Clobetasol propionate_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clobetasol propionate perturbation in HCT15 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clobetasol propionate_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.123848
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.111848
DSCAM Down syndrome cell adhesion molecule 0.094602
AHNAK AHNAK nucleoprotein 0.0873705
CANX calnexin 0.0809767
RBM39 RNA binding motif protein 39 0.0774401
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0771337
TXNRD1 thioredoxin reductase 1 0.0719881
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0693338
OGA O-GlcNAcase 0.0665889
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0633878
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0587838
CTNND1 catenin (cadherin-associated protein), delta 1 0.054194
ZFAND3 zinc finger, AN1-type domain 3 0.0517847
SETD5 SET domain containing 5 0.0514614
TMEM41B transmembrane protein 41B 0.0495228
PRELID2 PRELI domain containing 2 0.047747
ERBIN erbb2 interacting protein 0.0476035
SEC31A SEC31 homolog A (S. cerevisiae) 0.0448701
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0446838
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0445736
EXOC6B exocyst complex component 6B 0.0437442
PUM1 pumilio RNA-binding family member 1 0.0437048
COPB1 coatomer protein complex, subunit beta 1 0.0433237
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0431158
EZR ezrin 0.0429356
VCL vinculin 0.0411639
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0407024
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0406066
PDIA3 protein disulfide isomerase family A, member 3 0.0403163
KDM4C lysine (K)-specific demethylase 4C 0.0398033
PCBP2 poly(rC) binding protein 2 0.0391538
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0386808
RARS1 arginyl-tRNA synthetase 1 0.038097
TM9SF3 transmembrane 9 superfamily member 3 0.0373977
TMF1 TATA element modulatory factor 1 0.0371981
WDR26 WD repeat domain 26 0.0371474
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0365543
GOLGA4 golgin A4 0.0365387
JMJD1C jumonji domain containing 1C 0.0363545
ZNF292 zinc finger protein 292 0.0362547
ASNS asparagine synthetase (glutamine-hydrolyzing) 0.0360137
N4BP2L2 NEDD4 binding protein 2-like 2 0.0356502
RAB1A RAB1A, member RAS oncogene family 0.0355703
NIPBL Nipped-B homolog (Drosophila) 0.0354142
BIRC6 baculoviral IAP repeat containing 6 0.0350565
NF1 neurofibromin 1 0.0350503
YME1L1 YME1-like 1 ATPase 0.0348372
STRN3 striatin, calmodulin binding protein 3 0.0345465
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.03452
WDFY3 WD repeat and FYVE domain containing 3 0.0344707
USP34 ubiquitin specific peptidase 34 0.0344044
MED13L mediator complex subunit 13-like 0.033702
CSNK1A1 casein kinase 1, alpha 1 0.0333547
SEC24D SEC24 family member D 0.0333527
AFF4 AF4/FMR2 family, member 4 0.0329679
SREBF2 sterol regulatory element binding transcription factor 2 0.0327023
AKAP9 A kinase (PRKA) anchor protein 9 0.0325195
RBBP6 retinoblastoma binding protein 6 0.0324909
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0324231
MBD5 methyl-CpG binding domain protein 5 0.0323771
SUCO SUN domain containing ossification factor 0.0322175
WAC WW domain containing adaptor with coiled-coil 0.032161
SENP6 SUMO1/sentrin specific peptidase 6 0.0318456
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0318024
SFPQ splicing factor proline/glutamine-rich 0.031705
SETX senataxin 0.0315949
MED13 mediator complex subunit 13 0.0315803
SMC5 structural maintenance of chromosomes 5 0.0314336
ZNF207 zinc finger protein 207 0.0309097
SCFD1 sec1 family domain containing 1 0.0305534
BBX bobby sox homolog (Drosophila) 0.0302407
ARL5B ADP-ribosylation factor-like 5B 0.0300582
TOR1AIP2 torsin A interacting protein 2 0.0299447
CD2AP CD2-associated protein 0.0298515
GOLGB1 golgin B1 0.0297544
CSDE1 cold shock domain containing E1, RNA-binding 0.0296919
ANXA2 annexin A2 0.0296483
VMP1 vacuole membrane protein 1 0.0294828
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0293479
CCNL1 cyclin L1 0.0293249
EIF4B eukaryotic translation initiation factor 4B 0.0293016
LCOR ligand dependent nuclear receptor corepressor 0.0291816
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0291555
GARS1 glycyl-tRNA synthetase 1 0.0290082
YEATS2 YEATS domain containing 2 0.0289436
WNK1 WNK lysine deficient protein kinase 1 0.0288489
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.0287741
RAB5A RAB5A, member RAS oncogene family 0.0287517
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0284632
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0284632
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0284387
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0283922
SEC63 SEC63 homolog (S. cerevisiae) 0.0282709
GPHN gephyrin 0.028057
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0278622
PAPOLA poly(A) polymerase alpha 0.0277805
BRWD3 bromodomain and WD repeat domain containing 3 0.0277746
TPR translocated promoter region, nuclear basket protein 0.0277029
SOS1 son of sevenless homolog 1 (Drosophila) 0.0276488

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.226634
NDRG1 N-myc downstream regulated 1 -0.132791
TMSB10 thymosin beta 10 -0.115695
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.110364
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0837818
RPL35A ribosomal protein L35a -0.0813517
TPT1 tumor protein, translationally-controlled 1 -0.0642281
RPS6 ribosomal protein S6 -0.060109
MT2A metallothionein 2A -0.0525397
EGR1 early growth response 1 -0.0498783
RPS8 ribosomal protein S8 -0.0487496
RRM2 ribonucleotide reductase M2 -0.0405763
RPS19 ribosomal protein S19 -0.0404304
RPL37A ribosomal protein L37a -0.0401554
POTEF POTE ankyrin domain family, member F -0.0376326
INTS6 integrator complex subunit 6 -0.0375089
TOP2A topoisomerase (DNA) II alpha 170kDa -0.036849
HMGA2 high mobility group AT-hook 2 -0.0362632
S100A9 S100 calcium binding protein A9 -0.0361969
FTL ferritin, light polypeptide -0.0359981
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0359559
S100A10 S100 calcium binding protein A10 -0.0350328
HMGA1 high mobility group AT-hook 1 -0.0349031
RPL36 ribosomal protein L36 -0.0344717
RPL26 ribosomal protein L26 -0.0342559
ACTG1 actin gamma 1 -0.0336794
RPS3 ribosomal protein S3 -0.0328117
RPS21 ribosomal protein S21 -0.0325723
ENO1 enolase 1, (alpha) -0.0323181
RPL31 ribosomal protein L31 -0.0319311
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0314378
WWOX WW domain containing oxidoreductase -0.0307955
CTBP2 C-terminal binding protein 2 -0.0307814
RPLP1 ribosomal protein, large, P1 -0.0300852
RPS12 ribosomal protein S12 -0.0300761
RPLP2 ribosomal protein, large, P2 -0.0293612
VEGFA vascular endothelial growth factor A -0.029234
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0286623
RPL32 ribosomal protein L32 -0.028026
FAT1 FAT atypical cadherin 1 -0.0278278
IFITM3 interferon induced transmembrane protein 3 -0.0274842
TPI1 triosephosphate isomerase 1 -0.0266881
RPL34 ribosomal protein L34 -0.0266047
RPS13 ribosomal protein S13 -0.0266031
MIDN midnolin -0.0260004
CADPS Ca++-dependent secretion activator -0.0255098
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.025189
RPL7A ribosomal protein L7a -0.0251079
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.0249308
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0249107
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.024906
NAP1L1 nucleosome assembly protein 1-like 1 -0.0245476
RPL8 ribosomal protein L8 -0.0240506
HPCAL1 hippocalcin-like 1 -0.0240459
RPS15 ribosomal protein S15 -0.0237157
TUBA1B tubulin, alpha 1b -0.0232243
TUBB4B tubulin, beta 4B class IVb -0.0231349
HELLS helicase, lymphoid-specific -0.02284
TNS4 tensin 4 -0.0228287
ENO2 enolase 2 (gamma, neuronal) -0.022656
MKI67 marker of proliferation Ki-67 -0.0224949
RPL28 ribosomal protein L28 -0.0218028
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0216855
RPL12 ribosomal protein L12 -0.021351
BACE2 beta-site APP-cleaving enzyme 2 -0.021273
TUBB tubulin, beta class I -0.0210782
LMNA lamin A/C -0.0210525
CCND1 cyclin D1 -0.0208896
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0207576
PKM pyruvate kinase, muscle -0.0207066
RPS24 ribosomal protein S24 -0.0206372
RPL19 ribosomal protein L19 -0.020614
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0205653
HMGB1 high mobility group box 1 -0.0204166
DCAF7 DDB1 and CUL4 associated factor 7 -0.0203367
RPS27 ribosomal protein S27 -0.0202338
HLA-B major histocompatibility complex, class I, B -0.0202069
ITGB4 integrin, beta 4 -0.0195463
KRT19 keratin 19, type I -0.0194978
RPS20 ribosomal protein S20 -0.0194938
RPS11 ribosomal protein S11 -0.0194668
RPS23 ribosomal protein S23 -0.0193108
SNX14 sorting nexin 14 -0.0192129
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0191528
RCC1 regulator of chromosome condensation 1 -0.0190251
RPL38 ribosomal protein L38 -0.0190052
RPL11 ribosomal protein L11 -0.0188895
RPL5 ribosomal protein L5 -0.0188843
RPL23 ribosomal protein L23 -0.0187955
SHB Src homology 2 domain containing adaptor protein B -0.0187804
RPL27 ribosomal protein L27 -0.0187048
RPL35 ribosomal protein L35 -0.0186493
ESYT2 extended synaptotagmin-like protein 2 -0.0185275
RPS14 ribosomal protein S14 -0.0183918
RPL18 ribosomal protein L18 -0.0182764
BZW2 basic leucine zipper and W2 domains 2 -0.018273
PALD1 phosphatase domain containing, paladin 1 -0.0182312
MSI2 musashi RNA-binding protein 2 -0.0179921
NAV2 neuron navigator 2 -0.0178928
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0177983