Citalopram (hydrobromide)_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Citalopram (hydrobromide) perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Citalopram (hydrobromide)_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DTNA dystrobrevin, alpha 0.0940655
EXT1 exostosin glycosyltransferase 1 0.0769586
NUP58 nucleoporin 58 0.0645198
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0637407
TRIO trio Rho guanine nucleotide exchange factor 0.0637111
CALD1 caldesmon 1 0.0608008
RUNX1 runt-related transcription factor 1 0.0517055
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0476057
ADAM19 ADAM metallopeptidase domain 19 0.0417605
RACK1 receptor for activated C kinase 1 0.0402378
FRMD6 FERM domain containing 6 0.0381332
ADAM9 ADAM metallopeptidase domain 9 0.0371068
GLS2 glutaminase 2 (liver, mitochondrial) 0.0360756
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0347906
MALT1 MALT1 paracaspase 0.0345379
UBA6 ubiquitin-like modifier activating enzyme 6 0.0343005
PBX3 pre-B-cell leukemia homeobox 3 0.0341922
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0327222
VCL vinculin 0.0322257
TSC22D2 TSC22 domain family, member 2 0.0318797
FLNA filamin A, alpha 0.0308663
MARCHF6 membrane associated ring-CH-type finger 6 0.0306781
KDM3A lysine (K)-specific demethylase 3A 0.0305108
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0300968
MCTP1 multiple C2 domains, transmembrane 1 0.0295562
SAMD4A sterile alpha motif domain containing 4A 0.0284472
TLE4 transducin-like enhancer of split 4 0.0284366
ZNF292 zinc finger protein 292 0.0280639
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans) 0.0265717
SMAD3 SMAD family member 3 0.025798
LOC112694756 uncharaterized LOC112694756 0.0255385
ELL2 elongation factor, RNA polymerase II, 2 0.0250056
CORO1C coronin, actin binding protein, 1C 0.0247822
DST dystonin 0.0246598
SPAG9 sperm associated antigen 9 0.0244666
ZSWIM6 zinc finger, SWIM-type containing 6 0.0243523
PICALM phosphatidylinositol binding clathrin assembly protein 0.0235991
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0234899
RNF145 ring finger protein 145 0.0232072
EEF2 eukaryotic translation elongation factor 2 0.0227817
RB1CC1 RB1-inducible coiled-coil 1 0.0227325
CD163L1 CD163 molecule-like 1 0.0225451
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0217163
HSPA8 heat shock 70kDa protein 8 0.0216971
NCKAP1 NCK-associated protein 1 0.0216618
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0215386
MARCHF4 membrane associated ring-CH-type finger 4 0.0215205
PRKCE protein kinase C, epsilon 0.0207911
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0207895
FMNL2 formin-like 2 0.0207516
TRA2A transformer 2 alpha homolog (Drosophila) 0.0207291
ZFC3H1 zinc finger, C3H1-type containing 0.0205868
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0202053
ENKUR enkurin, TRPC channel interacting protein 0.0197954
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0193948
USP15 ubiquitin specific peptidase 15 0.0193174
ANO6 anoctamin 6 0.0192092
JMJD1C jumonji domain containing 1C 0.019161
STRN3 striatin, calmodulin binding protein 3 0.0190928
ACTN1 actinin, alpha 1 0.018904
PAWR PRKC, apoptosis, WT1, regulator 0.0186345
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0186087
WDR43 WD repeat domain 43 0.0185778
MYO10 myosin X 0.0184884
ABI1 abl-interactor 1 0.0184662
OSBPL8 oxysterol binding protein-like 8 0.0183763
WDR26 WD repeat domain 26 0.0183648
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0182241
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.018157
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0180862
CUL3 cullin 3 0.0179896
NRIP1 nuclear receptor interacting protein 1 0.0179884
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0179119
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0177961
ERBIN erbb2 interacting protein 0.0177323
YBX1 Y box binding protein 1 0.0173831
PNISR PNN-interacting serine/arginine-rich protein 0.0173727
CDC73 cell division cycle 73 0.0172946
GOLGA4 golgin A4 0.0172191
RAB8B RAB8B, member RAS oncogene family 0.0171218
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0169682
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0169183
PUM2 pumilio RNA-binding family member 2 0.016852
RLF rearranged L-myc fusion 0.0168239
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0167875
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0165828
CHD1 chromodomain helicase DNA binding protein 1 0.0165227
FGD6 FYVE, RhoGEF and PH domain containing 6 0.0164457
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0163696
HOOK2 hook microtubule-tethering protein 2 0.0163288
ZFAND3 zinc finger, AN1-type domain 3 0.0162778
APP amyloid beta (A4) precursor protein 0.0162685
SPRED1 sprouty-related, EVH1 domain containing 1 0.0162162
OSBPL9 oxysterol binding protein-like 9 0.0160978
RSRC2 arginine/serine-rich coiled-coil 2 0.016056
WDR45B WD repeat domain 45B 0.0159186
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0158098
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0157534
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0156481
KMT2C lysine (K)-specific methyltransferase 2C 0.0155964

decreased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 -0.270276
VIM vimentin -0.201406
FN1 fibronectin 1 -0.187422
HMGA2 high mobility group AT-hook 2 -0.114955
TMSB10 thymosin beta 10 -0.106904
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.106472
MT2A metallothionein 2A -0.0963063
HIPK2 homeodomain interacting protein kinase 2 -0.0865265
RPS6 ribosomal protein S6 -0.0751967
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0637325
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0605476
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0582013
POTEF POTE ankyrin domain family, member F -0.0507467
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0492251
PTPRG protein tyrosine phosphatase, receptor type, G -0.0481226
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0438775
PTMA prothymosin, alpha -0.043066
PHACTR1 phosphatase and actin regulator 1 -0.0412125
CDH13 cadherin 13 -0.0410471
AHNAK AHNAK nucleoprotein -0.0398236
ZMYND8 zinc finger, MYND-type containing 8 -0.0390202
LDHA lactate dehydrogenase A -0.038938
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0387517
MYOF myoferlin -0.0383255
MMP12 matrix metallopeptidase 12 -0.038227
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0375711
EGR1 early growth response 1 -0.0371866
FKBP5 FK506 binding protein 5 -0.036521
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0355556
CD109 CD109 molecule -0.0354239
PRKG1 protein kinase, cGMP-dependent, type I -0.0349296
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0348965
SAMD3 sterile alpha motif domain containing 3 -0.0340347
MT1E metallothionein 1E -0.0340293
MAML2 mastermind-like 2 (Drosophila) -0.0334905
CTSB cathepsin B -0.0328828
MT1X metallothionein 1X -0.0323018
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.031146
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0310709
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.0284691
GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4 -0.0280248
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0265807
HMGA1 high mobility group AT-hook 1 -0.026376
PTPN1 protein tyrosine phosphatase, non-receptor type 1 -0.0261868
ZFP36L1 ZFP36 ring finger protein-like 1 -0.026115
CAST calpastatin -0.0260339
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0257514
RPS13 ribosomal protein S13 -0.0250717
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0246075
JARID2 jumonji, AT rich interactive domain 2 -0.0244706
DNER delta/notch-like EGF repeat containing -0.0243713
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0243016
LPP LIM domain containing preferred translocation partner in lipoma -0.0242412
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0239866
RPS23 ribosomal protein S23 -0.0239516
CDK6 cyclin-dependent kinase 6 -0.0237023
PTCHD4 patched domain containing 4 -0.0236923
MCL1 myeloid cell leukemia 1 -0.0213433
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0211266
TBC1D5 TBC1 domain family, member 5 -0.0211227
TPM4 tropomyosin 4 -0.0210976
VDAC1 voltage-dependent anion channel 1 -0.0209471
TXNIP thioredoxin interacting protein -0.0209305
SLC38A2 solute carrier family 38, member 2 -0.0209254
PDE4D phosphodiesterase 4D, cAMP-specific -0.0208871
PFN1 profilin 1 -0.0208141
STC1 stanniocalcin 1 -0.0206244
ASPH aspartate beta-hydroxylase -0.0200271
KLF6 Kruppel-like factor 6 -0.0198599
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0196732
RPL7A ribosomal protein L7a -0.0196049
CAV1 caveolin 1, caveolae protein, 22kDa -0.0196011
RPLP2 ribosomal protein, large, P2 -0.0195179
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0194201
PKM pyruvate kinase, muscle -0.0194116
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0193096
NAMPT nicotinamide phosphoribosyltransferase -0.0192714
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 -0.0191948
RPL31 ribosomal protein L31 -0.0189288
UGP2 UDP-glucose pyrophosphorylase 2 -0.0188666
CCDC80 coiled-coil domain containing 80 -0.0187712
PTPRD protein tyrosine phosphatase, receptor type, D -0.0184754
RPS24 ribosomal protein S24 -0.0181844
PDIA3 protein disulfide isomerase family A, member 3 -0.0181091
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0180897
ANKRD28 ankyrin repeat domain 28 -0.0179136
RPL35A ribosomal protein L35a -0.0178013
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.017495
PCDH9 protocadherin 9 -0.0172005
RPS21 ribosomal protein S21 -0.0171541
BPTF bromodomain PHD finger transcription factor -0.0170084
CCL20 chemokine (C-C motif) ligand 20 -0.0167365
MAN2A1 mannosidase, alpha, class 2A, member 1 -0.0164601
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0163783
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0163206
KLF9 Kruppel-like factor 9 -0.0163049
KPNB1 karyopherin (importin) beta 1 -0.0161124
TPT1 tumor protein, translationally-controlled 1 -0.0159603
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0159266
IRS2 insulin receptor substrate 2 -0.0157436