Citalopram (hydrobromide)_AsPC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Citalopram (hydrobromide) perturbation in AsPC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Citalopram (hydrobromide)_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FLNB filamin B, beta 0.0451937
PSD3 pleckstrin and Sec7 domain containing 3 0.0435245
AKAP12 A kinase (PRKA) anchor protein 12 0.0403236
EGFR epidermal growth factor receptor 0.037677
IGFBP3 insulin-like growth factor binding protein 3 0.0335461
VCL vinculin 0.0333707
SMAD3 SMAD family member 3 0.0313234
ITGA6 integrin, alpha 6 0.0279879
ARHGAP42 Rho GTPase activating protein 42 0.0258447
EFNA5 ephrin-A5 0.025844
PLEC plectin 0.0251014
MYH9 myosin, heavy chain 9, non-muscle 0.022791
LMO7 LIM domain 7 0.0221483
MYOF myoferlin 0.022114
DOCK5 dedicator of cytokinesis 5 0.0216864
CORO1C coronin, actin binding protein, 1C 0.0212927
MPRIP myosin phosphatase Rho interacting protein 0.0210851
EZR ezrin 0.0202185
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0200784
SPTBN1 spectrin, beta, non-erythrocytic 1 0.019697
FGD6 FYVE, RhoGEF and PH domain containing 6 0.0188242
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0187663
FOXO1 forkhead box O1 0.0186648
BCL2L1 BCL2-like 1 0.0185461
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0185024
ITPRID2 ITPR interacting domain containing 2 0.0181942
ERBIN erbb2 interacting protein 0.0175934
FNDC3B fibronectin type III domain containing 3B 0.0172293
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.0169736
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0168967
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0168022
WWC1 WW and C2 domain containing 1 0.0166976
PTPRR protein tyrosine phosphatase, receptor type, R 0.0163118
BCAR3 breast cancer anti-estrogen resistance 3 0.0161972
DSCAM Down syndrome cell adhesion molecule 0.015929
HAPSTR1 HUWE1 associated protein modifying stress responses 0.0158683
ZEB1 zinc finger E-box binding homeobox 1 0.0157846
STK39 serine threonine kinase 39 0.0154688
ITCH itchy E3 ubiquitin protein ligase 0.0154586
DST dystonin 0.0153723
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0151182
EPS8 epidermal growth factor receptor pathway substrate 8 0.0150238
UBA6 ubiquitin-like modifier activating enzyme 6 0.0149146
SERTAD2 SERTA domain containing 2 0.0148206
VCAN versican 0.0147289
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0146942
SEPTIN9 septin 9 0.0145195
LAMA4 laminin, alpha 4 0.0145175
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0142604
CAPRIN2 caprin family member 2 0.0142246
TRIO trio Rho guanine nucleotide exchange factor 0.0141333
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0140365
CD59 CD59 molecule, complement regulatory protein 0.0138108
DSPP dentin sialophosphoprotein 0.0137301
ARHGAP29 Rho GTPase activating protein 29 0.0135508
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0135367
ANXA11 annexin A11 0.0134785
CAB39 calcium binding protein 39 0.0134136
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0133955
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.0133882
RACK1 receptor for activated C kinase 1 0.0133717
JMJD1C jumonji domain containing 1C 0.0131871
TSC22D2 TSC22 domain family, member 2 0.0131197
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0125091
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0121754
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0120816
AKAP13 A kinase (PRKA) anchor protein 13 0.0119738
TJP1 tight junction protein 1 0.0116539
RASAL2 RAS protein activator like 2 0.0115265
GLS2 glutaminase 2 (liver, mitochondrial) 0.011301
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0111732
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.011138
RHPN2 rhophilin, Rho GTPase binding protein 2 0.010974
GREB1L growth regulation by estrogen in breast cancer-like 0.0107297
DPYSL2 dihydropyrimidinase-like 2 0.0106556
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.010651
SLC38A2 solute carrier family 38, member 2 0.0105091
NEK7 NIMA-related kinase 7 0.010502
CLIP2 CAP-GLY domain containing linker protein 2 0.0104762
PDLIM5 PDZ and LIM domain 5 0.0104478
ANO6 anoctamin 6 0.0103295
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.010292
SAMD4A sterile alpha motif domain containing 4A 0.010268
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0102453
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0102317
FOXO3 forkhead box O3 0.0100098
SGMS2 sphingomyelin synthase 2 0.0099933
KIAA0040 KIAA0040 0.00995999
NCOA3 nuclear receptor coactivator 3 0.00992065
AHNAK2 AHNAK nucleoprotein 2 0.00988907
MACF1 microtubule-actin crosslinking factor 1 0.00987313
MED13L mediator complex subunit 13-like 0.0098705
PRELID2 PRELI domain containing 2 0.00985375
SH3RF1 SH3 domain containing ring finger 1 0.00981838
ARHGAP21 Rho GTPase activating protein 21 0.00971083
ARRDC3 arrestin domain containing 3 0.00959335
PALM2AKAP2 PALM2 and AKAP2 fusion 0.00952502
NPTN neuroplastin 0.00950963
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0094549
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein 0.00940138

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.119823
TPT1 tumor protein, translationally-controlled 1 -0.0671717
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0647351
DHRS9 dehydrogenase/reductase (SDR family) member 9 -0.0570605
FTL ferritin, light polypeptide -0.0560434
PTMA prothymosin, alpha -0.053893
VIM vimentin -0.0507169
HMGA1 high mobility group AT-hook 1 -0.0472745
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0408699
KLK10 kallikrein-related peptidase 10 -0.0393435
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.036742
RPL35A ribosomal protein L35a -0.0343024
LAMB3 laminin, beta 3 -0.033017
ACTG1 actin gamma 1 -0.0317174
SACK1A scaffolding CK1 anchoring protein A -0.0303943
RPL31 ribosomal protein L31 -0.0300259
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa -0.0299295
RPL37A ribosomal protein L37a -0.0294471
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.0292929
TXNIP thioredoxin interacting protein -0.0291604
RPS8 ribosomal protein S8 -0.0289956
POTEF POTE ankyrin domain family, member F -0.0283752
S100A10 S100 calcium binding protein A10 -0.0278645
TMBIM1 transmembrane BAX inhibitor motif containing 1 -0.0277764
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0276489
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0257917
MXD1 MAX dimerization protein 1 -0.0256405
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0250056
B2M beta-2-microglobulin -0.024465
RPS13 ribosomal protein S13 -0.0236392
RPS6 ribosomal protein S6 -0.0234744
EGR1 early growth response 1 -0.0234546
RPLP2 ribosomal protein, large, P2 -0.0230076
RPLP1 ribosomal protein, large, P1 -0.0224365
CLMP CXADR-like membrane protein -0.0223206
S100A6 S100 calcium binding protein A6 -0.0218254
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0215992
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0215955
EIF1 eukaryotic translation initiation factor 1 -0.0215393
RPS27A ribosomal protein S27a -0.0209701
RPS24 ribosomal protein S24 -0.0208182
RPS21 ribosomal protein S21 -0.0205868
S100A11 S100 calcium binding protein A11 -0.0203173
RAB7A RAB7A, member RAS oncogene family -0.0197757
RPL9 ribosomal protein L9 -0.0196073
F3 coagulation factor III (thromboplastin, tissue factor) -0.01951
RAB1A RAB1A, member RAS oncogene family -0.0193571
RPS23 ribosomal protein S23 -0.0191754
ANXA2 annexin A2 -0.0189311
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0187148
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0185787
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0184342
RIOK3 RIO kinase 3 -0.0181967
RPS29 ribosomal protein S29 -0.0181282
RPS3 ribosomal protein S3 -0.0179659
RPS16 ribosomal protein S16 -0.0174929
PGK1 phosphoglycerate kinase 1 -0.0172372
RPS25 ribosomal protein S25 -0.0171186
RPL34 ribosomal protein L34 -0.0170265
WSB1 WD repeat and SOCS box containing 1 -0.016761
FTH1 ferritin, heavy polypeptide 1 -0.016549
RPL8 ribosomal protein L8 -0.0162738
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0161893
RPL28 ribosomal protein L28 -0.0160176
RPL11 ribosomal protein L11 -0.0158566
LDHA lactate dehydrogenase A -0.0154538
SQSTM1 sequestosome 1 -0.0154494
RPS20 ribosomal protein S20 -0.0152286
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0152243
FOSL1 FOS-like antigen 1 -0.015221
RPL12 ribosomal protein L12 -0.014948
RPL37 ribosomal protein L37 -0.0147446
TM4SF1 transmembrane 4 L six family member 1 -0.0147381
RPS15 ribosomal protein S15 -0.0145824
BLZF1 basic leucine zipper nuclear factor 1 -0.0145447
EIF5B eukaryotic translation initiation factor 5B -0.0141952
NDRG1 N-myc downstream regulated 1 -0.0141698
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0138946
GNAS GNAS complex locus -0.0137011
RPS19 ribosomal protein S19 -0.0136309
HLA-A major histocompatibility complex, class I, A -0.0136247
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0135635
RPL30 ribosomal protein L30 -0.0134659
TPM4 tropomyosin 4 -0.0133733
RPL7A ribosomal protein L7a -0.0133153
IER3 immediate early response 3 -0.0132554
RPS27 ribosomal protein S27 -0.0129311
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0127694
UPP1 uridine phosphorylase 1 -0.0126898
MCL1 myeloid cell leukemia 1 -0.0125932
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0125635
MORF4L2 mortality factor 4 like 2 -0.0125413
NOP58 NOP58 ribonucleoprotein -0.0124641
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0124446
RPL38 ribosomal protein L38 -0.0124052
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0123669
MDK midkine (neurite growth-promoting factor 2) -0.0123502
VEZT vezatin, adherens junctions transmembrane protein -0.0122878
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0122113
UBE2B ubiquitin-conjugating enzyme E2B -0.0121569