Clobetasol propionate_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clobetasol propionate perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clobetasol propionate_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CADM2 cell adhesion molecule 2 0.056147
SLIT2 slit homolog 2 (Drosophila) 0.0330659
TOX thymocyte selection-associated high mobility group box 0.0296501
PCDH11X protocadherin 11 X-linked 0.0258574
GRID2 glutamate receptor, ionotropic, delta 2 0.0247912
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0219726
SHROOM3 shroom family member 3 0.0213597
CDH18 cadherin 18, type 2 0.0207622
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0173403
EFNA5 ephrin-A5 0.0164604
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0164265
PGAP1 post-GPI attachment to proteins 1 0.0156223
RNF145 ring finger protein 145 0.0148725
SPRED2 sprouty-related, EVH1 domain containing 2 0.0143418
CSNK1G3 casein kinase 1, gamma 3 0.0139343
NUP58 nucleoporin 58 0.0138534
RNF130 ring finger protein 130 0.0135775
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D 0.0133387
RUNX1 runt-related transcription factor 1 0.0132832
TENM2 teneurin transmembrane protein 2 0.0126234
OSMR oncostatin M receptor 0.0125382
DNMBP dynamin binding protein 0.0125037
USP3 ubiquitin specific peptidase 3 0.0124472
HHIP hedgehog interacting protein 0.0123609
CHRM3 cholinergic receptor, muscarinic 3 0.0121144
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 0.0120323
ADGRG6 adhesion G protein-coupled receptor G6 0.0119393
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.0116016
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0115936
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.011585
NCEH1 neutral cholesterol ester hydrolase 1 0.0114959
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.0114677
PALS2 protein associated with LIN7 2, MAGUK p55 family member 0.0112913
TUSC3 tumor suppressor candidate 3 0.0110671
SLF1 SMC5-SMC6 complex localization factor 1 0.0110624
HELB helicase (DNA) B 0.0109779
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0109413
RAB6A RAB6A, member RAS oncogene family 0.010932
EGR1 early growth response 1 0.010496
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0101764
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0101127
NAMPT nicotinamide phosphoribosyltransferase 0.0100761
CCNL1 cyclin L1 0.0100527
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0100092
ATN1 atrophin 1 0.00997929
NAV2 neuron navigator 2 0.00997642
IQCB1 IQ motif containing B1 0.00991295
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae) 0.00986089
MBTPS2 membrane-bound transcription factor peptidase, site 2 0.00983888
TJP1 tight junction protein 1 0.00968533
ECT2 epithelial cell transforming 2 0.00965151
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 0.00964207
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.00963039
NEGR1 neuronal growth regulator 1 0.00957084
ZNF141 zinc finger protein 141 0.0095529
ELAPOR2 endosome-lysosome associated apoptosis and autophagy regulator family member 2 0.00953446
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 0.00951788
KCNH7 potassium channel, voltage gated eag related subfamily H, member 7 0.00948952
TMEM117 transmembrane protein 117 0.00941622
WRN Werner syndrome, RecQ helicase-like 0.0094129
SLC30A7 solute carrier family 30 (zinc transporter), member 7 0.00936479
DCUN1D3 DCN1, defective in cullin neddylation 1, domain containing 3 0.00926768
SLC44A1 solute carrier family 44 (choline transporter), member 1 0.00926277
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 0.00924325
CCDC7 coiled-coil domain containing 7 0.00920831
AK1 adenylate kinase 1 0.00918391
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 0.00917879
HIBADH 3-hydroxyisobutyrate dehydrogenase 0.00915674
NUP54 nucleoporin 54kDa 0.00915382
PDLIM5 PDZ and LIM domain 5 0.00911929
DPY19L3 dpy-19-like 3 (C. elegans) 0.00911366
VRK2 vaccinia related kinase 2 0.00907038
SMYD2 SET and MYND domain containing 2 0.00906896
DCTN4 dynactin 4 (p62) 0.00904723
UTRN utrophin 0.00899751
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta 0.00897677
MAT2A methionine adenosyltransferase II, alpha 0.00895097
ERCC8 excision repair cross-complementation group 8 0.00889384
SLC36A4 solute carrier family 36 (proton/amino acid symporter), member 4 0.00883497
CUL2 cullin 2 0.00879356
MTSS1 metastasis suppressor 1 0.00878502
TSC22D2 TSC22 domain family, member 2 0.00872506
ZFAND6 zinc finger, AN1-type domain 6 0.00864811
F3 coagulation factor III (thromboplastin, tissue factor) 0.00862716
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like 0.0085818
PLSCR1 phospholipid scramblase 1 0.00856978
DDX18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 0.0085553
VEGFC vascular endothelial growth factor C 0.00855422
ZNF10 zinc finger protein 10 0.00853849
ACO2 aconitase 2, mitochondrial 0.00852791
GCLM glutamate-cysteine ligase, modifier subunit 0.00844075
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.00843833
CTTNBP2NL CTTNBP2 N-terminal like 0.00843361
LRRC8B leucine rich repeat containing 8 family, member B 0.00842762
CLASP2 cytoplasmic linker associated protein 2 0.00837584
SYN2 synapsin II 0.00832626
NDRG1 N-myc downstream regulated 1 0.00831879
PGAM4 phosphoglycerate mutase family member 4 0.00831651
SCN9A sodium channel, voltage gated, type IX alpha subunit 0.00827648
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1 0.00823679

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.169383
UBC ubiquitin C -0.135602
NEBL nebulette -0.127761
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.122449
ENO1 enolase 1, (alpha) -0.106464
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0979094
EEF2 eukaryotic translation elongation factor 2 -0.0909578
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0887065
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0873767
ZNF608 zinc finger protein 608 -0.0850527
PTMA prothymosin, alpha -0.0838671
TENM3 teneurin transmembrane protein 3 -0.0834498
RPS27A ribosomal protein S27a -0.0762246
TMSB10 thymosin beta 10 -0.0695743
ACTG1 actin gamma 1 -0.0679301
LDHA lactate dehydrogenase A -0.0657228
RPS8 ribosomal protein S8 -0.0648058
RERE arginine-glutamic acid dipeptide (RE) repeats -0.064102
SOX4 SRY (sex determining region Y)-box 4 -0.0634796
RPL23 ribosomal protein L23 -0.0629033
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0618509
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0606709
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0604061
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0600172
DSCAM Down syndrome cell adhesion molecule -0.0559766
SRRM2 serine/arginine repetitive matrix 2 -0.0550856
ATP11A ATPase, class VI, type 11A -0.0549949
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0545558
JUN jun proto-oncogene -0.0527698
DENND1A DENN/MADD domain containing 1A -0.0511165
RPL37A ribosomal protein L37a -0.0507284
GNAS GNAS complex locus -0.0506403
ARHGAP32 Rho GTPase activating protein 32 -0.0493903
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0491444
RPL11 ribosomal protein L11 -0.0491294
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0490834
RPL26 ribosomal protein L26 -0.0490407
WSB1 WD repeat and SOCS box containing 1 -0.0482379
VMP1 vacuole membrane protein 1 -0.0478625
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0462495
RPS21 ribosomal protein S21 -0.0461712
NAP1L1 nucleosome assembly protein 1-like 1 -0.0460154
SET SET nuclear proto-oncogene -0.0456628
GJA1 gap junction protein, alpha 1, 43kDa -0.0454599
RPS6 ribosomal protein S6 -0.0446361
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0437389
CENPF centromere protein F, 350/400kDa -0.0431931
RPS12 ribosomal protein S12 -0.0430328
RAD51B RAD51 paralog B -0.0429305
RPS3 ribosomal protein S3 -0.0422947
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0417882
SPDYA speedy/RINGO cell cycle regulator family member A -0.0416321
NFIA nuclear factor I/A -0.0415343
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0413021
RIGI RNA sensor RIG-I -0.0411877
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0411726
BPTF bromodomain PHD finger transcription factor -0.0409719
LOC112694756 uncharaterized LOC112694756 -0.0406852
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0406631
RBM25 RNA binding motif protein 25 -0.040114
B2M beta-2-microglobulin -0.040012
FUS FUS RNA binding protein -0.0397251
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0392343
PCBP2 poly(rC) binding protein 2 -0.0391962
RCC1 regulator of chromosome condensation 1 -0.0391437
SMYD3 SET and MYND domain containing 3 -0.0384752
RPS5 ribosomal protein S5 -0.0384705
PDE4D phosphodiesterase 4D, cAMP-specific -0.0383817
FMNL2 formin-like 2 -0.0380637
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0374406
RPL5 ribosomal protein L5 -0.0373611
RPL31 ribosomal protein L31 -0.0372369
KTN1 kinectin 1 (kinesin receptor) -0.0370884
PRICKLE1 prickle homolog 1 (Drosophila) -0.0370243
SERBP1 SERPINE1 mRNA binding protein 1 -0.0366209
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0365251
RPS4X ribosomal protein S4, X-linked -0.0362824
ZNF638 zinc finger protein 638 -0.0358174
USP34 ubiquitin specific peptidase 34 -0.0355398
SFPQ splicing factor proline/glutamine-rich -0.035355
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0352027
RPS24 ribosomal protein S24 -0.0350971
MKI67 marker of proliferation Ki-67 -0.034834
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.034783
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0347033
RPLP2 ribosomal protein, large, P2 -0.034094
RPL28 ribosomal protein L28 -0.0339405
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0333962
NIPBL Nipped-B homolog (Drosophila) -0.0333813
RPS11 ribosomal protein S11 -0.033338
IFI6 interferon, alpha-inducible protein 6 -0.0332967
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 -0.0331446
TRIO trio Rho guanine nucleotide exchange factor -0.0330804
CANX calnexin -0.0330361
NSD2 nuclear receptor binding SET domain protein 2 -0.0326945
NCOR1 nuclear receptor corepressor 1 -0.0326596
RPL7A ribosomal protein L7a -0.0325675
RPL19 ribosomal protein L19 -0.0318879
RPL13A ribosomal protein L13a -0.0312751
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0311794