Clobetasol propionate_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clobetasol propionate perturbation in A498 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clobetasol propionate_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FKBP5 FK506 binding protein 5 0.172978
HIPK2 homeodomain interacting protein kinase 2 0.131422
PTPRJ protein tyrosine phosphatase, receptor type, J 0.120798
HOMER2 homer scaffolding protein 2 0.113995
BIRC3 baculoviral IAP repeat containing 3 0.0955306
MT2A metallothionein 2A 0.0838753
IL6ST interleukin 6 signal transducer 0.080184
AHNAK AHNAK nucleoprotein 0.0742015
ZFAND5 zinc finger, AN1-type domain 5 0.0698183
MT1X metallothionein 1X 0.0677361
TSC22D3 TSC22 domain family, member 3 0.0627293
LAMB1 laminin, beta 1 0.0585406
PLIN2 perilipin 2 0.0556932
NFIA nuclear factor I/A 0.0539341
HPCAL1 hippocalcin-like 1 0.0520769
SSBP2 single-stranded DNA binding protein 2 0.0492605
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 0.0482694
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0482106
AKAP13 A kinase (PRKA) anchor protein 13 0.0481812
TOP1 topoisomerase (DNA) I 0.0440585
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0440178
EPS8 epidermal growth factor receptor pathway substrate 8 0.0432164
FMNL2 formin-like 2 0.0429694
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0408446
SOD2 superoxide dismutase 2, mitochondrial 0.0393494
SDK1 sidekick cell adhesion molecule 1 0.0388419
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0381925
SSH2 slingshot protein phosphatase 2 0.0381618
SPDYA speedy/RINGO cell cycle regulator family member A 0.0381132
ANXA2 annexin A2 0.0379199
MBNL1 muscleblind-like splicing regulator 1 0.036344
LDLRAD3 low density lipoprotein receptor class A domain containing 3 0.0355581
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.0348121
JAK1 Janus kinase 1 0.0347025
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0337318
GPC6 glypican 6 0.0337103
CLMP CXADR-like membrane protein 0.0335943
LPP LIM domain containing preferred translocation partner in lipoma 0.0333969
NFE2L1 nuclear factor, erythroid 2-like 1 0.0331693
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0329985
HIP1 huntingtin interacting protein 1 0.0323176
ESYT2 extended synaptotagmin-like protein 2 0.0312541
NRCAM neuronal cell adhesion molecule 0.0301045
ANKRD11 ankyrin repeat domain 11 0.0300985
TMEM178B transmembrane protein 178B 0.0298703
ENAH enabled homolog (Drosophila) 0.0298516
STOM stomatin 0.0297133
SAA2-SAA4 SAA2-SAA4 readthrough 0.029192
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0291364
ACSL1 acyl-CoA synthetase long-chain family member 1 0.028893
FOXO1 forkhead box O1 0.0285467
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L 0.0276085
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0269775
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0265701
PTPRG protein tyrosine phosphatase, receptor type, G 0.0264399
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0261416
RPL7 ribosomal protein L7 0.0261263
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0259853
PCBP3 poly(rC) binding protein 3 0.0255858
ERRFI1 ERBB receptor feedback inhibitor 1 0.0253124
SAA2 serum amyloid A2 0.0252778
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0249952
STK39 serine threonine kinase 39 0.0249382
BCL6 B-cell CLL/lymphoma 6 0.0245173
S100A6 S100 calcium binding protein A6 0.0242361
MGST1 microsomal glutathione S-transferase 1 0.0240326
KLF9 Kruppel-like factor 9 0.0236769
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0236581
FOXO3 forkhead box O3 0.0236441
TLN1 talin 1 0.023203
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0231345
GRB10 growth factor receptor-bound protein 10 0.0231291
ELL2 elongation factor, RNA polymerase II, 2 0.0226559
PYGB phosphorylase, glycogen; brain 0.0220716
SMIM44 small integral membrane protein 44 0.0220384
CEP70 centrosomal protein 70kDa 0.0218681
WDR43 WD repeat domain 43 0.0217937
TES testin LIM domain protein 0.0215229
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0211119
FSTL3 follistatin-like 3 (secreted glycoprotein) 0.0208983
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0208941
MYO10 myosin X 0.0208333
LDHA lactate dehydrogenase A 0.0204485
IRS2 insulin receptor substrate 2 0.0203676
GSR glutathione reductase 0.0201852
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2 0.0200315
ABHD2 abhydrolase domain containing 2 0.0199855
KCTD3 potassium channel tetramerization domain containing 3 0.0196363
PER1 period circadian clock 1 0.0194574
ADAM9 ADAM metallopeptidase domain 9 0.0193863
USP53 ubiquitin specific peptidase 53 0.0193272
ZMYND8 zinc finger, MYND-type containing 8 0.0192558
GOLGB1 golgin B1 0.0191036
APLP2 amyloid beta (A4) precursor-like protein 2 0.0188338
UTRN utrophin 0.0187268
PTK2 protein tyrosine kinase 2 0.0186472
EIF3E eukaryotic translation initiation factor 3, subunit E 0.0184537
ABLIM3 actin binding LIM protein family, member 3 0.0181993
CLMB calcimembrin 0.01809
ATXN2 ataxin 2 0.0180611

decreased expression

Symbol Name Standardized Value
ASPH aspartate beta-hydroxylase -0.344353
CD44 CD44 molecule (Indian blood group) -0.195534
CXCL8 chemokine (C-X-C motif) ligand 8 -0.175546
FRMD4A FERM domain containing 4A -0.155048
EXT1 exostosin glycosyltransferase 1 -0.13126
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.124653
NRP2 neuropilin 2 -0.0956846
FAT1 FAT atypical cadherin 1 -0.0935372
SMAD3 SMAD family member 3 -0.0919523
GLIS3 GLIS family zinc finger 3 -0.0911966
RAI14 retinoic acid induced 14 -0.0887395
LOXL2 lysyl oxidase-like 2 -0.0855834
TRIO trio Rho guanine nucleotide exchange factor -0.079727
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.076348
FTL ferritin, light polypeptide -0.0715294
ETV6 ets variant 6 -0.069581
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.066621
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0658081
CA12 carbonic anhydrase XII -0.0640335
CCL2 chemokine (C-C motif) ligand 2 -0.0628331
KYNU kynureninase -0.0626522
CADM1 cell adhesion molecule 1 -0.059826
STK17A serine/threonine kinase 17a -0.0591131
VCAM1 vascular cell adhesion molecule 1 -0.0589256
TSHZ2 teashirt zinc finger homeobox 2 -0.0581294
IGFBP3 insulin-like growth factor binding protein 3 -0.0574341
TGFB2 transforming growth factor, beta 2 -0.0533173
PTBP3 polypyrimidine tract binding protein 3 -0.0511604
NDRG1 N-myc downstream regulated 1 -0.0504896
CSF1 colony stimulating factor 1 (macrophage) -0.0490858
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0490805
PDE4D phosphodiesterase 4D, cAMP-specific -0.0477512
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -0.0465813
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0464526
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0461834
TUSC3 tumor suppressor candidate 3 -0.0458105
CREB5 cAMP responsive element binding protein 5 -0.0447651
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0436789
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 -0.0433103
BICD1 bicaudal D homolog 1 (Drosophila) -0.0432253
BHLHE40 basic helix-loop-helix family, member e40 -0.0430814
OSBPL3 oxysterol binding protein-like 3 -0.0427604
PLK2 polo-like kinase 2 -0.0427023
ADAM10 ADAM metallopeptidase domain 10 -0.0424652
G0S2 G0/G1 switch 2 -0.0414711
TGFA transforming growth factor, alpha -0.0412611
FAM107B family with sequence similarity 107, member B -0.0411293
SLC35F3 solute carrier family 35, member F3 -0.0400051
ICAM1 intercellular adhesion molecule 1 -0.0400022
FNDC3B fibronectin type III domain containing 3B -0.0399123
RRBP1 ribosome binding protein 1 -0.0381696
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0379885
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.037972
RUNX1 runt-related transcription factor 1 -0.0376886
RIPK2 receptor-interacting serine-threonine kinase 2 -0.0375727
MAP1B microtubule-associated protein 1B -0.0366064
GLS2 glutaminase 2 (liver, mitochondrial) -0.0364804
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0362374
TGFBI transforming growth factor, beta-induced, 68kDa -0.0356694
EHBP1 EH domain binding protein 1 -0.035506
CDCP1 CUB domain containing protein 1 -0.0353265
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0350006
GNA12 guanine nucleotide binding protein (G protein) alpha 12 -0.0349516
NRIP1 nuclear receptor interacting protein 1 -0.0345631
TNS3 tensin 3 -0.0342839
ALCAM activated leukocyte cell adhesion molecule -0.0339431
MSR1 macrophage scavenger receptor 1 -0.0337312
NCEH1 neutral cholesterol ester hydrolase 1 -0.033613
EML4 echinoderm microtubule associated protein like 4 -0.0333854
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0332263
ATP13A3 ATPase type 13A3 -0.032329
ADAM12 ADAM metallopeptidase domain 12 -0.0322728
GNAS GNAS complex locus -0.031947
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0317065
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0313532
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0310524
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0309786
CMIP c-Maf inducing protein -0.0304445
FRMD5 FERM domain containing 5 -0.0303683
CXCL2 chemokine (C-X-C motif) ligand 2 -0.030273
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0302481
APOL1 apolipoprotein L, 1 -0.0302419
LITAF lipopolysaccharide-induced TNF factor -0.0299084
GDF15 growth differentiation factor 15 -0.0293439
HLA-B major histocompatibility complex, class I, B -0.0290338
RIC8B RIC8 guanine nucleotide exchange factor B -0.0289062
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0287262
LHFPL2 lipoma HMGIC fusion partner-like 2 -0.0279224
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0279025
NPC1 Niemann-Pick disease, type C1 -0.0273561
ARHGAP26 Rho GTPase activating protein 26 -0.0272656
UBA6 ubiquitin-like modifier activating enzyme 6 -0.026805
KIRREL3 kin of IRRE like 3 (Drosophila) -0.0265334
PTMA prothymosin, alpha -0.0263256
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.026295
TSPAN13 tetraspanin 13 -0.0260876
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0258337
DOCK5 dedicator of cytokinesis 5 -0.0257053
SH3RF1 SH3 domain containing ring finger 1 -0.0254903
VCL vinculin -0.0254723