Citalopram (hydrobromide)_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Citalopram (hydrobromide) perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Citalopram (hydrobromide)_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERBB4 erb-b2 receptor tyrosine kinase 4 0.172977
RAD51B RAD51 paralog B 0.107864
SLIT2 slit homolog 2 (Drosophila) 0.0893612
NPAS3 neuronal PAS domain protein 3 0.0719989
EEF2 eukaryotic translation elongation factor 2 0.0684228
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.0620325
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0592484
CADM2 cell adhesion molecule 2 0.0551009
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0470417
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.045624
ADGRG6 adhesion G protein-coupled receptor G6 0.0444794
ZNF608 zinc finger protein 608 0.042454
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0419609
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0406391
TOX thymocyte selection-associated high mobility group box 0.040483
FMNL2 formin-like 2 0.0390464
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0381159
CCSER1 coiled-coil serine-rich protein 1 0.0374075
GRID2 glutamate receptor, ionotropic, delta 2 0.0372215
SOX5 SRY (sex determining region Y)-box 5 0.0371108
CDH18 cadherin 18, type 2 0.0365763
NEBL nebulette 0.0314389
RABGAP1L RAB GTPase activating protein 1-like 0.0310651
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0305987
TBC1D32 TBC1 domain family, member 32 0.0292621
EFNA5 ephrin-A5 0.0290382
ATP11A ATPase, class VI, type 11A 0.0287487
PTPRG protein tyrosine phosphatase, receptor type, G 0.028652
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.0260643
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.025113
ANKRD36 ankyrin repeat domain 36 0.0244783
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0243458
FLNA filamin A, alpha 0.0240942
MBD5 methyl-CpG binding domain protein 5 0.0237218
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0236111
PDE3B phosphodiesterase 3B, cGMP-inhibited 0.0234515
HSPA8 heat shock 70kDa protein 8 0.0221397
DST dystonin 0.022055
YEATS2 YEATS domain containing 2 0.0219808
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0219689
FN1 fibronectin 1 0.0219592
UBE2G2 ubiquitin-conjugating enzyme E2G 2 0.021791
GYS1 glycogen synthase 1 (muscle) 0.0214822
ZNF638 zinc finger protein 638 0.0213744
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0210676
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0207615
DENND1A DENN/MADD domain containing 1A 0.0207006
ZBTB20 zinc finger and BTB domain containing 20 0.0206164
AFG2A AFG2 AAA ATPase homolog A 0.0200855
AUTS2 autism susceptibility candidate 2 0.0193588
PHF21A PHD finger protein 21A 0.0193565
LARS1 leucyl-tRNA synthetase 1 0.0192881
TIAM1 T-cell lymphoma invasion and metastasis 1 0.0192445
TENM2 teneurin transmembrane protein 2 0.0190269
SPTBN1 spectrin, beta, non-erythrocytic 1 0.018958
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 0.0187698
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0186268
FBXL7 F-box and leucine-rich repeat protein 7 0.0185593
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0185179
KIF1B kinesin family member 1B 0.0183948
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.018228
HS6ST2 heparan sulfate 6-O-sulfotransferase 2 0.0180624
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 0.0179976
RNF150 ring finger protein 150 0.0179701
BPTF bromodomain PHD finger transcription factor 0.017908
ZCCHC7 zinc finger, CCHC domain containing 7 0.0178837
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0178544
RAB11FIP3 RAB11 family interacting protein 3 (class II) 0.0173836
SPIDR scaffolding protein involved in DNA repair 0.0173075
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0172435
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.0171556
ARRDC3 arrestin domain containing 3 0.0171347
USO1 USO1 vesicle transport factor 0.0170329
MINK1 misshapen-like kinase 1 0.0169852
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.016716
WWOX WW domain containing oxidoreductase 0.0167102
NELL2 NEL-like 2 (chicken) 0.0166851
LPP LIM domain containing preferred translocation partner in lipoma 0.0165257
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.016465
OSBPL10 oxysterol binding protein-like 10 0.0162946
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.0162847
DOCK1 dedicator of cytokinesis 1 0.016064
CEP250 centrosomal protein 250kDa 0.0157812
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 0.0157649
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0157568
RNF130 ring finger protein 130 0.0156155
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0155577
NBEA neurobeachin 0.0154535
STXBP4 syntaxin binding protein 4 0.0154409
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) 0.015345
DTNB dystrobrevin, beta 0.0153253
UBA1 ubiquitin-like modifier activating enzyme 1 0.0153162
PCDH11X protocadherin 11 X-linked 0.0152994
GJA1 gap junction protein, alpha 1, 43kDa 0.0152919
ACACA acetyl-CoA carboxylase alpha 0.0152321
RNF220 ring finger protein 220 0.0151522
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0150885
ARLN allregulin 0.0149833
COL11A1 collagen, type XI, alpha 1 0.0149465
UHMK1 U2AF homology motif (UHM) kinase 1 0.0148686

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.216356
PTMA prothymosin, alpha -0.117804
RPS8 ribosomal protein S8 -0.102338
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0944624
RPS6 ribosomal protein S6 -0.0907353
UBC ubiquitin C -0.0865265
RPS27A ribosomal protein S27a -0.0828862
TMSB10 thymosin beta 10 -0.0793689
RPS12 ribosomal protein S12 -0.0782452
RPL37A ribosomal protein L37a -0.0748704
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0738119
RPL26 ribosomal protein L26 -0.0733873
RPS21 ribosomal protein S21 -0.0725662
RPLP1 ribosomal protein, large, P1 -0.0712692
RBM25 RNA binding motif protein 25 -0.0675764
COL5A2 collagen, type V, alpha 2 -0.0667825
WSB1 WD repeat and SOCS box containing 1 -0.0652971
IFI6 interferon, alpha-inducible protein 6 -0.063605
RPL11 ribosomal protein L11 -0.0616223
RPL23 ribosomal protein L23 -0.0612512
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0604862
RPS3 ribosomal protein S3 -0.0603852
KTN1 kinectin 1 (kinesin receptor) -0.0598538
ACTG1 actin gamma 1 -0.0592828
RPL34 ribosomal protein L34 -0.0584151
RPL36 ribosomal protein L36 -0.0579099
RPL5 ribosomal protein L5 -0.0547379
RPLP2 ribosomal protein, large, P2 -0.0546204
RPL28 ribosomal protein L28 -0.0533249
RPS24 ribosomal protein S24 -0.053261
RPS5 ribosomal protein S5 -0.053234
RPL12 ribosomal protein L12 -0.051739
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0512164
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0506665
JMJD1C jumonji domain containing 1C -0.0489306
B2M beta-2-microglobulin -0.0471655
RPS13 ribosomal protein S13 -0.0468175
SETD5 SET domain containing 5 -0.0467541
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0466641
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.04596
PNISR PNN-interacting serine/arginine-rich protein -0.0455759
RPS19 ribosomal protein S19 -0.0453772
NKTR natural killer cell triggering receptor -0.0448736
RPS2 ribosomal protein S2 -0.0447658
RPS29 ribosomal protein S29 -0.0444493
ENO1 enolase 1, (alpha) -0.0440396
RPS17 ribosomal protein S17 -0.0434535
RPS25 ribosomal protein S25 -0.042798
RPL18 ribosomal protein L18 -0.0418021
RIGI RNA sensor RIG-I -0.0417707
NAP1L1 nucleosome assembly protein 1-like 1 -0.0405423
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0398511
RPL13A ribosomal protein L13a -0.0397102
ISG15 ISG15 ubiquitin-like modifier -0.0396281
YBX1 Y box binding protein 1 -0.0394237
MAP3K14 mitogen-activated protein kinase kinase kinase 14 -0.0391856
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0391073
RPS16 ribosomal protein S16 -0.0386094
RPL31 ribosomal protein L31 -0.0382902
RPS15 ribosomal protein S15 -0.0382424
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0380791
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0378319
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.0371096
SRSF11 serine/arginine-rich splicing factor 11 -0.0368224
MYL12B myosin, light chain 12B, regulatory -0.0361272
RPS11 ribosomal protein S11 -0.0361042
EPC1 enhancer of polycomb homolog 1 (Drosophila) -0.0360334
ZNF292 zinc finger protein 292 -0.0360069
RPL7A ribosomal protein L7a -0.0358715
RPL19 ribosomal protein L19 -0.0351
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0349452
KDM3A lysine (K)-specific demethylase 3A -0.034853
LOC112694756 uncharaterized LOC112694756 -0.034838
ARHGAP32 Rho GTPase activating protein 32 -0.0343999
TPD52 tumor protein D52 -0.0339358
CAMTA1 calmodulin binding transcription activator 1 -0.0336294
SCAF11 SR-related CTD-associated factor 11 -0.0334949
TMEM41B transmembrane protein 41B -0.0334162
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0334045
RBM39 RNA binding motif protein 39 -0.03335
ANKRD12 ankyrin repeat domain 12 -0.0330438
S100A9 S100 calcium binding protein A9 -0.0330325
TM9SF3 transmembrane 9 superfamily member 3 -0.0324688
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0323643
NALF1 NALCN channel auxiliary factor 1 -0.0321984
KMT2E lysine (K)-specific methyltransferase 2E -0.0321569
TPT1 tumor protein, translationally-controlled 1 -0.0319329
GNAS GNAS complex locus -0.0318336
RPL32 ribosomal protein L32 -0.0317735
RAB10 RAB10, member RAS oncogene family -0.0317064
RPL9 ribosomal protein L9 -0.0311711
ADAM9 ADAM metallopeptidase domain 9 -0.0310426
RPL37 ribosomal protein L37 -0.0304929
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0304286
ZFAND3 zinc finger, AN1-type domain 3 -0.0304121
RPL35 ribosomal protein L35 -0.0303161
SEPTIN7 septin 7 -0.030287
WDR45B WD repeat domain 45B -0.0301946
ATP5F1E ATP synthase F1 subunit epsilon -0.0301281
MIB1 mindbomb E3 ubiquitin protein ligase 1 -0.0298043