Citalopram (hydrobromide)_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Citalopram (hydrobromide) perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Citalopram (hydrobromide)_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.213228
CDH13 cadherin 13 0.12154
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.117938
TRIO trio Rho guanine nucleotide exchange factor 0.114898
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.112736
COL5A1 collagen, type V, alpha 1 0.0932643
SLC39A11 solute carrier family 39, member 11 0.0919909
NAV1 neuron navigator 1 0.0842164
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0787952
PODXL podocalyxin-like 0.0733894
AKAP12 A kinase (PRKA) anchor protein 12 0.0725456
EGFR epidermal growth factor receptor 0.0632506
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0613706
NAV2 neuron navigator 2 0.0579826
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.056206
DLG1 discs, large homolog 1 (Drosophila) 0.0555678
FLNB filamin B, beta 0.0543154
FLNA filamin A, alpha 0.0533127
SEPTIN9 septin 9 0.0522743
PBX3 pre-B-cell leukemia homeobox 3 0.0511534
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.050625
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0492306
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0483897
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0480658
MACF1 microtubule-actin crosslinking factor 1 0.0470135
TPM3 tropomyosin 3 0.0460939
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0449177
ABI3BP ABI family, member 3 (NESH) binding protein 0.0447747
EEF2 eukaryotic translation elongation factor 2 0.0442575
DST dystonin 0.0411819
MYH9 myosin, heavy chain 9, non-muscle 0.039743
HDAC9 histone deacetylase 9 0.0392606
MSI2 musashi RNA-binding protein 2 0.038824
FN1 fibronectin 1 0.0387018
EFNA5 ephrin-A5 0.0385947
CALR calreticulin 0.0375468
MSN moesin 0.0375316
L1CAM L1 cell adhesion molecule 0.0372729
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0370498
POTEF POTE ankyrin domain family, member F 0.0366601
ZMIZ1 zinc finger, MIZ-type containing 1 0.036367
PLAT plasminogen activator, tissue 0.035622
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.0329027
NCOR2 nuclear receptor corepressor 2 0.0326272
RACK1 receptor for activated C kinase 1 0.0322521
DSPP dentin sialophosphoprotein 0.0320255
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0314671
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0313289
ANKRD11 ankyrin repeat domain 11 0.0308532
FAM219A family with sequence similarity 219, member A 0.0307489
NDRG1 N-myc downstream regulated 1 0.0299443
SPIRE1 spire-type actin nucleation factor 1 0.0295293
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0295257
AUTS2 autism susceptibility candidate 2 0.0292429
BACE2 beta-site APP-cleaving enzyme 2 0.0292396
PLEC plectin 0.0292121
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.0288883
CD59 CD59 molecule, complement regulatory protein 0.0286999
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0284282
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0278984
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0278631
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0266191
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0259176
AFF3 AF4/FMR2 family, member 3 0.025674
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.0249815
SP3 Sp3 transcription factor 0.0247861
CEP170 centrosomal protein 170kDa 0.024641
AFDN afadin, adherens junction formation factor 0.0242651
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0242566
MCL1 myeloid cell leukemia 1 0.0235423
NFE2L1 nuclear factor, erythroid 2-like 1 0.0234772
RAB11FIP3 RAB11 family interacting protein 3 (class II) 0.0232262
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0230984
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0228958
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0226505
CENPF centromere protein F, 350/400kDa 0.0222651
CD109 CD109 molecule 0.0221468
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0220424
RUNX1 runt-related transcription factor 1 0.0218535
SUCNR1 succinate receptor 1 0.0215164
VEGFA vascular endothelial growth factor A 0.020872
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0206598
RNF144A ring finger protein 144A 0.0206417
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.020611
ADARB1 adenosine deaminase, RNA-specific, B1 0.0205884
DGKG diacylglycerol kinase, gamma 90kDa 0.0204192
FOSL1 FOS-like antigen 1 0.0203123
MYOF myoferlin 0.0201123
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0200353
ALCAM activated leukocyte cell adhesion molecule 0.0199849
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0199269
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0198008
ASPH aspartate beta-hydroxylase 0.0197586
XKR6 XK, Kell blood group complex subunit-related family, member 6 0.0197421
FLT1 fms-related tyrosine kinase 1 0.0194601
PIEZO1 piezo-type mechanosensitive ion channel component 1 0.0194435
ZEB1 zinc finger E-box binding homeobox 1 0.0192226
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0191826
SAMD4A sterile alpha motif domain containing 4A 0.0191074
CYTH3 cytohesin 3 0.0190971

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.178749
TMSB10 thymosin beta 10 -0.130167
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.113338
VIM vimentin -0.093015
HLA-B major histocompatibility complex, class I, B -0.0843497
FBN1 fibrillin 1 -0.0816966
MT2A metallothionein 2A -0.0816173
COL1A2 collagen, type I, alpha 2 -0.0771274
LOX lysyl oxidase -0.0729624
COL3A1 collagen, type III, alpha 1 -0.0698036
ANXA2 annexin A2 -0.0632471
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0618786
S100A10 S100 calcium binding protein A10 -0.0552329
SQSTM1 sequestosome 1 -0.0478564
PTMA prothymosin, alpha -0.042765
HLA-C major histocompatibility complex, class I, C -0.0379527
IFITM3 interferon induced transmembrane protein 3 -0.0370584
NAP1L1 nucleosome assembly protein 1-like 1 -0.0369857
IFITM1 interferon induced transmembrane protein 1 -0.033584
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0325924
CSTB cystatin B (stefin B) -0.0320408
COL5A2 collagen, type V, alpha 2 -0.0320033
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0313526
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0311816
OGA O-GlcNAcase -0.0308472
MX2 MX dynamin-like GTPase 2 -0.0307409
GLIS3 GLIS family zinc finger 3 -0.0302382
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0294583
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0294405
CAVIN1 caveolae associated protein 1 -0.028599
ZBTB20 zinc finger and BTB domain containing 20 -0.027651
GPC6 glypican 6 -0.0268745
TM4SF1 transmembrane 4 L six family member 1 -0.0266772
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0263796
THBS2 thrombospondin 2 -0.0261814
S100A6 S100 calcium binding protein A6 -0.0261491
MEIS2 Meis homeobox 2 -0.0254637
IFI16 interferon, gamma-inducible protein 16 -0.0250219
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 -0.024528
RPS24 ribosomal protein S24 -0.0243059
WWTR1 WW domain containing transcription regulator 1 -0.0242571
STC1 stanniocalcin 1 -0.0241457
TXNIP thioredoxin interacting protein -0.0237772
TPT1 tumor protein, translationally-controlled 1 -0.0237092
HLA-E major histocompatibility complex, class I, E -0.0234219
AHNAK AHNAK nucleoprotein -0.0233487
CD44 CD44 molecule (Indian blood group) -0.023284
ANKRD10 ankyrin repeat domain 10 -0.0232308
PXDN peroxidasin -0.0230397
ARF1 ADP-ribosylation factor 1 -0.0229853
ACTG1 actin gamma 1 -0.0229681
RAD21 RAD21 homolog (S. pombe) -0.0227043
IFIH1 interferon induced with helicase C domain 1 -0.0224326
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0219723
H3-3B H3.3 histone B -0.0218986
RAI14 retinoic acid induced 14 -0.0218104
RRBP1 ribosome binding protein 1 -0.021513
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0214561
RHOBTB3 Rho-related BTB domain containing 3 -0.0213641
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0212151
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0210586
RPL28 ribosomal protein L28 -0.0210544
SLC38A1 solute carrier family 38, member 1 -0.020561
NPR2 natriuretic peptide receptor 2 -0.0204704
SDC4 syndecan 4 -0.0203812
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0202182
DPYSL3 dihydropyrimidinase-like 3 -0.0198916
KIFAP3 kinesin-associated protein 3 -0.0198469
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0195271
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0194829
NF1 neurofibromin 1 -0.0193988
RTN4 reticulon 4 -0.0193222
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0192112
EPAS1 endothelial PAS domain protein 1 -0.0191494
PLAUR plasminogen activator, urokinase receptor -0.0190297
IFI6 interferon, alpha-inducible protein 6 -0.0189493
HSPB1 heat shock 27kDa protein 1 -0.0189138
LMAN1 lectin, mannose-binding, 1 -0.0187377
EIF1 eukaryotic translation initiation factor 1 -0.018557
GLG1 golgi glycoprotein 1 -0.0185194
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0184234
KDM3A lysine (K)-specific demethylase 3A -0.0181409
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0181403
ARL4C ADP-ribosylation factor-like 4C -0.0176278
CKAP4 cytoskeleton-associated protein 4 -0.0175336
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0172327
MPZL1 myelin protein zero-like 1 -0.0170129
TMEM263 transmembrane protein 263 -0.016976
PCNP PEST proteolytic signal containing nuclear protein -0.0166768
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0165012
GNAS GNAS complex locus -0.0164726
LMNA lamin A/C -0.0164183
TMSB4X thymosin beta 4, X-linked -0.0163625
MT1X metallothionein 1X -0.0163512
CCND1 cyclin D1 -0.0162349
PSD3 pleckstrin and Sec7 domain containing 3 -0.0162175
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0162106
UBC ubiquitin C -0.0161549
PLSCR1 phospholipid scramblase 1 -0.0160395
NKTR natural killer cell triggering receptor -0.0159127