Cinacalcet_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cinacalcet perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cinacalcet_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.173228
HOOK2 hook microtubule-tethering protein 2 0.0548344
MYH9 myosin, heavy chain 9, non-muscle 0.0513026
TGFBI transforming growth factor, beta-induced, 68kDa 0.045327
LOXL2 lysyl oxidase-like 2 0.0417778
AKAP9 A kinase (PRKA) anchor protein 9 0.0413725
OGA O-GlcNAcase 0.0406282
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.037191
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.036726
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0335629
DSCAM Down syndrome cell adhesion molecule 0.031508
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0306467
COPA coatomer protein complex, subunit alpha 0.0302772
COG5 component of oligomeric golgi complex 5 0.0297939
JARID2 jumonji, AT rich interactive domain 2 0.0288514
SEC24D SEC24 family member D 0.0287861
SOD2 superoxide dismutase 2, mitochondrial 0.0280372
NRXN3 neurexin 3 0.0273951
COG6 component of oligomeric golgi complex 6 0.0273904
ARRDC3 arrestin domain containing 3 0.0269754
SND1 staphylococcal nuclease and tudor domain containing 1 0.0268518
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0267982
PDLIM5 PDZ and LIM domain 5 0.0254046
ANXA5 annexin A5 0.0246114
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0244092
CDH13 cadherin 13 0.0242374
SPAG9 sperm associated antigen 9 0.0232168
FNDC3B fibronectin type III domain containing 3B 0.0231515
AVL9 AVL9 homolog (S. cerevisiase) 0.023123
CANX calnexin 0.0229899
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0228724
HDLBP high density lipoprotein binding protein 0.0226678
ELL2 elongation factor, RNA polymerase II, 2 0.0226223
RND3 Rho family GTPase 3 0.0225743
SEC31A SEC31 homolog A (S. cerevisiae) 0.0219549
NAMPT nicotinamide phosphoribosyltransferase 0.0216863
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0214536
AFF4 AF4/FMR2 family, member 4 0.0213927
WDFY3 WD repeat and FYVE domain containing 3 0.0212013
SUCO SUN domain containing ossification factor 0.0211894
FNIP1 folliculin interacting protein 1 0.0211518
COL5A1 collagen, type V, alpha 1 0.0210787
TPM3 tropomyosin 3 0.0207975
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0207156
PLEC plectin 0.0203706
NDRG1 N-myc downstream regulated 1 0.0202828
COPB1 coatomer protein complex, subunit beta 1 0.0202493
AHNAK AHNAK nucleoprotein 0.02021
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0196393
HIP1 huntingtin interacting protein 1 0.0194247
FLNA filamin A, alpha 0.0190407
SRP54 signal recognition particle 54kDa 0.0189961
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0183694
SAMD4A sterile alpha motif domain containing 4A 0.0183551
NFE2L1 nuclear factor, erythroid 2-like 1 0.0181633
TPST1 tyrosylprotein sulfotransferase 1 0.0180836
SEC24A SEC24 family member A 0.0180614
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0180213
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.0178681
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0178659
TRA2A transformer 2 alpha homolog (Drosophila) 0.0176913
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0176844
COL1A2 collagen, type I, alpha 2 0.0176496
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.01758
HELZ helicase with zinc finger 0.0172664
RAB8B RAB8B, member RAS oncogene family 0.0171821
GLS2 glutaminase 2 (liver, mitochondrial) 0.0168766
PCBP2 poly(rC) binding protein 2 0.0168211
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0167984
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0166353
MARCHF6 membrane associated ring-CH-type finger 6 0.0166133
CLINT1 clathrin interactor 1 0.016581
COL6A1 collagen, type VI, alpha 1 0.0164948
SKIC3 SKI3 subunit of superkiller complex 0.016094
ASCC3 activating signal cointegrator 1 complex subunit 3 0.016092
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0160691
FOXJ3 forkhead box J3 0.0160489
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0158558
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0157971
FAM13A family with sequence similarity 13, member A 0.015665
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0155499
ZSWIM6 zinc finger, SWIM-type containing 6 0.015513
IQGAP1 IQ motif containing GTPase activating protein 1 0.0154189
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.0153473
ANKHD1 ankyrin repeat and KH domain containing 1 0.0153312
MBNL2 muscleblind-like splicing regulator 2 0.015198
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0151052
HAPSTR1 HUWE1 associated protein modifying stress responses 0.0151012
DIDO1 death inducer-obliterator 1 0.0150111
XPO1 exportin 1 0.0149662
KMT2E lysine (K)-specific methyltransferase 2E 0.0149607
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0149437
TENT5A terminal nucleotidyltransferase 5A 0.0148924
YTHDC1 YTH domain containing 1 0.0148127
CALR calreticulin 0.0147717
SNX13 sorting nexin 13 0.0146518
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 0.0146312
PTBP2 polypyrimidine tract binding protein 2 0.0146011
COL5A2 collagen, type V, alpha 2 0.01446
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0144503

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.303974
MT2A metallothionein 2A -0.193295
VIM vimentin -0.136367
TMSB10 thymosin beta 10 -0.13133
PTMA prothymosin, alpha -0.092017
FTL ferritin, light polypeptide -0.0894379
HLA-B major histocompatibility complex, class I, B -0.0804896
MT1X metallothionein 1X -0.0725671
B2M beta-2-microglobulin -0.0671314
POTEF POTE ankyrin domain family, member F -0.0522675
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0484931
S100A9 S100 calcium binding protein A9 -0.047482
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0456207
ENO1 enolase 1, (alpha) -0.0455896
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0446686
RPS8 ribosomal protein S8 -0.0395774
RPS6 ribosomal protein S6 -0.0383967
RPLP1 ribosomal protein, large, P1 -0.0382133
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0380814
IGFBP3 insulin-like growth factor binding protein 3 -0.0372214
COL1A1 collagen, type I, alpha 1 -0.0370503
RPS19 ribosomal protein S19 -0.0358151
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.035311
RPLP2 ribosomal protein, large, P2 -0.0346969
RACK1 receptor for activated C kinase 1 -0.0333664
RPL37A ribosomal protein L37a -0.0329711
RPL35A ribosomal protein L35a -0.032191
S100A6 S100 calcium binding protein A6 -0.0317042
H3-3B H3.3 histone B -0.0299916
RPS24 ribosomal protein S24 -0.0298026
RPL28 ribosomal protein L28 -0.0296681
STC1 stanniocalcin 1 -0.0286445
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0285922
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0282394
RPL11 ribosomal protein L11 -0.0281542
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0269162
PTN pleiotrophin -0.0267666
TPT1 tumor protein, translationally-controlled 1 -0.026595
MAP1B microtubule-associated protein 1B -0.0264503
ACTG1 actin gamma 1 -0.026317
PFN1 profilin 1 -0.0261041
CCNI cyclin I -0.0255386
RPL15 ribosomal protein L15 -0.0255063
RPL23 ribosomal protein L23 -0.0252251
HLA-A major histocompatibility complex, class I, A -0.0250868
CD44 CD44 molecule (Indian blood group) -0.024534
RPL34 ribosomal protein L34 -0.0241002
RPL5 ribosomal protein L5 -0.0239039
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0237973
RPS5 ribosomal protein S5 -0.0232083
IGFBP7 insulin-like growth factor binding protein 7 -0.0230797
TPI1 triosephosphate isomerase 1 -0.0229867
NAP1L1 nucleosome assembly protein 1-like 1 -0.0228622
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0228156
PGK1 phosphoglycerate kinase 1 -0.0227844
FLOT1 flotillin 1 -0.0227481
CBX3 chromobox homolog 3 -0.0226631
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0225851
RPL26 ribosomal protein L26 -0.02218
EGR1 early growth response 1 -0.0219522
ZMYND8 zinc finger, MYND-type containing 8 -0.0214204
RPL12 ribosomal protein L12 -0.0210411
RPL19 ribosomal protein L19 -0.0209819
PRSS23 protease, serine, 23 -0.020717
RPL37 ribosomal protein L37 -0.0206427
EIF1 eukaryotic translation initiation factor 1 -0.0205546
LMNA lamin A/C -0.0205057
SEPTIN7 septin 7 -0.0203408
RPS23 ribosomal protein S23 -0.0200404
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0195625
RPS14 ribosomal protein S14 -0.0191933
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0188554
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0188521
RPS27A ribosomal protein S27a -0.0188281
SEC61G Sec61 gamma subunit -0.0187999
RPS12 ribosomal protein S12 -0.0185894
YBX1 Y box binding protein 1 -0.01858
RPL7 ribosomal protein L7 -0.0181775
RPS21 ribosomal protein S21 -0.018081
FN1 fibronectin 1 -0.0180526
TUBB tubulin, beta class I -0.0179157
IL6 interleukin 6 -0.0178639
RPL8 ribosomal protein L8 -0.0177003
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0176685
HMGB1 high mobility group box 1 -0.0176186
FRMD4A FERM domain containing 4A -0.0173499
RPS13 ribosomal protein S13 -0.0173245
RPL31 ribosomal protein L31 -0.0173007
RPS11 ribosomal protein S11 -0.0171319
CKAP4 cytoskeleton-associated protein 4 -0.0171249
TM4SF1 transmembrane 4 L six family member 1 -0.0169815
NAV2 neuron navigator 2 -0.0166398
SLC38A2 solute carrier family 38, member 2 -0.0165956
LDHA lactate dehydrogenase A -0.0165956
RPL32 ribosomal protein L32 -0.016587
TUBA1B tubulin, alpha 1b -0.0165796
UBC ubiquitin C -0.0165518
ANLN anillin, actin binding protein -0.0161539
HLA-C major histocompatibility complex, class I, C -0.0160879
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0158367