Citalopram (hydrobromide)_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Citalopram (hydrobromide) perturbation in H4 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Citalopram (hydrobromide)_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.0936114
FNDC3B fibronectin type III domain containing 3B 0.0694076
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0570321
MACF1 microtubule-actin crosslinking factor 1 0.0539099
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0524
DST dystonin 0.0523681
EXT1 exostosin glycosyltransferase 1 0.0520771
SMAD3 SMAD family member 3 0.0512086
NDRG1 N-myc downstream regulated 1 0.0492765
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0473877
SBF2 SET binding factor 2 0.0422419
DGKD diacylglycerol kinase, delta 130kDa 0.0408504
CALD1 caldesmon 1 0.0406213
ASPH aspartate beta-hydroxylase 0.0401739
ANKRD17 ankyrin repeat domain 17 0.035022
WWTR1 WW domain containing transcription regulator 1 0.0327894
OSMR oncostatin M receptor 0.0306299
TTC3 tetratricopeptide repeat domain 3 0.0302494
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0291625
DOCK5 dedicator of cytokinesis 5 0.0289096
HDAC9 histone deacetylase 9 0.0285822
MYH9 myosin, heavy chain 9, non-muscle 0.0284916
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0281848
AVL9 AVL9 homolog (S. cerevisiase) 0.0277598
VMP1 vacuole membrane protein 1 0.0274156
HDLBP high density lipoprotein binding protein 0.0272541
NF1 neurofibromin 1 0.0270134
MBD5 methyl-CpG binding domain protein 5 0.0267545
ZBTB20 zinc finger and BTB domain containing 20 0.0266868
CANX calnexin 0.0263154
ATP13A3 ATPase type 13A3 0.0262356
ANTXR2 anthrax toxin receptor 2 0.0262287
ATXN1 ataxin 1 0.0262093
SEC24D SEC24 family member D 0.0258773
STC1 stanniocalcin 1 0.0258233
TNNC1 troponin C type 1 (slow) 0.0257138
CXCL8 chemokine (C-X-C motif) ligand 8 0.0256344
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0251994
CLTC clathrin, heavy chain (Hc) 0.0251729
BBS9 Bardet-Biedl syndrome 9 0.0251394
ANKRD11 ankyrin repeat domain 11 0.0249687
RASA2 RAS p21 protein activator 2 0.0248576
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0248
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0246788
CD44 CD44 molecule (Indian blood group) 0.0244735
RTN4 reticulon 4 0.0242144
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0241521
EGFR epidermal growth factor receptor 0.0236955
GLIS3 GLIS family zinc finger 3 0.0235984
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0233322
GOLGB1 golgin B1 0.0232477
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0230202
GOLGA4 golgin A4 0.0227612
SPRED2 sprouty-related, EVH1 domain containing 2 0.0227124
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0224632
KYNU kynureninase 0.0224181
SCFD2 sec1 family domain containing 2 0.0222393
ZCCHC7 zinc finger, CCHC domain containing 7 0.0221176
SNX13 sorting nexin 13 0.0220544
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0218666
ATM ATM serine/threonine kinase 0.0215875
COL5A1 collagen, type V, alpha 1 0.0213809
MAST4 microtubule associated serine/threonine kinase family member 4 0.0211709
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0211633
COG5 component of oligomeric golgi complex 5 0.021122
CD59 CD59 molecule, complement regulatory protein 0.0209234
TRIO trio Rho guanine nucleotide exchange factor 0.0207853
METTL15 methyltransferase like 15 0.0207491
TMEM39A transmembrane protein 39A 0.0207376
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0205277
SAMD4A sterile alpha motif domain containing 4A 0.0204527
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0203275
CORO1C coronin, actin binding protein, 1C 0.0203173
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0203089
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0200375
NPC1 Niemann-Pick disease, type C1 0.0198681
ERBIN erbb2 interacting protein 0.0198626
HELZ helicase with zinc finger 0.0198589
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0197439
LPP LIM domain containing preferred translocation partner in lipoma 0.0197078
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0196201
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0193626
TRIP12 thyroid hormone receptor interactor 12 0.0193044
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0192971
AKAP12 A kinase (PRKA) anchor protein 12 0.0192747
VEGFC vascular endothelial growth factor C 0.0192179
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0192085
ZEB1 zinc finger E-box binding homeobox 1 0.0191815
AKAP9 A kinase (PRKA) anchor protein 9 0.0188808
STK17A serine/threonine kinase 17a 0.0186814
ANO6 anoctamin 6 0.0184013
ZFC3H1 zinc finger, C3H1-type containing 0.0182428
ANKRD36 ankyrin repeat domain 36 0.0181391
BIRC6 baculoviral IAP repeat containing 6 0.0181276
SEC31A SEC31 homolog A (S. cerevisiae) 0.0180596
RFX8 RFX family member 8, lacking RFX DNA binding domain 0.0180034
PHF3 PHD finger protein 3 0.0179622
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0179217
AHNAK AHNAK nucleoprotein 0.0178287
USP9Y ubiquitin specific peptidase 9, Y-linked 0.017617

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.16879
FTL ferritin, light polypeptide -0.139131
TMSB10 thymosin beta 10 -0.115377
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0967713
MT2A metallothionein 2A -0.0847059
PTMA prothymosin, alpha -0.0746527
VIM vimentin -0.0722196
HLA-B major histocompatibility complex, class I, B -0.0718532
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0712846
B2M beta-2-microglobulin -0.0644818
TGFBI transforming growth factor, beta-induced, 68kDa -0.0619403
IGFBP3 insulin-like growth factor binding protein 3 -0.0576995
RPS8 ribosomal protein S8 -0.0534659
FN1 fibronectin 1 -0.0505902
RPL37A ribosomal protein L37a -0.0485127
RPS6 ribosomal protein S6 -0.0482277
RPL35A ribosomal protein L35a -0.0466316
TPT1 tumor protein, translationally-controlled 1 -0.0448485
RPL28 ribosomal protein L28 -0.0365424
HILPDA hypoxia inducible lipid droplet-associated -0.0356376
HLA-A major histocompatibility complex, class I, A -0.0349808
RPLP1 ribosomal protein, large, P1 -0.0339244
RPL31 ribosomal protein L31 -0.0337931
ENO2 enolase 2 (gamma, neuronal) -0.0337558
RPL19 ribosomal protein L19 -0.0332523
PKM pyruvate kinase, muscle -0.0329682
WSB1 WD repeat and SOCS box containing 1 -0.0306743
RPL23 ribosomal protein L23 -0.0299335
IGF2 insulin-like growth factor 2 -0.0296751
RPS13 ribosomal protein S13 -0.0296189
ADM adrenomedullin -0.0294295
ACTG1 actin gamma 1 -0.0287007
RPL9 ribosomal protein L9 -0.0276231
CALR calreticulin -0.0273591
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0260573
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0254754
POTEF POTE ankyrin domain family, member F -0.0254062
RPS19 ribosomal protein S19 -0.0253592
RPS11 ribosomal protein S11 -0.0250222
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0249437
GNAS GNAS complex locus -0.0242934
RPLP2 ribosomal protein, large, P2 -0.0242879
RPS27A ribosomal protein S27a -0.024191
RPL34 ribosomal protein L34 -0.0239988
HIP1 huntingtin interacting protein 1 -0.0239909
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0236737
S100A9 S100 calcium binding protein A9 -0.0230272
RPS3 ribosomal protein S3 -0.0228644
RPS23 ribosomal protein S23 -0.0225305
S100A6 S100 calcium binding protein A6 -0.0224856
RPL12 ribosomal protein L12 -0.0223559
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0223368
SEPTIN7 septin 7 -0.0223136
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0218373
GRB10 growth factor receptor-bound protein 10 -0.0218227
RPS12 ribosomal protein S12 -0.0218111
PDIA3 protein disulfide isomerase family A, member 3 -0.0215274
TPM4 tropomyosin 4 -0.0208716
S100A10 S100 calcium binding protein A10 -0.0208111
RPL11 ribosomal protein L11 -0.020564
LDHA lactate dehydrogenase A -0.02051
RPS25 ribosomal protein S25 -0.0202715
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0202043
EGR1 early growth response 1 -0.0200947
RPLP0 ribosomal protein, large, P0 -0.0200062
RPS27 ribosomal protein S27 -0.0199566
LOC102724023 ES1 protein homolog, mitochondrial -0.0199436
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0194437
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.019424
ENO1 enolase 1, (alpha) -0.0193409
RPS14 ribosomal protein S14 -0.0185947
RPS29 ribosomal protein S29 -0.018225
EIF1 eukaryotic translation initiation factor 1 -0.0182087
SQSTM1 sequestosome 1 -0.0180131
RPS16 ribosomal protein S16 -0.0178076
LOX lysyl oxidase -0.0176813
SEC61G Sec61 gamma subunit -0.0176532
TSC22D3 TSC22 domain family, member 3 -0.0176094
RPS20 ribosomal protein S20 -0.017308
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0167486
RPS5 ribosomal protein S5 -0.0165252
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0164855
CTSD cathepsin D -0.0164116
ISG15 ISG15 ubiquitin-like modifier -0.0162952
TOP2A topoisomerase (DNA) II alpha 170kDa -0.01626
FTH1 ferritin, heavy polypeptide 1 -0.0161547
TPI1 triosephosphate isomerase 1 -0.0160967
IER3 immediate early response 3 -0.016073
VDAC1 voltage-dependent anion channel 1 -0.0159908
ANXA2 annexin A2 -0.015923
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) -0.0159014
RPS17 ribosomal protein S17 -0.0155852
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.015545
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0154919
RPS21 ribosomal protein S21 -0.0153231
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0149641
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0146961
RPL32 ribosomal protein L32 -0.0146682
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0145841
RPS24 ribosomal protein S24 -0.0145252