Citalopram (hydrobromide)_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Citalopram (hydrobromide) perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Citalopram (hydrobromide)_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.142395
FNDC3B fibronectin type III domain containing 3B 0.0717108
EFNA5 ephrin-A5 0.0667003
SDK1 sidekick cell adhesion molecule 1 0.0660391
PDE4D phosphodiesterase 4D, cAMP-specific 0.0591838
SOD2 superoxide dismutase 2, mitochondrial 0.053069
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0506352
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0474723
TRIO trio Rho guanine nucleotide exchange factor 0.0473791
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.044983
HMGA2 high mobility group AT-hook 2 0.0440359
HIPK2 homeodomain interacting protein kinase 2 0.0435146
CD44 CD44 molecule (Indian blood group) 0.0429147
DOCK5 dedicator of cytokinesis 5 0.0382906
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0363897
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0354244
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0334895
ZEB2 zinc finger E-box binding homeobox 2 0.0329973
USP34 ubiquitin specific peptidase 34 0.0322538
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0319651
TGM2 transglutaminase 2 0.0313422
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0309197
NAV2 neuron navigator 2 0.0306826
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0303088
ANKRD28 ankyrin repeat domain 28 0.0302942
FAM20C family with sequence similarity 20, member C 0.0294753
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0293358
PID1 phosphotyrosine interaction domain containing 1 0.0291046
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0291009
AKAP13 A kinase (PRKA) anchor protein 13 0.0275314
OSMR oncostatin M receptor 0.027451
SIK3 SIK family kinase 3 0.0260028
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0250891
GPC6 glypican 6 0.0239339
FKBP5 FK506 binding protein 5 0.023864
NRG1 neuregulin 1 0.0234203
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0233902
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0229551
PRELID2 PRELI domain containing 2 0.0227244
MACF1 microtubule-actin crosslinking factor 1 0.0225007
IRAK3 interleukin-1 receptor-associated kinase 3 0.0223358
ATXN1 ataxin 1 0.0220154
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0219362
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.021921
ADD3 adducin 3 (gamma) 0.0216912
DSCAM Down syndrome cell adhesion molecule 0.0212116
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0204917
DNER delta/notch-like EGF repeat containing 0.020457
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0204256
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0199468
MYO1E myosin IE 0.0197658
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0193771
MBNL1 muscleblind-like splicing regulator 1 0.0189259
RBM39 RNA binding motif protein 39 0.0186747
KYNU kynureninase 0.0186429
MSRB3 methionine sulfoxide reductase B3 0.018581
TOP1 topoisomerase (DNA) I 0.0184706
NPAS2 neuronal PAS domain protein 2 0.0184205
PCNX1 pecanex 1 0.0181546
NRCAM neuronal cell adhesion molecule 0.0181085
ARHGAP5 Rho GTPase activating protein 5 0.0179451
VMP1 vacuole membrane protein 1 0.0178813
DOCK4 dedicator of cytokinesis 4 0.0176667
MCL1 myeloid cell leukemia 1 0.0174232
EEF2 eukaryotic translation elongation factor 2 0.0173804
ASPH aspartate beta-hydroxylase 0.0171329
NRP1 neuropilin 1 0.0170678
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0169075
EPS8 epidermal growth factor receptor pathway substrate 8 0.0168374
PDLIM5 PDZ and LIM domain 5 0.016794
RAD51B RAD51 paralog B 0.0166756
FN1 fibronectin 1 0.0164497
RUNX2 runt-related transcription factor 2 0.0163582
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0163349
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0162508
NAMPT nicotinamide phosphoribosyltransferase 0.0161725
TPST1 tyrosylprotein sulfotransferase 1 0.0159961
ZC3H12C zinc finger CCCH-type containing 12C 0.0159501
RAB27B RAB27B, member RAS oncogene family 0.0156657
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0155256
CDH13 cadherin 13 0.0154221
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0152006
ZSWIM6 zinc finger, SWIM-type containing 6 0.0151572
SLC44A1 solute carrier family 44 (choline transporter), member 1 0.0151036
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0150133
SH3RF3 SH3 domain containing ring finger 3 0.0148322
GLCCI1 glucocorticoid induced 1 0.0147302
CTNND1 catenin (cadherin-associated protein), delta 1 0.014385
HDAC4 histone deacetylase 4 0.0143483
LOX lysyl oxidase 0.0143124
EXT1 exostosin glycosyltransferase 1 0.0142856
IL6ST interleukin 6 signal transducer 0.0142819
VEGFA vascular endothelial growth factor A 0.0140656
NTN4 netrin 4 0.0140365
ELL2 elongation factor, RNA polymerase II, 2 0.0139607
SLTM SAFB-like, transcription modulator 0.0138857
SEPTIN9 septin 9 0.0137406
ADAM10 ADAM metallopeptidase domain 10 0.0135795
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0134828
TSC22D3 TSC22 domain family, member 3 0.0134248

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.101548
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.080588
TMSB10 thymosin beta 10 -0.0613906
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0501925
FTL ferritin, light polypeptide -0.0465729
PTMA prothymosin, alpha -0.0385431
VIM vimentin -0.0378027
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0302519
IER3 immediate early response 3 -0.02878
RPLP1 ribosomal protein, large, P1 -0.0279585
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0255312
LMAN1 lectin, mannose-binding, 1 -0.0218933
C15ORF48 chromosome 15 open reading frame 48 -0.0210798
RPS19 ribosomal protein S19 -0.0207991
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.019182
RPL35A ribosomal protein L35a -0.0185084
SYT1 synaptotagmin I -0.0183185
RPL36 ribosomal protein L36 -0.0180787
RPS8 ribosomal protein S8 -0.0175481
RPS6 ribosomal protein S6 -0.017445
STC1 stanniocalcin 1 -0.0161988
HMGA1 high mobility group AT-hook 1 -0.0159241
RIOK3 RIO kinase 3 -0.0154865
RPL34 ribosomal protein L34 -0.0154146
RPL32 ribosomal protein L32 -0.0148558
DDIT3 DNA-damage-inducible transcript 3 -0.0147954
TMEM263 transmembrane protein 263 -0.0142151
MAP1B microtubule-associated protein 1B -0.0140565
B2M beta-2-microglobulin -0.0139883
EIF1 eukaryotic translation initiation factor 1 -0.0137803
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0136751
BHLHE40 basic helix-loop-helix family, member e40 -0.0136568
BASP1 brain abundant, membrane attached signal protein 1 -0.0136365
RPS21 ribosomal protein S21 -0.013374
PFN1 profilin 1 -0.0132565
S100A6 S100 calcium binding protein A6 -0.0131652
RPL12 ribosomal protein L12 -0.0131292
PGK1 phosphoglycerate kinase 1 -0.0128578
H1-0 H1.0 linker histone -0.0126983
GOLGA4 golgin A4 -0.0125498
NDRG1 N-myc downstream regulated 1 -0.012518
RPS5 ribosomal protein S5 -0.0125141
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.012492
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0119231
MRPS6 mitochondrial ribosomal protein S6 -0.0118359
WASF2 WAS protein family, member 2 -0.0118335
S100A9 S100 calcium binding protein A9 -0.0116779
KDM3A lysine (K)-specific demethylase 3A -0.0115499
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0115023
PDIA3 protein disulfide isomerase family A, member 3 -0.0114131
MT2A metallothionein 2A -0.0112296
RPL23 ribosomal protein L23 -0.0110655
RPS24 ribosomal protein S24 -0.0109391
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0107611
RPL18 ribosomal protein L18 -0.0106878
GARS1 glycyl-tRNA synthetase 1 -0.010675
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0106711
ENO1 enolase 1, (alpha) -0.0106528
BTG1 B-cell translocation gene 1, anti-proliferative -0.0106378
YBX3 Y box binding protein 3 -0.0104596
SEC61G Sec61 gamma subunit -0.0104376
RPL19 ribosomal protein L19 -0.0102532
PKM pyruvate kinase, muscle -0.0101905
WSB1 WD repeat and SOCS box containing 1 -0.0101506
S100A10 S100 calcium binding protein A10 -0.0100513
ACBD3 acyl-CoA binding domain containing 3 -0.00999952
RPLP2 ribosomal protein, large, P2 -0.00990475
CCNI cyclin I -0.00979597
GSTP1 glutathione S-transferase pi 1 -0.00965947
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.00952202
WDR45B WD repeat domain 45B -0.00949606
RPLP0 ribosomal protein, large, P0 -0.00946134
RAB7A RAB7A, member RAS oncogene family -0.00940584
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 -0.00936285
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.00931403
RPS29 ribosomal protein S29 -0.00909705
MECOM MDS1 and EVI1 complex locus -0.00908624
OXSR1 oxidative stress responsive 1 -0.00880185
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.00871833
SQSTM1 sequestosome 1 -0.00870223
LOC112694756 uncharaterized LOC112694756 -0.00866703
PSD3 pleckstrin and Sec7 domain containing 3 -0.00865446
ARF4 ADP-ribosylation factor 4 -0.00858584
PTGIS prostaglandin I2 (prostacyclin) synthase -0.00846175
EGR1 early growth response 1 -0.00840192
RAI1 retinoic acid induced 1 -0.00839943
RPS11 ribosomal protein S11 -0.00834661
EIF4A1 eukaryotic translation initiation factor 4A1 -0.00830464
RPS17 ribosomal protein S17 -0.00829999
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.00828199
SAMD9 sterile alpha motif domain containing 9 -0.00824998
IGFBP3 insulin-like growth factor binding protein 3 -0.00812702
PDIA4 protein disulfide isomerase family A, member 4 -0.00808305
HILPDA hypoxia inducible lipid droplet-associated -0.00803917
RPL28 ribosomal protein L28 -0.00802286
ADM adrenomedullin -0.00799789
PTPRR protein tyrosine phosphatase, receptor type, R -0.00792909
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.00789107
RPS12 ribosomal protein S12 -0.00779224
RPS16 ribosomal protein S16 -0.00776951