Citalopram (hydrobromide)_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Citalopram (hydrobromide) perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Citalopram (hydrobromide)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.234065
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.117622
THSD4 thrombospondin, type I, domain containing 4 0.0912227
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0814666
RAD51B RAD51 paralog B 0.0727203
MCL1 myeloid cell leukemia 1 0.0704091
PDE10A phosphodiesterase 10A 0.0664281
GRAMD1B GRAM domain containing 1B 0.064906
AFF3 AF4/FMR2 family, member 3 0.0573416
VMP1 vacuole membrane protein 1 0.0572922
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0556934
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0542812
DOCK5 dedicator of cytokinesis 5 0.0535516
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0502912
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0496387
OSMR oncostatin M receptor 0.0490778
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0471139
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0418894
TPM3 tropomyosin 3 0.04077
ACTN1 actinin, alpha 1 0.0393465
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.038767
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0387535
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0377893
EGFR epidermal growth factor receptor 0.036526
EML4 echinoderm microtubule associated protein like 4 0.0357037
ATXN1 ataxin 1 0.034907
PDE4D phosphodiesterase 4D, cAMP-specific 0.0345369
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0343731
CDK17 cyclin-dependent kinase 17 0.0335006
SAMD4A sterile alpha motif domain containing 4A 0.0327565
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0327128
SMAD3 SMAD family member 3 0.0326477
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0325311
HMGA2 high mobility group AT-hook 2 0.0325278
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0321614
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0316458
MACF1 microtubule-actin crosslinking factor 1 0.0314095
EHBP1 EH domain binding protein 1 0.0307969
PYGL phosphorylase, glycogen, liver 0.0297368
WWOX WW domain containing oxidoreductase 0.0293181
AEBP2 AE binding protein 2 0.029075
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0289789
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0288035
FMNL2 formin-like 2 0.0281891
ATP11A ATPase, class VI, type 11A 0.0280202
MYH9 myosin, heavy chain 9, non-muscle 0.0277289
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0276978
PRKCE protein kinase C, epsilon 0.027162
CALD1 caldesmon 1 0.0270489
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0268219
POTEF POTE ankyrin domain family, member F 0.0267003
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0266201
FNDC3B fibronectin type III domain containing 3B 0.0264913
RNF213 ring finger protein 213 0.0262594
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0261884
GSK3B glycogen synthase kinase 3 beta 0.0259909
EGR1 early growth response 1 0.0258492
ITSN1 intersectin 1 (SH3 domain protein) 0.0256021
ANO6 anoctamin 6 0.0249896
LOC102724023 ES1 protein homolog, mitochondrial 0.0249344
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0248458
IFI6 interferon, alpha-inducible protein 6 0.0245886
VCL vinculin 0.0243476
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0242942
DOCK1 dedicator of cytokinesis 1 0.024083
SYNE2 spectrin repeat containing, nuclear envelope 2 0.023872
TRIP12 thyroid hormone receptor interactor 12 0.0235381
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0233268
WWTR1 WW domain containing transcription regulator 1 0.0231348
EPAS1 endothelial PAS domain protein 1 0.0231103
PBX3 pre-B-cell leukemia homeobox 3 0.0230049
PRH1 proline-rich protein HaeIII subfamily 1 0.0230037
YAP1 Yes-associated protein 1 0.0229837
CUX1 cut-like homeobox 1 0.0229103
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0226819
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0226796
EXOC4 exocyst complex component 4 0.0223257
TAPBP TAP binding protein (tapasin) 0.0223122
PRELID2 PRELI domain containing 2 0.0222753
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0220369
CMIP c-Maf inducing protein 0.0219935
DIAPH2 diaphanous-related formin 2 0.0218087
MSN moesin 0.0216806
MCTP1 multiple C2 domains, transmembrane 1 0.0215354
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.021516
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0214941
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0213153
MMP12 matrix metallopeptidase 12 0.0212847
NTSR1 neurotensin receptor 1 (high affinity) 0.0212554
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0211619
LPP LIM domain containing preferred translocation partner in lipoma 0.0208177
ANKRD36 ankyrin repeat domain 36 0.0208017
CAPRIN2 caprin family member 2 0.0203306
LUZP1 leucine zipper protein 1 0.0202897
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0202388
ZSWIM6 zinc finger, SWIM-type containing 6 0.0201957
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0200283
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0199516
PTK2 protein tyrosine kinase 2 0.0198923
MARCHF4 membrane associated ring-CH-type finger 4 0.0198861

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.170939
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.134364
TFPI2 tissue factor pathway inhibitor 2 -0.133816
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.114622
PTMA prothymosin, alpha -0.106047
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.104357
TMSB10 thymosin beta 10 -0.0803784
RPS21 ribosomal protein S21 -0.0622105
TXNRD1 thioredoxin reductase 1 -0.0571219
KDM3A lysine (K)-specific demethylase 3A -0.0560141
NAP1L1 nucleosome assembly protein 1-like 1 -0.0523285
RPS3 ribosomal protein S3 -0.0513411
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0490755
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0486168
PGK1 phosphoglycerate kinase 1 -0.0470961
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0459983
OGA O-GlcNAcase -0.0455886
RPS8 ribosomal protein S8 -0.0454648
RPL12 ribosomal protein L12 -0.0450206
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0445641
WSB1 WD repeat and SOCS box containing 1 -0.0440954
RPS29 ribosomal protein S29 -0.0420973
RPLP1 ribosomal protein, large, P1 -0.0415745
MYL12B myosin, light chain 12B, regulatory -0.0411544
CSDE1 cold shock domain containing E1, RNA-binding -0.039921
RPL37 ribosomal protein L37 -0.0397728
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0383223
RPS27A ribosomal protein S27a -0.038238
RPL26 ribosomal protein L26 -0.0381325
BBX bobby sox homolog (Drosophila) -0.0378384
RPL34 ribosomal protein L34 -0.0376627
VIM vimentin -0.0376371
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0361413
RPL37A ribosomal protein L37a -0.0359453
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0358751
RPLP0 ribosomal protein, large, P0 -0.0353974
PHIP pleckstrin homology domain interacting protein -0.0349618
RPL23 ribosomal protein L23 -0.0346772
NIPBL Nipped-B homolog (Drosophila) -0.0343557
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0336679
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0336229
VDAC1 voltage-dependent anion channel 1 -0.0329925
MORF4L2 mortality factor 4 like 2 -0.0321771
RPL32 ribosomal protein L32 -0.0319475
CANX calnexin -0.0319225
ZFR zinc finger RNA binding protein -0.0318379
RPL19 ribosomal protein L19 -0.0316633
GARS1 glycyl-tRNA synthetase 1 -0.0315683
EIF4A1 eukaryotic translation initiation factor 4A1 -0.031513
ACTG1 actin gamma 1 -0.0311516
TPI1 triosephosphate isomerase 1 -0.030783
RPL38 ribosomal protein L38 -0.0306147
XPO1 exportin 1 -0.030307
PNISR PNN-interacting serine/arginine-rich protein -0.0299055
MATR3 matrin 3 -0.0297018
SRP72 signal recognition particle 72kDa -0.029339
KTN1 kinectin 1 (kinesin receptor) -0.0293008
RPS12 ribosomal protein S12 -0.0286875
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0285434
BSG basigin (Ok blood group) -0.0284667
RPL13A ribosomal protein L13a -0.0281551
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0281052
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0279602
NOP58 NOP58 ribonucleoprotein -0.0278981
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0277883
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0276639
KLF6 Kruppel-like factor 6 -0.0276044
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0273653
EIF1 eukaryotic translation initiation factor 1 -0.0269293
PREPL prolyl endopeptidase-like -0.0268082
TPT1 tumor protein, translationally-controlled 1 -0.0264747
WBP11 WW domain binding protein 11 -0.0264508
RPL36 ribosomal protein L36 -0.0259682
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0259289
RPS15 ribosomal protein S15 -0.0258972
WDR45B WD repeat domain 45B -0.0258095
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0255501
NCAPD2 non-SMC condensin I complex, subunit D2 -0.0254888
FTL ferritin, light polypeptide -0.0254838
RPS19 ribosomal protein S19 -0.0251998
H1-0 H1.0 linker histone -0.0249499
RPL9 ribosomal protein L9 -0.0247298
CCND2 cyclin D2 -0.0247098
RPL5 ribosomal protein L5 -0.0246267
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0245602
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0245209
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0244739
RPS24 ribosomal protein S24 -0.0243618
MIS18BP1 MIS18 binding protein 1 -0.0243258
RPL35A ribosomal protein L35a -0.0242326
GOLGA4 golgin A4 -0.0242268
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0239751
RPL8 ribosomal protein L8 -0.0238214
RPL28 ribosomal protein L28 -0.0238102
RPS10 ribosomal protein S10 -0.0234918
CEP95 centrosomal protein 95kDa -0.0234836
KIF5B kinesin family member 5B -0.0234394
CAVIN1 caveolae associated protein 1 -0.0234082
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0232027
WASF2 WAS protein family, member 2 -0.0230672