Clobetasol propionate_BT-474 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clobetasol propionate perturbation in BT-474 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clobetasol propionate_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CEP250 centrosomal protein 250kDa 0.0806125
RPL23 ribosomal protein L23 0.0764584
INTS6 integrator complex subunit 6 0.0621218
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0557078
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0440159
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.043938
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0419985
MCL1 myeloid cell leukemia 1 0.0407766
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0399496
RPL19 ribosomal protein L19 0.039884
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0394832
ATAD2 ATPase family, AAA domain containing 2 0.0389687
ITCH itchy E3 ubiquitin protein ligase 0.0375686
PTK2 protein tyrosine kinase 2 0.0373643
KRT86 keratin 86, type II 0.0371787
NEBL nebulette 0.0366702
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0348107
CATSPERB catsper channel auxiliary subunit beta 0.0336796
SRCIN1 SRC kinase signaling inhibitor 1 0.0336498
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0335348
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0330584
EHMT1 euchromatic histone-lysine N-methyltransferase 1 0.0322238
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0317232
GRB10 growth factor receptor-bound protein 10 0.0314695
VCL vinculin 0.0306412
PNN pinin, desmosome associated protein 0.0306406
CSNK1A1 casein kinase 1, alpha 1 0.0303735
MMP24OS MMP24 opposite strand 0.0285271
PCBP2 poly(rC) binding protein 2 0.0279804
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0279182
S100P S100 calcium binding protein P 0.0271748
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0271745
DSPP dentin sialophosphoprotein 0.0265406
SMC4 structural maintenance of chromosomes 4 0.02611
DTNA dystrobrevin, alpha 0.0260617
MT2A metallothionein 2A 0.025011
LIMCH1 LIM and calponin homology domains 1 0.0248757
VEGFA vascular endothelial growth factor A 0.0242645
ZSWIM6 zinc finger, SWIM-type containing 6 0.0242399
NCAPG2 non-SMC condensin II complex, subunit G2 0.0242097
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0237399
PRRC2C proline-rich coiled-coil 2C 0.0236837
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 0.0235414
SHROOM3 shroom family member 3 0.0234172
RUNX1 runt-related transcription factor 1 0.0230436
ANKRD11 ankyrin repeat domain 11 0.0229461
EXOC4 exocyst complex component 4 0.0228526
RAD51B RAD51 paralog B 0.0226452
SETD5 SET domain containing 5 0.022593
STXBP4 syntaxin binding protein 4 0.0223863
PLSCR2 phospholipid scramblase 2 0.0223565
MYH9 myosin, heavy chain 9, non-muscle 0.022267
ZMYND8 zinc finger, MYND-type containing 8 0.0222655
ESYT2 extended synaptotagmin-like protein 2 0.0220596
RPS3 ribosomal protein S3 0.0220567
FLNB filamin B, beta 0.0220465
AHNAK AHNAK nucleoprotein 0.0218479
TPD52 tumor protein D52 0.0215944
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0214928
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0214516
CCNY cyclin Y 0.0214386
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0212649
PDLIM5 PDZ and LIM domain 5 0.020991
MED13 mediator complex subunit 13 0.0206761
ANKRD17 ankyrin repeat domain 17 0.0206725
RCOR1 REST corepressor 1 0.0206056
ZNF207 zinc finger protein 207 0.0200948
GMDS GDP-mannose 4,6-dehydratase 0.0200746
DIAPH1 diaphanous-related formin 1 0.0200085
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0199955
ADIPOR2 adiponectin receptor 2 0.019985
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.0199662
RPL37A ribosomal protein L37a 0.0198573
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0198176
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0196119
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0195525
AKAP13 A kinase (PRKA) anchor protein 13 0.019551
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0194453
RFC3 replication factor C (activator 1) 3, 38kDa 0.019376
DENND1A DENN/MADD domain containing 1A 0.0193742
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0193381
APLP2 amyloid beta (A4) precursor-like protein 2 0.0193275
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0192204
HELZ helicase with zinc finger 0.0192179
KMT2C lysine (K)-specific methyltransferase 2C 0.0191503
ZNF292 zinc finger protein 292 0.0191477
AHCTF1 AT hook containing transcription factor 1 0.0190532
FAM168A family with sequence similarity 168, member A 0.0190422
EFNA5 ephrin-A5 0.0188249
IGF1R insulin-like growth factor 1 receptor 0.018797
RPL7 ribosomal protein L7 0.0184737
ANLN anillin, actin binding protein 0.0182905
COPA coatomer protein complex, subunit alpha 0.0181019
AEBP2 AE binding protein 2 0.0180836
KDM2A lysine (K)-specific demethylase 2A 0.0177473
SKA2 spindle and kinetochore associated complex subunit 2 0.01766
TRA2B transformer 2 beta homolog (Drosophila) 0.0176585
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0176548
FAF1 Fas (TNFRSF6) associated factor 1 0.0176374
SEC31A SEC31 homolog A (S. cerevisiae) 0.0174938

decreased expression

Symbol Name Standardized Value
ERBB2 erb-b2 receptor tyrosine kinase 2 -0.11969
ANKRD36C ankyrin repeat domain 36C -0.0857744
CEMIP cell migration inducing protein, hyaluronan binding -0.0807101
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0774623
FTH1 ferritin, heavy polypeptide 1 -0.0644423
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0588225
SLC38A1 solute carrier family 38, member 1 -0.0585952
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0585281
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0563394
NCOA7 nuclear receptor coactivator 7 -0.0562565
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 -0.0559958
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0537792
YPEL2 yippee-like 2 (Drosophila) -0.0519951
OSMR oncostatin M receptor -0.051244
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0500342
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 -0.0482444
CDH15 cadherin 15, type 1, M-cadherin (myotubule) -0.0472304
EXT1 exostosin glycosyltransferase 1 -0.0467224
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0447921
ASPH aspartate beta-hydroxylase -0.0438074
LASP1 LIM and SH3 protein 1 -0.0437376
IGFBP5 insulin-like growth factor binding protein 5 -0.0432165
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0423353
TPT1 tumor protein, translationally-controlled 1 -0.0411896
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0410237
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0391914
PTMA prothymosin, alpha -0.0383253
TMSB4X thymosin beta 4, X-linked -0.038265
NT5C2 5'-nucleotidase, cytosolic II -0.0375312
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 -0.0372761
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0364347
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0362085
TMEM45B transmembrane protein 45B -0.0361884
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0353804
NTN4 netrin 4 -0.0352942
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0351334
NRIP1 nuclear receptor interacting protein 1 -0.0345637
TC2N tandem C2 domains, nuclear -0.034487
GRB7 growth factor receptor-bound protein 7 -0.0342445
SDC4 syndecan 4 -0.0335906
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0334244
BZW1 basic leucine zipper and W2 domains 1 -0.0332546
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0326411
S100A8 S100 calcium binding protein A8 -0.0326374
UGCG UDP-glucose ceramide glucosyltransferase -0.0317279
SMAD3 SMAD family member 3 -0.0314607
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0314021
CCNI cyclin I -0.0308809
SYTL2 synaptotagmin-like 2 -0.0303851
ZNF217 zinc finger protein 217 -0.0300071
AREG amphiregulin -0.0297531
THSD4 thrombospondin, type I, domain containing 4 -0.0285763
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0283774
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0282728
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -0.0282457
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0277821
MLLT6 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 -0.0271773
ARID5B AT rich interactive domain 5B (MRF1-like) -0.0271008
RAB22A RAB22A, member RAS oncogene family -0.0270829
S100A9 S100 calcium binding protein A9 -0.0267558
ACTG1 actin gamma 1 -0.0262875
DUSP4 dual specificity phosphatase 4 -0.0258557
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0257371
RAB27B RAB27B, member RAS oncogene family -0.0249544
HLA-B major histocompatibility complex, class I, B -0.0248738
KIAA1217 KIAA1217 -0.0245802
GDPD1 glycerophosphodiester phosphodiesterase domain containing 1 -0.0243823
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0242427
TMEM165 transmembrane protein 165 -0.0240802
B2M beta-2-microglobulin -0.0239524
NAMPT nicotinamide phosphoribosyltransferase -0.0238744
LOC112694756 uncharaterized LOC112694756 -0.0237497
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0233391
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0232699
TMC5 transmembrane channel-like 5 -0.0231891
INSR insulin receptor -0.023074
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0229386
HLA-C major histocompatibility complex, class I, C -0.022839
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0227771
CFB complement factor B -0.0227411
SOD2 superoxide dismutase 2, mitochondrial -0.0225906
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0224774
IER3 immediate early response 3 -0.0221807
CAB39 calcium binding protein 39 -0.0221703
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0220858
GATA3 GATA binding protein 3 -0.0217497
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0216698
DUSP16 dual specificity phosphatase 16 -0.0215839
KLF6 Kruppel-like factor 6 -0.0214783
TMEM123 transmembrane protein 123 -0.021399
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0209536
TSC22D2 TSC22 domain family, member 2 -0.0209318
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0207706
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0206837
RESF1 retroelement silencing factor 1 -0.0204563
TNIK TRAF2 and NCK interacting kinase -0.0203125
CD164 CD164 molecule, sialomucin -0.0203014
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0201771
USP53 ubiquitin specific peptidase 53 -0.0201341
ICAM1 intercellular adhesion molecule 1 -0.0201257