Citalopram (hydrobromide)_Panc 03.27 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Citalopram (hydrobromide) perturbation in Panc 03.27 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Citalopram (hydrobromide)_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RACK1 receptor for activated C kinase 1 0.117689
EEF2 eukaryotic translation elongation factor 2 0.0579891
FTH1 ferritin, heavy polypeptide 1 0.0444071
EZR ezrin 0.0325361
MT2A metallothionein 2A 0.0300044
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.024414
TSC22D2 TSC22 domain family, member 2 0.0236966
DDIT4 DNA-damage-inducible transcript 4 0.0231557
CALR calreticulin 0.0217733
GSN gelsolin 0.0211762
RPL23 ribosomal protein L23 0.0207899
YBX1 Y box binding protein 1 0.0201823
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0199304
NFIB nuclear factor I/B 0.01959
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.019273
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0192285
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 0.0185474
DLG1 discs, large homolog 1 (Drosophila) 0.0183595
FLNA filamin A, alpha 0.0182913
IGFBP3 insulin-like growth factor binding protein 3 0.0182294
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0180956
RPS4X ribosomal protein S4, X-linked 0.0178976
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.0174252
KRT86 keratin 86, type II 0.01716
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.016862
ANXA1 annexin A1 0.016532
NUMA1 nuclear mitotic apparatus protein 1 0.0155537
FKBP5 FK506 binding protein 5 0.0155338
WFDC2 WAP four-disulfide core domain 2 0.0155255
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.0154636
NIBAN2 niban apoptosis regulator 2 0.0153195
FMNL2 formin-like 2 0.0147297
MARCHF6 membrane associated ring-CH-type finger 6 0.0145815
HPCAL1 hippocalcin-like 1 0.0143591
MKRN1 makorin ring finger protein 1 0.0143201
SEC31A SEC31 homolog A (S. cerevisiae) 0.0140871
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0140052
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0137833
RAD23B RAD23 homolog B (S. cerevisiae) 0.0134078
YME1L1 YME1-like 1 ATPase 0.0133878
CDC27 cell division cycle 27 0.0133245
NME2 NME/NM23 nucleoside diphosphate kinase 2 0.0131266
HDLBP high density lipoprotein binding protein 0.0127802
FNBP4 formin binding protein 4 0.0127399
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2 0.0127368
TGFB2 transforming growth factor, beta 2 0.0124298
SKAP2 src kinase associated phosphoprotein 2 0.0124076
EPS8 epidermal growth factor receptor pathway substrate 8 0.0122979
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0122047
TUBB tubulin, beta class I 0.0122028
LIN7C lin-7 homolog C (C. elegans) 0.0121888
CIRBP cold inducible RNA binding protein 0.0119224
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0118993
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0118442
SAFB2 scaffold attachment factor B2 0.0117968
TSC22D3 TSC22 domain family, member 3 0.0116913
TRA2A transformer 2 alpha homolog (Drosophila) 0.0116262
RPS15A ribosomal protein S15a 0.0115112
NPEPPS aminopeptidase puromycin sensitive 0.0113529
GANAB glucosidase, alpha; neutral AB 0.0113452
MT1X metallothionein 1X 0.0112097
USP9X ubiquitin specific peptidase 9, X-linked 0.0111909
HILPDA hypoxia inducible lipid droplet-associated 0.0108977
CUL3 cullin 3 0.0108489
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0108124
STC2 stanniocalcin 2 0.0107884
NEK6 NIMA-related kinase 6 0.0107626
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0105283
LRRC59 leucine rich repeat containing 59 0.0104482
OSER1 oxidative stress responsive serine-rich 1 0.0104313
UBAP2L ubiquitin associated protein 2-like 0.0104136
TOP1 topoisomerase (DNA) I 0.0103886
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.010328
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0102705
HYOU1 hypoxia up-regulated 1 0.0102169
IFRD1 interferon-related developmental regulator 1 0.0101661
COPG1 coatomer protein complex, subunit gamma 1 0.0100014
SMC3 structural maintenance of chromosomes 3 0.00999826
LCORL ligand dependent nuclear receptor corepressor-like 0.00998579
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.00997055
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.00992035
TACSTD2 tumor-associated calcium signal transducer 2 0.00982592
RNF169 ring finger protein 169 0.00981731
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.00980816
CEP250 centrosomal protein 250kDa 0.00979879
MYLIP myosin regulatory light chain interacting protein 0.00978853
TPI1 triosephosphate isomerase 1 0.00977409
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.00970907
SBNO2 strawberry notch homolog 2 (Drosophila) 0.00969948
RPL3 ribosomal protein L3 0.00969599
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.00967527
SEC24C SEC24 family member C 0.00959274
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.00957798
BRWD1 bromodomain and WD repeat domain containing 1 0.00941103
DCTN1 dynactin 1 0.00938434
SHROOM3 shroom family member 3 0.00936745
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.00931392
EFNA5 ephrin-A5 0.0093024
NOG noggin 0.00923602
ZFAND5 zinc finger, AN1-type domain 5 0.00914201

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.360906
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.191951
DSG2 desmoglein 2 -0.127724
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.12122
ACTG1 actin gamma 1 -0.106654
RPS6 ribosomal protein S6 -0.0990759
TPT1 tumor protein, translationally-controlled 1 -0.0897819
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0896975
LAMA4 laminin, alpha 4 -0.087424
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0849551
LAMC2 laminin, gamma 2 -0.0800757
ANXA2 annexin A2 -0.0766043
TMSB4X thymosin beta 4, X-linked -0.0749811
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0709376
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0696315
RNF213 ring finger protein 213 -0.0619169
PLSCR1 phospholipid scramblase 1 -0.0617198
PLAUR plasminogen activator, urokinase receptor -0.057986
SVIL supervillin -0.0578825
SQSTM1 sequestosome 1 -0.0563535
RPS2 ribosomal protein S2 -0.055603
CDCP1 CUB domain containing protein 1 -0.0543682
TXNIP thioredoxin interacting protein -0.0540953
TPM4 tropomyosin 4 -0.0539336
FNDC3B fibronectin type III domain containing 3B -0.0526992
SMAD3 SMAD family member 3 -0.0522136
CD44 CD44 molecule (Indian blood group) -0.051294
CD2AP CD2-associated protein -0.0509292
RIGI RNA sensor RIG-I -0.0509265
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0504142
HLA-B major histocompatibility complex, class I, B -0.0503556
ZBTB20 zinc finger and BTB domain containing 20 -0.0488094
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0477912
MAML2 mastermind-like 2 (Drosophila) -0.0476099
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0467257
RPL19 ribosomal protein L19 -0.0459299
RPS15 ribosomal protein S15 -0.0454067
POTEF POTE ankyrin domain family, member F -0.0451192
SMYD3 SET and MYND domain containing 3 -0.0450337
MX1 MX dynamin-like GTPase 1 -0.0446291
PCLO piccolo presynaptic cytomatrix protein -0.0443392
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0439598
RPS23 ribosomal protein S23 -0.0437587
PRRC2C proline-rich coiled-coil 2C -0.0431749
MACF1 microtubule-actin crosslinking factor 1 -0.043125
RPS13 ribosomal protein S13 -0.0430635
MBNL1 muscleblind-like splicing regulator 1 -0.0426815
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0424735
AFDN afadin, adherens junction formation factor -0.042307
IFIH1 interferon induced with helicase C domain 1 -0.0422359
UBE2H ubiquitin-conjugating enzyme E2H -0.042172
PATJ PATJ crumbs cell polarity complex component -0.0420703
ETV6 ets variant 6 -0.0419255
B2M beta-2-microglobulin -0.0416344
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0413795
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0413564
FN1 fibronectin 1 -0.040791
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0403716
IL6ST interleukin 6 signal transducer -0.0401012
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0400009
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0398804
ARHGAP5 Rho GTPase activating protein 5 -0.0392491
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0390396
DUSP5 dual specificity phosphatase 5 -0.0387072
ARHGAP26 Rho GTPase activating protein 26 -0.0386107
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0386077
MX2 MX dynamin-like GTPase 2 -0.0384851
RPS21 ribosomal protein S21 -0.038218
SH3KBP1 SH3-domain kinase binding protein 1 -0.0381934
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0376164
RTN4 reticulon 4 -0.0375257
RPS24 ribosomal protein S24 -0.0373616
RPL28 ribosomal protein L28 -0.0372354
RPS29 ribosomal protein S29 -0.0369428
FNIP1 folliculin interacting protein 1 -0.0368947
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0367556
EPSTI1 epithelial stromal interaction 1 (breast) -0.0367347
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0366618
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0366576
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0364896
MYO1E myosin IE -0.0363895
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0363507
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0361524
WWTR1 WW domain containing transcription regulator 1 -0.0359031
ERBIN erbb2 interacting protein -0.0358179
KRT19 keratin 19, type I -0.0357667
HMGA1 high mobility group AT-hook 1 -0.0355869
PICALM phosphatidylinositol binding clathrin assembly protein -0.035144
WWC1 WW and C2 domain containing 1 -0.0350571
RPL38 ribosomal protein L38 -0.0349263
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0347878
SDC4 syndecan 4 -0.0345677
ASPH aspartate beta-hydroxylase -0.0345384
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0343475
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.034294
XPO1 exportin 1 -0.0341174
BBX bobby sox homolog (Drosophila) -0.0340851
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0340186
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0337361
TAOK1 TAO kinase 1 -0.0333535