Citalopram (hydrobromide)_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Citalopram (hydrobromide) perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Citalopram (hydrobromide)_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF2 eukaryotic translation elongation factor 2 0.090413
ANXA1 annexin A1 0.0825445
RACK1 receptor for activated C kinase 1 0.0782108
DSPP dentin sialophosphoprotein 0.0685166
FRAS1 Fraser extracellular matrix complex subunit 1 0.0659836
HDAC2 histone deacetylase 2 0.0655235
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0527979
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0496589
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor 0.0494922
LAMB3 laminin, beta 3 0.0491952
RPS3 ribosomal protein S3 0.0486516
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0460599
HSPA8 heat shock 70kDa protein 8 0.0454958
IGFBP3 insulin-like growth factor binding protein 3 0.043601
PDLIM5 PDZ and LIM domain 5 0.0434687
RPL3 ribosomal protein L3 0.043068
CD9 CD9 molecule 0.0429608
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0414176
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.040641
EMP1 epithelial membrane protein 1 0.0384485
FERMT1 fermitin family member 1 0.038073
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 0.0353781
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0337643
DOCK5 dedicator of cytokinesis 5 0.0333866
KLF3 Kruppel-like factor 3 (basic) 0.033237
RAD51B RAD51 paralog B 0.0318951
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.031749
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0312354
LAMA4 laminin, alpha 4 0.0311746
PHF14 PHD finger protein 14 0.0301
MPRIP myosin phosphatase Rho interacting protein 0.0294495
UBE3C ubiquitin protein ligase E3C 0.029161
CUX1 cut-like homeobox 1 0.0288005
LOC102724023 ES1 protein homolog, mitochondrial 0.0278545
RCOR1 REST corepressor 1 0.0275675
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0274217
LMO7 LIM domain 7 0.0269362
SERINC5 serine incorporator 5 0.0258206
JARID2 jumonji, AT rich interactive domain 2 0.0252231
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0251263
OSBPL10 oxysterol binding protein-like 10 0.0251204
RPL23 ribosomal protein L23 0.0249282
THOC2 THO complex 2 0.0239229
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0238294
ITGA6 integrin, alpha 6 0.0236967
AOPEP aminopeptidase O (putative) 0.0235406
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0235359
YBX1 Y box binding protein 1 0.0233219
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.023093
ITPKC inositol-trisphosphate 3-kinase C 0.0229127
ANXA2 annexin A2 0.0227296
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0224996
PRRC2C proline-rich coiled-coil 2C 0.0224644
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0221279
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like 0.0217328
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0216964
CSNK1A1 casein kinase 1, alpha 1 0.0215934
VCL vinculin 0.0215263
FMNL2 formin-like 2 0.0213098
KLC1 kinesin light chain 1 0.021204
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.021151
RPS12 ribosomal protein S12 0.0210752
BAMBI BMP and activin membrane-bound inhibitor 0.0206994
BPTF bromodomain PHD finger transcription factor 0.0206627
OXR1 oxidation resistance 1 0.0206598
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0206497
TMSB10 thymosin beta 10 0.0206431
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0205301
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0204932
EHBP1 EH domain binding protein 1 0.020374
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0202982
EZR ezrin 0.0196273
SRRM1 serine/arginine repetitive matrix 1 0.0193436
PTMA prothymosin, alpha 0.0190153
SET SET nuclear proto-oncogene 0.0185687
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0185589
MYO1B myosin IB 0.0184577
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0184143
CANX calnexin 0.0182557
DGLUCY D-glutamate cyclase 0.0180659
MTAP methylthioadenosine phosphorylase 0.0179744
ZBTB7C zinc finger and BTB domain containing 7C 0.0176734
RSL1D1 ribosomal L1 domain containing 1 0.0176378
FHIT fragile histidine triad 0.0175822
ANXA3 annexin A3 0.0175159
SKP1 S-phase kinase-associated protein 1 0.0172605
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0171378
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0170626
DDIT4 DNA-damage-inducible transcript 4 0.0170479
FRMD8 FERM domain containing 8 0.0169698
GNPDA1 glucosamine-6-phosphate deaminase 1 0.01682
EEF1G eukaryotic translation elongation factor 1 gamma 0.016605
RAD23B RAD23 homolog B (S. cerevisiae) 0.0165783
SCFD1 sec1 family domain containing 1 0.0164354
EPHA2 EPH receptor A2 0.0163424
MYH14 myosin, heavy chain 14, non-muscle 0.0162745
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.016271
PARD3 par-3 family cell polarity regulator 0.0159411
YME1L1 YME1-like 1 ATPase 0.0159342
RPS4X ribosomal protein S4, X-linked 0.0159235

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0970616
IER3 immediate early response 3 -0.0861773
PDE4B phosphodiesterase 4B, cAMP-specific -0.0706495
ATXN1 ataxin 1 -0.0531354
RNF43 ring finger protein 43 -0.0477888
TPT1 tumor protein, translationally-controlled 1 -0.0472103
RPS24 ribosomal protein S24 -0.0380133
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0325821
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.031406
BIRC3 baculoviral IAP repeat containing 3 -0.0302201
KITLG KIT ligand -0.0299806
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0280355
NT5DC3 5'-nucleotidase domain containing 3 -0.0275159
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0251066
TOP1 topoisomerase (DNA) I -0.0250958
NAMPT nicotinamide phosphoribosyltransferase -0.0247969
KDM3A lysine (K)-specific demethylase 3A -0.0245226
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0243912
FHL2 four and a half LIM domains 2 -0.0243016
CD44 CD44 molecule (Indian blood group) -0.0236286
SDC4 syndecan 4 -0.0232631
YAP1 Yes-associated protein 1 -0.0226722
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0223888
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) -0.0211099
KLF6 Kruppel-like factor 6 -0.0200302
PKM pyruvate kinase, muscle -0.0199698
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.019909
RPS21 ribosomal protein S21 -0.019902
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0195493
TXNRD1 thioredoxin reductase 1 -0.0195098
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0191855
SGPP2 sphingosine-1-phosphate phosphatase 2 -0.0190201
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0189028
MSI2 musashi RNA-binding protein 2 -0.0187971
RPL9 ribosomal protein L9 -0.0186664
AHNAK AHNAK nucleoprotein -0.0184896
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0184582
NAV2 neuron navigator 2 -0.0184251
DSCAM Down syndrome cell adhesion molecule -0.0184235
MIS18BP1 MIS18 binding protein 1 -0.0183849
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0180121
PFKP phosphofructokinase, platelet -0.017751
ZNF292 zinc finger protein 292 -0.0177219
CCSER1 coiled-coil serine-rich protein 1 -0.0176651
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0173964
RAD21 RAD21 homolog (S. pombe) -0.0169891
SBF2 SET binding factor 2 -0.0169021
SMC4 structural maintenance of chromosomes 4 -0.0162571
NAP1L1 nucleosome assembly protein 1-like 1 -0.0162154
TES testin LIM domain protein -0.0158196
RPS6 ribosomal protein S6 -0.0156609
DIAPH3 diaphanous-related formin 3 -0.0155637
SEPTIN7 septin 7 -0.0154613
SEC24D SEC24 family member D -0.0153584
ARHGAP5 Rho GTPase activating protein 5 -0.0151754
RPS28 ribosomal protein S28 -0.0151228
AREG amphiregulin -0.0151115
LGALS8 lectin, galactoside-binding, soluble, 8 -0.0150097
ARL5B ADP-ribosylation factor-like 5B -0.014809
BBX bobby sox homolog (Drosophila) -0.0147946
RTN4 reticulon 4 -0.0147655
KIAA0040 KIAA0040 -0.0146712
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0145985
GPAT3 glycerol-3-phosphate acyltransferase 3 -0.0145466
GNAT3 guanine nucleotide binding protein, alpha transducing 3 -0.0144385
CDCP1 CUB domain containing protein 1 -0.0143513
EREG epiregulin -0.0140677
TEC tec protein tyrosine kinase -0.0138872
RPL28 ribosomal protein L28 -0.0138308
ECT2 epithelial cell transforming 2 -0.0138055
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.0137759
ARL15 ADP-ribosylation factor-like 15 -0.013759
ANKRD10 ankyrin repeat domain 10 -0.0135077
CXADR coxsackie virus and adenovirus receptor -0.013396
SPAG9 sperm associated antigen 9 -0.0132981
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.013242
RPS29 ribosomal protein S29 -0.0132088
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0131121
GPHN gephyrin -0.0130674
ALCAM activated leukocyte cell adhesion molecule -0.0130597
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0129384
TNPO3 transportin 3 -0.0128952
RPL38 ribosomal protein L38 -0.0127085
USP6NL USP6 N-terminal like -0.0126224
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0126002
KNL1 kinetochore scaffold 1 -0.0125433
PRELID2 PRELI domain containing 2 -0.0124803
ATP11B ATPase, class VI, type 11B -0.0124089
BRWD3 bromodomain and WD repeat domain containing 3 -0.0123524
ARRDC3 arrestin domain containing 3 -0.012271
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0122701
SVIL supervillin -0.0120823
RAB10 RAB10, member RAS oncogene family -0.0120794
SGO2 shugoshin 2 -0.0120415
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0119693
SF1 splicing factor 1 -0.0119415
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0117915
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0117631
RSRC1 arginine/serine-rich coiled-coil 1 -0.0117552
VEZT vezatin, adherens junctions transmembrane protein -0.0117177