Citalopram (hydrobromide)_CFPAC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Citalopram (hydrobromide) perturbation in CFPAC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Citalopram (hydrobromide)_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.113592
NDRG1 N-myc downstream regulated 1 0.0979792
SAMD4A sterile alpha motif domain containing 4A 0.0696983
BACE2 beta-site APP-cleaving enzyme 2 0.0592852
APLP2 amyloid beta (A4) precursor-like protein 2 0.0511713
PATJ PATJ crumbs cell polarity complex component 0.0497296
MEF2A myocyte enhancer factor 2A 0.0490543
SMAD3 SMAD family member 3 0.048946
DOCK5 dedicator of cytokinesis 5 0.0465313
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0458616
ESYT2 extended synaptotagmin-like protein 2 0.0426248
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0406487
APOL1 apolipoprotein L, 1 0.0397429
MACF1 microtubule-actin crosslinking factor 1 0.0397035
CEMIP cell migration inducing protein, hyaluronan binding 0.0393462
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0390906
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0382621
MACC1 metastasis associated in colon cancer 1 0.0368595
MUC4 mucin 4, cell surface associated 0.0354507
AKAP9 A kinase (PRKA) anchor protein 9 0.0353482
APP amyloid beta (A4) precursor protein 0.0345035
FNDC3B fibronectin type III domain containing 3B 0.0337943
MYO1E myosin IE 0.03348
GBP2 guanylate binding protein 2, interferon-inducible 0.0329828
PHF3 PHD finger protein 3 0.0328011
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0318096
EFNA5 ephrin-A5 0.031112
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0305059
MYH9 myosin, heavy chain 9, non-muscle 0.0299921
FTH1 ferritin, heavy polypeptide 1 0.0297403
CP ceruloplasmin (ferroxidase) 0.0288467
CTNND1 catenin (cadherin-associated protein), delta 1 0.0286835
IGFBP3 insulin-like growth factor binding protein 3 0.028578
ANXA11 annexin A11 0.0278334
NPC1 Niemann-Pick disease, type C1 0.0274183
TGM2 transglutaminase 2 0.0271666
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0267248
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0265869
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0265099
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0265037
DSCAM Down syndrome cell adhesion molecule 0.0263841
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0263181
SLC35F5 solute carrier family 35, member F5 0.0260944
BCL2L1 BCL2-like 1 0.0252738
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0248666
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0248243
PDZD8 PDZ domain containing 8 0.0247053
OPTN optineurin 0.0244295
ARHGAP5 Rho GTPase activating protein 5 0.0244071
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0239172
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0237753
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0236166
B2M beta-2-microglobulin 0.0235993
OSMR oncostatin M receptor 0.0234494
CCNL1 cyclin L1 0.0234023
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0233896
KIF13B kinesin family member 13B 0.0233831
ANO6 anoctamin 6 0.0231095
PLEC plectin 0.0230891
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0230589
NIBAN2 niban apoptosis regulator 2 0.0230093
EEF2 eukaryotic translation elongation factor 2 0.0229876
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0226787
PTEN phosphatase and tensin homolog 0.0223914
ZFC3H1 zinc finger, C3H1-type containing 0.0221279
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0220323
MCL1 myeloid cell leukemia 1 0.0218336
ZNF148 zinc finger protein 148 0.021767
NRIP1 nuclear receptor interacting protein 1 0.0215818
RSF1 remodeling and spacing factor 1 0.0213688
HLA-A major histocompatibility complex, class I, A 0.0203282
TMEM51 transmembrane protein 51 0.0203044
HLA-E major histocompatibility complex, class I, E 0.0200497
EZR ezrin 0.019975
YEATS2 YEATS domain containing 2 0.0199723
BCAR3 breast cancer anti-estrogen resistance 3 0.0197441
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0194595
RIN2 Ras and Rab interactor 2 0.019456
MT1E metallothionein 1E 0.0194349
PPARD peroxisome proliferator-activated receptor delta 0.0194087
CD2AP CD2-associated protein 0.0193393
STRN3 striatin, calmodulin binding protein 3 0.0193301
BICC1 BicC family RNA binding protein 1 0.0191197
AKAP13 A kinase (PRKA) anchor protein 13 0.0188435
TAPBP TAP binding protein (tapasin) 0.0187712
BOD1L1 biorientation of chromosomes in cell division 1-like 1 0.0185395
TJP1 tight junction protein 1 0.0182553
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.0181847
TMCC3 transmembrane and coiled-coil domain family 3 0.0180835
FNIP1 folliculin interacting protein 1 0.0180719
IRAK3 interleukin-1 receptor-associated kinase 3 0.0180404
SGPP2 sphingosine-1-phosphate phosphatase 2 0.0179089
AOPEP aminopeptidase O (putative) 0.0178322
HOMER2 homer scaffolding protein 2 0.0177192
TPM3 tropomyosin 3 0.0176835
ERBIN erbb2 interacting protein 0.0176321
SLK STE20-like kinase 0.0176023
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0175813
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0174575
NCOR2 nuclear receptor corepressor 2 0.01736

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.150837
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.11822
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.113063
PTMA prothymosin, alpha -0.110166
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0944138
ASPH aspartate beta-hydroxylase -0.0802259
FTL ferritin, light polypeptide -0.0752081
WSB1 WD repeat and SOCS box containing 1 -0.0714998
TSC22D2 TSC22 domain family, member 2 -0.0529097
ANXA2 annexin A2 -0.0480166
MMP7 matrix metallopeptidase 7 -0.0478048
HMGA1 high mobility group AT-hook 1 -0.0452072
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0442799
IER3 immediate early response 3 -0.0402845
HILPDA hypoxia inducible lipid droplet-associated -0.0374038
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0361888
PLAU plasminogen activator, urokinase -0.0359717
RPLP1 ribosomal protein, large, P1 -0.0354019
G0S2 G0/G1 switch 2 -0.0352743
PKM pyruvate kinase, muscle -0.034508
H1-0 H1.0 linker histone -0.0336695
EIF1 eukaryotic translation initiation factor 1 -0.0315241
RPS8 ribosomal protein S8 -0.0309314
SQSTM1 sequestosome 1 -0.0301868
PCDH7 protocadherin 7 -0.0296216
ACTG1 actin gamma 1 -0.0289545
VIM vimentin -0.0288543
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0284443
RPL23 ribosomal protein L23 -0.0281207
NRG3 neuregulin 3 -0.0277494
LAMA4 laminin, alpha 4 -0.0275711
DTNA dystrobrevin, alpha -0.0275206
ELL2 elongation factor, RNA polymerase II, 2 -0.0269944
ZSWIM6 zinc finger, SWIM-type containing 6 -0.026518
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0262034
DST dystonin -0.0261586
RPS19 ribosomal protein S19 -0.0257153
RPL35A ribosomal protein L35a -0.0255676
HMGA2 high mobility group AT-hook 2 -0.0248043
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0247623
RPS3 ribosomal protein S3 -0.0241099
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0237601
RPL19 ribosomal protein L19 -0.0231274
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0223667
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0221415
ENO1 enolase 1, (alpha) -0.0219475
S100A10 S100 calcium binding protein A10 -0.0214638
ARHGAP26 Rho GTPase activating protein 26 -0.0212686
MT2A metallothionein 2A -0.0211803
CANX calnexin -0.0208758
RPL11 ribosomal protein L11 -0.0207988
MAML2 mastermind-like 2 (Drosophila) -0.020371
ADM adrenomedullin -0.0203683
NABP1 nucleic acid binding protein 1 -0.0202861
DDIT4 DNA-damage-inducible transcript 4 -0.0201231
MAP1B microtubule-associated protein 1B -0.020056
RPS29 ribosomal protein S29 -0.0200433
TPT1 tumor protein, translationally-controlled 1 -0.0196559
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0193598
RAB1A RAB1A, member RAS oncogene family -0.0193165
ISG15 ISG15 ubiquitin-like modifier -0.0192786
RUNX1 runt-related transcription factor 1 -0.0192637
LMNA lamin A/C -0.019234
MYOF myoferlin -0.0192222
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0191591
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0191219
AREG amphiregulin -0.0188198
INTS6 integrator complex subunit 6 -0.0185724
BHLHE40 basic helix-loop-helix family, member e40 -0.0183717
TM4SF1 transmembrane 4 L six family member 1 -0.0183209
POTEF POTE ankyrin domain family, member F -0.0171863
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0170967
PLAUR plasminogen activator, urokinase receptor -0.0169186
STAT1 signal transducer and activator of transcription 1, 91kDa -0.016918
TFRC transferrin receptor -0.0167376
RPS27A ribosomal protein S27a -0.0166895
FGFR1 fibroblast growth factor receptor 1 -0.0166462
LAMC2 laminin, gamma 2 -0.0164055
RPL36AL ribosomal protein L36a-like -0.0163228
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0162728
RPS21 ribosomal protein S21 -0.0160994
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0160405
IFRD1 interferon-related developmental regulator 1 -0.0157642
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0155751
SH3KBP1 SH3-domain kinase binding protein 1 -0.0154161
MORF4L2 mortality factor 4 like 2 -0.0153814
LDHA lactate dehydrogenase A -0.0153095
TES testin LIM domain protein -0.0151803
RPL28 ribosomal protein L28 -0.014963
KYNU kynureninase -0.0149565
PDIA6 protein disulfide isomerase family A, member 6 -0.0149277
H3-3B H3.3 histone B -0.0148662
RPS6 ribosomal protein S6 -0.0146795
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0144633
ANKRD37 ankyrin repeat domain 37 -0.0144164
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0143906
CAV1 caveolin 1, caveolae protein, 22kDa -0.0143567
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.014352
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0142694
RPS14 ribosomal protein S14 -0.0141485