Clobetasol propionate_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clobetasol propionate perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clobetasol propionate_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AHNAK AHNAK nucleoprotein 0.204374
FKBP5 FK506 binding protein 5 0.190244
VCL vinculin 0.110272
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.109091
AKAP13 A kinase (PRKA) anchor protein 13 0.108048
EFNA5 ephrin-A5 0.106077
TRIO trio Rho guanine nucleotide exchange factor 0.101395
HMGA2 high mobility group AT-hook 2 0.101368
MT2A metallothionein 2A 0.0976407
CAPRIN2 caprin family member 2 0.0968678
ESYT2 extended synaptotagmin-like protein 2 0.0920413
ZMYND8 zinc finger, MYND-type containing 8 0.080769
PDLIM5 PDZ and LIM domain 5 0.074217
DOCK5 dedicator of cytokinesis 5 0.0741849
ALCAM activated leukocyte cell adhesion molecule 0.0741804
RBM39 RNA binding motif protein 39 0.0735256
MT1X metallothionein 1X 0.0696929
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0668546
MTSS1 metastasis suppressor 1 0.0636353
KRT6A keratin 6A, type II 0.0634115
MCL1 myeloid cell leukemia 1 0.0625185
ABLIM3 actin binding LIM protein family, member 3 0.062499
TXNIP thioredoxin interacting protein 0.0616626
YAP1 Yes-associated protein 1 0.0586255
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0577907
TOP1 topoisomerase (DNA) I 0.0576317
NIBAN2 niban apoptosis regulator 2 0.0566825
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0565504
EPS8 epidermal growth factor receptor pathway substrate 8 0.0560602
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0543107
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0526986
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0523095
IRS2 insulin receptor substrate 2 0.0521528
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0520308
BCL2L1 BCL2-like 1 0.0499766
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0497966
RASAL2 RAS protein activator like 2 0.049588
ERRFI1 ERBB receptor feedback inhibitor 1 0.04949
SOD2 superoxide dismutase 2, mitochondrial 0.0489438
ZFP36L1 ZFP36 ring finger protein-like 1 0.0462516
NRCAM neuronal cell adhesion molecule 0.0456457
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0449004
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0440611
GLUL glutamate-ammonia ligase 0.0440371
CLIC4 chloride intracellular channel 4 0.0439261
PID1 phosphotyrosine interaction domain containing 1 0.0438261
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0437885
FMNL2 formin-like 2 0.0433234
BCAR3 breast cancer anti-estrogen resistance 3 0.0430124
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0422211
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0419123
RABGAP1L RAB GTPase activating protein 1-like 0.0417619
INTS6 integrator complex subunit 6 0.0394233
LMO7 LIM domain 7 0.0392602
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0386687
ZFHX3 zinc finger homeobox 3 0.038415
PLXNA2 plexin A2 0.0370934
RTN4 reticulon 4 0.0370062
DGKH diacylglycerol kinase, eta 0.0369443
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0365627
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0365269
ZSWIM6 zinc finger, SWIM-type containing 6 0.0364057
KRT17 keratin 17, type I 0.0360952
UTRN utrophin 0.0356186
HIPK2 homeodomain interacting protein kinase 2 0.0350182
PSD3 pleckstrin and Sec7 domain containing 3 0.0349844
PLEC plectin 0.0347354
FTH1 ferritin, heavy polypeptide 1 0.0343853
JAK1 Janus kinase 1 0.0342043
NAV2 neuron navigator 2 0.0336199
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0330823
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0328918
CLMB calcimembrin 0.0327627
CD59 CD59 molecule, complement regulatory protein 0.0325223
EZR ezrin 0.0324485
LPP LIM domain containing preferred translocation partner in lipoma 0.0319675
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0318138
OSMR oncostatin M receptor 0.0315635
THSD4 thrombospondin, type I, domain containing 4 0.0313923
BIRC3 baculoviral IAP repeat containing 3 0.0311256
SAMD4A sterile alpha motif domain containing 4A 0.0309305
SKI SKI proto-oncogene 0.0305465
ABLIM2 actin binding LIM protein family, member 2 0.030535
TNS3 tensin 3 0.0304842
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0301898
ACSL3 acyl-CoA synthetase long-chain family member 3 0.029907
PTK2 protein tyrosine kinase 2 0.0290069
JPH2 junctophilin 2 0.0288018
LAMB1 laminin, beta 1 0.0286412
SASH1 SAM and SH3 domain containing 1 0.0284826
CDKL5 cyclin-dependent kinase-like 5 0.0283627
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0283168
TJP1 tight junction protein 1 0.0281509
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0279378
NEBL nebulette 0.0276837
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0275742
NCOA3 nuclear receptor coactivator 3 0.0274859
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0274467
CHIC2 cysteine-rich hydrophobic domain 2 0.0270275
ZHX3 zinc fingers and homeoboxes 3 0.026775

decreased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 -0.11287
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.108863
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0893986
B2M beta-2-microglobulin -0.0828514
ITGA6 integrin, alpha 6 -0.0801848
CLU clusterin -0.078709
CEMIP cell migration inducing protein, hyaluronan binding -0.0739545
CD44 CD44 molecule (Indian blood group) -0.0709143
MEF2A myocyte enhancer factor 2A -0.0708023
SULF1 sulfatase 1 -0.0683749
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0615045
KIAA1217 KIAA1217 -0.0590887
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0574844
STC1 stanniocalcin 1 -0.0548357
NRG1 neuregulin 1 -0.0544683
PTMA prothymosin, alpha -0.0517529
IFITM3 interferon induced transmembrane protein 3 -0.0496414
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.0486833
PODXL podocalyxin-like -0.047761
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.045921
GNAS GNAS complex locus -0.045701
IFITM1 interferon induced transmembrane protein 1 -0.0455036
ASPH aspartate beta-hydroxylase -0.0454899
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0448262
LOC112694756 uncharaterized LOC112694756 -0.044291
HSPG2 heparan sulfate proteoglycan 2 -0.0423124
HLA-B major histocompatibility complex, class I, B -0.0415752
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0408582
PKM pyruvate kinase, muscle -0.0402808
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0401822
DOK5 docking protein 5 -0.0389788
RIN2 Ras and Rab interactor 2 -0.0387378
LMNA lamin A/C -0.0387365
RPS6 ribosomal protein S6 -0.0375016
KTN1 kinectin 1 (kinesin receptor) -0.0371534
ENO1 enolase 1, (alpha) -0.0368307
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0344997
TMSB4X thymosin beta 4, X-linked -0.0339103
DSTN destrin (actin depolymerizing factor) -0.03368
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 -0.0327859
IGFBP4 insulin-like growth factor binding protein 4 -0.0325694
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -0.0323362
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0321383
SYNJ2 synaptojanin 2 -0.0315507
LIMA1 LIM domain and actin binding 1 -0.0313936
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0313799
PLAT plasminogen activator, tissue -0.0312054
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0298982
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 -0.0290026
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0285942
CAMK2D calcium/calmodulin-dependent protein kinase II delta -0.0285527
PFN1 profilin 1 -0.0281773
LNPEP leucyl/cystinyl aminopeptidase -0.0281366
MAML2 mastermind-like 2 (Drosophila) -0.0280805
MRPS6 mitochondrial ribosomal protein S6 -0.027885
KMT2E lysine (K)-specific methyltransferase 2E -0.0278797
FRMD5 FERM domain containing 5 -0.0277734
BHLHE40 basic helix-loop-helix family, member e40 -0.0276135
EPHA2 EPH receptor A2 -0.0273303
MBNL2 muscleblind-like splicing regulator 2 -0.027324
FTL ferritin, light polypeptide -0.0271956
SULF2 sulfatase 2 -0.026595
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0265273
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0263941
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.0261584
SLC35F3 solute carrier family 35, member F3 -0.0261444
EHF ets homologous factor -0.0260183
RPS19 ribosomal protein S19 -0.025772
IFI16 interferon, gamma-inducible protein 16 -0.0256871
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0252623
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0250824
S100A6 S100 calcium binding protein A6 -0.0250685
DLG1 discs, large homolog 1 (Drosophila) -0.0247167
RPLP2 ribosomal protein, large, P2 -0.024465
CNRIP1 cannabinoid receptor interacting protein 1 -0.0238006
GRB10 growth factor receptor-bound protein 10 -0.0237309
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0237302
GATA6 GATA binding protein 6 -0.023696
SOX7 SRY (sex determining region Y)-box 7 -0.0236181
AKAP9 A kinase (PRKA) anchor protein 9 -0.0231873
ARRDC3 arrestin domain containing 3 -0.0229458
EXT1 exostosin glycosyltransferase 1 -0.0226871
CMIP c-Maf inducing protein -0.0226812
MDK midkine (neurite growth-promoting factor 2) -0.0226293
SAMD9 sterile alpha motif domain containing 9 -0.0224982
FSCN1 fascin actin-bundling protein 1 -0.0224647
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0223459
FOSL1 FOS-like antigen 1 -0.0222452
DST dystonin -0.0222145
RALGDS ral guanine nucleotide dissociation stimulator -0.0221773
IFI6 interferon, alpha-inducible protein 6 -0.0221116
POTEF POTE ankyrin domain family, member F -0.0219481
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0219312
RPLP1 ribosomal protein, large, P1 -0.0218893
SH3PXD2A SH3 and PX domains 2A -0.0218549
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0218363
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0218014
RPL32 ribosomal protein L32 -0.0217402
IGF2 insulin-like growth factor 2 -0.021724
TAGLN2 transgelin 2 -0.0216863