Citalopram (hydrobromide)_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Citalopram (hydrobromide) perturbation in NCI-H460 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Citalopram (hydrobromide)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.19778
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.146911
PSD3 pleckstrin and Sec7 domain containing 3 0.145172
PDE10A phosphodiesterase 10A 0.103392
EFNA5 ephrin-A5 0.098913
COL5A2 collagen, type V, alpha 2 0.0982182
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0832069
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.082263
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0780689
CDH13 cadherin 13 0.0759604
DST dystonin 0.0753464
PDLIM5 PDZ and LIM domain 5 0.0686286
FN1 fibronectin 1 0.0605352
DOCK4 dedicator of cytokinesis 4 0.0593882
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0591934
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0589421
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.053966
IGFBP3 insulin-like growth factor binding protein 3 0.0516138
P3H2 prolyl 3-hydroxylase 2 0.0515458
COL4A5 collagen, type IV, alpha 5 0.0512656
GDA guanine deaminase 0.0512513
COL8A1 collagen, type VIII, alpha 1 0.0510139
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0507466
PCBP3 poly(rC) binding protein 3 0.0505373
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0488912
ASPH aspartate beta-hydroxylase 0.0486081
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0478622
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0473675
NALF1 NALCN channel auxiliary factor 1 0.0462846
FNDC3B fibronectin type III domain containing 3B 0.0462651
KYNU kynureninase 0.0451151
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0437936
COL4A6 collagen, type IV, alpha 6 0.0428599
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0425841
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.0413762
NRCAM neuronal cell adhesion molecule 0.0413754
NPAS2 neuronal PAS domain protein 2 0.0398483
PRKN parkin RBR E3 ubiquitin protein ligase 0.0381863
MAML3 mastermind-like 3 (Drosophila) 0.0374169
LIMCH1 LIM and calponin homology domains 1 0.0373631
SMOC1 SPARC related modular calcium binding 1 0.0366135
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0358557
SMYD3 SET and MYND domain containing 3 0.0357686
SAMD4A sterile alpha motif domain containing 4A 0.0331361
ADGRD1 adhesion G protein-coupled receptor D1 0.0321112
MYOF myoferlin 0.0306733
DOCK5 dedicator of cytokinesis 5 0.030641
TRIO trio Rho guanine nucleotide exchange factor 0.0296242
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0286341
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0273645
CD109 CD109 molecule 0.0273034
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0268851
AUTS2 autism susceptibility candidate 2 0.0266017
TTC28 tetratricopeptide repeat domain 28 0.0257885
NEK7 NIMA-related kinase 7 0.0257834
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0257343
CTNND2 catenin (cadherin-associated protein), delta 2 0.025722
TMX4 thioredoxin-related transmembrane protein 4 0.0256088
CTSC cathepsin C 0.0255903
GLIS3 GLIS family zinc finger 3 0.0250724
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0247949
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0247429
ZEB2 zinc finger E-box binding homeobox 2 0.0246735
LSAMP limbic system-associated membrane protein 0.0244068
RTN1 reticulon 1 0.0243836
ATXN1 ataxin 1 0.0243251
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0239358
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0238393
TGFBR1 transforming growth factor, beta receptor 1 0.0236636
VCL vinculin 0.0232582
GRAMD1B GRAM domain containing 1B 0.0230981
NTN4 netrin 4 0.0230435
ANTXR1 anthrax toxin receptor 1 0.0228694
RAD51B RAD51 paralog B 0.0228276
EXT1 exostosin glycosyltransferase 1 0.0227365
NCKAP5 NCK-associated protein 5 0.0223209
PDE7B phosphodiesterase 7B 0.0216709
PALLD palladin, cytoskeletal associated protein 0.0213156
BCAR3 breast cancer anti-estrogen resistance 3 0.0210612
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0209663
CTIF CBP80/20-dependent translation initiation factor 0.0209174
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0207688
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0207225
TENM3 teneurin transmembrane protein 3 0.0206561
PTEN phosphatase and tensin homolog 0.020632
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.020331
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 0.0203179
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0199373
THSD4 thrombospondin, type I, domain containing 4 0.0198626
PTPRM protein tyrosine phosphatase, receptor type, M 0.0198253
PBX1 pre-B-cell leukemia homeobox 1 0.0197233
RAB3B RAB3B, member RAS oncogene family 0.0196806
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit 0.0190676
FMNL2 formin-like 2 0.0187062
EXOC4 exocyst complex component 4 0.0173635
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0173456
CHL1 cell adhesion molecule L1-like 0.0172291
RABGAP1L RAB GTPase activating protein 1-like 0.0172177
MAP7 microtubule-associated protein 7 0.0170674
KIAA0825 KIAA0825 0.0168292

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.195885
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.133786
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.123038
TMSB10 thymosin beta 10 -0.0913976
PTMA prothymosin, alpha -0.0825556
FTL ferritin, light polypeptide -0.0736711
NAMPT nicotinamide phosphoribosyltransferase -0.0697393
VIM vimentin -0.0601926
TPT1 tumor protein, translationally-controlled 1 -0.0593729
RPLP1 ribosomal protein, large, P1 -0.0592014
RPS6 ribosomal protein S6 -0.0583422
RPS24 ribosomal protein S24 -0.0475719
MT2A metallothionein 2A -0.0459562
NAP1L1 nucleosome assembly protein 1-like 1 -0.0452774
SRGN serglycin -0.0436746
EIF1 eukaryotic translation initiation factor 1 -0.0431132
RPL12 ribosomal protein L12 -0.0421359
TM4SF1 transmembrane 4 L six family member 1 -0.040248
RPS23 ribosomal protein S23 -0.0381859
RPS8 ribosomal protein S8 -0.0381539
RPS19 ribosomal protein S19 -0.0380337
CANX calnexin -0.0372396
RPL35A ribosomal protein L35a -0.0370994
RPL31 ribosomal protein L31 -0.0367945
RPL19 ribosomal protein L19 -0.0362132
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0360521
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0359138
RPL37A ribosomal protein L37a -0.0352463
PGK1 phosphoglycerate kinase 1 -0.0350389
RPLP0 ribosomal protein, large, P0 -0.0343907
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0339369
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0326132
S100A10 S100 calcium binding protein A10 -0.0321728
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0314146
CXCL8 chemokine (C-X-C motif) ligand 8 -0.03126
DDIT4 DNA-damage-inducible transcript 4 -0.0305262
RPL23 ribosomal protein L23 -0.0301132
RPS27A ribosomal protein S27a -0.029846
PM20D1 peptidase M20 domain containing 1 -0.0297909
RPLP2 ribosomal protein, large, P2 -0.0295166
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0291631
ACTG1 actin gamma 1 -0.0289093
LDHA lactate dehydrogenase A -0.028898
RPL26 ribosomal protein L26 -0.0288808
B2M beta-2-microglobulin -0.0287637
RPL7A ribosomal protein L7a -0.027845
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0274453
RPS21 ribosomal protein S21 -0.0272212
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0270398
RGS2 regulator of G-protein signaling 2 -0.0267955
RPS29 ribosomal protein S29 -0.0267418
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0266703
RPS3 ribosomal protein S3 -0.026646
RPS16 ribosomal protein S16 -0.026221
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0261114
RTN4 reticulon 4 -0.0255571
TXNRD1 thioredoxin reductase 1 -0.0250763
ENO1 enolase 1, (alpha) -0.0250122
RPL34 ribosomal protein L34 -0.0240848
RPL9 ribosomal protein L9 -0.0240156
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0238637
UBC ubiquitin C -0.0237926
RPS13 ribosomal protein S13 -0.0231817
TFPI2 tissue factor pathway inhibitor 2 -0.0230836
BZW1 basic leucine zipper and W2 domains 1 -0.0230236
GARS1 glycyl-tRNA synthetase 1 -0.0228215
RPL32 ribosomal protein L32 -0.022534
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0225119
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0224724
KDM3A lysine (K)-specific demethylase 3A -0.0224383
RPL36 ribosomal protein L36 -0.0221898
RPS14 ribosomal protein S14 -0.02217
SPAG9 sperm associated antigen 9 -0.0221031
RPL38 ribosomal protein L38 -0.0219197
PDIA3 protein disulfide isomerase family A, member 3 -0.0219021
GNAS GNAS complex locus -0.0216068
RPL36A ribosomal protein L36a -0.0213819
RPL11 ribosomal protein L11 -0.0211517
VDAC1 voltage-dependent anion channel 1 -0.0209871
RPS12 ribosomal protein S12 -0.0209583
WDR45B WD repeat domain 45B -0.0208836
RPS25 ribosomal protein S25 -0.0207477
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0206871
RPL35 ribosomal protein L35 -0.020413
RPS4X ribosomal protein S4, X-linked -0.0200845
WSB1 WD repeat and SOCS box containing 1 -0.0200352
RBM39 RNA binding motif protein 39 -0.0197042
HLA-B major histocompatibility complex, class I, B -0.019484
WDFY2 WD repeat and FYVE domain containing 2 -0.0193406
RPL28 ribosomal protein L28 -0.0192642
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0191456
ELL2 elongation factor, RNA polymerase II, 2 -0.0191423
RPL5 ribosomal protein L5 -0.0190526
RPL37 ribosomal protein L37 -0.0189571
PDIA4 protein disulfide isomerase family A, member 4 -0.0187691
RPS27 ribosomal protein S27 -0.0184358
PKM pyruvate kinase, muscle -0.0182402
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0181717
RPL13A ribosomal protein L13a -0.0181391
MXI1 MAX interactor 1, dimerization protein -0.0180798