Citalopram (hydrobromide)_HOP62 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Citalopram (hydrobromide) perturbation in HOP62 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Citalopram (hydrobromide)_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ELL2 elongation factor, RNA polymerase II, 2 0.110582
FAM13A family with sequence similarity 13, member A 0.092376
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0843
IGFBP3 insulin-like growth factor binding protein 3 0.0646532
ERRFI1 ERBB receptor feedback inhibitor 1 0.0604388
FNDC3B fibronectin type III domain containing 3B 0.0542231
CXCL8 chemokine (C-X-C motif) ligand 8 0.0515178
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0514753
ZNF292 zinc finger protein 292 0.050543
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.050304
SPAG9 sperm associated antigen 9 0.0492232
STC1 stanniocalcin 1 0.0484734
NUP58 nucleoporin 58 0.0464304
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0457488
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0452418
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0426871
UBA6 ubiquitin-like modifier activating enzyme 6 0.0412687
PABPC1 poly(A) binding protein, cytoplasmic 1 0.041088
USP3 ubiquitin specific peptidase 3 0.0405681
DDIT4 DNA-damage-inducible transcript 4 0.0391284
HELZ helicase with zinc finger 0.0371751
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.037124
RNMT RNA (guanine-7-) methyltransferase 0.0365732
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0361528
SHB Src homology 2 domain containing adaptor protein B 0.0350024
FN1 fibronectin 1 0.0349852
NAMPT nicotinamide phosphoribosyltransferase 0.0342778
RLF rearranged L-myc fusion 0.03243
RNF24 ring finger protein 24 0.0324078
TRIO trio Rho guanine nucleotide exchange factor 0.0322633
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.0321363
BHLHE40 basic helix-loop-helix family, member e40 0.0320745
NGLY1 N-glycanase 1 0.0320073
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0318621
ATP13A3 ATPase type 13A3 0.0318578
JUN jun proto-oncogene 0.0308699
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0308428
MIMS1 mitochondrial inner membrane scaffold 1 0.0308224
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0307536
WDR45B WD repeat domain 45B 0.030218
ARRDC3 arrestin domain containing 3 0.0300377
RACK1 receptor for activated C kinase 1 0.0288139
KMT2E lysine (K)-specific methyltransferase 2E 0.0287191
OGA O-GlcNAcase 0.0283849
AFF4 AF4/FMR2 family, member 4 0.0282276
YBX1 Y box binding protein 1 0.0282028
RNF145 ring finger protein 145 0.0275695
HILPDA hypoxia inducible lipid droplet-associated 0.0275677
TAC4 tachykinin 4 (hemokinin) 0.0271348
PDE10A phosphodiesterase 10A 0.0269166
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0267636
GOLGA4 golgin A4 0.0264065
TFG TRK-fused gene 0.0253333
ZNF148 zinc finger protein 148 0.025274
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0251373
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0250843
ADAM9 ADAM metallopeptidase domain 9 0.0248188
SEC24A SEC24 family member A 0.0246827
HOOK2 hook microtubule-tethering protein 2 0.0246219
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0238641
EEF2 eukaryotic translation elongation factor 2 0.0234474
LOC112694756 uncharaterized LOC112694756 0.0232031
CD109 CD109 molecule 0.0229627
PGK1 phosphoglycerate kinase 1 0.0228842
ANXA5 annexin A5 0.0225207
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0224556
MARCHF6 membrane associated ring-CH-type finger 6 0.0224176
HSPA8 heat shock 70kDa protein 8 0.0217277
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0216646
QKI QKI, KH domain containing, RNA binding 0.0211681
CANX calnexin 0.0211583
CLEC1B C-type lectin domain family 1, member B 0.0210644
JARID2 jumonji, AT rich interactive domain 2 0.0207764
PPARD peroxisome proliferator-activated receptor delta 0.020771
NPTN neuroplastin 0.0205222
RPL3 ribosomal protein L3 0.0205199
RAB8B RAB8B, member RAS oncogene family 0.0202152
KDM3A lysine (K)-specific demethylase 3A 0.0194574
MATR3 matrin 3 0.0192859
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0192845
AMPD3 adenosine monophosphate deaminase 3 0.0192338
HDLBP high density lipoprotein binding protein 0.0191595
ADAM17 ADAM metallopeptidase domain 17 0.0188232
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0188094
SRP54 signal recognition particle 54kDa 0.0187815
MXI1 MAX interactor 1, dimerization protein 0.0186301
TNIP1 TNFAIP3 interacting protein 1 0.0185504
FAM162A family with sequence similarity 162, member A 0.0185224
RB1CC1 RB1-inducible coiled-coil 1 0.0185054
UGCG UDP-glucose ceramide glucosyltransferase 0.0184368
SETD5 SET domain containing 5 0.0183452
PDIA4 protein disulfide isomerase family A, member 4 0.0183109
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 0.0182592
SMAD3 SMAD family member 3 0.0180572
NBAS neuroblastoma amplified sequence 0.0177423
DOT1L DOT1-like histone H3K79 methyltransferase 0.0176486
INSIG2 insulin induced gene 2 0.0174474
SYAP1 synapse associated protein 1 0.0173778
NR1D2 nuclear receptor subfamily 1, group D, member 2 0.0173362
RICTOR RPTOR independent companion of MTOR, complex 2 0.017295

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.430758
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.175641
TPT1 tumor protein, translationally-controlled 1 -0.146817
HMGA2 high mobility group AT-hook 2 -0.143812
ASPH aspartate beta-hydroxylase -0.127767
TMSB10 thymosin beta 10 -0.12
MT2A metallothionein 2A -0.10661
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.104476
ACTG1 actin gamma 1 -0.103925
EXT1 exostosin glycosyltransferase 1 -0.0972331
CDH13 cadherin 13 -0.0840136
CD44 CD44 molecule (Indian blood group) -0.0799089
IGF2 insulin-like growth factor 2 -0.0788141
NAV1 neuron navigator 1 -0.0736147
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0681838
RPL35A ribosomal protein L35a -0.0668032
EGR1 early growth response 1 -0.0658057
PTMA prothymosin, alpha -0.0629676
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0604525
RPS6 ribosomal protein S6 -0.0596527
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0596172
COL1A1 collagen, type I, alpha 1 -0.0592689
COL5A1 collagen, type V, alpha 1 -0.0575841
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.056718
RPLP1 ribosomal protein, large, P1 -0.0542246
VCL vinculin -0.0537304
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0531972
RPS24 ribosomal protein S24 -0.05299
COL6A1 collagen, type VI, alpha 1 -0.0487589
NALF1 NALCN channel auxiliary factor 1 -0.0472846
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0464277
RPL9 ribosomal protein L9 -0.0456502
ZBTB20 zinc finger and BTB domain containing 20 -0.0449155
RPL31 ribosomal protein L31 -0.0448266
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0441264
CLMP CXADR-like membrane protein -0.0439681
CAVIN1 caveolae associated protein 1 -0.0437343
RFX8 RFX family member 8, lacking RFX DNA binding domain -0.0435494
ANKRD12 ankyrin repeat domain 12 -0.0433946
RPS8 ribosomal protein S8 -0.0422263
RPLP2 ribosomal protein, large, P2 -0.0419716
BICD1 bicaudal D homolog 1 (Drosophila) -0.0405589
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.040506
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0403312
RPS16 ribosomal protein S16 -0.0401861
RPS13 ribosomal protein S13 -0.0394654
INTS6 integrator complex subunit 6 -0.0391645
MT1E metallothionein 1E -0.03884
COL6A2 collagen, type VI, alpha 2 -0.0380721
FRMD4A FERM domain containing 4A -0.0378347
ENO2 enolase 2 (gamma, neuronal) -0.0371613
LPP LIM domain containing preferred translocation partner in lipoma -0.0367768
RPL37A ribosomal protein L37a -0.0364396
ATXN1 ataxin 1 -0.0362236
S100A10 S100 calcium binding protein A10 -0.0358074
HLA-B major histocompatibility complex, class I, B -0.0357054
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0355059
TAS2R14 taste receptor, type 2, member 14 -0.0352604
CCND1 cyclin D1 -0.0346501
RAI14 retinoic acid induced 14 -0.0344507
RPS27A ribosomal protein S27a -0.0343254
RAD51B RAD51 paralog B -0.034145
ARHGAP22 Rho GTPase activating protein 22 -0.0336242
RPS23 ribosomal protein S23 -0.0334279
BPTF bromodomain PHD finger transcription factor -0.0332699
FMN1 formin 1 -0.0332351
MYO10 myosin X -0.032983
RPL38 ribosomal protein L38 -0.0328592
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 -0.0322762
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0320771
SMYD3 SET and MYND domain containing 3 -0.0320095
DIAPH2 diaphanous-related formin 2 -0.0318326
PTPRG protein tyrosine phosphatase, receptor type, G -0.0315581
MAML3 mastermind-like 3 (Drosophila) -0.0314953
PRKCA protein kinase C, alpha -0.031297
CAPN2 calpain 2, (m/II) large subunit -0.0312356
CUX1 cut-like homeobox 1 -0.0306966
KPNB1 karyopherin (importin) beta 1 -0.0296754
RPL15 ribosomal protein L15 -0.0295984
VASP vasodilator-stimulated phosphoprotein -0.0293395
EGFR epidermal growth factor receptor -0.0289998
RPL23 ribosomal protein L23 -0.0288539
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0288444
SDK1 sidekick cell adhesion molecule 1 -0.0286494
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0285791
MAP4 microtubule-associated protein 4 -0.0285136
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0284481
RPS19 ribosomal protein S19 -0.0283621
PDE4D phosphodiesterase 4D, cAMP-specific -0.0283426
RPS29 ribosomal protein S29 -0.0281968
RPS25 ribosomal protein S25 -0.0281888
CLIC4 chloride intracellular channel 4 -0.0278752
ZMYND8 zinc finger, MYND-type containing 8 -0.027845
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0277956
ATG7 autophagy related 7 -0.027718
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0276782
MPRIP myosin phosphatase Rho interacting protein -0.0276654
RPL34 ribosomal protein L34 -0.0271253
SHISA5 shisa family member 5 -0.0270185
MARK4 MAP/microtubule affinity-regulating kinase 4 -0.0263715