Citalopram (hydrobromide)_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Citalopram (hydrobromide) perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Citalopram (hydrobromide)_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.132789
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0595657
DSCAM Down syndrome cell adhesion molecule 0.0531578
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0507976
CCNL1 cyclin L1 0.0466564
MACC1 metastasis associated in colon cancer 1 0.0451218
VMP1 vacuole membrane protein 1 0.0448566
EZR ezrin 0.0406162
EPS8 epidermal growth factor receptor pathway substrate 8 0.0400909
NCKAP5 NCK-associated protein 5 0.0399108
TJP1 tight junction protein 1 0.0395609
STK24 serine/threonine kinase 24 0.03687
MYO1E myosin IE 0.0363203
AKAP13 A kinase (PRKA) anchor protein 13 0.0360913
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0353987
MYH9 myosin, heavy chain 9, non-muscle 0.0341901
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0336673
ATP11A ATPase, class VI, type 11A 0.0324447
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0291923
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0272439
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0264087
EEF2 eukaryotic translation elongation factor 2 0.0262177
EPHB2 EPH receptor B2 0.0261172
GCLC glutamate-cysteine ligase, catalytic subunit 0.0259078
MCU mitochondrial calcium uniporter 0.0257263
MAP7 microtubule-associated protein 7 0.024905
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0245971
OARD1 O-acyl-ADP-ribose deacylase 1 0.0241129
INTS6 integrator complex subunit 6 0.0232547
OCLN occludin 0.0228121
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0225893
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0218161
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0217214
PDZD8 PDZ domain containing 8 0.0217056
SAMD12 sterile alpha motif domain containing 12 0.0214957
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0212181
CDHR2 cadherin-related family member 2 0.0210371
SEC31A SEC31 homolog A (S. cerevisiae) 0.0205682
RAD51B RAD51 paralog B 0.0205362
NAMPT nicotinamide phosphoribosyltransferase 0.0204424
PRELID2 PRELI domain containing 2 0.0202994
AFF1 AF4/FMR2 family, member 1 0.0202031
YAP1 Yes-associated protein 1 0.0200751
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0197456
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0196417
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0196395
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0194952
TRIM2 tripartite motif containing 2 0.0191799
MKI67 marker of proliferation Ki-67 0.0191764
RBM47 RNA binding motif protein 47 0.0191178
SMYD3 SET and MYND domain containing 3 0.0189865
CANX calnexin 0.0184418
RNF213 ring finger protein 213 0.0184363
ATXN1 ataxin 1 0.0182002
MUC13 mucin 13, cell surface associated 0.018185
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0180633
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0177324
DGKH diacylglycerol kinase, eta 0.0176755
ARGLU1 arginine and glutamate rich 1 0.0176588
MSI2 musashi RNA-binding protein 2 0.0176306
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0175807
DUSP10 dual specificity phosphatase 10 0.0173255
MYO5B myosin VB 0.0171459
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0170754
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0170238
EXT1 exostosin glycosyltransferase 1 0.0169013
BCLAF1 BCL2-associated transcription factor 1 0.0168465
FNIP2 folliculin interacting protein 2 0.0166092
SERINC5 serine incorporator 5 0.0166012
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0163652
APP amyloid beta (A4) precursor protein 0.0163489
HDAC4 histone deacetylase 4 0.0163425
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0163255
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0160402
LPP LIM domain containing preferred translocation partner in lipoma 0.0160224
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.016013
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0159511
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0159481
RUNX1 runt-related transcription factor 1 0.0158957
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0158464
MTREX Mtr4 exosome RNA helicase 0.0157966
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.015793
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0157627
ERBIN erbb2 interacting protein 0.0157586
SPATA13 spermatogenesis associated 13 0.0156389
DOCK1 dedicator of cytokinesis 1 0.0154576
CKAP2 cytoskeleton associated protein 2 0.0153811
EREG epiregulin 0.0153588
PHACTR4 phosphatase and actin regulator 4 0.0150703
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.015056
ZFC3H1 zinc finger, C3H1-type containing 0.0149925
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0149771
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0146459
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0143738
ARL15 ADP-ribosylation factor-like 15 0.0143158
AKAP11 A kinase (PRKA) anchor protein 11 0.0141958
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0140584
UTRN utrophin 0.0139725
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0138905
ITGA6 integrin, alpha 6 0.0138881

decreased expression

Symbol Name Standardized Value
B2M beta-2-microglobulin -0.0883728
TPT1 tumor protein, translationally-controlled 1 -0.0858724
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0790623
HLA-B major histocompatibility complex, class I, B -0.0727347
IFI6 interferon, alpha-inducible protein 6 -0.0708344
PTMA prothymosin, alpha -0.0687698
FTL ferritin, light polypeptide -0.0604073
TMSB10 thymosin beta 10 -0.0562445
RPL35A ribosomal protein L35a -0.0519029
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0511906
LCN2 lipocalin 2 -0.0504864
TXNIP thioredoxin interacting protein -0.04607
ZMYND8 zinc finger, MYND-type containing 8 -0.0445561
IFI27 interferon, alpha-inducible protein 27 -0.0435389
RPLP1 ribosomal protein, large, P1 -0.0432814
RPL34 ribosomal protein L34 -0.0428571
RPS6 ribosomal protein S6 -0.0423302
MT2A metallothionein 2A -0.0397713
S100A6 S100 calcium binding protein A6 -0.0371943
RPL23 ribosomal protein L23 -0.0366462
PKM pyruvate kinase, muscle -0.0362079
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0356407
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0349812
HLA-E major histocompatibility complex, class I, E -0.0348187
RPL26 ribosomal protein L26 -0.0337357
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0336641
H1-0 H1.0 linker histone -0.0336519
EPSTI1 epithelial stromal interaction 1 (breast) -0.0324642
NDRG1 N-myc downstream regulated 1 -0.0321745
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0315482
RPS8 ribosomal protein S8 -0.0315052
RPS27 ribosomal protein S27 -0.030403
RIGI RNA sensor RIG-I -0.0282164
RPS19 ribosomal protein S19 -0.0275754
RPL11 ribosomal protein L11 -0.0272526
RPL12 ribosomal protein L12 -0.0267039
RPL31 ribosomal protein L31 -0.0265293
C6ORF132 chromosome 6 open reading frame 132 -0.0262027
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0249756
HLA-C major histocompatibility complex, class I, C -0.0248806
LIMA1 LIM domain and actin binding 1 -0.0245012
FTH1 ferritin, heavy polypeptide 1 -0.024408
HLA-A major histocompatibility complex, class I, A -0.0239582
PERP PERP, TP53 apoptosis effector -0.0237274
RPL38 ribosomal protein L38 -0.0232875
IGFBP3 insulin-like growth factor binding protein 3 -0.0231849
ESYT2 extended synaptotagmin-like protein 2 -0.0231819
S100A9 S100 calcium binding protein A9 -0.0231689
RPS20 ribosomal protein S20 -0.0230836
XAF1 XIAP associated factor 1 -0.0227916
TPI1 triosephosphate isomerase 1 -0.0226278
LOC112694756 uncharaterized LOC112694756 -0.0225179
SQSTM1 sequestosome 1 -0.0222649
CSTB cystatin B (stefin B) -0.0218931
ANXA2 annexin A2 -0.0216381
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0216336
RPL28 ribosomal protein L28 -0.0216316
ARHGAP26 Rho GTPase activating protein 26 -0.0215675
S100P S100 calcium binding protein P -0.021379
RPL35 ribosomal protein L35 -0.021332
AGR2 anterior gradient 2 -0.0210119
RPS3 ribosomal protein S3 -0.0209668
IFITM3 interferon induced transmembrane protein 3 -0.0209599
RPS12 ribosomal protein S12 -0.0209242
MUC20 mucin 20, cell surface associated -0.0207868
TFF3 trefoil factor 3 (intestinal) -0.0206032
WDR45B WD repeat domain 45B -0.0206005
MPHOSPH8 M-phase phosphoprotein 8 -0.0205657
VDAC1 voltage-dependent anion channel 1 -0.0204184
WSB1 WD repeat and SOCS box containing 1 -0.0202874
RPL37A ribosomal protein L37a -0.020071
NPSR1 neuropeptide S receptor 1 -0.0199805
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.019929
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0196743
RPL19 ribosomal protein L19 -0.0189724
PGK1 phosphoglycerate kinase 1 -0.0185001
NAP1L1 nucleosome assembly protein 1-like 1 -0.0182974
MX2 MX dynamin-like GTPase 2 -0.0182701
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0180636
RPS27A ribosomal protein S27a -0.0177305
ACTG1 actin gamma 1 -0.0177118
AKAP9 A kinase (PRKA) anchor protein 9 -0.0176296
RPLP2 ribosomal protein, large, P2 -0.0175667
TSC22D2 TSC22 domain family, member 2 -0.0175415
PRRC2C proline-rich coiled-coil 2C -0.0175072
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0172909
SLC38A1 solute carrier family 38, member 1 -0.0172623
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0171246
CST3 cystatin C -0.0170703
KRT19 keratin 19, type I -0.0168985
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0167444
VIM vimentin -0.0166426
MT1X metallothionein 1X -0.0165713
ARHGAP5 Rho GTPase activating protein 5 -0.0165526
RPS24 ribosomal protein S24 -0.0163916
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0162897
FAF2 Fas associated factor family member 2 -0.0162634
RPS17 ribosomal protein S17 -0.0162436
DYNC2I1 dynein 2 intermediate chain 1 -0.0161533
GOLGA4 golgin A4 -0.0161001