Citalopram (hydrobromide)_AN3 CA Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Citalopram (hydrobromide) perturbation in AN3 CA cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Citalopram (hydrobromide)_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.0997182
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0982207
CENPF centromere protein F, 350/400kDa 0.0830785
EEF2 eukaryotic translation elongation factor 2 0.0757994
PABPC1 poly(A) binding protein, cytoplasmic 1 0.070324
MKI67 marker of proliferation Ki-67 0.0668495
MED13L mediator complex subunit 13-like 0.0667733
TRIO trio Rho guanine nucleotide exchange factor 0.0540611
PRELID2 PRELI domain containing 2 0.0511246
ZNF608 zinc finger protein 608 0.0510767
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0506129
OGA O-GlcNAcase 0.0499434
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0493368
AFF4 AF4/FMR2 family, member 4 0.0473869
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0464838
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0464742
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0445578
TOP2B topoisomerase (DNA) II beta 180kDa 0.0438384
XPO1 exportin 1 0.0433518
TRIP12 thyroid hormone receptor interactor 12 0.0427459
GPHN gephyrin 0.042252
ARHGAP21 Rho GTPase activating protein 21 0.0419646
KMT2C lysine (K)-specific methyltransferase 2C 0.0412332
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0406662
CANX calnexin 0.0394979
MACF1 microtubule-actin crosslinking factor 1 0.0394935
RACK1 receptor for activated C kinase 1 0.0388692
JMJD1C jumonji domain containing 1C 0.0385058
CDC73 cell division cycle 73 0.0376023
IPO7 importin 7 0.0374504
FMNL2 formin-like 2 0.0368472
SSBP2 single-stranded DNA binding protein 2 0.0362608
SFPQ splicing factor proline/glutamine-rich 0.035657
SPIDR scaffolding protein involved in DNA repair 0.0350669
ZNF292 zinc finger protein 292 0.0349067
LDHA lactate dehydrogenase A 0.0347485
VEGFA vascular endothelial growth factor A 0.0344337
RPL3 ribosomal protein L3 0.0337983
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0335491
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0333555
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0329235
SMAP1 small ArfGAP 1 0.0328345
TMSB4X thymosin beta 4, X-linked 0.0326961
GSE1 Gse1 coiled-coil protein 0.0325502
SRPK2 SRSF protein kinase 2 0.0325396
YEATS2 YEATS domain containing 2 0.03246
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.032061
AKAP13 A kinase (PRKA) anchor protein 13 0.0319694
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0314479
SH3RF1 SH3 domain containing ring finger 1 0.030981
FGFR1 fibroblast growth factor receptor 1 0.0308465
PPME1 protein phosphatase methylesterase 1 0.0306442
DOCK3 dedicator of cytokinesis 3 0.0305897
SMC1A structural maintenance of chromosomes 1A 0.0305684
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0300637
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0299424
PHF21A PHD finger protein 21A 0.0297964
HMGB2 high mobility group box 2 0.0294282
HOXA3 homeobox A3 0.0293945
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0293904
PCBP2 poly(rC) binding protein 2 0.0291227
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0291197
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0289766
CALR calreticulin 0.0289379
NCKAP1 NCK-associated protein 1 0.0289281
TRA2A transformer 2 alpha homolog (Drosophila) 0.0288526
FUS FUS RNA binding protein 0.0284186
SKP1 S-phase kinase-associated protein 1 0.0282336
PUM2 pumilio RNA-binding family member 2 0.0282327
CHD9 chromodomain helicase DNA binding protein 9 0.0282323
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0281539
SBF2 SET binding factor 2 0.0281067
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0281014
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0278882
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0278173
ELOVL5 ELOVL fatty acid elongase 5 0.0278161
FN1 fibronectin 1 0.0277705
MATR3 matrin 3 0.0277253
GPC6 glypican 6 0.0277133
RREB1 ras responsive element binding protein 1 0.027605
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0275678
NCOR1 nuclear receptor corepressor 1 0.0273455
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0269515
TPR translocated promoter region, nuclear basket protein 0.0269362
SPAG9 sperm associated antigen 9 0.0268923
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.026811
CD2AP CD2-associated protein 0.0268062
MYH9 myosin, heavy chain 9, non-muscle 0.0266293
KTN1 kinectin 1 (kinesin receptor) 0.0265796
DENND1A DENN/MADD domain containing 1A 0.0264724
MYO9A myosin IXA 0.0263434
PARD3 par-3 family cell polarity regulator 0.026332
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0262908
MICU1 mitochondrial calcium uptake 1 0.0261209
AKAP12 A kinase (PRKA) anchor protein 12 0.0260046
MCL1 myeloid cell leukemia 1 0.0258364
APLP2 amyloid beta (A4) precursor-like protein 2 0.025813
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0257114
FAM168A family with sequence similarity 168, member A 0.0256239
YAP1 Yes-associated protein 1 0.0254119

decreased expression

Symbol Name Standardized Value
MEST mesoderm specific transcript -0.12743
MGP matrix Gla protein -0.0811152
VIM vimentin -0.0719358
PTMA prothymosin, alpha -0.0691548
PRKG1 protein kinase, cGMP-dependent, type I -0.0572432
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0562453
CADM2 cell adhesion molecule 2 -0.0556299
MEOX2 mesenchyme homeobox 2 -0.0413364
ZBTB20 zinc finger and BTB domain containing 20 -0.0398627
TMSB10 thymosin beta 10 -0.0391435
BCAS3 breast carcinoma amplified sequence 3 -0.0364222
FTL ferritin, light polypeptide -0.0357496
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.034718
RPS8 ribosomal protein S8 -0.0344947
DLG1 discs, large homolog 1 (Drosophila) -0.0317559
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0292639
SEPTIN11 septin 11 -0.0283956
MAP1B microtubule-associated protein 1B -0.0272065
RPS24 ribosomal protein S24 -0.0257788
TPK1 thiamin pyrophosphokinase 1 -0.0257444
SIRT1 sirtuin 1 -0.0250267
PHF14 PHD finger protein 14 -0.0248548
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0242918
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.0242312
SERBP1 SERPINE1 mRNA binding protein 1 -0.0238307
FNDC3B fibronectin type III domain containing 3B -0.0225197
EGFR epidermal growth factor receptor -0.0222277
HMGA1 high mobility group AT-hook 1 -0.0221702
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0220137
COL1A2 collagen, type I, alpha 2 -0.0218686
TAS2R14 taste receptor, type 2, member 14 -0.0215677
IGFBP3 insulin-like growth factor binding protein 3 -0.0214963
COL5A2 collagen, type V, alpha 2 -0.0213952
PLS3 plastin 3 -0.0212447
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0212258
RPS5 ribosomal protein S5 -0.0209804
RPL11 ribosomal protein L11 -0.0209588
GMDS GDP-mannose 4,6-dehydratase -0.0205955
KLHDC10 kelch domain containing 10 -0.0202235
MAML2 mastermind-like 2 (Drosophila) -0.0201051
RPL37 ribosomal protein L37 -0.0200689
ACTG1 actin gamma 1 -0.0199736
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0199216
RPL28 ribosomal protein L28 -0.0196974
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0196234
RPS2 ribosomal protein S2 -0.0195407
TNS3 tensin 3 -0.0191514
RPS23 ribosomal protein S23 -0.0189566
GMCL1 germ cell-less, spermatogenesis associated 1 -0.0187578
TTC3 tetratricopeptide repeat domain 3 -0.0185262
S100A9 S100 calcium binding protein A9 -0.0185205
UBE3A ubiquitin protein ligase E3A -0.018469
WBP11 WW domain binding protein 11 -0.0184441
ITGAV integrin, alpha V -0.0183571
MEIS2 Meis homeobox 2 -0.0183211
DNAH14 dynein, axonemal, heavy chain 14 -0.0179861
NF1 neurofibromin 1 -0.0178875
FBXO11 F-box protein 11 -0.017874
RPS27A ribosomal protein S27a -0.0177923
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 -0.0177669
RPS15 ribosomal protein S15 -0.0177191
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0176685
FOXK1 forkhead box K1 -0.0176679
NDUFA4 NDUFA4, mitochondrial complex associated -0.0176644
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0176628
TTYH3 tweety family member 3 -0.0174266
CWC27 CWC27 spliceosome-associated protein homolog (S. cerevisiae) -0.0174155
RHEB Ras homolog enriched in brain -0.0173807
GSTP1 glutathione S-transferase pi 1 -0.0173034
TM9SF4 transmembrane 9 superfamily protein member 4 -0.0173024
LUC7L LUC7-like (S. cerevisiae) -0.0172959
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0172703
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0171348
RNF130 ring finger protein 130 -0.0170687
FERMT2 fermitin family member 2 -0.0170237
PTMS parathymosin -0.0170135
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0167804
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 -0.0167706
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa -0.0167491
SLC38A2 solute carrier family 38, member 2 -0.0164651
RPS17 ribosomal protein S17 -0.0163009
CLMP CXADR-like membrane protein -0.0161375
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 -0.0161283
NRF1 nuclear respiratory factor 1 -0.016109
YME1L1 YME1-like 1 ATPase -0.0159459
CARNMT1 carnosine N-methyltransferase 1 -0.0159116
HDAC7 histone deacetylase 7 -0.0158069
RHOBTB3 Rho-related BTB domain containing 3 -0.0157393
NIPBL Nipped-B homolog (Drosophila) -0.0157229
NT5C2 5'-nucleotidase, cytosolic II -0.015596
MSRA methionine sulfoxide reductase A -0.0155702
RASA2 RAS p21 protein activator 2 -0.0154097
ARL5A ADP-ribosylation factor-like 5A -0.0153447
KPNA6 karyopherin alpha 6 (importin alpha 7) -0.0152562
TMX4 thioredoxin-related transmembrane protein 4 -0.0151861
ARHGAP19 Rho GTPase activating protein 19 -0.0150749
SSH1 slingshot protein phosphatase 1 -0.0150746
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0150621
HDAC2 histone deacetylase 2 -0.0149972
RPS14 ribosomal protein S14 -0.014968