Citalopram (hydrobromide)_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Citalopram (hydrobromide) perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Citalopram (hydrobromide)_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NKD1 naked cuticle homolog 1 (Drosophila) 0.0794891
EZR ezrin 0.0556986
NAV2 neuron navigator 2 0.0548029
EEF2 eukaryotic translation elongation factor 2 0.0508178
CDH13 cadherin 13 0.0415964
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.040908
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0408115
MYH9 myosin, heavy chain 9, non-muscle 0.0405951
MACF1 microtubule-actin crosslinking factor 1 0.0400112
ITGA6 integrin, alpha 6 0.0393911
VCL vinculin 0.0374989
DST dystonin 0.0362773
DSPP dentin sialophosphoprotein 0.0357056
PLEC plectin 0.035325
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0352808
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.032515
AKAP12 A kinase (PRKA) anchor protein 12 0.0319351
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0305592
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0305269
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0291469
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0286148
HSPA8 heat shock 70kDa protein 8 0.0282933
MAML2 mastermind-like 2 (Drosophila) 0.0264323
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0263578
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0257612
ETNK1 ethanolamine kinase 1 0.0247448
ITPRID2 ITPR interacting domain containing 2 0.0243669
ASPH aspartate beta-hydroxylase 0.0242154
LMO7 LIM domain 7 0.023932
RPL3 ribosomal protein L3 0.0235014
VMP1 vacuole membrane protein 1 0.0228457
FLNA filamin A, alpha 0.0226162
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0218303
SPATA13 spermatogenesis associated 13 0.021728
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0215822
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0213286
ATXN1 ataxin 1 0.0207325
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0204089
KRT18 keratin 18, type I 0.0204011
TPM3 tropomyosin 3 0.0202479
INTS6 integrator complex subunit 6 0.0199835
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0196977
FLNB filamin B, beta 0.0194347
TNIK TRAF2 and NCK interacting kinase 0.0192783
RACK1 receptor for activated C kinase 1 0.0189936
HDAC4 histone deacetylase 4 0.0189714
ESYT2 extended synaptotagmin-like protein 2 0.0187857
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0184499
CANX calnexin 0.0183389
SFPQ splicing factor proline/glutamine-rich 0.0179474
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0178429
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0178359
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0178104
IGFBP3 insulin-like growth factor binding protein 3 0.0177567
USP9X ubiquitin specific peptidase 9, X-linked 0.017724
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0176907
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.017688
ANLN anillin, actin binding protein 0.017567
CSNK1A1 casein kinase 1, alpha 1 0.0174874
ERRFI1 ERBB receptor feedback inhibitor 1 0.0174778
CEMIP cell migration inducing protein, hyaluronan binding 0.0173386
PCBP2 poly(rC) binding protein 2 0.0172691
SEPTIN9 septin 9 0.0170568
BIRC6 baculoviral IAP repeat containing 6 0.0169122
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0168642
AHNAK AHNAK nucleoprotein 0.0167867
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0167679
ANO1 anoctamin 1, calcium activated chloride channel 0.0165997
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.01652
ACTN1 actinin, alpha 1 0.0165057
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0163103
FNDC3B fibronectin type III domain containing 3B 0.0162675
CDK6 cyclin-dependent kinase 6 0.0160706
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0160453
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0160382
MYOF myoferlin 0.0157295
MSI2 musashi RNA-binding protein 2 0.0156818
GMDS GDP-mannose 4,6-dehydratase 0.0153345
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0152437
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0151965
RBM26 RNA binding motif protein 26 0.0151933
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.015181
ECT2 epithelial cell transforming 2 0.0151804
PROX1 prospero homeobox 1 0.0151418
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0148686
AFDN afadin, adherens junction formation factor 0.0144933
LPP LIM domain containing preferred translocation partner in lipoma 0.0144772
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0144642
EIF4B eukaryotic translation initiation factor 4B 0.0144414
SDK1 sidekick cell adhesion molecule 1 0.0142623
MED13 mediator complex subunit 13 0.0141891
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.014173
ANXA3 annexin A3 0.0141448
KIZ kizuna centrosomal protein 0.0141273
CTBP2 C-terminal binding protein 2 0.0140979
FMNL2 formin-like 2 0.0139722
ARHGAP32 Rho GTPase activating protein 32 0.0139429
EXOC4 exocyst complex component 4 0.0138668
PDLIM5 PDZ and LIM domain 5 0.0137559
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.013701

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.226983
TMSB10 thymosin beta 10 -0.129726
RPS6 ribosomal protein S6 -0.124963
RPL35A ribosomal protein L35a -0.119701
TPT1 tumor protein, translationally-controlled 1 -0.109243
RPLP1 ribosomal protein, large, P1 -0.0955655
RPS19 ribosomal protein S19 -0.0815476
RPLP2 ribosomal protein, large, P2 -0.0806032
PTMA prothymosin, alpha -0.0783031
MT2A metallothionein 2A -0.0754865
RPS24 ribosomal protein S24 -0.0704305
RPS3 ribosomal protein S3 -0.0682489
RPL26 ribosomal protein L26 -0.0662772
RPS8 ribosomal protein S8 -0.0640833
RPL12 ribosomal protein L12 -0.0619784
RPS13 ribosomal protein S13 -0.0615792
RPL23 ribosomal protein L23 -0.0598631
RPL37A ribosomal protein L37a -0.0582991
RPL31 ribosomal protein L31 -0.0569643
RPS23 ribosomal protein S23 -0.0548747
RPL32 ribosomal protein L32 -0.0521914
RPL11 ribosomal protein L11 -0.0514177
RPS21 ribosomal protein S21 -0.0496501
RPL9 ribosomal protein L9 -0.0496046
RPL19 ribosomal protein L19 -0.0495678
RPS27A ribosomal protein S27a -0.0493157
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0489019
RPS12 ribosomal protein S12 -0.0486527
RPL36A ribosomal protein L36a -0.0469083
ACTG1 actin gamma 1 -0.0468919
VIM vimentin -0.0436053
RPL28 ribosomal protein L28 -0.0433191
RPS29 ribosomal protein S29 -0.0431956
RPL5 ribosomal protein L5 -0.0429358
RPLP0 ribosomal protein, large, P0 -0.042873
RPL36 ribosomal protein L36 -0.0426812
RPS25 ribosomal protein S25 -0.0423932
RPL34 ribosomal protein L34 -0.0410155
RPL37 ribosomal protein L37 -0.0404963
RPL38 ribosomal protein L38 -0.0401578
RPS16 ribosomal protein S16 -0.0399413
RPL7A ribosomal protein L7a -0.0398541
RPS11 ribosomal protein S11 -0.0375644
FTL ferritin, light polypeptide -0.0375162
RPS5 ribosomal protein S5 -0.0350686
RPS14 ribosomal protein S14 -0.0350586
RPL35 ribosomal protein L35 -0.0337286
RPS15 ribosomal protein S15 -0.0335198
EIF1 eukaryotic translation initiation factor 1 -0.0330824
RPL27A ribosomal protein L27a -0.0330433
RPL13A ribosomal protein L13a -0.0329643
RPL18 ribosomal protein L18 -0.0289342
RPS17 ribosomal protein S17 -0.0284239
H3-3B H3.3 histone B -0.0283618
RPS20 ribosomal protein S20 -0.0282779
RPL8 ribosomal protein L8 -0.0278472
S100A9 S100 calcium binding protein A9 -0.0254217
RPS10 ribosomal protein S10 -0.0254193
HMGB1 high mobility group box 1 -0.025286
RPL7 ribosomal protein L7 -0.0252262
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0252196
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0250049
RPS4X ribosomal protein S4, X-linked -0.0244472
RPS27 ribosomal protein S27 -0.0234962
EGR1 early growth response 1 -0.0234176
MYL12B myosin, light chain 12B, regulatory -0.0233823
NAP1L1 nucleosome assembly protein 1-like 1 -0.0232438
RPL30 ribosomal protein L30 -0.0230551
SOX4 SRY (sex determining region Y)-box 4 -0.0224627
HMGA1 high mobility group AT-hook 1 -0.0222793
RPL10A ribosomal protein L10a -0.0210447
RPL27 ribosomal protein L27 -0.0209933
IER3 immediate early response 3 -0.0208286
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0203501
EIF5B eukaryotic translation initiation factor 5B -0.0203352
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0200536
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0196934
S100A6 S100 calcium binding protein A6 -0.0193044
ATP5F1E ATP synthase F1 subunit epsilon -0.0191863
GNAS GNAS complex locus -0.018948
SEC61G Sec61 gamma subunit -0.0187849
MT1X metallothionein 1X -0.0187563
RPL39 ribosomal protein L39 -0.0185853
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0185842
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0179702
TUBA1B tubulin, alpha 1b -0.0179227
RPL15 ribosomal protein L15 -0.0177334
PFN1 profilin 1 -0.0176714
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0173577
SMC4 structural maintenance of chromosomes 4 -0.0173519
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0171829
S100A10 S100 calcium binding protein A10 -0.0171304
TXNIP thioredoxin interacting protein -0.0166941
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0165439
TUBB4B tubulin, beta 4B class IVb -0.0164759
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0164377
KPNB1 karyopherin (importin) beta 1 -0.0160993
NACA nascent polypeptide-associated complex alpha subunit -0.0158026
RPL36AL ribosomal protein L36a-like -0.0154305
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0154246