Clobetasol propionate_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clobetasol propionate perturbation in HS-578T cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Clobetasol propionate_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.326269
MT2A metallothionein 2A 0.180658
LDHA lactate dehydrogenase A 0.12507
HIPK2 homeodomain interacting protein kinase 2 0.119956
FN1 fibronectin 1 0.117913
LOX lysyl oxidase 0.113642
ERRFI1 ERBB receptor feedback inhibitor 1 0.11039
MT1X metallothionein 1X 0.10618
FTH1 ferritin, heavy polypeptide 1 0.0993477
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.095856
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0926764
EPS8 epidermal growth factor receptor pathway substrate 8 0.0857635
MAML2 mastermind-like 2 (Drosophila) 0.080806
PTPRG protein tyrosine phosphatase, receptor type, G 0.0729209
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0658734
AKAP12 A kinase (PRKA) anchor protein 12 0.0628685
NAV2 neuron navigator 2 0.0582802
ANKRD28 ankyrin repeat domain 28 0.0557305
TOP1 topoisomerase (DNA) I 0.0550299
TGFBI transforming growth factor, beta-induced, 68kDa 0.053626
MBNL1 muscleblind-like splicing regulator 1 0.0533234
LPP LIM domain containing preferred translocation partner in lipoma 0.052661
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L 0.052427
PID1 phosphotyrosine interaction domain containing 1 0.0515445
MED13L mediator complex subunit 13-like 0.0508734
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0501985
CD109 CD109 molecule 0.0499734
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0482245
FOXO3 forkhead box O3 0.0478949
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0474269
SORBS2 sorbin and SH3 domain containing 2 0.0466458
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0440312
ESYT2 extended synaptotagmin-like protein 2 0.0432466
JAK1 Janus kinase 1 0.0427763
MYO1B myosin IB 0.0422626
CCN4 cellular communication network factor 4 0.0400433
DPYD dihydropyrimidine dehydrogenase 0.0400131
SLC38A2 solute carrier family 38, member 2 0.0397264
SH3RF3 SH3 domain containing ring finger 3 0.0395889
SOD2 superoxide dismutase 2, mitochondrial 0.0394104
FKBP5 FK506 binding protein 5 0.0385056
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0376835
JAK2 Janus kinase 2 0.0376493
PTEN phosphatase and tensin homolog 0.0376443
IL1R1 interleukin 1 receptor, type I 0.0368966
UTRN utrophin 0.0364906
AHNAK AHNAK nucleoprotein 0.035819
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0351522
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0341519
ZFHX3 zinc finger homeobox 3 0.032768
ANGPTL4 angiopoietin-like 4 0.0326534
ABLIM3 actin binding LIM protein family, member 3 0.03215
PRELID2 PRELI domain containing 2 0.0318131
TGFBR3 transforming growth factor, beta receptor III 0.0317497
SSBP2 single-stranded DNA binding protein 2 0.0315846
HIP1 huntingtin interacting protein 1 0.0312804
AKAP13 A kinase (PRKA) anchor protein 13 0.0309699
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.0302395
LTBP1 latent transforming growth factor beta binding protein 1 0.03011
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0281541
DNER delta/notch-like EGF repeat containing 0.0271151
F3 coagulation factor III (thromboplastin, tissue factor) 0.0265305
COL8A1 collagen, type VIII, alpha 1 0.0262309
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0260703
BIRC3 baculoviral IAP repeat containing 3 0.0258027
ZMYND8 zinc finger, MYND-type containing 8 0.0253884
IL6ST interleukin 6 signal transducer 0.0252718
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0246613
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0242658
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0239735
DOCK5 dedicator of cytokinesis 5 0.0235178
TSC22D3 TSC22 domain family, member 3 0.0231011
PDIA5 protein disulfide isomerase family A, member 5 0.0229246
OXR1 oxidation resistance 1 0.0226235
CARMIL1 capping protein regulator and myosin 1 linker 1 0.0224155
COL7A1 collagen, type VII, alpha 1 0.0223869
GOLGB1 golgin B1 0.0220159
FAM13A family with sequence similarity 13, member A 0.0219789
DCLK1 doublecortin-like kinase 1 0.0217927
MGP matrix Gla protein 0.0213306
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0213157
NNMT nicotinamide N-methyltransferase 0.0209853
RPL7 ribosomal protein L7 0.0208883
EFNA5 ephrin-A5 0.0204176
ANXA2 annexin A2 0.0204153
MTDH metadherin 0.0201754
MGST1 microsomal glutathione S-transferase 1 0.0199734
MACF1 microtubule-actin crosslinking factor 1 0.0197597
BCL2L1 BCL2-like 1 0.0197221
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0195054
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0193809
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.019182
KLF9 Kruppel-like factor 9 0.0188911
TRAM2 translocation associated membrane protein 2 0.0187889
TMEM164 transmembrane protein 164 0.018722
PRICKLE2 prickle homolog 2 (Drosophila) 0.0182032
AMPH amphiphysin 0.0178035
LDLRAD3 low density lipoprotein receptor class A domain containing 3 0.0177616
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0176069
DCN decorin 0.0173992

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.248671
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.188828
CD44 CD44 molecule (Indian blood group) -0.17819
CXCL8 chemokine (C-X-C motif) ligand 8 -0.167243
EXT1 exostosin glycosyltransferase 1 -0.161693
NDRG1 N-myc downstream regulated 1 -0.153844
TRIO trio Rho guanine nucleotide exchange factor -0.128606
TIMP3 TIMP metallopeptidase inhibitor 3 -0.115639
COL1A1 collagen, type I, alpha 1 -0.109601
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.106508
LOXL2 lysyl oxidase-like 2 -0.100734
ATP13A3 ATPase type 13A3 -0.099842
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0923709
TM4SF1 transmembrane 4 L six family member 1 -0.0881724
NKAIN3 Na+/K+ transporting ATPase interacting 3 -0.0868827
PDE10A phosphodiesterase 10A -0.0810974
VIM vimentin -0.0797617
IER3 immediate early response 3 -0.0692384
INHBA inhibin, beta A -0.0690667
STC1 stanniocalcin 1 -0.0639809
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0606993
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0597046
SMAD3 SMAD family member 3 -0.0577016
CADM1 cell adhesion molecule 1 -0.0573598
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0567545
COL1A2 collagen, type I, alpha 2 -0.0562257
ASPH aspartate beta-hydroxylase -0.0530988
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0510904
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0494047
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.0489919
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0486382
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0482794
ANTXR2 anthrax toxin receptor 2 -0.0473331
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0448821
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0428889
FBN1 fibrillin 1 -0.0418978
CDH13 cadherin 13 -0.041714
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0404897
ECE1 endothelin converting enzyme 1 -0.040386
PSD3 pleckstrin and Sec7 domain containing 3 -0.0402262
NALF1 NALCN channel auxiliary factor 1 -0.0398446
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.037889
DPYSL3 dihydropyrimidinase-like 3 -0.0373279
TPM4 tropomyosin 4 -0.0367523
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0356311
JARID2 jumonji, AT rich interactive domain 2 -0.0353334
ICAM1 intercellular adhesion molecule 1 -0.0342959
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0340453
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0331547
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0329426
RIGI RNA sensor RIG-I -0.032898
CLIC4 chloride intracellular channel 4 -0.0322217
MTSS1 metastasis suppressor 1 -0.0317967
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0317141
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0316781
WWTR1 WW domain containing transcription regulator 1 -0.0309718
IL6 interleukin 6 -0.0308194
KIAA1217 KIAA1217 -0.0306738
MAP1B microtubule-associated protein 1B -0.0303811
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0299169
PDE4D phosphodiesterase 4D, cAMP-specific -0.0289872
PLAUR plasminogen activator, urokinase receptor -0.0287926
RIPK2 receptor-interacting serine-threonine kinase 2 -0.028655
PTMA prothymosin, alpha -0.0283514
HLA-B major histocompatibility complex, class I, B -0.0281179
ARHGAP29 Rho GTPase activating protein 29 -0.0278784
HAS2 hyaluronan synthase 2 -0.0275186
MRPS6 mitochondrial ribosomal protein S6 -0.0274011
BHLHE40 basic helix-loop-helix family, member e40 -0.0270169
MYO10 myosin X -0.0270145
FAT1 FAT atypical cadherin 1 -0.0266718
FAM20C family with sequence similarity 20, member C -0.0265662
RASA2 RAS p21 protein activator 2 -0.0265398
SHB Src homology 2 domain containing adaptor protein B -0.0263892
SYNJ2 synaptojanin 2 -0.0257542
RRBP1 ribosome binding protein 1 -0.0255366
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0243535
ADAM12 ADAM metallopeptidase domain 12 -0.0240567
MX2 MX dynamin-like GTPase 2 -0.0240441
KDM7A lysine (K)-specific demethylase 7A -0.0236768
SAMD9 sterile alpha motif domain containing 9 -0.0236374
ACTN4 actinin, alpha 4 -0.0235758
VEGFC vascular endothelial growth factor C -0.0235145
DLG1 discs, large homolog 1 (Drosophila) -0.0234727
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0230916
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0229168
NAV1 neuron navigator 1 -0.0227515
LOC112694756 uncharaterized LOC112694756 -0.022024
FRMD4A FERM domain containing 4A -0.0219989
VCAN versican -0.0218884
SMYD3 SET and MYND domain containing 3 -0.0216099
LHFPL2 lipoma HMGIC fusion partner-like 2 -0.021065
CAVIN1 caveolae associated protein 1 -0.0210072
ELL2 elongation factor, RNA polymerase II, 2 -0.020587
RFX8 RFX family member 8, lacking RFX DNA binding domain -0.02055
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0203942
MYO9B myosin IXB -0.0202255
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0201321
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0200785
CLMP CXADR-like membrane protein -0.0198451