Citalopram (hydrobromide)_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Citalopram (hydrobromide) perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Citalopram (hydrobromide)_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF2 eukaryotic translation elongation factor 2 0.0762189
PDE4D phosphodiesterase 4D, cAMP-specific 0.0740521
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0682928
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0640433
YAP1 Yes-associated protein 1 0.0514839
RACK1 receptor for activated C kinase 1 0.0486278
TENM3 teneurin transmembrane protein 3 0.0450437
PDGFC platelet derived growth factor C 0.0441758
HMGA2 high mobility group AT-hook 2 0.0440369
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0433335
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0424731
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0338711
CCNL1 cyclin L1 0.0327803
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0326025
PDK4 pyruvate dehydrogenase kinase, isozyme 4 0.0315961
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0309278
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0306173
RPL3 ribosomal protein L3 0.0299352
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0292089
EPHA6 EPH receptor A6 0.0278451
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.027342
MED13L mediator complex subunit 13-like 0.0268265
HDAC9 histone deacetylase 9 0.0267744
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0263946
INTS6 integrator complex subunit 6 0.025402
NCKAP1 NCK-associated protein 1 0.0234438
HSPA8 heat shock 70kDa protein 8 0.02313
GASK1B golgi associated kinase 1B 0.0229418
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0227455
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0225962
TXNRD1 thioredoxin reductase 1 0.0221822
ATP11A ATPase, class VI, type 11A 0.0220309
TPM3 tropomyosin 3 0.0219938
CLDND1 claudin domain containing 1 0.0217367
NUMA1 nuclear mitotic apparatus protein 1 0.0215968
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0213943
MSRB3 methionine sulfoxide reductase B3 0.0210552
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0209085
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0208845
DENND5A DENN/MADD domain containing 5A 0.0206071
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0205622
RAD51B RAD51 paralog B 0.0196781
ZBTB20 zinc finger and BTB domain containing 20 0.0195535
USP9X ubiquitin specific peptidase 9, X-linked 0.0192818
ADGRG6 adhesion G protein-coupled receptor G6 0.0190422
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0186083
PCBP2 poly(rC) binding protein 2 0.01853
ZSWIM6 zinc finger, SWIM-type containing 6 0.0184282
DST dystonin 0.018197
NFIB nuclear factor I/B 0.0180474
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0176462
SRRM2 serine/arginine repetitive matrix 2 0.0176354
WNK1 WNK lysine deficient protein kinase 1 0.0175925
NFE2L1 nuclear factor, erythroid 2-like 1 0.017364
ETNK1 ethanolamine kinase 1 0.0172044
PHC3 polyhomeotic homolog 3 (Drosophila) 0.017093
WWOX WW domain containing oxidoreductase 0.0170595
EXOC6B exocyst complex component 6B 0.0169338
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0165426
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0165028
RCOR1 REST corepressor 1 0.0161729
BRD2 bromodomain containing 2 0.016136
PER1 period circadian clock 1 0.0161173
ARHGAP12 Rho GTPase activating protein 12 0.0160735
VCL vinculin 0.0159191
MPG N-methylpurine-DNA glycosylase 0.0157249
CPOX coproporphyrinogen oxidase 0.0156945
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0156048
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0155755
GSK3B glycogen synthase kinase 3 beta 0.015551
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 0.0155503
ARRDC3 arrestin domain containing 3 0.0154108
SFPQ splicing factor proline/glutamine-rich 0.0153802
TFG TRK-fused gene 0.0152461
PCM1 pericentriolar material 1 0.0152021
AHR aryl hydrocarbon receptor 0.0151919
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0151822
KDM6A lysine (K)-specific demethylase 6A 0.0151451
DSPP dentin sialophosphoprotein 0.0150462
MYH9 myosin, heavy chain 9, non-muscle 0.014995
YBX1 Y box binding protein 1 0.0149816
CCSER1 coiled-coil serine-rich protein 1 0.0149712
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0148322
KIF5B kinesin family member 5B 0.0148271
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.014827
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.014732
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 0.0145534
AXIN2 axin 2 0.0145244
SERTAD2 SERTA domain containing 2 0.0145183
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0144724
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0143927
RNF13 ring finger protein 13 0.0143379
NEK7 NIMA-related kinase 7 0.0142701
DCAF8 DDB1 and CUL4 associated factor 8 0.0142374
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0142059
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0140844
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0140071
BIRC2 baculoviral IAP repeat containing 2 0.0139024
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0137699
KLC1 kinesin light chain 1 0.0137072

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.409042
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.322283
TMSB10 thymosin beta 10 -0.149755
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.113901
PTMA prothymosin, alpha -0.113248
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.108806
ACTG1 actin gamma 1 -0.090964
MYL12B myosin, light chain 12B, regulatory -0.090005
TPT1 tumor protein, translationally-controlled 1 -0.0735896
ANKRD12 ankyrin repeat domain 12 -0.069986
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0670486
NAP1L1 nucleosome assembly protein 1-like 1 -0.0645134
IFIH1 interferon induced with helicase C domain 1 -0.0614608
FTL ferritin, light polypeptide -0.060104
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0561347
RPL35A ribosomal protein L35a -0.0497643
RPS6 ribosomal protein S6 -0.0491593
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0486524
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0478304
RPS27A ribosomal protein S27a -0.0473007
KPNB1 karyopherin (importin) beta 1 -0.0444968
S100A6 S100 calcium binding protein A6 -0.0435946
CUBN cubilin (intrinsic factor-cobalamin receptor) -0.0412749
VDAC1 voltage-dependent anion channel 1 -0.0412056
HSPB1 heat shock 27kDa protein 1 -0.0404942
AREG amphiregulin -0.0399964
RPS8 ribosomal protein S8 -0.0389398
HMGA1 high mobility group AT-hook 1 -0.0388934
RPS24 ribosomal protein S24 -0.037793
YBX3 Y box binding protein 3 -0.0376309
CCND1 cyclin D1 -0.0360972
TUBA1B tubulin, alpha 1b -0.0356933
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.034958
RPLP1 ribosomal protein, large, P1 -0.0347925
TMEM41B transmembrane protein 41B -0.0343008
S100A10 S100 calcium binding protein A10 -0.0337469
TMEM123 transmembrane protein 123 -0.0323878
PRDX1 peroxiredoxin 1 -0.0315431
PGK1 phosphoglycerate kinase 1 -0.0312269
SMC4 structural maintenance of chromosomes 4 -0.0308311
RPL38 ribosomal protein L38 -0.0306233
RPS29 ribosomal protein S29 -0.0303168
RPLP0 ribosomal protein, large, P0 -0.0296224
ENO1 enolase 1, (alpha) -0.0294657
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0293236
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0291002
RPL19 ribosomal protein L19 -0.0289226
RPLP2 ribosomal protein, large, P2 -0.0288834
CLDN1 claudin 1 -0.0287955
RPS23 ribosomal protein S23 -0.028694
RASAL2 RAS protein activator like 2 -0.028614
ATP5F1B ATP synthase F1 subunit beta -0.0286101
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.028556
RPL34 ribosomal protein L34 -0.0283077
GNAS GNAS complex locus -0.0282097
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0278552
RPS13 ribosomal protein S13 -0.0276984
RPS21 ribosomal protein S21 -0.0276965
WSB1 WD repeat and SOCS box containing 1 -0.0275475
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0273084
RPS3 ribosomal protein S3 -0.0272068
TM4SF1 transmembrane 4 L six family member 1 -0.0269512
AKAP12 A kinase (PRKA) anchor protein 12 -0.026826
PA2G4 proliferation-associated 2G4, 38kDa -0.0262304
RPL37A ribosomal protein L37a -0.0261901
RPL37 ribosomal protein L37 -0.0261705
SLC38A1 solute carrier family 38, member 1 -0.0257078
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0256418
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0253727
BRI3BP BRI3 binding protein -0.0252395
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0249883
RPL12 ribosomal protein L12 -0.0248066
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0246166
LDHB lactate dehydrogenase B -0.0245156
RPS16 ribosomal protein S16 -0.0244495
GCG glucagon -0.0243468
SEPTIN7 septin 7 -0.0231257
RPL28 ribosomal protein L28 -0.0231199
RPS15 ribosomal protein S15 -0.0226903
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) -0.0226006
RPL26 ribosomal protein L26 -0.0225214
RPL31 ribosomal protein L31 -0.0225185
RPL9 ribosomal protein L9 -0.0225139
RPL36A ribosomal protein L36a -0.0224803
RPL11 ribosomal protein L11 -0.0224129
RTN4 reticulon 4 -0.0222541
PFN1 profilin 1 -0.0221647
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.022068
MKI67 marker of proliferation Ki-67 -0.0218452
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.021701
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0216946
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0215328
RPL7A ribosomal protein L7a -0.0211695
CCNI cyclin I -0.0209906
LDHA lactate dehydrogenase A -0.0207443
EHBP1 EH domain binding protein 1 -0.0206128
RAB1A RAB1A, member RAS oncogene family -0.0204447
RPS19 ribosomal protein S19 -0.0203929
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0202854
RPL27A ribosomal protein L27a -0.0201572