Citalopram (hydrobromide)_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Citalopram (hydrobromide) perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Citalopram (hydrobromide)_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 0.088273
LMO7 LIM domain 7 0.0712228
PDLIM5 PDZ and LIM domain 5 0.0622064
KRT6A keratin 6A, type II 0.0591618
SLC35F3 solute carrier family 35, member F3 0.0575856
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0518335
ALCAM activated leukocyte cell adhesion molecule 0.048957
TRIO trio Rho guanine nucleotide exchange factor 0.046535
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0451169
RACK1 receptor for activated C kinase 1 0.0449579
FTH1 ferritin, heavy polypeptide 1 0.0448268
FKBP5 FK506 binding protein 5 0.0435737
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0409459
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.039197
AKAP13 A kinase (PRKA) anchor protein 13 0.0361698
ESYT2 extended synaptotagmin-like protein 2 0.0345005
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0328916
RASAL2 RAS protein activator like 2 0.0319096
PDE4D phosphodiesterase 4D, cAMP-specific 0.0318883
GRB10 growth factor receptor-bound protein 10 0.0307182
HSPG2 heparan sulfate proteoglycan 2 0.0293686
MPRIP myosin phosphatase Rho interacting protein 0.0290287
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0274153
PSD3 pleckstrin and Sec7 domain containing 3 0.0265132
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0264467
PLEC plectin 0.0258685
F3 coagulation factor III (thromboplastin, tissue factor) 0.0258603
CALB1 calbindin 1, 28kDa 0.0255238
ANO1 anoctamin 1, calcium activated chloride channel 0.0239148
HMGA2 high mobility group AT-hook 2 0.0236643
PALLD palladin, cytoskeletal associated protein 0.0232708
TJP1 tight junction protein 1 0.0232124
FLNA filamin A, alpha 0.0230262
RNF217 ring finger protein 217 0.0230226
EGR1 early growth response 1 0.0227029
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.022622
ABI3BP ABI family, member 3 (NESH) binding protein 0.0224917
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0223299
KIAA1671 KIAA1671 0.0222363
RCOR1 REST corepressor 1 0.0222341
LAMA5 laminin, alpha 5 0.0220147
RABGAP1L RAB GTPase activating protein 1-like 0.0212865
THSD4 thrombospondin, type I, domain containing 4 0.0209173
IGF2 insulin-like growth factor 2 0.0208074
EFNA5 ephrin-A5 0.0205405
DSPP dentin sialophosphoprotein 0.0195421
PODXL podocalyxin-like 0.0191918
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.019083
ZMIZ1 zinc finger, MIZ-type containing 1 0.0188602
VCL vinculin 0.0184617
ABLIM3 actin binding LIM protein family, member 3 0.0183043
MTSS1 metastasis suppressor 1 0.017677
TINAGL1 tubulointerstitial nephritis antigen-like 1 0.0175886
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0173592
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0172817
TNS3 tensin 3 0.017214
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0164868
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 0.015837
INTS6 integrator complex subunit 6 0.0156761
SULF1 sulfatase 1 0.0154712
BCAR3 breast cancer anti-estrogen resistance 3 0.0151357
LAMC2 laminin, gamma 2 0.015073
PRSS23 protease, serine, 23 0.0150164
UTRN utrophin 0.0149758
DPYD dihydropyrimidine dehydrogenase 0.0147737
GLUL glutamate-ammonia ligase 0.01445
THBD thrombomodulin 0.0144232
DGKH diacylglycerol kinase, eta 0.0143289
FBXO11 F-box protein 11 0.0143123
IGFBP6 insulin-like growth factor binding protein 6 0.0141282
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0138317
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 0.0137427
CAPRIN2 caprin family member 2 0.013585
ANKRD11 ankyrin repeat domain 11 0.0135049
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0134337
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0133536
PGM3 phosphoglucomutase 3 0.0131437
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0130444
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0129977
ZFP36L1 ZFP36 ring finger protein-like 1 0.0128197
PTHLH parathyroid hormone-like hormone 0.0128003
EFNB1 ephrin-B1 0.0125904
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 0.0125783
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0125704
CLMB calcimembrin 0.0125533
MT1X metallothionein 1X 0.0124812
FZD4 frizzled class receptor 4 0.0124743
AMOTL1 angiomotin like 1 0.0124212
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.0123586
PCDH1 protocadherin 1 0.0121823
IGFBP3 insulin-like growth factor binding protein 3 0.0120843
ZSWIM6 zinc finger, SWIM-type containing 6 0.0120682
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0120502
WNT2B wingless-type MMTV integration site family, member 2B 0.0119293
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.0119107
RPS15A ribosomal protein S15a 0.0118247
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0117526
PLXNA2 plexin A2 0.0117352
FLG filaggrin 0.0116782
RPL3 ribosomal protein L3 0.0116199

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.21751
ENO1 enolase 1, (alpha) -0.153317
UBC ubiquitin C -0.118426
ASPH aspartate beta-hydroxylase -0.107561
NAMPT nicotinamide phosphoribosyltransferase -0.10542
MYOF myoferlin -0.105188
AHNAK AHNAK nucleoprotein -0.102319
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0923627
CLU clusterin -0.0906931
PTMA prothymosin, alpha -0.0880195
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0807105
RPS27A ribosomal protein S27a -0.0777914
KRT17 keratin 17, type I -0.0737548
RPS21 ribosomal protein S21 -0.0716457
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0702864
CANX calnexin -0.069404
TMSB10 thymosin beta 10 -0.0687065
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0664472
CD44 CD44 molecule (Indian blood group) -0.0656804
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.064602
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0645993
B2M beta-2-microglobulin -0.062848
STC1 stanniocalcin 1 -0.0627901
KMT2E lysine (K)-specific methyltransferase 2E -0.0604337
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0600934
KIAA1217 KIAA1217 -0.0577147
TMSB4X thymosin beta 4, X-linked -0.0575174
PKM pyruvate kinase, muscle -0.0573884
ITGA6 integrin, alpha 6 -0.0564457
PGK1 phosphoglycerate kinase 1 -0.0556533
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0554212
NAP1L1 nucleosome assembly protein 1-like 1 -0.0544853
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0542783
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0540619
LDHA lactate dehydrogenase A -0.0518482
RPLP2 ribosomal protein, large, P2 -0.0512781
MBNL1 muscleblind-like splicing regulator 1 -0.0510428
LMNA lamin A/C -0.0498424
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -0.049045
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0480755
CEMIP cell migration inducing protein, hyaluronan binding -0.0475381
HLA-B major histocompatibility complex, class I, B -0.0470166
H1-0 H1.0 linker histone -0.0464147
KTN1 kinectin 1 (kinesin receptor) -0.0458097
RBM39 RNA binding motif protein 39 -0.0457947
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0454752
TPT1 tumor protein, translationally-controlled 1 -0.0453375
OGA O-GlcNAcase -0.0450365
POTEF POTE ankyrin domain family, member F -0.0446772
RPS6 ribosomal protein S6 -0.0443296
RPS8 ribosomal protein S8 -0.0443178
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0442707
SERINC3 serine incorporator 3 -0.0442097
STAU1 staufen double-stranded RNA binding protein 1 -0.0438104
ANXA2 annexin A2 -0.0432182
RPS13 ribosomal protein S13 -0.0428812
YBX3 Y box binding protein 3 -0.0423637
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0418506
KDM3A lysine (K)-specific demethylase 3A -0.0414635
CALU calumenin -0.0404958
MYH9 myosin, heavy chain 9, non-muscle -0.0399772
ANLN anillin, actin binding protein -0.0395967
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.0395095
RPS24 ribosomal protein S24 -0.0391212
TM4SF1 transmembrane 4 L six family member 1 -0.0389997
RPS3 ribosomal protein S3 -0.0385485
COPB1 coatomer protein complex, subunit beta 1 -0.0383371
CAV1 caveolin 1, caveolae protein, 22kDa -0.0381827
IFI16 interferon, gamma-inducible protein 16 -0.0379477
S100A10 S100 calcium binding protein A10 -0.0376412
GOLGA4 golgin A4 -0.037491
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0372794
FOXP1 forkhead box P1 -0.0372516
ZNF292 zinc finger protein 292 -0.0364502
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.036127
PLAT plasminogen activator, tissue -0.0354579
PCBP2 poly(rC) binding protein 2 -0.0353846
S100A6 S100 calcium binding protein A6 -0.0350494
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0350321
LOC112694756 uncharaterized LOC112694756 -0.0346842
PDIA3 protein disulfide isomerase family A, member 3 -0.0344572
ARHGAP29 Rho GTPase activating protein 29 -0.0344184
CAMK2D calcium/calmodulin-dependent protein kinase II delta -0.0339548
GNAS GNAS complex locus -0.0339359
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0339246
CD99 CD99 molecule -0.0337466
RPL7A ribosomal protein L7a -0.0337437
RIN2 Ras and Rab interactor 2 -0.033532
TPX2 TPX2, microtubule-associated -0.0331637
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0330877
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0328357
SMAD3 SMAD family member 3 -0.0327946
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0313124
PRRC2C proline-rich coiled-coil 2C -0.0311236
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0309382
VMP1 vacuole membrane protein 1 -0.0309138
RPS12 ribosomal protein S12 -0.030614
RPS25 ribosomal protein S25 -0.0305007
PTK2 protein tyrosine kinase 2 -0.0304856
DSTN destrin (actin depolymerizing factor) -0.0301846