Citalopram (hydrobromide)_C32 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Citalopram (hydrobromide) perturbation in C32 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Citalopram (hydrobromide)_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.211394
NDRG1 N-myc downstream regulated 1 0.132295
CD109 CD109 molecule 0.10032
ESYT2 extended synaptotagmin-like protein 2 0.0779957
AKAP12 A kinase (PRKA) anchor protein 12 0.0742915
DDIT4 DNA-damage-inducible transcript 4 0.0530859
NPAS2 neuronal PAS domain protein 2 0.0456317
CCNL1 cyclin L1 0.0450003
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0403723
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0403012
NRCAM neuronal cell adhesion molecule 0.0401085
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0400555
NUP58 nucleoporin 58 0.0393789
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0370078
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0341038
FKBP5 FK506 binding protein 5 0.0317711
CSNK1A1 casein kinase 1, alpha 1 0.0315332
SLC26A2 solute carrier family 26 (anion exchanger), member 2 0.0315157
KMT2C lysine (K)-specific methyltransferase 2C 0.0308138
HILPDA hypoxia inducible lipid droplet-associated 0.0289208
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0288939
ADM adrenomedullin 0.0288019
KMT2E lysine (K)-specific methyltransferase 2E 0.028505
RNF145 ring finger protein 145 0.0268813
PER1 period circadian clock 1 0.0255918
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 0.0250816
LMCD1 LIM and cysteine-rich domains 1 0.0244947
MACF1 microtubule-actin crosslinking factor 1 0.0240003
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0238017
PTCHD4 patched domain containing 4 0.0237595
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0236037
EMP1 epithelial membrane protein 1 0.0235461
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0235297
VEGFA vascular endothelial growth factor A 0.023354
RACK1 receptor for activated C kinase 1 0.0232071
SSBP2 single-stranded DNA binding protein 2 0.0230975
HELZ helicase with zinc finger 0.0230232
VGF VGF nerve growth factor inducible 0.0229813
PDE10A phosphodiesterase 10A 0.0226733
SEC24A SEC24 family member A 0.0226387
GRIK5 glutamate receptor, ionotropic, kainate 5 0.022578
CALD1 caldesmon 1 0.0225401
EGR1 early growth response 1 0.0224125
RPL3 ribosomal protein L3 0.0222593
USP53 ubiquitin specific peptidase 53 0.022203
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.022073
EEF2 eukaryotic translation elongation factor 2 0.0218703
TFRC transferrin receptor 0.0217785
IRS2 insulin receptor substrate 2 0.0217544
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0215807
TPR translocated promoter region, nuclear basket protein 0.0213258
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0212668
GDF15 growth differentiation factor 15 0.0211624
CDC73 cell division cycle 73 0.0209946
CABIN1 calcineurin binding protein 1 0.0209301
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0208835
MCL1 myeloid cell leukemia 1 0.0207323
RBM39 RNA binding motif protein 39 0.0205626
USP37 ubiquitin specific peptidase 37 0.0203075
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0202518
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0201548
WDR43 WD repeat domain 43 0.0200339
IGFBP3 insulin-like growth factor binding protein 3 0.0199376
IFRD1 interferon-related developmental regulator 1 0.0195248
KDM3A lysine (K)-specific demethylase 3A 0.0195214
MIDEAS mitotic deacetylase associated SANT domain protein 0.019519
A2M alpha-2-macroglobulin 0.0192827
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 0.0191197
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0189471
DENND1A DENN/MADD domain containing 1A 0.018943
MT2A metallothionein 2A 0.0186735
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0185707
MKRN1 makorin ring finger protein 1 0.018442
RLF rearranged L-myc fusion 0.0183905
STXBP1 syntaxin binding protein 1 0.0179899
LRRC23 leucine rich repeat containing 23 0.0176875
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0176857
ANKRD11 ankyrin repeat domain 11 0.017533
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0175319
STRIP2 striatin interacting protein 2 0.0174289
EIF4H eukaryotic translation initiation factor 4H 0.0172647
SYNM synemin, intermediate filament protein 0.0171109
PPME1 protein phosphatase methylesterase 1 0.0171031
SCARB1 scavenger receptor class B, member 1 0.0170002
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0167322
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0167309
IGF2 insulin-like growth factor 2 0.0164726
GSN gelsolin 0.0162395
AFDN afadin, adherens junction formation factor 0.016096
EZR ezrin 0.0160061
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0159671
COPA coatomer protein complex, subunit alpha 0.0158639
FNDC3A fibronectin type III domain containing 3A 0.015715
RIOK3 RIO kinase 3 0.0156699
OSBPL10 oxysterol binding protein-like 10 0.0155279
WDFY2 WD repeat and FYVE domain containing 2 0.0154867
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.01537
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0151158
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.0151057
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0149096

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.505566
VIM vimentin -0.281933
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.204777
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.132675
UBC ubiquitin C -0.112295
ASPH aspartate beta-hydroxylase -0.0966849
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0892868
S100A6 S100 calcium binding protein A6 -0.0823675
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0820749
LOC112694756 uncharaterized LOC112694756 -0.0730779
ENO1 enolase 1, (alpha) -0.0726882
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0614981
PDIA4 protein disulfide isomerase family A, member 4 -0.0584626
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0580544
ICAM1 intercellular adhesion molecule 1 -0.0578551
NAMPT nicotinamide phosphoribosyltransferase -0.0553509
TMSB10 thymosin beta 10 -0.0546516
ACTG1 actin gamma 1 -0.0539979
AHNAK AHNAK nucleoprotein -0.0529181
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0514518
WWTR1 WW domain containing transcription regulator 1 -0.0477114
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0476288
PKM pyruvate kinase, muscle -0.0462979
IER3 immediate early response 3 -0.0440543
FMN1 formin 1 -0.0440496
RTN4 reticulon 4 -0.0410436
PTMA prothymosin, alpha -0.0400728
TNNC1 troponin C type 1 (slow) -0.0390589
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0382061
FRMD4A FERM domain containing 4A -0.038111
GSK3B glycogen synthase kinase 3 beta -0.037671
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.035914
COG5 component of oligomeric golgi complex 5 -0.0349892
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0349477
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0348807
TM4SF1 transmembrane 4 L six family member 1 -0.0345839
SDC2 syndecan 2 -0.034528
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0343681
GPC6 glypican 6 -0.033614
RPS27A ribosomal protein S27a -0.0334506
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0334505
TAGLN2 transgelin 2 -0.0332982
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) -0.0332152
PCDH7 protocadherin 7 -0.0331032
NAV1 neuron navigator 1 -0.0329837
NLGN1 neuroligin 1 -0.0326385
HLA-B major histocompatibility complex, class I, B -0.0326105
RHEB Ras homolog enriched in brain -0.0321216
SRPK2 SRSF protein kinase 2 -0.0320909
TSC22D1 TSC22 domain family, member 1 -0.0317804
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0314827
LRMDA leucine rich melanocyte differentiation associated -0.0314292
RPLP1 ribosomal protein, large, P1 -0.030783
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0305054
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0304657
FMNL2 formin-like 2 -0.030304
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0301827
SPRED1 sprouty-related, EVH1 domain containing 1 -0.0299953
ACTN4 actinin, alpha 4 -0.0299916
APP amyloid beta (A4) precursor protein -0.0294587
ANKRD28 ankyrin repeat domain 28 -0.0294382
CPEB2 cytoplasmic polyadenylation element binding protein 2 -0.0290903
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0290444
CHSY1 chondroitin sulfate synthase 1 -0.0286169
MYO10 myosin X -0.0285501
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0283565
POTEF POTE ankyrin domain family, member F -0.0280931
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma -0.0279812
LDHA lactate dehydrogenase A -0.0275962
IFI6 interferon, alpha-inducible protein 6 -0.0274372
PALM2AKAP2 PALM2 and AKAP2 fusion -0.026113
DUSP6 dual specificity phosphatase 6 -0.0260763
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0250987
INPP5F inositol polyphosphate-5-phosphatase F -0.0250744
SMYD3 SET and MYND domain containing 3 -0.0248552
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0246377
BABAM2 BRISC and BRCA1 A complex member 2 -0.0245026
ZBTB20 zinc finger and BTB domain containing 20 -0.0244092
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0241382
S100A9 S100 calcium binding protein A9 -0.0240883
S100A10 S100 calcium binding protein A10 -0.0238868
FNDC3B fibronectin type III domain containing 3B -0.023648
PCBP2 poly(rC) binding protein 2 -0.0235611
FBXL7 F-box and leucine-rich repeat protein 7 -0.0227712
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0226588
CALU calumenin -0.0224373
AHR aryl hydrocarbon receptor -0.0223687
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0223221
MTPN myotrophin -0.022255
RPLP2 ribosomal protein, large, P2 -0.0221263
ZYX zyxin -0.0220943
MITF microphthalmia-associated transcription factor -0.0218665
ADAM19 ADAM metallopeptidase domain 19 -0.0217725
RUNX1 runt-related transcription factor 1 -0.0215346
WDPCP WD repeat containing planar cell polarity effector -0.0214831
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.0210992
MACROD2 MACRO domain containing 2 -0.0210141
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0208576
PRELID2 PRELI domain containing 2 -0.0208157
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 -0.0205922