Citalopram (hydrobromide)_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Citalopram (hydrobromide) perturbation in HEC-1-A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Citalopram (hydrobromide)_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.0774717
ASPH aspartate beta-hydroxylase 0.0649143
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.063988
PSD3 pleckstrin and Sec7 domain containing 3 0.0632657
PRELID2 PRELI domain containing 2 0.0590473
PAX8 paired box 8 0.0548043
SVIL supervillin 0.0535802
RACK1 receptor for activated C kinase 1 0.0535523
FLNA filamin A, alpha 0.0501721
RAD51B RAD51 paralog B 0.0484335
CD44 CD44 molecule (Indian blood group) 0.0475343
MKI67 marker of proliferation Ki-67 0.046243
DIAPH3 diaphanous-related formin 3 0.0449622
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0448562
LPP LIM domain containing preferred translocation partner in lipoma 0.0432095
HMGA2 high mobility group AT-hook 2 0.0428142
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0422439
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0414151
DLC1 DLC1 Rho GTPase activating protein 0.0409769
VCL vinculin 0.0394814
EGFR epidermal growth factor receptor 0.0394385
ZBTB20 zinc finger and BTB domain containing 20 0.0385112
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0379996
IGFBP3 insulin-like growth factor binding protein 3 0.0374485
LAMC2 laminin, gamma 2 0.0372869
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0366485
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0364788
WWC1 WW and C2 domain containing 1 0.0356348
OSBPL10 oxysterol binding protein-like 10 0.0342785
SMYD3 SET and MYND domain containing 3 0.0341861
SEPTIN9 septin 9 0.0338036
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0316296
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0289406
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0285677
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0285403
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0285319
TRIO trio Rho guanine nucleotide exchange factor 0.0281783
BCAR3 breast cancer anti-estrogen resistance 3 0.0279281
FHIT fragile histidine triad 0.0277041
ANO6 anoctamin 6 0.0274383
DOCK1 dedicator of cytokinesis 1 0.0264892
NF1 neurofibromin 1 0.0260786
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.02604
PTK2 protein tyrosine kinase 2 0.0256319
CAPN2 calpain 2, (m/II) large subunit 0.0254157
RBMS3 RNA binding motif, single stranded interacting protein 3 0.025219
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0247436
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0247036
BICD1 bicaudal D homolog 1 (Drosophila) 0.0246903
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0243835
PTPRK protein tyrosine phosphatase, receptor type, K 0.0243686
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0242453
PDGFC platelet derived growth factor C 0.0240174
EHBP1 EH domain binding protein 1 0.0238395
NRIP1 nuclear receptor interacting protein 1 0.0231891
DOCK4 dedicator of cytokinesis 4 0.0230975
THSD4 thrombospondin, type I, domain containing 4 0.0229357
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0227193
NSD2 nuclear receptor binding SET domain protein 2 0.0224659
PLEC plectin 0.0224343
ANKRD36 ankyrin repeat domain 36 0.0222806
CSNK1A1 casein kinase 1, alpha 1 0.0222352
CCDC138 coiled-coil domain containing 138 0.0220752
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0216715
AEBP2 AE binding protein 2 0.0216662
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0214438
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0213622
RPS12 ribosomal protein S12 0.0213598
ARHGAP29 Rho GTPase activating protein 29 0.0211733
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0210632
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0209736
ERBIN erbb2 interacting protein 0.0209511
GPR39 G protein-coupled receptor 39 0.0209394
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0207149
LIMCH1 LIM and calponin homology domains 1 0.0206447
MTAP methylthioadenosine phosphorylase 0.0204451
RPL3 ribosomal protein L3 0.0204101
ATG7 autophagy related 7 0.0203672
MACF1 microtubule-actin crosslinking factor 1 0.0202324
FAF1 Fas (TNFRSF6) associated factor 1 0.020105
GPATCH8 G patch domain containing 8 0.02
BTBD10 BTB (POZ) domain containing 10 0.0199906
TBC1D22A TBC1 domain family, member 22A 0.0199785
SRRM2 serine/arginine repetitive matrix 2 0.0197874
MMS22L MMS22-like, DNA repair protein 0.0196982
MACROH2A1 macroH2A.1 histone 0.0196754
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0193355
MAPK8 mitogen-activated protein kinase 8 0.0192038
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 0.0189824
PCED1B PC-esterase domain containing 1B 0.0187563
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0186445
PICALM phosphatidylinositol binding clathrin assembly protein 0.0182713
RFC3 replication factor C (activator 1) 3, 38kDa 0.0181462
ATXN7 ataxin 7 0.0179282
SCLT1 sodium channel and clathrin linker 1 0.0178943
UBASH3B ubiquitin associated and SH3 domain containing B 0.0178301
SH3KBP1 SH3-domain kinase binding protein 1 0.017815
PRRC2C proline-rich coiled-coil 2C 0.0178102
GPATCH2L G patch domain containing 2-like 0.0177011
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.0176878

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0955008
ANXA1 annexin A1 -0.0483837
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0436533
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0427974
NDRG1 N-myc downstream regulated 1 -0.0416441
KDM3A lysine (K)-specific demethylase 3A -0.041199
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.040411
EGR1 early growth response 1 -0.0402986
PGK1 phosphoglycerate kinase 1 -0.038845
EREG epiregulin -0.0352359
DDIT4 DNA-damage-inducible transcript 4 -0.0344786
PTMA prothymosin, alpha -0.0340671
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.033671
LDHA lactate dehydrogenase A -0.0328215
SQSTM1 sequestosome 1 -0.0327409
CANX calnexin -0.0323906
APP amyloid beta (A4) precursor protein -0.0323158
CCND1 cyclin D1 -0.0316784
FTL ferritin, light polypeptide -0.03033
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0299869
TMSB4X thymosin beta 4, X-linked -0.0294104
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0289889
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0284314
EZR ezrin -0.0275872
TES testin LIM domain protein -0.0262926
GARS1 glycyl-tRNA synthetase 1 -0.0253453
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.024904
MATR3 matrin 3 -0.0239476
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0238286
UGCG UDP-glucose ceramide glucosyltransferase -0.0237709
PKM pyruvate kinase, muscle -0.0237436
RBM39 RNA binding motif protein 39 -0.0235217
NAMPT nicotinamide phosphoribosyltransferase -0.0227179
WDR45B WD repeat domain 45B -0.0225722
ZNF292 zinc finger protein 292 -0.0220138
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0218237
FOSL1 FOS-like antigen 1 -0.0217171
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0215611
NR1D2 nuclear receptor subfamily 1, group D, member 2 -0.0212575
SOD2 superoxide dismutase 2, mitochondrial -0.0212245
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0209023
H1-0 H1.0 linker histone -0.0207448
RLF rearranged L-myc fusion -0.0205582
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0201177
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.019659
DSTN destrin (actin depolymerizing factor) -0.0196267
EMP1 epithelial membrane protein 1 -0.0196091
BHLHE40 basic helix-loop-helix family, member e40 -0.019583
RSL1D1 ribosomal L1 domain containing 1 -0.0194516
TXNRD1 thioredoxin reductase 1 -0.0192896
ENO1 enolase 1, (alpha) -0.0191509
DUSP5 dual specificity phosphatase 5 -0.0190899
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0189829
PPP1R15A protein phosphatase 1, regulatory subunit 15A -0.0188144
PDIA6 protein disulfide isomerase family A, member 6 -0.0187707
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0184715
SINHCAF SIN3-HDAC complex associated factor -0.0184154
MLF1 myeloid leukemia factor 1 -0.0182723
IARS1 isoleucyl-tRNA synthetase 1 -0.0182181
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0181827
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0181582
IER3 immediate early response 3 -0.0176936
UPP1 uridine phosphorylase 1 -0.0176756
TRA2A transformer 2 alpha homolog (Drosophila) -0.0176173
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.0176084
SEPTIN7 septin 7 -0.0174194
RSRC2 arginine/serine-rich coiled-coil 2 -0.0170726
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0170288
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0169588
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.016708
AZIN1 antizyme inhibitor 1 -0.0166721
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0166254
BRD2 bromodomain containing 2 -0.0164752
PDIA3 protein disulfide isomerase family A, member 3 -0.0164101
KRT7 keratin 7, type II -0.0163731
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0160659
SDC4 syndecan 4 -0.0159768
ARHGAP26 Rho GTPase activating protein 26 -0.0155685
TRAM1 translocation associated membrane protein 1 -0.0154562
ANXA2 annexin A2 -0.015224
FBXL2 F-box and leucine-rich repeat protein 2 -0.0151377
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0150377
IFRD1 interferon-related developmental regulator 1 -0.0150099
APOL1 apolipoprotein L, 1 -0.0147658
KMT2E lysine (K)-specific methyltransferase 2E -0.0147062
RNMT RNA (guanine-7-) methyltransferase -0.0146238
ADGRE5 adhesion G protein-coupled receptor E5 -0.0145713
KLF6 Kruppel-like factor 6 -0.014547
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.0144423
SKAP2 src kinase associated phosphoprotein 2 -0.0143783
CCT8 chaperonin containing TCP1, subunit 8 (theta) -0.0143639
TFRC transferrin receptor -0.0143278
CCNL1 cyclin L1 -0.0142703
NOP58 NOP58 ribonucleoprotein -0.0142393
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0142241
LMNA lamin A/C -0.0141322
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0141225
ZC3H15 zinc finger CCCH-type containing 15 -0.0141121
DSG2 desmoglein 2 -0.0139963
CDA cytidine deaminase -0.0138873