Citalopram (hydrobromide)_PANC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Citalopram (hydrobromide) perturbation in PANC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Citalopram (hydrobromide)_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERRFI1 ERBB receptor feedback inhibitor 1 0.124833
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0850319
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0775658
TXNRD1 thioredoxin reductase 1 0.0641392
MED13L mediator complex subunit 13-like 0.0465347
VMP1 vacuole membrane protein 1 0.0459498
SMAD3 SMAD family member 3 0.0450993
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0445172
ZFP36 ZFP36 ring finger protein 0.0434519
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 0.0432651
EPAS1 endothelial PAS domain protein 1 0.0421071
MYH9 myosin, heavy chain 9, non-muscle 0.0406541
EEF2 eukaryotic translation elongation factor 2 0.0405929
FKBP5 FK506 binding protein 5 0.0403556
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 0.0397716
UTRN utrophin 0.038648
WWTR1 WW domain containing transcription regulator 1 0.0378564
ARRDC3 arrestin domain containing 3 0.0377038
JMJD1C jumonji domain containing 1C 0.0368416
RERE arginine-glutamic acid dipeptide (RE) repeats 0.036835
CSNK1A1 casein kinase 1, alpha 1 0.0365875
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0362558
SOD2 superoxide dismutase 2, mitochondrial 0.0356298
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0351169
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0339011
ACTN4 actinin, alpha 4 0.0331304
AKAP13 A kinase (PRKA) anchor protein 13 0.032292
BIRC2 baculoviral IAP repeat containing 2 0.0315964
APLP2 amyloid beta (A4) precursor-like protein 2 0.0312102
CARD18 caspase recruitment domain family, member 18 0.0306936
NAMPT nicotinamide phosphoribosyltransferase 0.0304947
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.029792
FNDC3B fibronectin type III domain containing 3B 0.0286091
PTEN phosphatase and tensin homolog 0.0280307
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0279963
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0275124
SAMD4B sterile alpha motif domain containing 4B 0.027054
ITGB5 integrin, beta 5 0.0268481
WNK1 WNK lysine deficient protein kinase 1 0.0267408
XPO1 exportin 1 0.0267083
ITGAV integrin, alpha V 0.0266687
EFNA5 ephrin-A5 0.0266465
BIRC3 baculoviral IAP repeat containing 3 0.026605
YAP1 Yes-associated protein 1 0.0264822
SLC38A2 solute carrier family 38, member 2 0.0263861
ZNF780B zinc finger protein 780B 0.0261999
KTN1 kinectin 1 (kinesin receptor) 0.0249907
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0239073
DPY19L1 dpy-19-like 1 (C. elegans) 0.0235906
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.023501
IPO7 importin 7 0.0232299
DSCAM Down syndrome cell adhesion molecule 0.0232141
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0226908
PDE3B phosphodiesterase 3B, cGMP-inhibited 0.0224632
PCBP2 poly(rC) binding protein 2 0.022354
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0222398
IL6ST interleukin 6 signal transducer 0.0219923
BCL2L1 BCL2-like 1 0.0218613
ANGPTL4 angiopoietin-like 4 0.0218402
PLEC plectin 0.0216843
DNAH5 dynein, axonemal, heavy chain 5 0.021681
ARID1A AT rich interactive domain 1A (SWI-like) 0.0214556
NFIA nuclear factor I/A 0.0213128
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1 0.0212175
HIPK3 homeodomain interacting protein kinase 3 0.0211285
TPM3 tropomyosin 3 0.0210712
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0210599
NFE2L2 nuclear factor, erythroid 2-like 2 0.0209426
AKT2 v-akt murine thymoma viral oncogene homolog 2 0.0205683
SNX13 sorting nexin 13 0.0204863
CCNL1 cyclin L1 0.0198257
ATF6 activating transcription factor 6 0.0196294
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.019617
FOXO3 forkhead box O3 0.0195686
EGFR epidermal growth factor receptor 0.0194609
MKI67 marker of proliferation Ki-67 0.0193474
TNRC6A trinucleotide repeat containing 6A 0.0193166
SEC14L1 SEC14-like 1 (S. cerevisiae) 0.0191284
ADGRG6 adhesion G protein-coupled receptor G6 0.0190333
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0189496
LDLRAD3 low density lipoprotein receptor class A domain containing 3 0.0189028
CENPF centromere protein F, 350/400kDa 0.0187251
SFPQ splicing factor proline/glutamine-rich 0.0184964
NFE2L1 nuclear factor, erythroid 2-like 1 0.0183879
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0183437
SMYD3 SET and MYND domain containing 3 0.0180256
ESYT2 extended synaptotagmin-like protein 2 0.0179321
ARHGAP26 Rho GTPase activating protein 26 0.017916
HPCAL1 hippocalcin-like 1 0.0178463
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.017738
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0176134
NCKAP1 NCK-associated protein 1 0.0173545
OGA O-GlcNAcase 0.0172944
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0170143
ATP11B ATPase, class VI, type 11B 0.0168712
MELK maternal embryonic leucine zipper kinase 0.0167213
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit 0.0166176
NRDC nardilysin convertase 0.0166158
ERBIN erbb2 interacting protein 0.0165902
ARHGAP29 Rho GTPase activating protein 29 0.0165354

decreased expression

Symbol Name Standardized Value
RPS16 ribosomal protein S16 -0.267687
VIM vimentin -0.231248
PTMA prothymosin, alpha -0.205022
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.190032
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.141567
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.129568
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.113943
TMSB10 thymosin beta 10 -0.104054
RPL35A ribosomal protein L35a -0.0740258
FTL ferritin, light polypeptide -0.0728453
VCL vinculin -0.0644901
ACTG1 actin gamma 1 -0.0644885
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0626537
SLC35F3 solute carrier family 35, member F3 -0.0584614
RPS3 ribosomal protein S3 -0.0541311
RPLP1 ribosomal protein, large, P1 -0.0536967
S100A6 S100 calcium binding protein A6 -0.0530457
FBL fibrillarin -0.0519908
AHNAK AHNAK nucleoprotein -0.0517104
RPS8 ribosomal protein S8 -0.0511853
THSD4 thrombospondin, type I, domain containing 4 -0.0496874
TRIO trio Rho guanine nucleotide exchange factor -0.0496617
TM4SF1 transmembrane 4 L six family member 1 -0.0482922
RPLP2 ribosomal protein, large, P2 -0.0481307
RPS24 ribosomal protein S24 -0.0480141
SQSTM1 sequestosome 1 -0.041792
RPL37A ribosomal protein L37a -0.0404197
RPS25 ribosomal protein S25 -0.0378416
RPS12 ribosomal protein S12 -0.0377755
RPLP0 ribosomal protein, large, P0 -0.0374435
ATG7 autophagy related 7 -0.036722
TPT1 tumor protein, translationally-controlled 1 -0.0365063
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0351864
HSPG2 heparan sulfate proteoglycan 2 -0.0345284
RPS27A ribosomal protein S27a -0.0334305
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 -0.0333895
RPS5 ribosomal protein S5 -0.0326114
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0324403
WSB1 WD repeat and SOCS box containing 1 -0.0321936
RPL26 ribosomal protein L26 -0.0319948
RPL12 ribosomal protein L12 -0.0309176
HMGA1 high mobility group AT-hook 1 -0.0306396
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0304349
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0302664
NAV2 neuron navigator 2 -0.0292302
RPS17 ribosomal protein S17 -0.0291364
EIF1 eukaryotic translation initiation factor 1 -0.0290346
RPL27A ribosomal protein L27a -0.0286237
RPL11 ribosomal protein L11 -0.0283923
TPM1 tropomyosin 1 (alpha) -0.0281994
RPL34 ribosomal protein L34 -0.0280344
RNF220 ring finger protein 220 -0.0276111
INTS6 integrator complex subunit 6 -0.0271947
MYO10 myosin X -0.0268951
RPL31 ribosomal protein L31 -0.0263212
RPL38 ribosomal protein L38 -0.0257515
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0254763
RPS13 ribosomal protein S13 -0.0254592
LDHA lactate dehydrogenase A -0.0251205
CANX calnexin -0.0249508
CAVIN1 caveolae associated protein 1 -0.0240796
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 -0.0240782
UPP1 uridine phosphorylase 1 -0.0237481
CTSD cathepsin D -0.0232241
RPS19 ribosomal protein S19 -0.0231716
RPS21 ribosomal protein S21 -0.0227946
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0227544
EHBP1 EH domain binding protein 1 -0.0226843
LOC112694756 uncharaterized LOC112694756 -0.0225763
PTK2 protein tyrosine kinase 2 -0.0223873
TNS3 tensin 3 -0.0221816
RPL9 ribosomal protein L9 -0.0221719
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0216092
RPS10 ribosomal protein S10 -0.0215245
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0214651
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) -0.021326
RPS6 ribosomal protein S6 -0.0211838
HLA-B major histocompatibility complex, class I, B -0.0210124
RPL37 ribosomal protein L37 -0.0208194
IFITM3 interferon induced transmembrane protein 3 -0.020091
GOLGA4 golgin A4 -0.0200404
RPL28 ribosomal protein L28 -0.0200149
LMNA lamin A/C -0.0198216
RAB1A RAB1A, member RAS oncogene family -0.0197867
EGR1 early growth response 1 -0.0197506
EXT1 exostosin glycosyltransferase 1 -0.0196688
RPL36 ribosomal protein L36 -0.0196128
PKM pyruvate kinase, muscle -0.0196027
GNAS GNAS complex locus -0.0193281
PDGFB platelet-derived growth factor beta polypeptide -0.0192105
RPS20 ribosomal protein S20 -0.0191968
HDAC9 histone deacetylase 9 -0.0191037
RPS29 ribosomal protein S29 -0.0187337
RPS23 ribosomal protein S23 -0.0186769
RPS14 ribosomal protein S14 -0.0186523
EIF3K eukaryotic translation initiation factor 3, subunit K -0.0184174
C15ORF48 chromosome 15 open reading frame 48 -0.0183765
MYO1E myosin IE -0.0183636
H1-0 H1.0 linker histone -0.0183045
PDE10A phosphodiesterase 10A -0.0180917