Citalopram (hydrobromide)_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Citalopram (hydrobromide) perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Citalopram (hydrobromide)_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.141536
AKAP12 A kinase (PRKA) anchor protein 12 0.107763
FMN1 formin 1 0.101976
TRIO trio Rho guanine nucleotide exchange factor 0.0877598
NRG1 neuregulin 1 0.087016
EEF2 eukaryotic translation elongation factor 2 0.0698018
PLAT plasminogen activator, tissue 0.0546657
PRRC2C proline-rich coiled-coil 2C 0.0486718
KLF9 Kruppel-like factor 9 0.048184
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0481314
CEMIP cell migration inducing protein, hyaluronan binding 0.0449258
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0419279
MACF1 microtubule-actin crosslinking factor 1 0.0416087
NAMPT nicotinamide phosphoribosyltransferase 0.0393884
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0380902
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.037525
ANTXR1 anthrax toxin receptor 1 0.0372579
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0345163
TOP1 topoisomerase (DNA) I 0.0336618
BPTF bromodomain PHD finger transcription factor 0.0323467
MYO6 myosin VI 0.0314105
TLE4 transducin-like enhancer of split 4 0.0301894
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0300547
APP amyloid beta (A4) precursor protein 0.030011
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0296139
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0282686
FRMD4A FERM domain containing 4A 0.0280089
SMAD3 SMAD family member 3 0.0278822
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0277793
VMP1 vacuole membrane protein 1 0.0270003
SEPTIN9 septin 9 0.0268364
SOS1 son of sevenless homolog 1 (Drosophila) 0.0268222
RB1CC1 RB1-inducible coiled-coil 1 0.026756
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.026329
AMOTL1 angiomotin like 1 0.0261984
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0259478
ENAH enabled homolog (Drosophila) 0.0256662
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0253061
ITPRID2 ITPR interacting domain containing 2 0.0252059
CCND1 cyclin D1 0.0249204
ITGA1 integrin, alpha 1 0.0249179
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 0.0249174
PCBP2 poly(rC) binding protein 2 0.0249117
NSUN6 NOP2/Sun domain family, member 6 0.0248987
NALF1 NALCN channel auxiliary factor 1 0.0247673
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0245059
GNG2 guanine nucleotide binding protein (G protein), gamma 2 0.0239916
PAPOLA poly(A) polymerase alpha 0.0239568
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 0.0239387
PRRC2B proline-rich coiled-coil 2B 0.023906
ZFC3H1 zinc finger, C3H1-type containing 0.0238114
ARHGAP9 Rho GTPase activating protein 9 0.0237116
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0235118
AOPEP aminopeptidase O (putative) 0.0232301
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0230445
ATF6 activating transcription factor 6 0.0230247
TPR translocated promoter region, nuclear basket protein 0.0230031
NRP1 neuropilin 1 0.0227644
CSDE1 cold shock domain containing E1, RNA-binding 0.0227285
BICD1 bicaudal D homolog 1 (Drosophila) 0.0227072
ATRNL1 attractin-like 1 0.0226546
ANGPT1 angiopoietin 1 0.0226012
HSPA8 heat shock 70kDa protein 8 0.0225003
TLK2 tousled-like kinase 2 0.0222385
WDR43 WD repeat domain 43 0.0221889
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.0220605
GNA13 guanine nucleotide binding protein (G protein), alpha 13 0.0216153
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1 0.0215711
TXNRD1 thioredoxin reductase 1 0.0215364
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0214139
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0214091
MSI2 musashi RNA-binding protein 2 0.0213142
XPO1 exportin 1 0.0212932
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.021273
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0211745
SCG2 secretogranin II 0.0209854
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.020894
ANKRD28 ankyrin repeat domain 28 0.0208273
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0207568
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0206719
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0205875
CSNK1A1 casein kinase 1, alpha 1 0.0205062
NRIP1 nuclear receptor interacting protein 1 0.0204459
AFDN afadin, adherens junction formation factor 0.0203264
DPH6 diphthamine biosynthesis 6 0.0201285
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0200711
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0199801
EDEM3 ER degradation enhancer, mannosidase alpha-like 3 0.0199046
PCBP3 poly(rC) binding protein 3 0.0196168
CDK8 cyclin-dependent kinase 8 0.0195681
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0194818
FKBP5 FK506 binding protein 5 0.0194704
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0194647
TPST1 tyrosylprotein sulfotransferase 1 0.0192974
COL4A5 collagen, type IV, alpha 5 0.0192469
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0191884
USP15 ubiquitin specific peptidase 15 0.0190797
GPC5 glypican 5 0.0190587
SLC35F3 solute carrier family 35, member F3 0.0190506
CD46 CD46 molecule, complement regulatory protein 0.0190181

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.133852
PTMA prothymosin, alpha -0.104129
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0864402
VCL vinculin -0.0816728
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0737495
RPL35A ribosomal protein L35a -0.0656323
MEF2A myocyte enhancer factor 2A -0.0595248
RPLP1 ribosomal protein, large, P1 -0.0571392
RPS6 ribosomal protein S6 -0.0552874
RPL23 ribosomal protein L23 -0.0473801
ACTG1 actin gamma 1 -0.0470274
NDRG1 N-myc downstream regulated 1 -0.045966
RPL38 ribosomal protein L38 -0.0450226
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0443073
RPL31 ribosomal protein L31 -0.0421759
TMSB10 thymosin beta 10 -0.04123
EXT1 exostosin glycosyltransferase 1 -0.0403541
RPL11 ribosomal protein L11 -0.0402755
NREP neuronal regeneration related protein -0.0392846
RPL19 ribosomal protein L19 -0.0386887
FNBP1 formin binding protein 1 -0.0379233
RPL34 ribosomal protein L34 -0.0363675
ENO1 enolase 1, (alpha) -0.0357246
LSAMP limbic system-associated membrane protein -0.0346294
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0342516
RPS19 ribosomal protein S19 -0.0321181
TPT1 tumor protein, translationally-controlled 1 -0.0317716
FTL ferritin, light polypeptide -0.031379
B2M beta-2-microglobulin -0.0312257
VIM vimentin -0.0309503
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0302936
RPS24 ribosomal protein S24 -0.0297091
IER3 immediate early response 3 -0.0296136
TPM1 tropomyosin 1 (alpha) -0.0290412
S100A9 S100 calcium binding protein A9 -0.0283871
RPS27 ribosomal protein S27 -0.0281338
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0277048
TPM4 tropomyosin 4 -0.0272959
RPS12 ribosomal protein S12 -0.0271618
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -0.0271063
S100A6 S100 calcium binding protein A6 -0.0264089
EGR1 early growth response 1 -0.026224
MYO1E myosin IE -0.0258866
RPS17 ribosomal protein S17 -0.0255882
RPS3 ribosomal protein S3 -0.0254731
RPL26 ribosomal protein L26 -0.0253303
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0250941
GNAS GNAS complex locus -0.0250552
RPS8 ribosomal protein S8 -0.0249834
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0248439
CDC27 cell division cycle 27 -0.0246894
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.024396
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0242178
RPL12 ribosomal protein L12 -0.0239985
EEF1G eukaryotic translation elongation factor 1 gamma -0.0239323
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.023885
AKAP9 A kinase (PRKA) anchor protein 9 -0.0238452
RPS29 ribosomal protein S29 -0.0237169
RPS25 ribosomal protein S25 -0.0234824
RPL18 ribosomal protein L18 -0.0231513
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0230102
RPS11 ribosomal protein S11 -0.0228163
RPS14 ribosomal protein S14 -0.0224646
SOX4 SRY (sex determining region Y)-box 4 -0.0223861
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0217279
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0213757
KDM2A lysine (K)-specific demethylase 2A -0.0208093
LIMA1 LIM domain and actin binding 1 -0.0207319
RPL37A ribosomal protein L37a -0.0206677
RPS27A ribosomal protein S27a -0.0205652
WSB1 WD repeat and SOCS box containing 1 -0.0205565
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0205469
DTNA dystrobrevin, alpha -0.0203555
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0202818
PBX1 pre-B-cell leukemia homeobox 1 -0.0202494
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.0202471
SQSTM1 sequestosome 1 -0.0200347
KDM5B lysine (K)-specific demethylase 5B -0.0197533
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0197363
NFIX nuclear factor I/X (CCAAT-binding transcription factor) -0.0197252
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0195153
CANX calnexin -0.0190667
LCORL ligand dependent nuclear receptor corepressor-like -0.0189535
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0188766
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0188634
EGFR epidermal growth factor receptor -0.0186993
GPC6 glypican 6 -0.0186809
ZNF395 zinc finger protein 395 -0.0186567
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0185005
RIGI RNA sensor RIG-I -0.018473
RPS10 ribosomal protein S10 -0.0184552
RPL36 ribosomal protein L36 -0.0181419
RPL35 ribosomal protein L35 -0.01793
HELZ helicase with zinc finger -0.0178521
RPS5 ribosomal protein S5 -0.017726
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0176586
PNISR PNN-interacting serine/arginine-rich protein -0.0176308
RPLP0 ribosomal protein, large, P0 -0.0175986
SLIT2 slit homolog 2 (Drosophila) -0.017562
HMGA1 high mobility group AT-hook 1 -0.0174369