Citalopram (hydrobromide)_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Citalopram (hydrobromide) perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

129 genes differentially expressed following the Citalopram (hydrobromide)_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTK2 protein tyrosine kinase 2 0.101554
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0954472
AKAP13 A kinase (PRKA) anchor protein 13 0.0911773
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0862303
EXT1 exostosin glycosyltransferase 1 0.0765357
ELOVL5 ELOVL fatty acid elongase 5 0.0756738
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.073182
ALCAM activated leukocyte cell adhesion molecule 0.0703017
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0659091
NDRG1 N-myc downstream regulated 1 0.0655362
EEF2 eukaryotic translation elongation factor 2 0.0637623
CERS6 ceramide synthase 6 0.0580298
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0518072
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0503927
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0449296
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.044795
TXNRD1 thioredoxin reductase 1 0.0423389
KMT2C lysine (K)-specific methyltransferase 2C 0.0423095
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0400226
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0397482
FNDC3A fibronectin type III domain containing 3A 0.0380577
RORA RAR-related orphan receptor A 0.0379313
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0362412
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0361314
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.035098
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0341659
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0324629
PGK1 phosphoglycerate kinase 1 0.0318989
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0311423
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0307037
TAS2R14 taste receptor, type 2, member 14 0.0303951
GDA guanine deaminase 0.0296616
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.028944
CTIF CBP80/20-dependent translation initiation factor 0.0271594
MYOF myoferlin 0.027034
GMDS GDP-mannose 4,6-dehydratase 0.0264124
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0251574
GRB10 growth factor receptor-bound protein 10 0.0250398
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0235887
COL8A1 collagen, type VIII, alpha 1 0.0221983
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0213428
PDLIM5 PDZ and LIM domain 5 0.0199893
HSPH1 heat shock 105kDa/110kDa protein 1 0.0195141
CD109 CD109 molecule 0.0192421
PRKD3 protein kinase D3 0.0190801
PARD3 par-3 family cell polarity regulator 0.0176947
AKAP12 A kinase (PRKA) anchor protein 12 0.0174681
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0173841
BBX bobby sox homolog (Drosophila) 0.0166194
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0165047
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.01609
TCF12 transcription factor 12 0.0159602
MARCHF7 membrane associated ring-CH-type finger 7 0.0144009
TPT1 tumor protein, translationally-controlled 1 0.0112429
PRRC2C proline-rich coiled-coil 2C 0.0110403
APP amyloid beta (A4) precursor protein 0.0106246
NPAS2 neuronal PAS domain protein 2 0.0098029
AOPEP aminopeptidase O (putative) 0.00943227
SETD5 SET domain containing 5 0.00862192
SRPK2 SRSF protein kinase 2 0.00751878
DST dystonin 0.00720659
CDH13 cadherin 13 0.00671431
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.00632344
SPTBN1 spectrin, beta, non-erythrocytic 1 0.00621342
SAMD4A sterile alpha motif domain containing 4A 0.00381553
SMAD3 SMAD family member 3 0.00380979
PDE10A phosphodiesterase 10A 0.00159079
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 9.34622E-4
FN1 fibronectin 1 2.81244E-4

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.152819
EGFR epidermal growth factor receptor -0.119336
PRKCA protein kinase C, alpha -0.118004
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.116482
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.105244
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0934948
VIM vimentin -0.08598
RPS6 ribosomal protein S6 -0.0836295
FNDC3B fibronectin type III domain containing 3B -0.0834671
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0828235
THSD4 thrombospondin, type I, domain containing 4 -0.072223
COL6A3 collagen, type VI, alpha 3 -0.0704774
PSD3 pleckstrin and Sec7 domain containing 3 -0.0667831
CD44 CD44 molecule (Indian blood group) -0.0665635
LPP LIM domain containing preferred translocation partner in lipoma -0.0656835
PDE4D phosphodiesterase 4D, cAMP-specific -0.0652681
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0571987
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0565636
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0560423
SLTM SAFB-like, transcription modulator -0.0549133
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0545615
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0531126
ANKRD12 ankyrin repeat domain 12 -0.0518623
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0475985
PTMA prothymosin, alpha -0.0466123
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.042942
TRIO trio Rho guanine nucleotide exchange factor -0.0426584
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.039608
INHBA inhibin, beta A -0.0388835
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0388283
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0363791
MYO1E myosin IE -0.0358786
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0358101
NALF1 NALCN channel auxiliary factor 1 -0.0355618
FLNB filamin B, beta -0.0322126
ANXA2 annexin A2 -0.0287287
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0237948
WSB1 WD repeat and SOCS box containing 1 -0.0220672
MAML3 mastermind-like 3 (Drosophila) -0.0207728
IGF2 insulin-like growth factor 2 -0.0200915
LMO7 LIM domain 7 -0.0199966
FMNL2 formin-like 2 -0.0184182
DOCK4 dedicator of cytokinesis 4 -0.0182526
KDM2A lysine (K)-specific demethylase 2A -0.0125733
DSCAM Down syndrome cell adhesion molecule -0.0119934
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0114206
MED13L mediator complex subunit 13-like -0.0111364
ASPH aspartate beta-hydroxylase -0.0102257
COL6A1 collagen, type VI, alpha 1 -0.00842254
ERRFI1 ERBB receptor feedback inhibitor 1 -0.00834445
ESYT2 extended synaptotagmin-like protein 2 -0.00718813
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -0.00711028
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.00690031
GOLGA4 golgin A4 -0.00599915
JMJD1C jumonji domain containing 1C -0.00536221
LAMB3 laminin, beta 3 -0.00381362
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.00285468
EFNA5 ephrin-A5 -0.00274733
NBEAL1 neurobeachin-like 1 -0.00230559
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -9.46139E-4