Citalopram (hydrobromide)_J82 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Citalopram (hydrobromide) perturbation in J82 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Citalopram (hydrobromide)_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.310277
AKAP12 A kinase (PRKA) anchor protein 12 0.180186
FTH1 ferritin, heavy polypeptide 1 0.0818064
SOD2 superoxide dismutase 2, mitochondrial 0.0606238
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0575193
CCBE1 collagen and calcium binding EGF domains 1 0.046754
CUL4B cullin 4B 0.0398698
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0379136
NAV2 neuron navigator 2 0.0373718
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0332645
ANXA1 annexin A1 0.030777
HIPK2 homeodomain interacting protein kinase 2 0.0292588
KLF9 Kruppel-like factor 9 0.0278889
LOX lysyl oxidase 0.0266231
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0264507
NUP58 nucleoporin 58 0.025108
NCOA3 nuclear receptor coactivator 3 0.0244677
ZMYND8 zinc finger, MYND-type containing 8 0.0242852
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0241036
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0227665
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0227231
ABLIM3 actin binding LIM protein family, member 3 0.0226936
ZFP36L1 ZFP36 ring finger protein-like 1 0.0220424
MT1X metallothionein 1X 0.0215043
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0213125
PTPRM protein tyrosine phosphatase, receptor type, M 0.0206649
PTX3 pentraxin 3, long 0.0203838
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0203723
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.019929
RACK1 receptor for activated C kinase 1 0.0196555
CCNL1 cyclin L1 0.0184014
RUNX2 runt-related transcription factor 2 0.0175818
FKBP5 FK506 binding protein 5 0.0172482
EPS8 epidermal growth factor receptor pathway substrate 8 0.0165292
STARD13 StAR-related lipid transfer (START) domain containing 13 0.0160809
FNDC3B fibronectin type III domain containing 3B 0.0160609
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0159377
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0158845
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0158237
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.01563
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.0155131
ADM adrenomedullin 0.0155025
UBQLN1 ubiquilin 1 0.0153602
SAA2 serum amyloid A2 0.0152324
ERRFI1 ERBB receptor feedback inhibitor 1 0.0148931
TRAM2 translocation associated membrane protein 2 0.0143627
TMTC1 transmembrane and tetratricopeptide repeat containing 1 0.0142269
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.01346
PTPRG protein tyrosine phosphatase, receptor type, G 0.0129184
HLA-C major histocompatibility complex, class I, C 0.0128649
NEBL nebulette 0.0127945
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0126687
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0121576
IRS2 insulin receptor substrate 2 0.0121448
ARRDC3 arrestin domain containing 3 0.0120935
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0120492
STC2 stanniocalcin 2 0.0117495
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 0.0116744
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2 0.0116455
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0115439
MYO1B myosin IB 0.0114942
TMED2 transmembrane emp24 domain trafficking protein 2 0.0113563
GLIS3 GLIS family zinc finger 3 0.0113384
KLF6 Kruppel-like factor 6 0.0112445
DUSP12 dual specificity phosphatase 12 0.0110969
PER1 period circadian clock 1 0.0104637
ESYT2 extended synaptotagmin-like protein 2 0.0104175
LPP LIM domain containing preferred translocation partner in lipoma 0.0103978
PLEC plectin 0.0103389
RLIM ring finger protein, LIM domain interacting 0.0102649
SDK1 sidekick cell adhesion molecule 1 0.0102221
NRCAM neuronal cell adhesion molecule 0.0101917
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) 0.0101796
IL1R1 interleukin 1 receptor, type I 0.00993854
ANGPTL4 angiopoietin-like 4 0.00993647
CEP250 centrosomal protein 250kDa 0.00977501
MYLIP myosin regulatory light chain interacting protein 0.00964783
SAA2-SAA4 SAA2-SAA4 readthrough 0.00963901
AHR aryl hydrocarbon receptor 0.00961623
FAM13A family with sequence similarity 13, member A 0.00951602
YEATS2 YEATS domain containing 2 0.00949689
CRYBG3 beta-gamma crystallin domain containing 3 0.00942292
MYH9 myosin, heavy chain 9, non-muscle 0.00940951
AFF1 AF4/FMR2 family, member 1 0.00938469
JPH2 junctophilin 2 0.00936971
DIAPH2 diaphanous-related formin 2 0.0093693
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.00932061
USP37 ubiquitin specific peptidase 37 0.00926453
PHF21A PHD finger protein 21A 0.00918154
AGTPBP1 ATP/GTP binding protein 1 0.00912362
MYOF myoferlin 0.00910895
ACSL3 acyl-CoA synthetase long-chain family member 3 0.00904586
TBC1D5 TBC1 domain family, member 5 0.00870637
ELOVL5 ELOVL fatty acid elongase 5 0.00870304
RNF144B ring finger protein 144B 0.00866417
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.00859858
TNS3 tensin 3 0.00859832
FOXN3 forkhead box N3 0.00857752
PTPRJ protein tyrosine phosphatase, receptor type, J 0.00851618
PCBP3 poly(rC) binding protein 3 0.00849958

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.244996
HLA-B major histocompatibility complex, class I, B -0.175789
FTL ferritin, light polypeptide -0.145311
ENO1 enolase 1, (alpha) -0.104884
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0961057
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0873703
UBC ubiquitin C -0.0868362
CD44 CD44 molecule (Indian blood group) -0.0818567
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0666648
EXT1 exostosin glycosyltransferase 1 -0.0647071
TMSB10 thymosin beta 10 -0.0586253
PTMA prothymosin, alpha -0.0573472
DLG1 discs, large homolog 1 (Drosophila) -0.0556221
VIM vimentin -0.0513105
LOC112694756 uncharaterized LOC112694756 -0.0499848
AHNAK AHNAK nucleoprotein -0.0499082
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0465793
RPLP2 ribosomal protein, large, P2 -0.0462242
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0462144
DEK DEK proto-oncogene -0.0452127
PKM pyruvate kinase, muscle -0.0443195
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0435397
RPS6 ribosomal protein S6 -0.0428452
TRIO trio Rho guanine nucleotide exchange factor -0.0416987
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0412722
NALF1 NALCN channel auxiliary factor 1 -0.0406221
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0374681
HLA-A major histocompatibility complex, class I, A -0.0369848
CALR calreticulin -0.0369164
RPS27A ribosomal protein S27a -0.0363388
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0356186
ASPH aspartate beta-hydroxylase -0.0355366
GOLGA4 golgin A4 -0.0351766
KRT8 keratin 8, type II -0.0348727
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0346115
SQSTM1 sequestosome 1 -0.0345689
IFI6 interferon, alpha-inducible protein 6 -0.0336326
PDIA3 protein disulfide isomerase family A, member 3 -0.0329433
ERBIN erbb2 interacting protein -0.032371
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0321987
RPS8 ribosomal protein S8 -0.0310894
DIAPH3 diaphanous-related formin 3 -0.0309544
MT2A metallothionein 2A -0.0305638
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0301893
SET SET nuclear proto-oncogene -0.0297966
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0292635
ACTG1 actin gamma 1 -0.0291084
STAU1 staufen double-stranded RNA binding protein 1 -0.0288445
RPL23 ribosomal protein L23 -0.028245
S100A6 S100 calcium binding protein A6 -0.0278716
SMC4 structural maintenance of chromosomes 4 -0.0277702
TXNRD1 thioredoxin reductase 1 -0.0276225
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0275757
LDHA lactate dehydrogenase A -0.0272762
CANX calnexin -0.0271829
NAP1L1 nucleosome assembly protein 1-like 1 -0.0270777
MAP1B microtubule-associated protein 1B -0.0268762
POTEF POTE ankyrin domain family, member F -0.0265219
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.026286
PCBP2 poly(rC) binding protein 2 -0.0256626
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0254355
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0251687
HMGB2 high mobility group box 2 -0.0250277
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.0249103
ATP13A3 ATPase type 13A3 -0.0246017
NPPB natriuretic peptide B -0.0244491
S100A10 S100 calcium binding protein A10 -0.0242646
TPT1 tumor protein, translationally-controlled 1 -0.0241646
AXL AXL receptor tyrosine kinase -0.0237862
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0237731
RPL19 ribosomal protein L19 -0.0236572
PDIA4 protein disulfide isomerase family A, member 4 -0.0233091
JUN jun proto-oncogene -0.0227062
CALU calumenin -0.0226245
RPLP1 ribosomal protein, large, P1 -0.0223697
HMGB1 high mobility group box 1 -0.0223374
RPL12 ribosomal protein L12 -0.0220343
PFN1 profilin 1 -0.0218891
NEK7 NIMA-related kinase 7 -0.0216147
ANKRD12 ankyrin repeat domain 12 -0.0213853
RPL35 ribosomal protein L35 -0.0207969
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) -0.0206407
RPL37 ribosomal protein L37 -0.0205939
TPM1 tropomyosin 1 (alpha) -0.0202404
TUBA1B tubulin, alpha 1b -0.0201665
TUBB4B tubulin, beta 4B class IVb -0.0201663
ANXA2 annexin A2 -0.0198677
RPS13 ribosomal protein S13 -0.0197495
RPL28 ribosomal protein L28 -0.0193744
GNAS GNAS complex locus -0.0193664
RTN4 reticulon 4 -0.0191916
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.0188277
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B -0.0186468
COL5A1 collagen, type V, alpha 1 -0.0184221
COPB1 coatomer protein complex, subunit beta 1 -0.0184162
UGCG UDP-glucose ceramide glucosyltransferase -0.0184089
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.018335
PGK1 phosphoglycerate kinase 1 -0.0182161
POMP proteasome maturation protein -0.0181015
IER3 immediate early response 3 -0.0180289