Citalopram (hydrobromide)_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Citalopram (hydrobromide) perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Citalopram (hydrobromide)_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.114748
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0969902
EEF2 eukaryotic translation elongation factor 2 0.0902556
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.075019
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0681728
TXNRD1 thioredoxin reductase 1 0.0669422
JMJD1C jumonji domain containing 1C 0.0579942
MCTP1 multiple C2 domains, transmembrane 1 0.0509926
MCL1 myeloid cell leukemia 1 0.0504385
NUP58 nucleoporin 58 0.0491147
JUN jun proto-oncogene 0.0415746
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0392493
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.038378
HDAC9 histone deacetylase 9 0.036938
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0366577
KDM3A lysine (K)-specific demethylase 3A 0.0365502
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0356198
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0343598
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.033632
CALU calumenin 0.0328952
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 0.0308788
DSCAM Down syndrome cell adhesion molecule 0.0301953
USP34 ubiquitin specific peptidase 34 0.0301228
CANX calnexin 0.0301104
CAPRIN2 caprin family member 2 0.0301013
MYH9 myosin, heavy chain 9, non-muscle 0.0296446
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0291519
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0286677
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0283443
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.027974
IARS1 isoleucyl-tRNA synthetase 1 0.0276155
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0270427
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.026903
APLP2 amyloid beta (A4) precursor-like protein 2 0.0265683
FKBP15 FK506 binding protein 15, 133kDa 0.0262748
UPP1 uridine phosphorylase 1 0.0260917
VMP1 vacuole membrane protein 1 0.0256895
NCKAP1 NCK-associated protein 1 0.0247621
RAD21 RAD21 homolog (S. pombe) 0.0246618
RLF rearranged L-myc fusion 0.0246
ELL2 elongation factor, RNA polymerase II, 2 0.0239545
CLTC clathrin, heavy chain (Hc) 0.0236911
OGA O-GlcNAcase 0.0235389
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.023491
HDLBP high density lipoprotein binding protein 0.0231069
STC1 stanniocalcin 1 0.0228104
FAM91A1 family with sequence similarity 91, member A1 0.02253
CSNK1A1 casein kinase 1, alpha 1 0.0223664
CCNL1 cyclin L1 0.0215856
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0215422
AFF4 AF4/FMR2 family, member 4 0.0213866
ZEB1 zinc finger E-box binding homeobox 1 0.0212681
NAV2 neuron navigator 2 0.0212638
YTHDC1 YTH domain containing 1 0.0211913
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0209617
PDE4D phosphodiesterase 4D, cAMP-specific 0.0208502
ADAM17 ADAM metallopeptidase domain 17 0.0202657
CAPN2 calpain 2, (m/II) large subunit 0.0201923
KMT2C lysine (K)-specific methyltransferase 2C 0.0201031
ANXA5 annexin A5 0.0200101
FLNA filamin A, alpha 0.0198721
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.019363
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0189258
SPAG9 sperm associated antigen 9 0.0188649
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0188156
INTS6 integrator complex subunit 6 0.0187794
KDM7A lysine (K)-specific demethylase 7A 0.0187203
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0184714
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0183069
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0183036
WNK1 WNK lysine deficient protein kinase 1 0.0182849
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0182501
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0181425
ZFAND3 zinc finger, AN1-type domain 3 0.0181239
PPME1 protein phosphatase methylesterase 1 0.0180285
RNMT RNA (guanine-7-) methyltransferase 0.0179702
HSPA8 heat shock 70kDa protein 8 0.0178361
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0178219
RB1CC1 RB1-inducible coiled-coil 1 0.0177482
ADAM9 ADAM metallopeptidase domain 9 0.0175408
KDM6A lysine (K)-specific demethylase 6A 0.0174084
CRYBG3 beta-gamma crystallin domain containing 3 0.0173354
FOXO3 forkhead box O3 0.0172165
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0171853
USP9X ubiquitin specific peptidase 9, X-linked 0.0168938
NUMA1 nuclear mitotic apparatus protein 1 0.0168455
ZC3H11A zinc finger CCCH-type containing 11A 0.0167279
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0165905
BRD2 bromodomain containing 2 0.0165623
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0165186
LAMB3 laminin, beta 3 0.0163691
KMT2E lysine (K)-specific methyltransferase 2E 0.0163127
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0162795
PGK1 phosphoglycerate kinase 1 0.0162761
UBC ubiquitin C 0.0162325
WDR26 WD repeat domain 26 0.0161911
RBM39 RNA binding motif protein 39 0.016101
SERINC3 serine incorporator 3 0.0160517
NARS1 asparaginyl-tRNA synthetase 1 0.0160471
TOP2B topoisomerase (DNA) II beta 180kDa 0.0159875

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.223846
RPS6 ribosomal protein S6 -0.131339
DLC1 DLC1 Rho GTPase activating protein -0.114063
RPS8 ribosomal protein S8 -0.0846971
RPL35A ribosomal protein L35a -0.0819666
RPLP1 ribosomal protein, large, P1 -0.0790559
RPL12 ribosomal protein L12 -0.0783617
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0724722
RPLP2 ribosomal protein, large, P2 -0.0647541
TMSB10 thymosin beta 10 -0.0643531
RPL35 ribosomal protein L35 -0.0629156
RPL8 ribosomal protein L8 -0.0602278
ZNF438 zinc finger protein 438 -0.0599005
PTMA prothymosin, alpha -0.0572144
IFI16 interferon, gamma-inducible protein 16 -0.0570022
FTL ferritin, light polypeptide -0.0563716
RPL37A ribosomal protein L37a -0.0561436
RPL26 ribosomal protein L26 -0.0553301
RPL9 ribosomal protein L9 -0.0550757
RPS12 ribosomal protein S12 -0.0550511
RPS21 ribosomal protein S21 -0.0549531
RPL23 ribosomal protein L23 -0.0544659
ARHGAP22 Rho GTPase activating protein 22 -0.0542796
RPS19 ribosomal protein S19 -0.0532945
RPS3 ribosomal protein S3 -0.0510344
RPL34 ribosomal protein L34 -0.050026
RPL11 ribosomal protein L11 -0.0492437
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0488382
TPT1 tumor protein, translationally-controlled 1 -0.0485753
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0477841
RPL19 ribosomal protein L19 -0.0465673
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0443612
RPS17 ribosomal protein S17 -0.0432626
RPS29 ribosomal protein S29 -0.0430624
HMGA1 high mobility group AT-hook 1 -0.0426805
RPS27A ribosomal protein S27a -0.0418748
RPL5 ribosomal protein L5 -0.0416797
RPS25 ribosomal protein S25 -0.0412219
CALD1 caldesmon 1 -0.0411303
FLNB filamin B, beta -0.0409076
HMGA2 high mobility group AT-hook 2 -0.0407141
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0406341
RPL36 ribosomal protein L36 -0.0404676
RPLP0 ribosomal protein, large, P0 -0.0402078
RPL7A ribosomal protein L7a -0.0392942
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0392699
RAD51B RAD51 paralog B -0.0392662
S100A9 S100 calcium binding protein A9 -0.0391464
RPL30 ribosomal protein L30 -0.0386905
RPS24 ribosomal protein S24 -0.0381583
RPL32 ribosomal protein L32 -0.0371391
RIGI RNA sensor RIG-I -0.0359318
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0359146
PBX3 pre-B-cell leukemia homeobox 3 -0.0351288
BNC2 basonuclin 2 -0.0350698
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0345244
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0343579
PFN1 profilin 1 -0.03398
RPL37 ribosomal protein L37 -0.0339065
LPP LIM domain containing preferred translocation partner in lipoma -0.033603
RPS16 ribosomal protein S16 -0.0330364
RPL28 ribosomal protein L28 -0.0321247
RPL31 ribosomal protein L31 -0.0320989
RPL13A ribosomal protein L13a -0.0320545
RPS14 ribosomal protein S14 -0.0319472
FRMD4A FERM domain containing 4A -0.0316795
RPL7 ribosomal protein L7 -0.0316346
RPS20 ribosomal protein S20 -0.0315106
RPL27 ribosomal protein L27 -0.0311787
SLC38A2 solute carrier family 38, member 2 -0.0308507
RPS13 ribosomal protein S13 -0.0305576
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0304408
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0302745
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) -0.0301812
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0298659
RPS15 ribosomal protein S15 -0.0290372
IFI6 interferon, alpha-inducible protein 6 -0.0289024
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0288662
RPL38 ribosomal protein L38 -0.0283596
RPL18 ribosomal protein L18 -0.0282935
RPS2 ribosomal protein S2 -0.0281643
FHIT fragile histidine triad -0.0281469
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) -0.0276791
ISG15 ISG15 ubiquitin-like modifier -0.0275706
NAV3 neuron navigator 3 -0.0273805
RAB3IP RAB3A interacting protein -0.0273087
RPS5 ribosomal protein S5 -0.0269008
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0268531
FRMD6 FERM domain containing 6 -0.026644
RPS11 ribosomal protein S11 -0.0264114
RPS10 ribosomal protein S10 -0.0260751
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0260623
ALCAM activated leukocyte cell adhesion molecule -0.0259139
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.025875
RPL10A ribosomal protein L10a -0.0258398
MT1X metallothionein 1X -0.0255386
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0246447
PCNX4 pecanex 4 -0.024529
KPNB1 karyopherin (importin) beta 1 -0.0245063
CUX1 cut-like homeobox 1 -0.0241476