Citalopram (hydrobromide)_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Citalopram (hydrobromide) perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Citalopram (hydrobromide)_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
THSD4 thrombospondin, type I, domain containing 4 0.13523
EEF2 eukaryotic translation elongation factor 2 0.118565
RACK1 receptor for activated C kinase 1 0.0974376
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0529912
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0521032
FLNB filamin B, beta 0.0422168
DSPP dentin sialophosphoprotein 0.0410016
EZR ezrin 0.0408993
MSI2 musashi RNA-binding protein 2 0.0405502
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0362131
FAT1 FAT atypical cadherin 1 0.0309506
MPRIP myosin phosphatase Rho interacting protein 0.0279609
CEMIP cell migration inducing protein, hyaluronan binding 0.0266813
PON2 paraoxonase 2 0.0261228
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0242101
CTBP2 C-terminal binding protein 2 0.0235349
GMDS GDP-mannose 4,6-dehydratase 0.0232396
RPL3 ribosomal protein L3 0.0224885
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0220981
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0220822
BACE2 beta-site APP-cleaving enzyme 2 0.0217423
JUN jun proto-oncogene 0.0216806
DDIT4 DNA-damage-inducible transcript 4 0.0211835
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0202703
NCOR2 nuclear receptor corepressor 2 0.0198584
HSPA8 heat shock 70kDa protein 8 0.019795
DNM2 dynamin 2 0.0189942
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0187052
HDLBP high density lipoprotein binding protein 0.0177931
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0175235
AHNAK AHNAK nucleoprotein 0.0174679
RIMKLB ribosomal modification protein rimK-like family member B 0.0174549
PELI1 pellino E3 ubiquitin protein ligase 1 0.0167127
YBX1 Y box binding protein 1 0.0165234
ESYT2 extended synaptotagmin-like protein 2 0.0160096
KRT18 keratin 18, type I 0.0158195
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0155819
SRRM2 serine/arginine repetitive matrix 2 0.0151556
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0151399
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0150875
MYH14 myosin, heavy chain 14, non-muscle 0.0143275
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0139179
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0138444
FRMD3 FERM domain containing 3 0.0136304
LPP LIM domain containing preferred translocation partner in lipoma 0.0133226
FMNL2 formin-like 2 0.0132578
EIF4B eukaryotic translation initiation factor 4B 0.0130884
EPHA2 EPH receptor A2 0.0128973
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0127966
IFRD1 interferon-related developmental regulator 1 0.0126539
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0126349
EMP1 epithelial membrane protein 1 0.0124123
PLEC plectin 0.012306
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough 0.0123015
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0121662
SKP1 S-phase kinase-associated protein 1 0.0121598
ITGA6 integrin, alpha 6 0.0121404
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.01178
NPSR1 neuropeptide S receptor 1 0.0117075
PYGB phosphorylase, glycogen; brain 0.0115312
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0113477
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0113269
TOP1 topoisomerase (DNA) I 0.0113116
AHNAK2 AHNAK nucleoprotein 2 0.0113062
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0112986
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0112921
PER1 period circadian clock 1 0.0112754
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 0.0108189
ANXA11 annexin A11 0.0106856
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0105792
SFPQ splicing factor proline/glutamine-rich 0.0105605
MYH9 myosin, heavy chain 9, non-muscle 0.0105424
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.010495
MACF1 microtubule-actin crosslinking factor 1 0.010422
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0103938
TPI1 triosephosphate isomerase 1 0.0103269
F3 coagulation factor III (thromboplastin, tissue factor) 0.0103182
ENO1 enolase 1, (alpha) 0.0101883
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0101805
ABLIM2 actin binding LIM protein family, member 2 0.0101566
FLNA filamin A, alpha 0.0100317
RPS4X ribosomal protein S4, X-linked 0.00994501
MARCHF3 membrane associated ring-CH-type finger 3 0.00981117
COBL cordon-bleu WH2 repeat protein 0.00980538
LARP1 La ribonucleoprotein domain family, member 1 0.00974874
HS6ST2 heparan sulfate 6-O-sulfotransferase 2 0.00973145
SPIDR scaffolding protein involved in DNA repair 0.00965433
SSBP3 single stranded DNA binding protein 3 0.00962786
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.00952165
DENND1A DENN/MADD domain containing 1A 0.00951814
IQGAP2 IQ motif containing GTPase activating protein 2 0.00950038
FOS FBJ murine osteosarcoma viral oncogene homolog 0.00938264
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 0.0093821
CUX1 cut-like homeobox 1 0.00925536
TPM3 tropomyosin 3 0.00920417
LIN54 lin-54 DREAM MuvB core complex component 0.0091682
DGKH diacylglycerol kinase, eta 0.00916759
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0091295
CD9 CD9 molecule 0.00910844
SEPTIN9 septin 9 0.00905924

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.116952
RPS6 ribosomal protein S6 -0.0928648
RPLP1 ribosomal protein, large, P1 -0.0729509
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0649164
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0644018
RPS2 ribosomal protein S2 -0.0622865
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0542625
RPS23 ribosomal protein S23 -0.0516804
PTPRR protein tyrosine phosphatase, receptor type, R -0.0500788
RPS19 ribosomal protein S19 -0.0428658
RPLP2 ribosomal protein, large, P2 -0.0424722
GOLGA4 golgin A4 -0.0424633
RPS12 ribosomal protein S12 -0.0418777
PTMA prothymosin, alpha -0.0374643
PDE4D phosphodiesterase 4D, cAMP-specific -0.037455
RPS8 ribosomal protein S8 -0.0357108
RPS13 ribosomal protein S13 -0.0349563
RPLP0 ribosomal protein, large, P0 -0.0349325
TXNRD1 thioredoxin reductase 1 -0.0345697
ITPRID2 ITPR interacting domain containing 2 -0.0331651
RPL12 ribosomal protein L12 -0.0326897
RPL26 ribosomal protein L26 -0.0326403
RPS29 ribosomal protein S29 -0.0323374
EXT1 exostosin glycosyltransferase 1 -0.0321517
TPT1 tumor protein, translationally-controlled 1 -0.0320607
RNF145 ring finger protein 145 -0.03201
RPS16 ribosomal protein S16 -0.0319781
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0319672
RPS25 ribosomal protein S25 -0.031841
KCNK1 potassium channel, two pore domain subfamily K, member 1 -0.0317964
RPS27A ribosomal protein S27a -0.030715
MUC13 mucin 13, cell surface associated -0.0306715
RPL9 ribosomal protein L9 -0.0299358
RPL37A ribosomal protein L37a -0.0297583
PRSS3 protease, serine, 3 -0.0297559
WWC1 WW and C2 domain containing 1 -0.0294588
RPL28 ribosomal protein L28 -0.0289836
RPL34 ribosomal protein L34 -0.0287916
RPL21 ribosomal protein L21 -0.027682
RPS17 ribosomal protein S17 -0.0275661
RPS21 ribosomal protein S21 -0.0257083
RPS24 ribosomal protein S24 -0.0255821
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 -0.0253139
MYO1E myosin IE -0.0252628
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0251536
RPL11 ribosomal protein L11 -0.0247687
FOXO1 forkhead box O1 -0.0243614
VCL vinculin -0.0241315
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0234781
ARHGAP29 Rho GTPase activating protein 29 -0.0234589
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0229308
ATXN1 ataxin 1 -0.0228282
RPS5 ribosomal protein S5 -0.022764
RPL38 ribosomal protein L38 -0.0223712
PKP2 plakophilin 2 -0.0223323
RPL19 ribosomal protein L19 -0.0222144
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0221139
RPL32 ribosomal protein L32 -0.0218902
ASPH aspartate beta-hydroxylase -0.0217748
JMJD1C jumonji domain containing 1C -0.0217675
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0217448
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0216965
RAP1B RAP1B, member of RAS oncogene family -0.0214357
RPL31 ribosomal protein L31 -0.0213766
TMSB10 thymosin beta 10 -0.0213221
CXADR coxsackie virus and adenovirus receptor -0.0211562
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0210696
TRIM2 tripartite motif containing 2 -0.0205222
PTBP3 polypyrimidine tract binding protein 3 -0.0202609
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 -0.0200936
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0200917
NKTR natural killer cell triggering receptor -0.020058
HLA-B major histocompatibility complex, class I, B -0.0200123
RPS15 ribosomal protein S15 -0.0199967
RPL37 ribosomal protein L37 -0.0197138
TSPAN8 tetraspanin 8 -0.0196928
RPS20 ribosomal protein S20 -0.0196025
NAMPT nicotinamide phosphoribosyltransferase -0.0195983
RPS27 ribosomal protein S27 -0.0195846
RIGI RNA sensor RIG-I -0.0195544
SETD5 SET domain containing 5 -0.0193374
EIF1 eukaryotic translation initiation factor 1 -0.0191835
RPS11 ribosomal protein S11 -0.0189861
NAP1L1 nucleosome assembly protein 1-like 1 -0.0189425
AKAP9 A kinase (PRKA) anchor protein 9 -0.0187963
PDIA3 protein disulfide isomerase family A, member 3 -0.0183404
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0182931
COG5 component of oligomeric golgi complex 5 -0.0182795
RPS3 ribosomal protein S3 -0.0182769
TMEM45B transmembrane protein 45B -0.0181577
FRMD5 FERM domain containing 5 -0.0179548
TMEM165 transmembrane protein 165 -0.0178261
GDF15 growth differentiation factor 15 -0.0176539
FHL2 four and a half LIM domains 2 -0.0176465
LIMA1 LIM domain and actin binding 1 -0.0175625
RPL5 ribosomal protein L5 -0.0175149
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0172769
RPS14 ribosomal protein S14 -0.0172231
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 -0.0171689
EREG epiregulin -0.0167694