Citalopram (hydrobromide)_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Citalopram (hydrobromide) perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Citalopram (hydrobromide)_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.0768883
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0647644
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0578747
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0561776
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0560562
PTMA prothymosin, alpha 0.055174
EEF2 eukaryotic translation elongation factor 2 0.0541084
ZNF292 zinc finger protein 292 0.0533163
NUP58 nucleoporin 58 0.0528697
RACK1 receptor for activated C kinase 1 0.0498822
TXNRD1 thioredoxin reductase 1 0.0497066
TPX2 TPX2, microtubule-associated 0.0477126
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0463571
CSNK1A1 casein kinase 1, alpha 1 0.0459845
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0453871
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0438826
DIAPH3 diaphanous-related formin 3 0.0429525
YBX3 Y box binding protein 3 0.0429414
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0405816
RPL23 ribosomal protein L23 0.0397892
ANKRD28 ankyrin repeat domain 28 0.0395856
GOLGA4 golgin A4 0.0387477
RBM39 RNA binding motif protein 39 0.0381386
RSRC2 arginine/serine-rich coiled-coil 2 0.037556
MKI67 marker of proliferation Ki-67 0.0368925
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0355634
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0354569
PDE4D phosphodiesterase 4D, cAMP-specific 0.034768
WAC WW domain containing adaptor with coiled-coil 0.0345957
MATR3 matrin 3 0.0337532
B2M beta-2-microglobulin 0.0336863
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0320596
NCAPD2 non-SMC condensin I complex, subunit D2 0.0317532
CHD1 chromodomain helicase DNA binding protein 1 0.0317427
YBX1 Y box binding protein 1 0.0316658
NF1 neurofibromin 1 0.0316044
CEP250 centrosomal protein 250kDa 0.031516
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0308764
CENPF centromere protein F, 350/400kDa 0.030564
PNISR PNN-interacting serine/arginine-rich protein 0.030279
ANKHD1 ankyrin repeat and KH domain containing 1 0.0301061
RPL12 ribosomal protein L12 0.0297671
JMJD1C jumonji domain containing 1C 0.0292519
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0292497
KTN1 kinectin 1 (kinesin receptor) 0.0291039
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0291039
SET SET nuclear proto-oncogene 0.0287441
BIRC3 baculoviral IAP repeat containing 3 0.0284469
MARCHF6 membrane associated ring-CH-type finger 6 0.0281696
SMYD3 SET and MYND domain containing 3 0.0276706
KIF5B kinesin family member 5B 0.0275473
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0273844
AHCTF1 AT hook containing transcription factor 1 0.0272104
LOC112694756 uncharaterized LOC112694756 0.0267286
XPO1 exportin 1 0.0252518
CANX calnexin 0.0250916
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0247965
SMC4 structural maintenance of chromosomes 4 0.0247278
HMMR hyaluronan-mediated motility receptor (RHAMM) 0.0246149
PHIP pleckstrin homology domain interacting protein 0.0244964
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0240188
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0240126
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0237161
R3HDM1 R3H domain containing 1 0.0236925
YAP1 Yes-associated protein 1 0.0236631
CUL4B cullin 4B 0.0234705
MYH9 myosin, heavy chain 9, non-muscle 0.0233375
HILPDA hypoxia inducible lipid droplet-associated 0.0233201
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.0233136
DLG1 discs, large homolog 1 (Drosophila) 0.023193
HJURP Holliday junction recognition protein 0.0230765
RSF1 remodeling and spacing factor 1 0.0230009
SETD5 SET domain containing 5 0.022978
NPTN neuroplastin 0.0229305
DERA deoxyribose-phosphate aldolase (putative) 0.022873
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.0227926
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0226987
GIGYF2 GRB10 interacting GYF protein 2 0.0225253
AKAP12 A kinase (PRKA) anchor protein 12 0.0223434
MIS18BP1 MIS18 binding protein 1 0.0220845
TM9SF2 transmembrane 9 superfamily member 2 0.0219852
KDM2A lysine (K)-specific demethylase 2A 0.0219108
ANKRD36 ankyrin repeat domain 36 0.0218822
PRC1 protein regulator of cytokinesis 1 0.0218452
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0218086
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0217141
IQGAP1 IQ motif containing GTPase activating protein 1 0.0215308
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0214107
RNF145 ring finger protein 145 0.021344
TPR translocated promoter region, nuclear basket protein 0.0213179
RIMKLB ribosomal modification protein rimK-like family member B 0.021277
KIAA1328 KIAA1328 0.021246
COG5 component of oligomeric golgi complex 5 0.021191
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.021134
BPTF bromodomain PHD finger transcription factor 0.0211076
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0210698
CEP57 centrosomal protein 57kDa 0.0209875
TTK TTK protein kinase 0.0209759
SLMAP sarcolemma associated protein 0.0209257
ERBIN erbb2 interacting protein 0.0209241

decreased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B -0.0687623
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0668015
INTS6 integrator complex subunit 6 -0.0530842
HMGA2 high mobility group AT-hook 2 -0.0520784
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0391267
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0384781
EGFR epidermal growth factor receptor -0.0363115
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0355355
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0326819
PCED1B PC-esterase domain containing 1B -0.0324845
TPT1 tumor protein, translationally-controlled 1 -0.0316194
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0307728
AHNAK AHNAK nucleoprotein -0.0303686
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0293957
PRR16 proline rich 16 -0.0292864
SH3KBP1 SH3-domain kinase binding protein 1 -0.028521
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0282684
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0274695
IER3 immediate early response 3 -0.0273144
ANGPTL4 angiopoietin-like 4 -0.0269495
ATG7 autophagy related 7 -0.026856
PRKCA protein kinase C, alpha -0.0262099
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0258031
DENND1A DENN/MADD domain containing 1A -0.0255203
SLC38A2 solute carrier family 38, member 2 -0.0254631
NPAS2 neuronal PAS domain protein 2 -0.0250346
SQSTM1 sequestosome 1 -0.0246556
VCL vinculin -0.0244352
SLC35F3 solute carrier family 35, member F3 -0.023574
SVIL supervillin -0.0235555
ELOF1 elongation factor 1 homolog (S. cerevisiae) -0.0234591
ZBTB20 zinc finger and BTB domain containing 20 -0.0228885
GPC5 glypican 5 -0.0228355
RAI14 retinoic acid induced 14 -0.0223119
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0210966
IGF2 insulin-like growth factor 2 -0.0209109
CEMIP2 cell migration inducing hyaluronidase 2 -0.0206598
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -0.0205701
FMN1 formin 1 -0.0201296
ASPH aspartate beta-hydroxylase -0.0194701
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0194428
NABP1 nucleic acid binding protein 1 -0.0193747
FLNB filamin B, beta -0.0192613
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0192095
PODXL podocalyxin-like -0.0184836
RUNX1 runt-related transcription factor 1 -0.0182781
AEBP2 AE binding protein 2 -0.0178651
KLF3 Kruppel-like factor 3 (basic) -0.0177142
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0175212
TRIO trio Rho guanine nucleotide exchange factor -0.0170714
LRRC23 leucine rich repeat containing 23 -0.0170537
APOLD1 apolipoprotein L domain containing 1 -0.0169952
ITGAV integrin, alpha V -0.0169768
NT5E 5'-nucleotidase, ecto (CD73) -0.0169058
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.016886
PLEK2 pleckstrin 2 -0.0164037
NINL ninein-like -0.0162438
PUM1 pumilio RNA-binding family member 1 -0.016105
JAZF1 JAZF zinc finger 1 -0.0159833
LPP LIM domain containing preferred translocation partner in lipoma -0.0158102
LAMA5 laminin, alpha 5 -0.0157871
COL5A1 collagen, type V, alpha 1 -0.0157647
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -0.0155664
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0155473
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0155364
THBS1 thrombospondin 1 -0.0154088
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0153714
CDR2 cerebellar degeneration-related protein 2, 62kDa -0.0151541
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0150646
WDFY3 WD repeat and FYVE domain containing 3 -0.0149484
USP53 ubiquitin specific peptidase 53 -0.014946
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.014869
WNT2B wingless-type MMTV integration site family, member 2B -0.0148279
DOCK3 dedicator of cytokinesis 3 -0.0147765
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.0147582
ABR active BCR-related -0.0146699
CNIH3 cornichon family AMPA receptor auxiliary protein 3 -0.0146071
PDGFA platelet-derived growth factor alpha polypeptide -0.0145836
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0143582
DPYD dihydropyrimidine dehydrogenase -0.0143552
CAMK4 calcium/calmodulin-dependent protein kinase IV -0.0143262
BCAR3 breast cancer anti-estrogen resistance 3 -0.0142111
PCNX4 pecanex 4 -0.01403
LNPEP leucyl/cystinyl aminopeptidase -0.0140139
SOD2 superoxide dismutase 2, mitochondrial -0.0139717
ZC3H12C zinc finger CCCH-type containing 12C -0.0139385
TRAM2 translocation associated membrane protein 2 -0.0138169
FBXL2 F-box and leucine-rich repeat protein 2 -0.0136978
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0136308
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0135273
TARS3 threonyl-tRNA synthetase 3 -0.0134282
UBE2E1 ubiquitin-conjugating enzyme E2E 1 -0.0133849
NRG1 neuregulin 1 -0.0133447
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 -0.0132744
TSC22D1 TSC22 domain family, member 1 -0.0132404
FMNL2 formin-like 2 -0.0132113
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0132027
CDC42 cell division cycle 42 -0.0131901
ZNF407 zinc finger protein 407 -0.0131776
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0130363