Clobetasol propionate_HT-29 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clobetasol propionate perturbation in HT-29 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clobetasol propionate_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 0.115323
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0941361
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0870965
RAD21 RAD21 homolog (S. pombe) 0.0808024
PTK2 protein tyrosine kinase 2 0.0724804
GCLC glutamate-cysteine ligase, catalytic subunit 0.0667198
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0657511
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0642671
EPS8 epidermal growth factor receptor pathway substrate 8 0.0616543
KRT18 keratin 18, type I 0.0609951
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0608766
NF1 neurofibromin 1 0.0605302
ACACA acetyl-CoA carboxylase alpha 0.0583626
PDIA3 protein disulfide isomerase family A, member 3 0.0559048
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0553299
PATJ PATJ crumbs cell polarity complex component 0.0537749
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0530897
CANX calnexin 0.0518027
PICALM phosphatidylinositol binding clathrin assembly protein 0.0517669
PTPRK protein tyrosine phosphatase, receptor type, K 0.0507014
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.050273
LYZ lysozyme 0.0502678
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0490809
ATXN1 ataxin 1 0.0477806
BIRC6 baculoviral IAP repeat containing 6 0.0474593
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0466941
CD2AP CD2-associated protein 0.0443715
HDLBP high density lipoprotein binding protein 0.0436545
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.0429577
LMO7 LIM domain 7 0.0428087
OGA O-GlcNAcase 0.0409018
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.039506
NECTIN2 nectin cell adhesion molecule 2 0.0394524
KMT2C lysine (K)-specific methyltransferase 2C 0.0392577
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0392405
WWC1 WW and C2 domain containing 1 0.0383023
TRPS1 trichorhinophalangeal syndrome I 0.0380218
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0378651
ZMYM2 zinc finger, MYM-type 2 0.0377841
CLTC clathrin, heavy chain (Hc) 0.0377051
IQGAP1 IQ motif containing GTPase activating protein 1 0.0375907
FTH1 ferritin, heavy polypeptide 1 0.0374104
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0362755
AKAP13 A kinase (PRKA) anchor protein 13 0.0360953
ZFAND3 zinc finger, AN1-type domain 3 0.0355614
CALU calumenin 0.035444
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0354438
GOLGA4 golgin A4 0.0352182
PDZD8 PDZ domain containing 8 0.0351189
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0345441
GCC2 GRIP and coiled-coil domain containing 2 0.0340793
CHD7 chromodomain helicase DNA binding protein 7 0.0338408
PCDHB16 protocadherin beta 16 0.0337306
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0337239
KIAA0232 KIAA0232 0.0337114
EPB41 erythrocyte membrane protein band 4.1 0.0336957
USP3 ubiquitin specific peptidase 3 0.0336707
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0325826
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.032124
DGKH diacylglycerol kinase, eta 0.0319872
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0318648
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 0.0316139
CDK13 cyclin-dependent kinase 13 0.0311746
TM9SF3 transmembrane 9 superfamily member 3 0.0311504
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0309833
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 0.0308658
CALR calreticulin 0.0308141
STK24 serine/threonine kinase 24 0.030769
KDM3A lysine (K)-specific demethylase 3A 0.030559
PLAUR plasminogen activator, urokinase receptor 0.0303296
TM4SF4 transmembrane 4 L six family member 4 0.0303253
FAM135A family with sequence similarity 135, member A 0.0303102
CCSER1 coiled-coil serine-rich protein 1 0.0302287
COG5 component of oligomeric golgi complex 5 0.0295239
KDM6A lysine (K)-specific demethylase 6A 0.0294891
DNM2 dynamin 2 0.0294182
PDIA4 protein disulfide isomerase family A, member 4 0.0289474
AFDN afadin, adherens junction formation factor 0.0286432
ANXA2 annexin A2 0.0284575
TAS2R14 taste receptor, type 2, member 14 0.0281013
IARS1 isoleucyl-tRNA synthetase 1 0.0280592
NFIA nuclear factor I/A 0.0279941
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0279113
USP54 ubiquitin specific peptidase 54 0.0278813
MBNL2 muscleblind-like splicing regulator 2 0.0278582
PGK1 phosphoglycerate kinase 1 0.0274675
DST dystonin 0.0273057
FNDC3A fibronectin type III domain containing 3A 0.0272441
FNIP1 folliculin interacting protein 1 0.027044
FNBP4 formin binding protein 4 0.0270414
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0270201
ANKHD1 ankyrin repeat and KH domain containing 1 0.0270028
COPB1 coatomer protein complex, subunit beta 1 0.0269768
OSBPL10 oxysterol binding protein-like 10 0.0267902
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0265521
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0262203
ARHGAP29 Rho GTPase activating protein 29 0.0261738
UBAC2 UBA domain containing 2 0.0258905
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 0.0258472
TJP2 tight junction protein 2 0.0257904

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.120004
ADARB1 adenosine deaminase, RNA-specific, B1 -0.108388
RPLP1 ribosomal protein, large, P1 -0.102822
RPS6 ribosomal protein S6 -0.102413
RPS19 ribosomal protein S19 -0.0921574
INTS6 integrator complex subunit 6 -0.0920697
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0904773
EGR1 early growth response 1 -0.0892666
POTEF POTE ankyrin domain family, member F -0.0831141
RPL23 ribosomal protein L23 -0.0809843
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0790293
TPT1 tumor protein, translationally-controlled 1 -0.0767413
FTL ferritin, light polypeptide -0.0720083
RPS8 ribosomal protein S8 -0.0660556
RPLP2 ribosomal protein, large, P2 -0.0650181
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0647471
RPL9 ribosomal protein L9 -0.0634437
TMSB10 thymosin beta 10 -0.0621272
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0617532
KRT20 keratin 20, type I -0.0615815
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0612326
MYH14 myosin, heavy chain 14, non-muscle -0.0572466
NDRG1 N-myc downstream regulated 1 -0.0555638
MCL1 myeloid cell leukemia 1 -0.0534334
RPL35A ribosomal protein L35a -0.0525966
RPL34 ribosomal protein L34 -0.0508117
TRIB1 tribbles pseudokinase 1 -0.0507382
ACTG1 actin gamma 1 -0.049946
RPL28 ribosomal protein L28 -0.0479205
RPS16 ribosomal protein S16 -0.0470379
SMAD3 SMAD family member 3 -0.0462858
PRELID2 PRELI domain containing 2 -0.0460036
RPS12 ribosomal protein S12 -0.0458009
AREG amphiregulin -0.0453778
RPS13 ribosomal protein S13 -0.0452916
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.04405
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0437694
RPS3 ribosomal protein S3 -0.0421939
JUN jun proto-oncogene -0.0421404
RPL37A ribosomal protein L37a -0.0420142
RPL21 ribosomal protein L21 -0.0415858
RPL31 ribosomal protein L31 -0.0403342
RPS11 ribosomal protein S11 -0.0400278
GNAS GNAS complex locus -0.0396228
VCL vinculin -0.0393114
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0388494
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0388072
RPL13A ribosomal protein L13a -0.0380072
LAMA4 laminin, alpha 4 -0.0372307
RPL5 ribosomal protein L5 -0.0371488
RPS17 ribosomal protein S17 -0.0370978
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0370443
RPL11 ribosomal protein L11 -0.0366635
NCEH1 neutral cholesterol ester hydrolase 1 -0.0356037
RPS24 ribosomal protein S24 -0.034872
ATP5F1E ATP synthase F1 subunit epsilon -0.0317474
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0313828
S100A10 S100 calcium binding protein A10 -0.0308086
RPS4X ribosomal protein S4, X-linked -0.0307225
LOC112694756 uncharaterized LOC112694756 -0.0302052
RPL36 ribosomal protein L36 -0.0299389
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0298004
PKM pyruvate kinase, muscle -0.0287928
LOC102724023 ES1 protein homolog, mitochondrial -0.0287902
RPS14 ribosomal protein S14 -0.0287414
RPS23 ribosomal protein S23 -0.0286843
GLS2 glutaminase 2 (liver, mitochondrial) -0.0285997
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0284462
VIM vimentin -0.0279959
HMGB1 high mobility group box 1 -0.027828
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0276648
RPS5 ribosomal protein S5 -0.0274847
RPLP0 ribosomal protein, large, P0 -0.0271155
RPL27 ribosomal protein L27 -0.0267602
RPS29 ribosomal protein S29 -0.0264306
RPS2 ribosomal protein S2 -0.0263679
NABP1 nucleic acid binding protein 1 -0.0263582
SPTAN1 spectrin, alpha, non-erythrocytic 1 -0.0261877
RPS21 ribosomal protein S21 -0.0260761
RPL35 ribosomal protein L35 -0.0259468
PRR5L proline rich 5 like -0.025838
TM4SF1 transmembrane 4 L six family member 1 -0.0251246
MT2A metallothionein 2A -0.025109
RPL37 ribosomal protein L37 -0.0246154
RPL7A ribosomal protein L7a -0.0245244
FOXO3 forkhead box O3 -0.0245034
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0244444
RPL19 ribosomal protein L19 -0.024303
SLC38A2 solute carrier family 38, member 2 -0.0242119
GSN gelsolin -0.0241076
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0240539
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0234354
MAML2 mastermind-like 2 (Drosophila) -0.0233516
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0233422
LMNA lamin A/C -0.0230555
CEMIP2 cell migration inducing hyaluronidase 2 -0.0227647
VMP1 vacuole membrane protein 1 -0.022658
KRT19 keratin 19, type I -0.022553
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0222837
RPS25 ribosomal protein S25 -0.0216804