Cinacalcet_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cinacalcet perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cinacalcet_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF2 eukaryotic translation elongation factor 2 0.261589
CPED1 cadherin-like and PC-esterase domain containing 1 0.139117
TMSB4X thymosin beta 4, X-linked 0.13046
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.122317
PDE4B phosphodiesterase 4B, cAMP-specific 0.100468
LPP LIM domain containing preferred translocation partner in lipoma 0.100084
GOLGA4 golgin A4 0.0971214
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0950623
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0937253
VCL vinculin 0.087198
TJP1 tight junction protein 1 0.0856141
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0817457
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0795649
ENO2 enolase 2 (gamma, neuronal) 0.076504
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0751293
HDLBP high density lipoprotein binding protein 0.0739055
PCBP2 poly(rC) binding protein 2 0.0698166
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0644373
LOC112694756 uncharaterized LOC112694756 0.0623705
PDGFC platelet derived growth factor C 0.062337
SSBP2 single-stranded DNA binding protein 2 0.0615324
TTC3 tetratricopeptide repeat domain 3 0.0611301
COPA coatomer protein complex, subunit alpha 0.0570624
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0570033
CANX calnexin 0.056064
LDHA lactate dehydrogenase A 0.0558917
ELOVL5 ELOVL fatty acid elongase 5 0.0556757
ZCCHC7 zinc finger, CCHC domain containing 7 0.0551443
SEC31A SEC31 homolog A (S. cerevisiae) 0.0541225
PGK1 phosphoglycerate kinase 1 0.0536883
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0511491
CAMKMT calmodulin-lysine N-methyltransferase 0.0505698
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.050393
ZEB1 zinc finger E-box binding homeobox 1 0.0503073
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 0.0499005
ECT2 epithelial cell transforming 2 0.0490488
EVI5 ecotropic viral integration site 5 0.0477253
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0472031
NFIA nuclear factor I/A 0.0458803
ADAM9 ADAM metallopeptidase domain 9 0.0458432
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0458274
COG6 component of oligomeric golgi complex 6 0.0455398
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0453288
FBLN2 fibulin 2 0.0417562
EIF4A1 eukaryotic translation initiation factor 4A1 0.0411089
CALR calreticulin 0.0410862
FHIT fragile histidine triad 0.0403922
BIRC6 baculoviral IAP repeat containing 6 0.0391996
NEBL nebulette 0.0390943
TAC4 tachykinin 4 (hemokinin) 0.0376136
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0376015
EIF4A2 eukaryotic translation initiation factor 4A2 0.0365742
PLXNA1 plexin A1 0.0360196
ENO1 enolase 1, (alpha) 0.0357589
ZNF608 zinc finger protein 608 0.0357367
RAB6A RAB6A, member RAS oncogene family 0.035727
GSK3B glycogen synthase kinase 3 beta 0.0356358
SPRED2 sprouty-related, EVH1 domain containing 2 0.0351753
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0346429
EPB41 erythrocyte membrane protein band 4.1 0.0344041
CD47 CD47 molecule 0.0340625
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0338452
EPS8 epidermal growth factor receptor pathway substrate 8 0.0337318
ANKRD17 ankyrin repeat domain 17 0.0335569
SOX6 SRY (sex determining region Y)-box 6 0.0331256
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.0329146
CALU calumenin 0.0328535
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0328234
PMM2 phosphomannomutase 2 0.032526
VMP1 vacuole membrane protein 1 0.0321862
XPOT exportin, tRNA 0.0321542
AMOTL2 angiomotin like 2 0.0320324
FKBP10 FK506 binding protein 10, 65 kDa 0.0316372
AHI1 Abelson helper integration site 1 0.0314912
ATP7B ATPase, Cu++ transporting, beta polypeptide 0.0314002
MON2 MON2 homolog (S. cerevisiae) 0.0312862
RPSA ribosomal protein SA 0.0312654
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0310268
ZC3H11A zinc finger CCCH-type containing 11A 0.0308397
GDI2 GDP dissociation inhibitor 2 0.0308267
PRPF38B pre-mRNA processing factor 38B 0.030477
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0303907
CSF1 colony stimulating factor 1 (macrophage) 0.0303903
FNDC3B fibronectin type III domain containing 3B 0.0302307
PNISR PNN-interacting serine/arginine-rich protein 0.0302259
SMC3 structural maintenance of chromosomes 3 0.0301746
SEC23A Sec23 homolog A (S. cerevisiae) 0.0300624
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0299481
GARS1 glycyl-tRNA synthetase 1 0.0296811
HDAC9 histone deacetylase 9 0.0294296
TGFBR3 transforming growth factor, beta receptor III 0.029411
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0293778
GANAB glucosidase, alpha; neutral AB 0.0289839
TXNIP thioredoxin interacting protein 0.0286651
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0284829
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0282973
SMYD3 SET and MYND domain containing 3 0.0282938
TMEM87A transmembrane protein 87A 0.0280975
YARS1 tyrosyl-tRNA synthetase 1 0.0279361
HELZ helicase with zinc finger 0.0279134

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.211249
PDE4D phosphodiesterase 4D, cAMP-specific -0.17676
RPS6 ribosomal protein S6 -0.106271
TPT1 tumor protein, translationally-controlled 1 -0.0879871
RPS2 ribosomal protein S2 -0.0797119
AHNAK AHNAK nucleoprotein -0.0780427
MKI67 marker of proliferation Ki-67 -0.0660228
RPS8 ribosomal protein S8 -0.065689
RPL26 ribosomal protein L26 -0.0494586
BMP10 bone morphogenetic protein 10 -0.0489294
RPL34 ribosomal protein L34 -0.0445741
RPLP1 ribosomal protein, large, P1 -0.0438358
ACTG1 actin gamma 1 -0.0432657
EIF1 eukaryotic translation initiation factor 1 -0.0427345
RPL38 ribosomal protein L38 -0.0417879
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0406199
ANXA1 annexin A1 -0.0403837
RPS19 ribosomal protein S19 -0.0403119
RPL9 ribosomal protein L9 -0.0402856
TM4SF1 transmembrane 4 L six family member 1 -0.0392396
MACROD2 MACRO domain containing 2 -0.0392045
RPL7 ribosomal protein L7 -0.0390628
MYO5C myosin VC -0.0382841
H1-4 H1.4 linker histone, cluster member -0.0378658
ADAM10 ADAM metallopeptidase domain 10 -0.0372342
RPL19 ribosomal protein L19 -0.0370692
RPL7A ribosomal protein L7a -0.0370348
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0357827
CCND1 cyclin D1 -0.0352286
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 -0.0351174
RPL37A ribosomal protein L37a -0.035115
RPL12 ribosomal protein L12 -0.0347753
NAMPT nicotinamide phosphoribosyltransferase -0.0342607
PKM pyruvate kinase, muscle -0.0341206
RPL36 ribosomal protein L36 -0.0338699
CENPF centromere protein F, 350/400kDa -0.0334637
RPS12 ribosomal protein S12 -0.0318396
DIAPH3 diaphanous-related formin 3 -0.0315883
RPL28 ribosomal protein L28 -0.0315584
SP100 SP100 nuclear antigen -0.031153
IFI16 interferon, gamma-inducible protein 16 -0.031091
RPS13 ribosomal protein S13 -0.0307254
TUBB4B tubulin, beta 4B class IVb -0.0306832
RPS23 ribosomal protein S23 -0.0291196
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0280204
RPL35A ribosomal protein L35a -0.0280098
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0279547
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0276645
RPS17 ribosomal protein S17 -0.0276441
HJURP Holliday junction recognition protein -0.0274748
S100A11 S100 calcium binding protein A11 -0.0269262
NIPBL Nipped-B homolog (Drosophila) -0.0264216
GLI3 GLI family zinc finger 3 -0.0263033
FER fer (fps/fes related) tyrosine kinase -0.0262755
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0261271
TRIO trio Rho guanine nucleotide exchange factor -0.0260172
TXNRD1 thioredoxin reductase 1 -0.0259271
RPS16 ribosomal protein S16 -0.0258079
RPL11 ribosomal protein L11 -0.0252042
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.025013
RPL23 ribosomal protein L23 -0.0249006
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0243571
PAPOLA poly(A) polymerase alpha -0.0240992
SPRY4 sprouty homolog 4 (Drosophila) -0.0240853
RIGI RNA sensor RIG-I -0.0237706
RPL21 ribosomal protein L21 -0.023687
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0236461
CARD16 caspase recruitment domain family, member 16 -0.0233317
NIN ninein (GSK3B interacting protein) -0.0227954
KIAA1958 KIAA1958 -0.0227581
RPLP2 ribosomal protein, large, P2 -0.0224972
WSB1 WD repeat and SOCS box containing 1 -0.0223547
HDGFL3 HDGF like 3 -0.0222893
RPS24 ribosomal protein S24 -0.0220645
GCLM glutamate-cysteine ligase, modifier subunit -0.0218278
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0217863
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0217486
RSRC1 arginine/serine-rich coiled-coil 1 -0.0217005
SDK1 sidekick cell adhesion molecule 1 -0.0216953
TRA2B transformer 2 beta homolog (Drosophila) -0.0215424
RFC3 replication factor C (activator 1) 3, 38kDa -0.0211263
RPS29 ribosomal protein S29 -0.0209546
B2M beta-2-microglobulin -0.0206862
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) -0.0206018
TAOK1 TAO kinase 1 -0.020567
RPL27 ribosomal protein L27 -0.0202172
MPHOSPH8 M-phase phosphoprotein 8 -0.0201102
ARL15 ADP-ribosylation factor-like 15 -0.0201011
PRH1 proline-rich protein HaeIII subfamily 1 -0.0199627
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0198596
TNPO3 transportin 3 -0.0198356
RPL14 ribosomal protein L14 -0.019749
CKAP2 cytoskeleton associated protein 2 -0.0191997
PRRC2C proline-rich coiled-coil 2C -0.0191597
NMD3 NMD3 ribosome export adaptor -0.0190808
ATP11B ATPase, class VI, type 11B -0.0190664
RPL32 ribosomal protein L32 -0.0188807
RPS3 ribosomal protein S3 -0.0187431
PHIP pleckstrin homology domain interacting protein -0.0186594
CREBBP CREB binding protein -0.0186489