Clobetasol propionate_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clobetasol propionate perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clobetasol propionate_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.205972
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.116134
LMO7 LIM domain 7 0.106556
BTBD9 BTB (POZ) domain containing 9 0.102053
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0950997
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0903024
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0886202
MBNL2 muscleblind-like splicing regulator 2 0.0738667
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0687456
RNF43 ring finger protein 43 0.0587705
GOLGB1 golgin B1 0.05872
INTS6 integrator complex subunit 6 0.0583972
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0572813
RUNX1 runt-related transcription factor 1 0.0531506
NRIP1 nuclear receptor interacting protein 1 0.0490129
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0487321
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0475898
PHF3 PHD finger protein 3 0.0465666
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0458013
SPRED1 sprouty-related, EVH1 domain containing 1 0.0441526
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0416893
DSCAM Down syndrome cell adhesion molecule 0.0414801
AHNAK AHNAK nucleoprotein 0.0390919
TC2N tandem C2 domains, nuclear 0.0376525
HDLBP high density lipoprotein binding protein 0.0374021
SREBF2 sterol regulatory element binding transcription factor 2 0.0368965
CANX calnexin 0.0365163
ZBTB20 zinc finger and BTB domain containing 20 0.0354276
COG6 component of oligomeric golgi complex 6 0.0345842
AOPEP aminopeptidase O (putative) 0.0339005
FNIP1 folliculin interacting protein 1 0.033728
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 0.0329966
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0319433
PRELID2 PRELI domain containing 2 0.0314509
SEC24D SEC24 family member D 0.0306347
FNDC3A fibronectin type III domain containing 3A 0.0306344
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0303239
ARHGAP32 Rho GTPase activating protein 32 0.0302953
NEBL nebulette 0.0299875
SHB Src homology 2 domain containing adaptor protein B 0.0298665
SMAD3 SMAD family member 3 0.0292409
SERINC5 serine incorporator 5 0.0282841
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0281665
GCLC glutamate-cysteine ligase, catalytic subunit 0.0278272
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0275518
YAP1 Yes-associated protein 1 0.0270993
UBL3 ubiquitin-like 3 0.0266376
MON2 MON2 homolog (S. cerevisiae) 0.0260258
DST dystonin 0.0259303
TMEM135 transmembrane protein 135 0.0254324
SREBF1 sterol regulatory element binding transcription factor 1 0.0251427
EIF4B eukaryotic translation initiation factor 4B 0.0245798
MYH9 myosin, heavy chain 9, non-muscle 0.0245232
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0244088
EHF ets homologous factor 0.0243274
MLPH melanophilin 0.0242293
MCTP2 multiple C2 domains, transmembrane 2 0.0241467
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.0237353
HBS1L HBS1-like translational GTPase 0.0236736
ATXN1 ataxin 1 0.0236724
CTNND1 catenin (cadherin-associated protein), delta 1 0.0235676
USO1 USO1 vesicle transport factor 0.0232517
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0232224
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0230781
PDZD8 PDZ domain containing 8 0.0228976
NCOA3 nuclear receptor coactivator 3 0.0227743
GOLGA3 golgin A3 0.0223331
ASPH aspartate beta-hydroxylase 0.0222262
ANKRD10 ankyrin repeat domain 10 0.0221097
MCU mitochondrial calcium uniporter 0.022088
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 0.0219306
EPB41 erythrocyte membrane protein band 4.1 0.0218515
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.0215297
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0212653
PDIA4 protein disulfide isomerase family A, member 4 0.021183
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0211045
KIAA1217 KIAA1217 0.0209891
COPB1 coatomer protein complex, subunit beta 1 0.0207892
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0207465
RBM39 RNA binding motif protein 39 0.0203055
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0202816
POF1B premature ovarian failure, 1B 0.0200854
AGR2 anterior gradient 2 0.0200104
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0199506
CLTC clathrin, heavy chain (Hc) 0.0198282
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.019793
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0195538
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.019404
CD46 CD46 molecule, complement regulatory protein 0.0193287
TTC3 tetratricopeptide repeat domain 3 0.0192539
ACACA acetyl-CoA carboxylase alpha 0.0192535
MECOM MDS1 and EVI1 complex locus 0.0189784
PMM2 phosphomannomutase 2 0.018945
TMED2 transmembrane emp24 domain trafficking protein 2 0.0188356
USPL1 ubiquitin specific peptidase like 1 0.0185465
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0185067
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0181768
UTRN utrophin 0.0181433
APLP2 amyloid beta (A4) precursor-like protein 2 0.0181286
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0180204

decreased expression

Symbol Name Standardized Value
B2M beta-2-microglobulin -0.21158
EPSTI1 epithelial stromal interaction 1 (breast) -0.17996
TPT1 tumor protein, translationally-controlled 1 -0.162833
LCN2 lipocalin 2 -0.160605
PTMA prothymosin, alpha -0.114798
EGR1 early growth response 1 -0.105459
RNF213 ring finger protein 213 -0.104518
STS steroid sulfatase (microsomal), isozyme S -0.0997986
LYZ lysozyme -0.0953001
MACC1 metastasis associated in colon cancer 1 -0.0948693
MX2 MX dynamin-like GTPase 2 -0.0865202
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0858407
HLA-B major histocompatibility complex, class I, B -0.0848669
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0787108
FTL ferritin, light polypeptide -0.0754326
IFI6 interferon, alpha-inducible protein 6 -0.0686389
LOC102724023 ES1 protein homolog, mitochondrial -0.0684153
AREG amphiregulin -0.0672378
IFI27 interferon, alpha-inducible protein 27 -0.0652065
RIGI RNA sensor RIG-I -0.0645659
MX1 MX dynamin-like GTPase 1 -0.0632577
TMSB10 thymosin beta 10 -0.0617858
TJP1 tight junction protein 1 -0.0607409
ERBIN erbb2 interacting protein -0.0593163
NDRG1 N-myc downstream regulated 1 -0.05888
RAB7A RAB7A, member RAS oncogene family -0.0569863
C6ORF132 chromosome 6 open reading frame 132 -0.0548285
RPL35A ribosomal protein L35a -0.0543979
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0532233
SP100 SP100 nuclear antigen -0.0516759
ZMYND8 zinc finger, MYND-type containing 8 -0.0475237
RPS6 ribosomal protein S6 -0.0464192
JUN jun proto-oncogene -0.0461247
PERP PERP, TP53 apoptosis effector -0.0459807
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0457744
CCNL1 cyclin L1 -0.0457655
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0449827
ACTG1 actin gamma 1 -0.0443608
POTEF POTE ankyrin domain family, member F -0.0438615
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0437059
CLDN4 claudin 4 -0.0428462
HLA-A major histocompatibility complex, class I, A -0.0421651
SLC38A1 solute carrier family 38, member 1 -0.0420631
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0418956
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0418556
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.040549
IGFBP3 insulin-like growth factor binding protein 3 -0.039742
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0396036
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0395248
PKM pyruvate kinase, muscle -0.039072
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0390161
RPL23 ribosomal protein L23 -0.0389456
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0387383
IFITM3 interferon induced transmembrane protein 3 -0.0378372
RSAD2 radical S-adenosyl methionine domain containing 2 -0.03758
EZR ezrin -0.0374305
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0372523
TSC22D1 TSC22 domain family, member 1 -0.0367538
LY6E lymphocyte antigen 6 complex, locus E -0.0362215
TM4SF1 transmembrane 4 L six family member 1 -0.0354447
CSTB cystatin B (stefin B) -0.0350326
HLA-C major histocompatibility complex, class I, C -0.0342198
TPI1 triosephosphate isomerase 1 -0.0338615
RPS8 ribosomal protein S8 -0.0337402
PMP22 peripheral myelin protein 22 -0.0333758
MT2A metallothionein 2A -0.0328341
RPS24 ribosomal protein S24 -0.0326771
SERF2 small EDRK-rich factor 2 -0.0326314
KLF6 Kruppel-like factor 6 -0.0324254
TRIO trio Rho guanine nucleotide exchange factor -0.0323553
S100A6 S100 calcium binding protein A6 -0.0321597
AKAP13 A kinase (PRKA) anchor protein 13 -0.0320843
KRT19 keratin 19, type I -0.0319694
IFIH1 interferon induced with helicase C domain 1 -0.0316278
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0315334
HLA-E major histocompatibility complex, class I, E -0.0314455
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0312861
PLAUR plasminogen activator, urokinase receptor -0.0312139
TXNIP thioredoxin interacting protein -0.030721
ITGA6 integrin, alpha 6 -0.0305303
RPS3 ribosomal protein S3 -0.0300704
FTH1 ferritin, heavy polypeptide 1 -0.0300051
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0294259
ISG15 ISG15 ubiquitin-like modifier -0.0293771
LOC112694756 uncharaterized LOC112694756 -0.0291171
MUC13 mucin 13, cell surface associated -0.0290397
OASL 2'-5'-oligoadenylate synthetase-like -0.0288369
XAF1 XIAP associated factor 1 -0.0282967
RABGAP1L RAB GTPase activating protein 1-like -0.0282902
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0282783
GMDS GDP-mannose 4,6-dehydratase -0.0282644
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0280625
UBC ubiquitin C -0.0277709
TSHZ2 teashirt zinc finger homeobox 2 -0.0275349
RPS19 ribosomal protein S19 -0.0274506
RPL7L1 ribosomal protein L7-like 1 -0.0274381
CTSD cathepsin D -0.0274078
CST3 cystatin C -0.0273906
BLZF1 basic leucine zipper nuclear factor 1 -0.027229
VCL vinculin -0.0271364