Citalopram (hydrobromide)_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Citalopram (hydrobromide) perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Citalopram (hydrobromide)_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.128153
RACK1 receptor for activated C kinase 1 0.0939515
NAMPT nicotinamide phosphoribosyltransferase 0.0898196
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0864211
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0750928
MYH9 myosin, heavy chain 9, non-muscle 0.0726263
CANX calnexin 0.0719119
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.065812
AHR aryl hydrocarbon receptor 0.0648038
VCL vinculin 0.0599014
GLIS3 GLIS family zinc finger 3 0.058688
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0559766
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0557956
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0553065
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0550087
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0480756
MT2A metallothionein 2A 0.0464947
HMGA2 high mobility group AT-hook 2 0.0462077
HIPK2 homeodomain interacting protein kinase 2 0.0442453
EXT1 exostosin glycosyltransferase 1 0.0428276
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0423554
ZC3H11A zinc finger CCCH-type containing 11A 0.0401526
YBX1 Y box binding protein 1 0.0367798
PDLIM5 PDZ and LIM domain 5 0.0365289
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0357539
EEF2 eukaryotic translation elongation factor 2 0.0356094
NCKAP1 NCK-associated protein 1 0.0355817
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0349125
SOD2 superoxide dismutase 2, mitochondrial 0.0345412
ENAH enabled homolog (Drosophila) 0.0340566
KMT2C lysine (K)-specific methyltransferase 2C 0.0340041
PRRC2C proline-rich coiled-coil 2C 0.0338756
IL6ST interleukin 6 signal transducer 0.0334443
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.033317
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0329999
FNDC3B fibronectin type III domain containing 3B 0.0329329
HSPA8 heat shock 70kDa protein 8 0.0328067
STC2 stanniocalcin 2 0.0325834
TOP1 topoisomerase (DNA) I 0.0325562
HDLBP high density lipoprotein binding protein 0.0321003
TPM3 tropomyosin 3 0.0305129
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0301393
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0299087
PHF3 PHD finger protein 3 0.0296464
NEK7 NIMA-related kinase 7 0.0294043
APLP2 amyloid beta (A4) precursor-like protein 2 0.0290854
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0289046
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0288799
RPL26 ribosomal protein L26 0.0281765
UBAP2L ubiquitin associated protein 2-like 0.0278673
TXNIP thioredoxin interacting protein 0.0278091
YME1L1 YME1-like 1 ATPase 0.027671
RAB8B RAB8B, member RAS oncogene family 0.0275279
FN1 fibronectin 1 0.0275169
GOLT1B golgi transport 1B 0.0273318
OGA O-GlcNAcase 0.0270766
SERINC1 serine incorporator 1 0.0270505
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0269864
ERRFI1 ERBB receptor feedback inhibitor 1 0.0268568
SEPTIN9 septin 9 0.0265515
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.026477
WDR43 WD repeat domain 43 0.0264155
TFG TRK-fused gene 0.0262092
FLNA filamin A, alpha 0.026135
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0260587
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0255152
CALR calreticulin 0.0252928
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0250977
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0248965
B2M beta-2-microglobulin 0.0246541
BICD1 bicaudal D homolog 1 (Drosophila) 0.024647
KDM6A lysine (K)-specific demethylase 6A 0.0244849
SSBP2 single-stranded DNA binding protein 2 0.0244441
SPAG9 sperm associated antigen 9 0.0244161
CORO1C coronin, actin binding protein, 1C 0.0242015
TPI1 triosephosphate isomerase 1 0.0238624
MBD5 methyl-CpG binding domain protein 5 0.0236918
ANXA5 annexin A5 0.0236349
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0233453
AEBP2 AE binding protein 2 0.0231244
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0231122
RBM39 RNA binding motif protein 39 0.023028
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0229854
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 0.0229803
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 0.0229424
TPR translocated promoter region, nuclear basket protein 0.0228016
TMEM156 transmembrane protein 156 0.0228002
IDS iduronate 2-sulfatase 0.0227419
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0226588
RANBP2 RAN binding protein 2 0.0226255
RASAL2 RAS protein activator like 2 0.0226166
NUP58 nucleoporin 58 0.0225621
RBM33 RNA binding motif protein 33 0.0225099
RUNX2 runt-related transcription factor 2 0.0224451
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0223763
NPTN neuroplastin 0.0221332
HELZ helicase with zinc finger 0.0219219
RO60 Ro60, Y RNA binding protein 0.021801
TOR1AIP2 torsin A interacting protein 2 0.0216228
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0215659

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.248617
PTMA prothymosin, alpha -0.120873
VIM vimentin -0.0830405
HLA-B major histocompatibility complex, class I, B -0.071677
FTL ferritin, light polypeptide -0.0709411
SQSTM1 sequestosome 1 -0.0662158
TPT1 tumor protein, translationally-controlled 1 -0.0650783
IFI27 interferon, alpha-inducible protein 27 -0.0622442
TMSB10 thymosin beta 10 -0.0593627
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0580716
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0564555
ENO2 enolase 2 (gamma, neuronal) -0.0527089
PLIN2 perilipin 2 -0.0516832
RPL35A ribosomal protein L35a -0.0505808
MRPS6 mitochondrial ribosomal protein S6 -0.050574
S100A6 S100 calcium binding protein A6 -0.0451116
IER3 immediate early response 3 -0.044069
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0434605
ACTG1 actin gamma 1 -0.0428007
LOC102724023 ES1 protein homolog, mitochondrial -0.0424314
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0403926
ITGA1 integrin, alpha 1 -0.0397164
RPL31 ribosomal protein L31 -0.0385649
HILPDA hypoxia inducible lipid droplet-associated -0.0381315
RPS6 ribosomal protein S6 -0.0367454
RPS8 ribosomal protein S8 -0.0352106
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0346886
RPS29 ribosomal protein S29 -0.0337114
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0316821
RPL38 ribosomal protein L38 -0.0307853
SOX4 SRY (sex determining region Y)-box 4 -0.0307396
RPS23 ribosomal protein S23 -0.0306654
HLA-A major histocompatibility complex, class I, A -0.0300928
RPL9 ribosomal protein L9 -0.0296703
RPL37 ribosomal protein L37 -0.0290332
RPS16 ribosomal protein S16 -0.0287447
POTEF POTE ankyrin domain family, member F -0.0285205
RPS25 ribosomal protein S25 -0.0279014
RPS11 ribosomal protein S11 -0.0276111
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0268086
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0254362
RPS14 ribosomal protein S14 -0.0252605
TM4SF1 transmembrane 4 L six family member 1 -0.025171
IFI6 interferon, alpha-inducible protein 6 -0.0246766
CTSD cathepsin D -0.0245678
EIF1 eukaryotic translation initiation factor 1 -0.0245456
CADM1 cell adhesion molecule 1 -0.0230241
RPS24 ribosomal protein S24 -0.0229415
RPS27 ribosomal protein S27 -0.0227042
FLNB filamin B, beta -0.0223983
IGFBP3 insulin-like growth factor binding protein 3 -0.0223832
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0222105
KPNB1 karyopherin (importin) beta 1 -0.0220122
LMNA lamin A/C -0.0216765
S100A10 S100 calcium binding protein A10 -0.0216007
TMEM165 transmembrane protein 165 -0.0215256
ZMYND8 zinc finger, MYND-type containing 8 -0.0214582
NALF1 NALCN channel auxiliary factor 1 -0.0209449
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) -0.0208187
RPS27A ribosomal protein S27a -0.0207494
LY6E lymphocyte antigen 6 complex, locus E -0.0203686
RPL7A ribosomal protein L7a -0.0196677
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0195119
RAI14 retinoic acid induced 14 -0.0193704
RPL36A ribosomal protein L36a -0.0192772
HSPB1 heat shock 27kDa protein 1 -0.0191618
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0188687
CTBP2 C-terminal binding protein 2 -0.0187257
NDRG1 N-myc downstream regulated 1 -0.0186553
RPS13 ribosomal protein S13 -0.0184588
RPL37A ribosomal protein L37a -0.0182971
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0179054
RPS15 ribosomal protein S15 -0.0175438
RPLP2 ribosomal protein, large, P2 -0.017248
GCC2 GRIP and coiled-coil domain containing 2 -0.0171764
NBEAL1 neurobeachin-like 1 -0.0169469
TUBA1B tubulin, alpha 1b -0.016881
FOSL1 FOS-like antigen 1 -0.0165583
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0164283
TGFA transforming growth factor, alpha -0.0164007
RPS10 ribosomal protein S10 -0.0163886
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0163676
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0163413
RPL39 ribosomal protein L39 -0.0162457
IFITM1 interferon induced transmembrane protein 1 -0.0162261
CD44 CD44 molecule (Indian blood group) -0.0159542
S100A9 S100 calcium binding protein A9 -0.0159267
RPLP1 ribosomal protein, large, P1 -0.0157049
KRT81 keratin 81, type II -0.0157021
DDX18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 -0.0156533
ZNF395 zinc finger protein 395 -0.0153852
ITGB4 integrin, beta 4 -0.0152476
ATP5F1B ATP synthase F1 subunit beta -0.015074
RPL28 ribosomal protein L28 -0.0150048
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0149959
PIM3 Pim-3 proto-oncogene, serine/threonine kinase -0.014942
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 -0.014898
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0148511
RTN4 reticulon 4 -0.0147943
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0147893