Citalopram (hydrobromide)_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Citalopram (hydrobromide) perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Citalopram (hydrobromide)_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0917378
HOOK2 hook microtubule-tethering protein 2 0.0569625
TENT5A terminal nucleotidyltransferase 5A 0.0487187
ERRFI1 ERBB receptor feedback inhibitor 1 0.0479389
STC1 stanniocalcin 1 0.0459734
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0443082
MORF4L2 mortality factor 4 like 2 0.0425751
ARRDC3 arrestin domain containing 3 0.0402294
NAMPT nicotinamide phosphoribosyltransferase 0.0401392
JARID2 jumonji, AT rich interactive domain 2 0.0376425
ATP13A3 ATPase type 13A3 0.0344985
CSMD2 CUB and Sushi multiple domains 2 0.032605
PRKCA protein kinase C, alpha 0.0320367
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0309252
FTH1 ferritin, heavy polypeptide 1 0.030891
TRA2A transformer 2 alpha homolog (Drosophila) 0.0305597
SRP72 signal recognition particle 72kDa 0.0296114
DLG1 discs, large homolog 1 (Drosophila) 0.0284172
RPL23 ribosomal protein L23 0.0273039
STXBP1 syntaxin binding protein 1 0.0271754
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0264755
IGFBP3 insulin-like growth factor binding protein 3 0.0259047
ANKHD1 ankyrin repeat and KH domain containing 1 0.0257895
SCAF11 SR-related CTD-associated factor 11 0.0253951
PLEC plectin 0.0251363
COL6A3 collagen, type VI, alpha 3 0.0250919
CXCL3 chemokine (C-X-C motif) ligand 3 0.0248319
SND1 staphylococcal nuclease and tudor domain containing 1 0.0247155
RNF38 ring finger protein 38 0.0243541
NKD1 naked cuticle homolog 1 (Drosophila) 0.0241393
SPAG9 sperm associated antigen 9 0.0239159
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 0.0236513
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0232727
NRXN3 neurexin 3 0.0231584
SLC35F5 solute carrier family 35, member F5 0.0231352
COL5A1 collagen, type V, alpha 1 0.023032
NBEAL1 neurobeachin-like 1 0.0227859
CAPN2 calpain 2, (m/II) large subunit 0.022584
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0224954
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0224083
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0222845
PRELID2 PRELI domain containing 2 0.0222707
LMAN1 lectin, mannose-binding, 1 0.0222693
CDH13 cadherin 13 0.0220103
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0217684
SEPTIN10 septin 10 0.0216958
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0215412
CTSB cathepsin B 0.0213734
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0212549
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0212321
TMEM167A transmembrane protein 167A 0.0210591
TTC3 tetratricopeptide repeat domain 3 0.020811
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0207452
SEC63 SEC63 homolog (S. cerevisiae) 0.0205625
PSD3 pleckstrin and Sec7 domain containing 3 0.0203882
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 0.0203489
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0202531
FBXW11 F-box and WD repeat domain containing 11 0.0202299
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0202107
FLNA filamin A, alpha 0.0201057
MBD5 methyl-CpG binding domain protein 5 0.0200166
FCHO2 FCH domain only 2 0.0196495
N4BP2L2 NEDD4 binding protein 2-like 2 0.0194416
TMEM161B transmembrane protein 161B 0.0191892
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0191028
IL6 interleukin 6 0.0190723
DTNA dystrobrevin, alpha 0.0190693
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.019047
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0189267
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0188971
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0185713
CCDC93 coiled-coil domain containing 93 0.018538
ZNF292 zinc finger protein 292 0.0184675
HPCAL1 hippocalcin-like 1 0.0183306
CD46 CD46 molecule, complement regulatory protein 0.0183234
RINT1 RAD50 interactor 1 0.0183162
NECTIN3 nectin cell adhesion molecule 3 0.0183088
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0182861
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0182811
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0181967
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.0181144
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0180507
SREBF2 sterol regulatory element binding transcription factor 2 0.0180132
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.017935
TMF1 TATA element modulatory factor 1 0.0178763
IFT88 intraflagellar transport 88 0.0178713
L1CAM L1 cell adhesion molecule 0.0177178
LASP1 LIM and SH3 protein 1 0.0177024
KANSL3 KAT8 regulatory NSL complex subunit 3 0.0176482
GDI2 GDP dissociation inhibitor 2 0.0176107
PHF14 PHD finger protein 14 0.0175418
PGM3 phosphoglucomutase 3 0.0175411
FAM193A family with sequence similarity 193, member A 0.0174977
MAT2B methionine adenosyltransferase II, beta 0.0174818
ARHGAP35 Rho GTPase activating protein 35 0.0174272
COL4A2 collagen, type IV, alpha 2 0.0173868
EEF2 eukaryotic translation elongation factor 2 0.0173483
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 0.0173155
KAZN kazrin, periplakin interacting protein 0.0173108
MALT1 MALT1 paracaspase 0.0173046

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.223889
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.152596
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.10601
TGFBI transforming growth factor, beta-induced, 68kDa -0.090756
FN1 fibronectin 1 -0.0904565
FTL ferritin, light polypeptide -0.0821263
TIMP3 TIMP metallopeptidase inhibitor 3 -0.079928
TMSB10 thymosin beta 10 -0.0753816
PKM pyruvate kinase, muscle -0.0745758
MT1X metallothionein 1X -0.067595
HLA-B major histocompatibility complex, class I, B -0.06711
POTEF POTE ankyrin domain family, member F -0.0645668
HIP1 huntingtin interacting protein 1 -0.0637603
HIPK2 homeodomain interacting protein kinase 2 -0.06287
SDC4 syndecan 4 -0.0627192
VIM vimentin -0.0584367
ANXA2 annexin A2 -0.0478019
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0476044
TPM4 tropomyosin 4 -0.0463358
MAP1B microtubule-associated protein 1B -0.0440263
CALU calumenin -0.042534
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0415359
EGFR epidermal growth factor receptor -0.0410806
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0408329
EMP1 epithelial membrane protein 1 -0.0388317
LOX lysyl oxidase -0.0387026
MSN moesin -0.0364684
COL1A2 collagen, type I, alpha 2 -0.0362847
CALD1 caldesmon 1 -0.0358414
SOD2 superoxide dismutase 2, mitochondrial -0.0350316
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0341721
F3 coagulation factor III (thromboplastin, tissue factor) -0.0332825
TPST1 tyrosylprotein sulfotransferase 1 -0.0329529
LDHA lactate dehydrogenase A -0.0324722
JUN jun proto-oncogene -0.0322426
S100A6 S100 calcium binding protein A6 -0.0316204
ZMYND8 zinc finger, MYND-type containing 8 -0.0312554
AKAP12 A kinase (PRKA) anchor protein 12 -0.0312356
TXNIP thioredoxin interacting protein -0.0311115
SEPTIN7 septin 7 -0.0309964
RND3 Rho family GTPase 3 -0.0306762
SSBP2 single-stranded DNA binding protein 2 -0.029964
AKAP9 A kinase (PRKA) anchor protein 9 -0.029906
MYH9 myosin, heavy chain 9, non-muscle -0.0286282
TAGLN2 transgelin 2 -0.0284517
NDRG1 N-myc downstream regulated 1 -0.0279322
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0275227
RPL15 ribosomal protein L15 -0.0274844
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0274737
CAV1 caveolin 1, caveolae protein, 22kDa -0.027445
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0273007
RNF24 ring finger protein 24 -0.0268886
RPL37A ribosomal protein L37a -0.0267478
XPO1 exportin 1 -0.0267361
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.02656
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0262647
VEGFA vascular endothelial growth factor A -0.0258865
H3-3B H3.3 histone B -0.0258703
RLF rearranged L-myc fusion -0.0257358
ADM adrenomedullin -0.0257185
DSTN destrin (actin depolymerizing factor) -0.0252137
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0248047
INHBA inhibin, beta A -0.0246237
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0243718
COL6A1 collagen, type VI, alpha 1 -0.0240693
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0236723
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0234091
LOC112694756 uncharaterized LOC112694756 -0.0229961
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0227695
ENO1 enolase 1, (alpha) -0.0227601
RPL28 ribosomal protein L28 -0.0226411
KDM4B lysine (K)-specific demethylase 4B -0.0226087
ANXA5 annexin A5 -0.0224573
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0222278
CD63 CD63 molecule -0.0220333
JMJD1C jumonji domain containing 1C -0.0220004
ANKRD17 ankyrin repeat domain 17 -0.0214407
HLA-C major histocompatibility complex, class I, C -0.0214229
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0212921
PDZD2 PDZ domain containing 2 -0.0210159
POMP proteasome maturation protein -0.0209285
GCC2 GRIP and coiled-coil domain containing 2 -0.0207402
AHNAK AHNAK nucleoprotein -0.0206655
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0206168
RPS6 ribosomal protein S6 -0.020418
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.020368
WDR43 WD repeat domain 43 -0.0202329
RNF145 ring finger protein 145 -0.0201491
RASAL2 RAS protein activator like 2 -0.0200633
VDAC1 voltage-dependent anion channel 1 -0.0200525
USP34 ubiquitin specific peptidase 34 -0.0199455
RNF216 ring finger protein 216 -0.0198321
UBC ubiquitin C -0.019745
BIRC3 baculoviral IAP repeat containing 3 -0.0196405
ALCAM activated leukocyte cell adhesion molecule -0.0195969
TRAM1 translocation associated membrane protein 1 -0.0194416
RPLP0 ribosomal protein, large, P0 -0.0194092
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0193833
RCOR1 REST corepressor 1 -0.0193427
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0193065