Citalopram (hydrobromide)_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Citalopram (hydrobromide) perturbation in HCT15 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Citalopram (hydrobromide)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF2 eukaryotic translation elongation factor 2 0.20958
DSCAM Down syndrome cell adhesion molecule 0.103693
CANX calnexin 0.0921138
HDLBP high density lipoprotein binding protein 0.0913712
MYH9 myosin, heavy chain 9, non-muscle 0.0855773
TXNRD1 thioredoxin reductase 1 0.0765351
PRELID2 PRELI domain containing 2 0.0754024
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0743207
APLP2 amyloid beta (A4) precursor-like protein 2 0.0718004
EZR ezrin 0.0712319
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0707499
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0689421
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0633974
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0624811
AKAP9 A kinase (PRKA) anchor protein 9 0.0621376
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.060161
ZNF638 zinc finger protein 638 0.059198
DSPP dentin sialophosphoprotein 0.0585552
RACK1 receptor for activated C kinase 1 0.0576358
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0566033
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0550233
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0517534
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0515758
GOLGA4 golgin A4 0.051262
SRRM2 serine/arginine repetitive matrix 2 0.0509738
RPL3 ribosomal protein L3 0.0506999
TRA2A transformer 2 alpha homolog (Drosophila) 0.0497341
TTC3 tetratricopeptide repeat domain 3 0.0491056
CSNK1A1 casein kinase 1, alpha 1 0.0489778
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0485365
PCBP2 poly(rC) binding protein 2 0.0473152
KDM4C lysine (K)-specific demethylase 4C 0.0464428
GOLGB1 golgin B1 0.0449226
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0443505
KMT2C lysine (K)-specific methyltransferase 2C 0.0435533
TMF1 TATA element modulatory factor 1 0.0433553
CNOT1 CCR4-NOT transcription complex, subunit 1 0.043341
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.04235
LDHA lactate dehydrogenase A 0.0422967
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0418618
BRD2 bromodomain containing 2 0.0417994
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0415962
BPTF bromodomain PHD finger transcription factor 0.0415291
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0409829
LOC112694756 uncharaterized LOC112694756 0.0409567
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0407976
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0407616
TMED2 transmembrane emp24 domain trafficking protein 2 0.0402171
SFPQ splicing factor proline/glutamine-rich 0.0400916
KTN1 kinectin 1 (kinesin receptor) 0.0400265
RBM39 RNA binding motif protein 39 0.0398734
WWC2 WW and C2 domain containing 2 0.0398014
MATR3 matrin 3 0.039725
ASNS asparagine synthetase (glutamine-hydrolyzing) 0.0395924
PCM1 pericentriolar material 1 0.0394396
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0391092
PGM3 phosphoglucomutase 3 0.0382873
CSDE1 cold shock domain containing E1, RNA-binding 0.0374917
GOLGA2 golgin A2 0.0371858
NUP58 nucleoporin 58 0.0370522
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0368348
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0365066
ATM ATM serine/threonine kinase 0.0362168
EIF1 eukaryotic translation initiation factor 1 0.0359456
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0356183
PAPOLA poly(A) polymerase alpha 0.0355918
PHF3 PHD finger protein 3 0.0351331
MCL1 myeloid cell leukemia 1 0.0342252
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.034163
TOR1AIP2 torsin A interacting protein 2 0.033943
ZC3H11A zinc finger CCCH-type containing 11A 0.0339266
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0335261
GOLGA3 golgin A3 0.0334784
USO1 USO1 vesicle transport factor 0.03334
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0332562
TPM3 tropomyosin 3 0.0329737
FLNA filamin A, alpha 0.0328454
SBNO1 strawberry notch homolog 1 (Drosophila) 0.0327617
N4BP2L2 NEDD4 binding protein 2-like 2 0.0327435
VEGFA vascular endothelial growth factor A 0.0326173
MORF4L2 mortality factor 4 like 2 0.0325402
OGA O-GlcNAcase 0.0324002
NEBL nebulette 0.031914
TRIP12 thyroid hormone receptor interactor 12 0.0317701
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.0316277
SEC31A SEC31 homolog A (S. cerevisiae) 0.0315651
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0313814
HELZ helicase with zinc finger 0.0309111
ZFC3H1 zinc finger, C3H1-type containing 0.0307739
USP37 ubiquitin specific peptidase 37 0.0303568
JUN jun proto-oncogene 0.0302817
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.030274
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0297676
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0295395
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.029417
PRRC2C proline-rich coiled-coil 2C 0.0292066
TLN1 talin 1 0.0291526
PLEC plectin 0.0290696
FXR1 fragile X mental retardation, autosomal homolog 1 0.0290154
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0289973

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.193912
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.15382
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.120764
TMSB10 thymosin beta 10 -0.118372
TPT1 tumor protein, translationally-controlled 1 -0.109135
RPS6 ribosomal protein S6 -0.0645145
RPL35A ribosomal protein L35a -0.0561077
RPS8 ribosomal protein S8 -0.0559281
TOP2A topoisomerase (DNA) II alpha 170kDa -0.048821
MT2A metallothionein 2A -0.0428845
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0399806
ACTG1 actin gamma 1 -0.0385825
RPS24 ribosomal protein S24 -0.0369501
RPLP2 ribosomal protein, large, P2 -0.0369345
TUBA1B tubulin, alpha 1b -0.0367366
POTEF POTE ankyrin domain family, member F -0.0353617
RPLP1 ribosomal protein, large, P1 -0.0350959
RPS27A ribosomal protein S27a -0.0348149
S100A6 S100 calcium binding protein A6 -0.0341694
S100A9 S100 calcium binding protein A9 -0.0338935
TPM4 tropomyosin 4 -0.0329464
RPL34 ribosomal protein L34 -0.0322871
RPLP0 ribosomal protein, large, P0 -0.0319469
RPS29 ribosomal protein S29 -0.0310752
RPL37A ribosomal protein L37a -0.0307775
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.030378
CENPF centromere protein F, 350/400kDa -0.0295196
FHIT fragile histidine triad -0.0294547
HMGA2 high mobility group AT-hook 2 -0.0293035
RPL31 ribosomal protein L31 -0.0286819
NDRG1 N-myc downstream regulated 1 -0.0285562
S100A10 S100 calcium binding protein A10 -0.0277556
HMGA1 high mobility group AT-hook 1 -0.0273036
HLA-B major histocompatibility complex, class I, B -0.0272889
RPS16 ribosomal protein S16 -0.0271802
RPS15 ribosomal protein S15 -0.0269146
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0263468
RPL12 ribosomal protein L12 -0.0261581
TUBB4B tubulin, beta 4B class IVb -0.0260193
CCND1 cyclin D1 -0.0259285
RPS25 ribosomal protein S25 -0.0255731
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0251744
RPL35 ribosomal protein L35 -0.0250813
HMGB1 high mobility group box 1 -0.0250454
RPS23 ribosomal protein S23 -0.0247224
RRM2 ribonucleotide reductase M2 -0.0247187
RPS21 ribosomal protein S21 -0.0243551
IFITM3 interferon induced transmembrane protein 3 -0.0241879
EGFR epidermal growth factor receptor -0.0241406
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0237033
RPS17 ribosomal protein S17 -0.0236008
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0231494
CDCP1 CUB domain containing protein 1 -0.0225119
RPL27 ribosomal protein L27 -0.0222032
RPL9 ribosomal protein L9 -0.0221572
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0220906
RPL32 ribosomal protein L32 -0.021975
PFN1 profilin 1 -0.0217643
STMN1 stathmin 1 -0.0216652
WSB1 WD repeat and SOCS box containing 1 -0.0214754
FRMD5 FERM domain containing 5 -0.0207642
RPS3 ribosomal protein S3 -0.0203606
RPS10 ribosomal protein S10 -0.0202396
KRT19 keratin 19, type I -0.0201449
RPL38 ribosomal protein L38 -0.0201297
HLA-A major histocompatibility complex, class I, A -0.0200017
MKI67 marker of proliferation Ki-67 -0.0199875
IGFBP4 insulin-like growth factor binding protein 4 -0.019977
ITGB4 integrin, beta 4 -0.0199131
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0198612
WWOX WW domain containing oxidoreductase -0.0197461
MORC4 MORC family CW-type zinc finger 4 -0.0196156
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0194603
RPL26 ribosomal protein L26 -0.0192835
KRT8 keratin 8, type II -0.0192571
RTN4 reticulon 4 -0.0191624
SMC4 structural maintenance of chromosomes 4 -0.0188322
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0187453
RPL28 ribosomal protein L28 -0.0187386
RPS20 ribosomal protein S20 -0.0185242
PKM pyruvate kinase, muscle -0.0180508
RPS5 ribosomal protein S5 -0.0179926
MEF2A myocyte enhancer factor 2A -0.0179173
EIF5B eukaryotic translation initiation factor 5B -0.017833
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0177931
KIF14 kinesin family member 14 -0.0170291
NOP56 NOP56 ribonucleoprotein -0.0169192
RPS28 ribosomal protein S28 -0.0168753
ANLN anillin, actin binding protein -0.016768
HELLS helicase, lymphoid-specific -0.0166968
RPS13 ribosomal protein S13 -0.0164168
SERINC5 serine incorporator 5 -0.0160433
RPS19 ribosomal protein S19 -0.0157842
RPL19 ribosomal protein L19 -0.0156671
DLG1 discs, large homolog 1 (Drosophila) -0.015529
RPL36AL ribosomal protein L36a-like -0.0154961
RPL36 ribosomal protein L36 -0.0154215
IFITM2 interferon induced transmembrane protein 2 -0.015397
DEK DEK proto-oncogene -0.0153386
EGR1 early growth response 1 -0.0153308