Citalopram (hydrobromide)_BT-474 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Citalopram (hydrobromide) perturbation in BT-474 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Citalopram (hydrobromide)_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VMP1 vacuole membrane protein 1 0.129433
RPL19 ribosomal protein L19 0.0793506
NDRG1 N-myc downstream regulated 1 0.0740594
FTH1 ferritin, heavy polypeptide 1 0.0687232
ITCH itchy E3 ubiquitin protein ligase 0.066244
RPL23 ribosomal protein L23 0.0609927
ANKRD36C ankyrin repeat domain 36C 0.0556503
RAB7A RAB7A, member RAS oncogene family 0.0553418
CEMIP cell migration inducing protein, hyaluronan binding 0.0526486
CEP250 centrosomal protein 250kDa 0.0491675
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 0.0481888
CATSPERB catsper channel auxiliary subunit beta 0.0477328
DTNA dystrobrevin, alpha 0.0471361
NRIP1 nuclear receptor interacting protein 1 0.0440493
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0440202
GRB10 growth factor receptor-bound protein 10 0.0431047
LASP1 LIM and SH3 protein 1 0.0424158
SRCIN1 SRC kinase signaling inhibitor 1 0.0407609
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0404857
PDLIM5 PDZ and LIM domain 5 0.0402866
IFI6 interferon, alpha-inducible protein 6 0.040012
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0386564
CLTC clathrin, heavy chain (Hc) 0.0372283
NCOA3 nuclear receptor coactivator 3 0.0362877
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0351494
LPP LIM domain containing preferred translocation partner in lipoma 0.0346526
MCL1 myeloid cell leukemia 1 0.0343558
RAD51B RAD51 paralog B 0.0329854
RAB22A RAB22A, member RAS oncogene family 0.0322849
TSC22D2 TSC22 domain family, member 2 0.0318865
SBF2 SET binding factor 2 0.0289082
ENAH enabled homolog (Drosophila) 0.0288211
BRD4 bromodomain containing 4 0.0279157
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0276726
KTN1 kinectin 1 (kinesin receptor) 0.0273023
ZFAND3 zinc finger, AN1-type domain 3 0.0272718
PNN pinin, desmosome associated protein 0.0266281
USP53 ubiquitin specific peptidase 53 0.0265269
ATXN1 ataxin 1 0.0265008
ZSWIM6 zinc finger, SWIM-type containing 6 0.0263609
VEGFA vascular endothelial growth factor A 0.0262578
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0257309
JMJD1C jumonji domain containing 1C 0.0255102
APP amyloid beta (A4) precursor protein 0.0254475
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0254365
SP100 SP100 nuclear antigen 0.0252608
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0251911
NTN4 netrin 4 0.025089
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0247104
DOCK5 dedicator of cytokinesis 5 0.0246657
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0246603
RBPMS RNA binding protein with multiple splicing 0.0245026
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0242834
SRPK2 SRSF protein kinase 2 0.0242814
SEPTIN9 septin 9 0.0242208
INSR insulin receptor 0.0239392
ANKRD12 ankyrin repeat domain 12 0.0239252
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.023873
LIMCH1 LIM and calponin homology domains 1 0.0238486
VCL vinculin 0.023764
PATJ PATJ crumbs cell polarity complex component 0.0233811
CEMIP2 cell migration inducing hyaluronidase 2 0.0232637
CDH15 cadherin 15, type 1, M-cadherin (myotubule) 0.0231534
AHR aryl hydrocarbon receptor 0.0229981
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0228582
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0227274
UBE2H ubiquitin-conjugating enzyme E2H 0.0225121
ARID5B AT rich interactive domain 5B (MRF1-like) 0.022381
NRP1 neuropilin 1 0.0222717
FNDC3A fibronectin type III domain containing 3A 0.0222097
CAB39 calcium binding protein 39 0.0220781
PLSCR1 phospholipid scramblase 1 0.0217577
ACSS2 acyl-CoA synthetase short-chain family member 2 0.021527
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0215101
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0213441
PRRC2B proline-rich coiled-coil 2B 0.0213249
SRRM2 serine/arginine repetitive matrix 2 0.0210519
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.0209865
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.0208191
MYO1B myosin IB 0.020711
RCOR1 REST corepressor 1 0.020489
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0202943
EFNA5 ephrin-A5 0.0202707
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0200031
MYH9 myosin, heavy chain 9, non-muscle 0.0199074
RBM25 RNA binding motif protein 25 0.0197784
RPS12 ribosomal protein S12 0.0194791
IL1RAPL2 interleukin 1 receptor accessory protein-like 2 0.0194038
UBAP1 ubiquitin associated protein 1 0.0190557
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0188944
LARP4B La ribonucleoprotein domain family, member 4B 0.0188534
MSI2 musashi RNA-binding protein 2 0.0188115
YAP1 Yes-associated protein 1 0.0187638
TTC17 tetratricopeptide repeat domain 17 0.0186491
ATP9A ATPase, class II, type 9A 0.0186422
CUL3 cullin 3 0.0186318
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0185899
EPAS1 endothelial PAS domain protein 1 0.0185496
MCU mitochondrial calcium uniporter 0.0185368
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0184058

decreased expression

Symbol Name Standardized Value
ERBB2 erb-b2 receptor tyrosine kinase 2 -0.101211
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0626357
ALCAM activated leukocyte cell adhesion molecule -0.0587474
NAMPT nicotinamide phosphoribosyltransferase -0.0521903
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.044326
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0376376
AHNAK AHNAK nucleoprotein -0.0372736
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0370546
CCND1 cyclin D1 -0.0339707
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0333146
ZMYND8 zinc finger, MYND-type containing 8 -0.0295987
BIRC3 baculoviral IAP repeat containing 3 -0.0271029
IGFBP5 insulin-like growth factor binding protein 5 -0.0265398
EHMT1 euchromatic histone-lysine N-methyltransferase 1 -0.025017
SDC4 syndecan 4 -0.0245644
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0242227
CANX calnexin -0.0236606
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0233469
KAZN kazrin, periplakin interacting protein -0.0232496
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0229688
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.022895
MT2A metallothionein 2A -0.0224288
S100A8 S100 calcium binding protein A8 -0.0222812
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 -0.0221705
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 -0.0219727
ANXA2 annexin A2 -0.0217444
ACACA acetyl-CoA carboxylase alpha -0.0210306
NEBL nebulette -0.0208971
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0203094
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 -0.0197922
KLF6 Kruppel-like factor 6 -0.0195637
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0193905
MSMO1 methylsterol monooxygenase 1 -0.019044
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0189974
SLC38A1 solute carrier family 38, member 1 -0.0188389
SMIM14 small integral membrane protein 14 -0.0181323
JUN jun proto-oncogene -0.0178801
LMAN1 lectin, mannose-binding, 1 -0.0172356
ZC3H11A zinc finger CCCH-type containing 11A -0.017037
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0170235
XBP1 X-box binding protein 1 -0.016799
ACSL1 acyl-CoA synthetase long-chain family member 1 -0.0166804
TRAPPC9 trafficking protein particle complex 9 -0.0164329
GPHN gephyrin -0.0159919
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0159642
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0156155
LONP2 lon peptidase 2, peroxisomal -0.0154468
SDCCAG8 serologically defined colon cancer antigen 8 -0.0154261
H1-0 H1.0 linker histone -0.0153152
GPC5 glypican 5 -0.0153038
BCAS1 breast carcinoma amplified sequence 1 -0.0152585
TSC22D1 TSC22 domain family, member 1 -0.0147438
SHROOM3 shroom family member 3 -0.0146861
TFRC transferrin receptor -0.0144625
ZBTB16 zinc finger and BTB domain containing 16 -0.0143798
RAB1B RAB1B, member RAS oncogene family -0.0143474
RAD21 RAD21 homolog (S. pombe) -0.0143078
FBXO32 F-box protein 32 -0.0141939
NCAM2 neural cell adhesion molecule 2 -0.014174
DDX27 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 -0.0138844
NIPBL Nipped-B homolog (Drosophila) -0.0138439
IER3 immediate early response 3 -0.01378
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) -0.013652
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0135964
ZNF217 zinc finger protein 217 -0.0135485
DSPP dentin sialophosphoprotein -0.0134364
IFNGR1 interferon gamma receptor 1 -0.0132748
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0132376
TC2N tandem C2 domains, nuclear -0.0132164
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0131409
RUNX1 runt-related transcription factor 1 -0.0128244
RTF2 replication termination factor 2 -0.0128007
DCAF5 DDB1 and CUL4 associated factor 5 -0.0127886
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -0.0127359
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0123076
RAB14 RAB14, member RAS oncogene family -0.0122113
TPCN1 two pore segment channel 1 -0.0121091
CALCOCO2 calcium binding and coiled-coil domain 2 -0.0120993
RREB1 ras responsive element binding protein 1 -0.0118086
NRCAM neuronal cell adhesion molecule -0.0118026
SOD2 superoxide dismutase 2, mitochondrial -0.0116853
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0116441
GRHL2 grainyhead-like 2 (Drosophila) -0.0112928
GSE1 Gse1 coiled-coil protein -0.0112676
LDHA lactate dehydrogenase A -0.0112266
KDM3A lysine (K)-specific demethylase 3A -0.0111119
PDE4D phosphodiesterase 4D, cAMP-specific -0.0110977
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0109063
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -0.010837
NFIA nuclear factor I/A -0.0108133
PRLR prolactin receptor -0.0107578
PGK1 phosphoglycerate kinase 1 -0.0107093
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0106326
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0106186
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0105584
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0105384
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0104555
SLC2A14 solute carrier family 2 (facilitated glucose transporter), member 14 -0.010454
LITAF lipopolysaccharide-induced TNF factor -0.0104034
CAPRIN1 cell cycle associated protein 1 -0.0103857