase 2C 0.0239098
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0235284
WASL Wiskott-Aldrich syndrome-like 0.0234827
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0234328
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0232591
CPNE8 copine VIII 0.0231244
HDAC9 histone deacetylase 9 0.0227836
TBC1D12 TBC1 domain family, member 12 0.022484
MEF2A myocyte enhancer factor 2A 0.0224502
CSE1L CSE1 chromosome segregation 1-like (yeast) 0.0224097
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0220179
CXADR coxsackie virus and adenovirus receptor 0.0219298
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0218577
FOXP2 forkhead box P2 0.021703
PPP4R1 protein phosphatase 4, regulatory subunit 1 0.0216889
KDM3A lysine (K)-specific demethylase 3A 0.0213526
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0212942
XPR1 xenotropic and polytropic retrovirus receptor 1 0.0211722
NUP153 nucleoporin 153kDa 0.0210684
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0210019
RIOK3 RIO kinase 3 0.0208522
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0205704
ZNF451 zinc finger protein 451 0.0203358
APP amyloid beta (A4) precursor protein 0.0202054
GRB2 growth factor receptor-bound protein 2 0.02016
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0200295
MDFIC MyoD family inhibitor domain containing 0.0199421
QKI QKI, KH domain containing, RNA binding 0.0199158
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0198617
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0198429
NAMPT nicotinamide phosphoribosyltransferase 0.0198136
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0197764
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0195406
FIP1L1 factor interacting with PAPOLA and CPSF1 0.0195035
FNDC3A fibronectin type III domain containing 3A 0.0194609
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0193664
ODR4 odr-4 GPCR localization factor homolog 0.0193588
ORC4 origin recognition complex, subunit 4 0.0192596
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 0.0192471
ZNF711 zinc finger protein 711 0.0192321
ATP5F1B ATP synthase F1 subunit beta 0.0191751
FAM171B family with sequence similarity 171, member B 0.0191124
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0188643
SCAF4 SR-related CTD-associated factor 4 0.0184643
TMEM59 transmembrane protein 59 0.0184255
SUCO SUN domain containing ossification factor 0.0183236
TMEM87A transmembrane protein 87A 0.0182949
CLASRP CLK4-associating serine/arginine rich protein 0.0182533
KPNA1 karyopherin alpha 1 (importin alpha 5) 0.0182392
OSBPL9 oxysterol binding protein-like 9 0.0182271
ZNF207 zinc finger protein 207 0.0181528
ARF1 ADP-ribosylation factor 1 0.0181491
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0180602
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0179341
RASAL2 RAS protein activator like 2 0.0179312
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0178751
SAFB scaffold attachment factor B 0.0178645

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.14591
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.13528
TMSB10 thymosin beta 10 -0.109009
COL11A1 collagen, type XI, alpha 1 -0.0808266
CADM2 cell adhesion molecule 2 -0.0733947
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0727911
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0707459
PTMA prothymosin, alpha -0.065278
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0620288
RPS6 ribosomal protein S6 -0.0601133
MEIS2 Meis homeobox 2 -0.057616
RPL12 ribosomal protein L12 -0.0572238
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0543268
RPS8 ribosomal protein S8 -0.0540941
RPL23 ribosomal protein L23 -0.052921
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0522732
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0484963
DST dystonin -0.0484619
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.0477495
RPS16 ribosomal protein S16 -0.0468426
RPLP1 ribosomal protein, large, P1 -0.0463214
DOCK5 dedicator of cytokinesis 5 -0.0455107
PDE4D phosphodiesterase 4D, cAMP-specific -0.0451956
NPAS3 neuronal PAS domain protein 3 -0.0435979
COL5A2 collagen, type V, alpha 2 -0.0433843
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0428607
RPL19 ribosomal protein L19 -0.0418271
LDHA lactate dehydrogenase A -0.0416531
RACK1 receptor for activated C kinase 1 -0.041496
ANKRD12 ankyrin repeat domain 12 -0.0414772
NTM neurotrimin -0.0414026
RPL37 ribosomal protein L37 -0.040215
PGK1 phosphoglycerate kinase 1 -0.0398045
TPT1 tumor protein, translationally-controlled 1 -0.0384307
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0381272
PCDH9 protocadherin 9 -0.0380973
TNRC6B trinucleotide repeat containing 6B -0.0376134
HMGB1 high mobility group box 1 -0.0373718
ACTG1 actin gamma 1 -0.0364444
RPL36 ribosomal protein L36 -0.0362391
RPS12 ribosomal protein S12 -0.0359281
MKI67 marker of proliferation Ki-67 -0.0351324
RPS3 ribosomal protein S3 -0.034902
RPL35A ribosomal protein L35a -0.0347112
GNAS GNAS complex locus -0.0341889
PCDH7 protocadherin 7 -0.0339614
CNRIP1 cannabinoid receptor interacting protein 1 -0.0338407
CUX1 cut-like homeobox 1 -0.0338285
BAZ1A bromodomain adjacent to zinc finger domain, 1A -0.0324337
CSNK1A1 casein kinase 1, alpha 1 -0.0321261
PARD3B par-3 family cell polarity regulator beta -0.0319553
NEBL nebulette -0.0318633
ADGRV1 adhesion G protein-coupled receptor V1 -0.0312815
WNK1 WNK lysine deficient protein kinase 1 -0.0310392
RPL37A ribosomal protein L37a -0.030612
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 -0.0305852
RPL9 ribosomal protein L9 -0.0301105
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.029916
RPL11 ribosomal protein L11 -0.0292813
RAI1 retinoic acid induced 1 -0.0290779
SNX6 sorting nexin 6 -0.02868
MBD5 methyl-CpG binding domain protein 5 -0.0285435
RPL5 ribosomal protein L5 -0.0281931
RAD51B RAD51 paralog B -0.028129
TENM3 teneurin transmembrane protein 3 -0.0280243
RPS24 ribosomal protein S24 -0.0279111
RPS14 ribosomal protein S14 -0.0277873
RPS19 ribosomal protein S19 -0.0272785
RPL31 ribosomal protein L31 -0.0271805
HSPB1 heat shock 27kDa protein 1 -0.0269816
AKAP12 A kinase (PRKA) anchor protein 12 -0.0269743
PPP1R12A protein phosphatase 1, regulatory subunit 12A -0.0269165
RPLP0 ribosomal protein, large, P0 -0.0267091
RAB31 RAB31, member RAS oncogene family -0.0266626
FTL ferritin, light polypeptide -0.0265029
RPL28 ribosomal protein L28 -0.0264863
FN1 fibronectin 1 -0.0263637
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0262148
GJA1 gap junction protein, alpha 1, 43kDa -0.0262088
RPLP2 ribosomal protein, large, P2 -0.0252708
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0251895
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0248536
AKAP9 A kinase (PRKA) anchor protein 9 -0.024661
BPTF bromodomain PHD finger transcription factor -0.0242657
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 -0.0242635
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0242128
SYT1 synaptotagmin I -0.0241352
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 -0.0240317
RPL26 ribosomal protein L26 -0.023979
MACF1 microtubule-actin crosslinking factor 1 -0.0239179
ATXN1 ataxin 1 -0.023839
SSH2 slingshot protein phosphatase 2 -0.0237918
PCLO piccolo presynaptic cytomatrix protein -0.0237905
RPS21 ribosomal protein S21 -0.0237517
KTN1 kinectin 1 (kinesin receptor) -0.0234745
NBEAL1 neurobeachin-like 1 -0.0231156
MT2A metallothionein 2A -0.0231004
RPS27A ribosomal protein S27a -0.0230903
PDIA3 protein disulfide isomerase family A, member 3 -0.0229859
TENM2 teneurin transmembrane protein 2 -0.0227052