Citalopram (hydrobromide)_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Citalopram (hydrobromide) perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Citalopram (hydrobromide)_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EZR ezrin 0.0569084
MAML2 mastermind-like 2 (Drosophila) 0.0563085
CEMIP cell migration inducing protein, hyaluronan binding 0.0555012
VEGFA vascular endothelial growth factor A 0.0553211
HYOU1 hypoxia up-regulated 1 0.0535346
MYH9 myosin, heavy chain 9, non-muscle 0.0531107
B2M beta-2-microglobulin 0.0525458
DSPP dentin sialophosphoprotein 0.0486056
APLP2 amyloid beta (A4) precursor-like protein 2 0.0476315
ITGA6 integrin, alpha 6 0.0463627
MBNL2 muscleblind-like splicing regulator 2 0.0460499
EEF2 eukaryotic translation elongation factor 2 0.0456795
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0451547
RACK1 receptor for activated C kinase 1 0.0437536
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0437307
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0434945
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0432619
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.036219
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0359356
FAT1 FAT atypical cadherin 1 0.0355857
FLNB filamin B, beta 0.0335806
NDRG1 N-myc downstream regulated 1 0.033461
ANXA1 annexin A1 0.0334459
RPL23 ribosomal protein L23 0.0331239
CALR calreticulin 0.0321824
PLEC plectin 0.0314262
ENO1 enolase 1, (alpha) 0.0293846
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0293773
NFE2L1 nuclear factor, erythroid 2-like 1 0.0290529
TPM3 tropomyosin 3 0.0287779
KRT18 keratin 18, type I 0.028591
ATXN1 ataxin 1 0.0278967
AKAP9 A kinase (PRKA) anchor protein 9 0.0276129
FTH1 ferritin, heavy polypeptide 1 0.0276035
PDIA6 protein disulfide isomerase family A, member 6 0.0274459
RPS3 ribosomal protein S3 0.0272985
RPS12 ribosomal protein S12 0.0266447
SRRM2 serine/arginine repetitive matrix 2 0.0264554
DSTN destrin (actin depolymerizing factor) 0.0260395
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0255581
EMP1 epithelial membrane protein 1 0.0243415
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.023338
ANKRD11 ankyrin repeat domain 11 0.0232878
MACF1 microtubule-actin crosslinking factor 1 0.0232006
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0230697
HSPA8 heat shock 70kDa protein 8 0.0228862
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0220688
SET SET nuclear proto-oncogene 0.0218169
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0215679
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0213094
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0212408
AHR aryl hydrocarbon receptor 0.0209319
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0209085
PCBP2 poly(rC) binding protein 2 0.0209012
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0205427
SERF2 small EDRK-rich factor 2 0.0205228
PGM3 phosphoglucomutase 3 0.0204318
PCM1 pericentriolar material 1 0.0203674
TNIK TRAF2 and NCK interacting kinase 0.02021
ESYT2 extended synaptotagmin-like protein 2 0.0200034
GOLGA4 golgin A4 0.0200018
TMF1 TATA element modulatory factor 1 0.0199789
CSNK1A1 casein kinase 1, alpha 1 0.0199111
YBX1 Y box binding protein 1 0.0197341
MPRIP myosin phosphatase Rho interacting protein 0.0196748
HKDC1 hexokinase domain containing 1 0.0196715
ASPH aspartate beta-hydroxylase 0.0195846
NUMA1 nuclear mitotic apparatus protein 1 0.0193578
KTN1 kinectin 1 (kinesin receptor) 0.0193131
RAI1 retinoic acid induced 1 0.0191625
FNDC3B fibronectin type III domain containing 3B 0.0190115
RAB6A RAB6A, member RAS oncogene family 0.0187552
SMC1A structural maintenance of chromosomes 1A 0.0187344
TPI1 triosephosphate isomerase 1 0.0185378
TMED2 transmembrane emp24 domain trafficking protein 2 0.0183721
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 0.0181402
RPL3 ribosomal protein L3 0.017763
PGK1 phosphoglycerate kinase 1 0.0176863
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0175657
EHBP1 EH domain binding protein 1 0.0172787
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0171308
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.017107
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.017039
NCOR2 nuclear receptor corepressor 2 0.0167205
KMT2E lysine (K)-specific methyltransferase 2E 0.0166749
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.0165177
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0164678
KIF16B kinesin family member 16B 0.016332
RPL26 ribosomal protein L26 0.0163142
FLNA filamin A, alpha 0.0162318
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0159899
KLHL29 kelch-like family member 29 0.0158653
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.015844
ADAM10 ADAM metallopeptidase domain 10 0.0157616
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0157319
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2 0.0156949
FTL ferritin, light polypeptide 0.0156599
NPSR1 neuropeptide S receptor 1 0.0152099
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0151615
MCL1 myeloid cell leukemia 1 0.0151398

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.073699
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0588482
H1-0 H1.0 linker histone -0.0406513
CD2AP CD2-associated protein -0.0387431
ANXA2 annexin A2 -0.037703
AGR2 anterior gradient 2 -0.0294114
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0285556
GMDS GDP-mannose 4,6-dehydratase -0.0283681
GPX2 glutathione peroxidase 2 -0.027857
LMO7 LIM domain 7 -0.0275219
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.023963
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0227938
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0220263
RAB7A RAB7A, member RAS oncogene family -0.0207244
PLSCR1 phospholipid scramblase 1 -0.0206516
RRBP1 ribosome binding protein 1 -0.0203589
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0203504
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0203264
TPT1 tumor protein, translationally-controlled 1 -0.0203259
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0200214
RPS24 ribosomal protein S24 -0.0199998
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.018915
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0188879
RAB1A RAB1A, member RAS oncogene family -0.0178899
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0178511
PRSS3 protease, serine, 3 -0.0175633
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0175624
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0172769
NCOA7 nuclear receptor coactivator 7 -0.0172052
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0168777
IER3 immediate early response 3 -0.0168341
GPHN gephyrin -0.0163366
ZC3H12B zinc finger CCCH-type containing 12B -0.0161612
XAF1 XIAP associated factor 1 -0.0160798
STAU1 staufen double-stranded RNA binding protein 1 -0.0157929
HLA-C major histocompatibility complex, class I, C -0.0151317
HMGB1 high mobility group box 1 -0.0148591
S100A10 S100 calcium binding protein A10 -0.0146316
MUC17 mucin 17, cell surface associated -0.0144729
HLA-E major histocompatibility complex, class I, E -0.0143641
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0142198
WDR45B WD repeat domain 45B -0.0142035
RIGI RNA sensor RIG-I -0.014179
ARF1 ADP-ribosylation factor 1 -0.0140529
LLGL2 lethal giant larvae homolog 2 (Drosophila) -0.0135256
PUM2 pumilio RNA-binding family member 2 -0.0133012
MECOM MDS1 and EVI1 complex locus -0.0132488
ALDOC aldolase C, fructose-bisphosphate -0.013196
RTN3 reticulon 3 -0.0130603
MCU mitochondrial calcium uniporter -0.0130089
CAMKMT calmodulin-lysine N-methyltransferase -0.0129689
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.012947
SMC4 structural maintenance of chromosomes 4 -0.0128925
H3-3B H3.3 histone B -0.0125008
IARS1 isoleucyl-tRNA synthetase 1 -0.0124415
OSBPL3 oxysterol binding protein-like 3 -0.0122756
ACTG1 actin gamma 1 -0.0120641
LY6E lymphocyte antigen 6 complex, locus E -0.0120639
NF1 neurofibromin 1 -0.0116986
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0116819
MX2 MX dynamin-like GTPase 2 -0.0116815
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0116274
FAF1 Fas (TNFRSF6) associated factor 1 -0.0115055
RPN1 ribophorin I -0.0112768
MACC1 metastasis associated in colon cancer 1 -0.0111431
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0110379
TM4SF1 transmembrane 4 L six family member 1 -0.0109036
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0108093
PDIA4 protein disulfide isomerase family A, member 4 -0.0106417
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.010588
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0105742
MED13 mediator complex subunit 13 -0.0105364
ST14 suppression of tumorigenicity 14 (colon carcinoma) -0.0105205
RAB1B RAB1B, member RAS oncogene family -0.0104452
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.010295
TSPAN8 tetraspanin 8 -0.0102439
TASP1 taspase, threonine aspartase, 1 -0.0102436
NT5C2 5'-nucleotidase, cytosolic II -0.0102338
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase -0.0102125
ATAD5 ATPase family, AAA domain containing 5 -0.0101239
ACTN4 actinin, alpha 4 -0.010092
LAMA4 laminin, alpha 4 -0.0100853
MTAP methylthioadenosine phosphorylase -0.0100193
MUC1 mucin 1, cell surface associated -0.00998746
NECTIN2 nectin cell adhesion molecule 2 -0.00995596
RAD21 RAD21 homolog (S. pombe) -0.009937
PTBP3 polypyrimidine tract binding protein 3 -0.00993117
KDM3A lysine (K)-specific demethylase 3A -0.00993075
RPLP0 ribosomal protein, large, P0 -0.00989226
TFRC transferrin receptor -0.00983257
UBE2I ubiquitin-conjugating enzyme E2I -0.00981257
MDK midkine (neurite growth-promoting factor 2) -0.00972479
RSAD2 radical S-adenosyl methionine domain containing 2 -0.00960123
GRB2 growth factor receptor-bound protein 2 -0.00944011
NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit -0.00942599
ACACA acetyl-CoA carboxylase alpha -0.00938253
SH3RF1 SH3 domain containing ring finger 1 -0.00935544
NPR2 natriuretic peptide receptor 2 -0.00935151
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.00931295
CDK13 cyclin-dependent kinase 13 -0.00929921