Clathrin-mediated endocytosis Gene Set

Dataset Reactome Pathways 2024
Category structural or functional annotations
Type pathway
Description An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles. (Gene Ontology, GO_0072583)
External Link https://reactome.org/PathwayBrowser/#/R-HSA-8856828
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Genes

145 proteins participating in the Clathrin-mediated endocytosis pathway from the Reactome Pathways 2024 dataset.

Symbol Name
AAK1 AP2 associated kinase 1
ACTB actin, beta
ACTG1 actin gamma 1
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ACTR3 ARP3 actin-related protein 3 homolog (yeast)
ADRB2 adrenoceptor beta 2, surface
AGFG1 ArfGAP with FG repeats 1
AGTR1 angiotensin II receptor, type 1
AMPH amphiphysin
AP2A1 adaptor-related protein complex 2, alpha 1 subunit
AP2A2 adaptor-related protein complex 2, alpha 2 subunit
AP2B1 adaptor-related protein complex 2, beta 1 subunit
AP2M1 adaptor-related protein complex 2, mu 1 subunit
AP2S1 adaptor-related protein complex 2, sigma 1 subunit
APOB apolipoprotein B
AREG amphiregulin
ARF6 ADP-ribosylation factor 6
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa
ARRB1 arrestin, beta 1
ARRB2 arrestin, beta 2
AVP arginine vasopressin
AVPR2 arginine vasopressin receptor 2
BIN1 bridging integrator 1
BTC betacellulin
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CD3D CD3d molecule, delta (CD3-TCR complex)
CD3G CD3g molecule, gamma (CD3-TCR complex)
CD4 CD4 molecule
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHRM2 cholinergic receptor, muscarinic 2
CLTA clathrin, light chain A
CLTB clathrin, light chain B
CLTC clathrin, heavy chain (Hc)
CLTCL1 clathrin, heavy chain-like 1
COPS2 COP9 signalosome subunit 2
COPS3 COP9 signalosome subunit 3
COPS4 COP9 signalosome subunit 4
COPS5 COP9 signalosome subunit 5
COPS6 COP9 signalosome subunit 6
COPS7A COP9 signalosome subunit 7A
COPS7B COP9 signalosome subunit 7B
COPS8 COP9 signalosome subunit 8
CTTN cortactin
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DNM1 dynamin 1
DNM2 dynamin 2
DNM3 dynamin 3
DVL2 dishevelled segment polarity protein 2
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EPGN epithelial mitogen
EPN1 epsin 1
EPN2 epsin 2
EPS15 epidermal growth factor receptor pathway substrate 15
EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1
EREG epiregulin
FCHO1 FCH domain only 1
FCHO2 FCH domain only 2
FNBP1 formin binding protein 1
FNBP1L formin binding protein 1-like
FZD4 frizzled class receptor 4
GAK cyclin G associated kinase
GAPVD1 GTPase activating protein and VPS9 domains 1
GPS1 G protein pathway suppressor 1
GRB2 growth factor receptor-bound protein 2
GRK2 G protein-coupled receptor kinase 2
GRK3 G protein-coupled receptor kinase 3
HBEGF heparin-binding EGF-like growth factor
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
HIP1 huntingtin interacting protein 1
HIP1R huntingtin interacting protein 1 related
HSPA8 heat shock 70kDa protein 8
IGF2R insulin-like growth factor 2 receptor
IL7R interleukin 7 receptor
ITSN1 intersectin 1 (SH3 domain protein)
ITSN2 intersectin 2
KIAA0319 KIAA0319
LDLR low density lipoprotein receptor
LDLRAP1 low density lipoprotein receptor adaptor protein 1
LRP2 low density lipoprotein receptor-related protein 2
M6PR mannose-6-phosphate receptor (cation dependent)
NECAP1 NECAP endocytosis associated 1
NECAP2 NECAP endocytosis associated 2
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
OCRL oculocerebrorenal syndrome of Lowe
PACSIN1 protein kinase C and casein kinase substrate in neurons 1
PACSIN2 protein kinase C and casein kinase substrate in neurons 2
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PICALM phosphatidylinositol binding clathrin assembly protein
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
RAB5A RAB5A, member RAS oncogene family
RAB5B RAB5B, member RAS oncogene family
RAB5C RAB5C, member RAS oncogene family
REPS1 RALBP1 associated Eps domain containing 1
REPS2 RALBP1 associated Eps domain containing 2
RPS27A ribosomal protein S27a
SCARB2 scavenger receptor class B, member 2
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1
SH3GL1 SH3-domain GRB2-like 1
SH3GL2 SH3-domain GRB2-like 2
SH3GL3 SH3-domain GRB2-like 3
SH3KBP1 SH3-domain kinase binding protein 1
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SNAP91 synaptosomal-associated protein, 91kDa
SNX18 sorting nexin 18
SNX9 sorting nexin 9
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
STON1 stonin 1
STON2 stonin 2
SYNJ1 synaptojanin 1
SYNJ2 synaptojanin 2
SYT1 synaptotagmin I
SYT11 synaptotagmin XI
SYT2 synaptotagmin II
SYT8 synaptotagmin VIII
SYT9 synaptotagmin IX
TACR1 tachykinin receptor 1
TF transferrin
TFRC transferrin receptor
TGFA transforming growth factor, alpha
TGOLN2 trans-golgi network protein 2
TOR1A torsin family 1, member A (torsin A)
TOR1B torsin family 1, member B (torsin B)
TRIP10 thyroid hormone receptor interactor 10
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBB ubiquitin B
UBC ubiquitin C
UBQLN1 ubiquilin 1
UBQLN2 ubiquilin 2
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
VAMP3 vesicle-associated membrane protein 3
VAMP4 vesicle-associated membrane protein 4
VAMP7 vesicle-associated membrane protein 7
VAMP8 vesicle-associated membrane protein 8
WASL Wiskott-Aldrich syndrome-like
WNT5A wingless-type MMTV integration site family, member 5A