Clobetasol propionate_J82 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clobetasol propionate perturbation in J82 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clobetasol propionate_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.18512
FN1 fibronectin 1 0.160749
AHNAK AHNAK nucleoprotein 0.0847143
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0805838
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0800531
FNDC3B fibronectin type III domain containing 3B 0.0725535
CCBE1 collagen and calcium binding EGF domains 1 0.0678763
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0633005
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0437379
PTPRM protein tyrosine phosphatase, receptor type, M 0.0424625
STARD13 StAR-related lipid transfer (START) domain containing 13 0.0384282
PPME1 protein phosphatase methylesterase 1 0.0371343
PTPRG protein tyrosine phosphatase, receptor type, G 0.0346338
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0345158
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.034208
SDK1 sidekick cell adhesion molecule 1 0.0334713
EFNA5 ephrin-A5 0.0331707
TENM3 teneurin transmembrane protein 3 0.032809
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0327704
DST dystonin 0.0301319
NAV2 neuron navigator 2 0.0294991
SOD2 superoxide dismutase 2, mitochondrial 0.0294402
ZMYND8 zinc finger, MYND-type containing 8 0.0285584
NALF1 NALCN channel auxiliary factor 1 0.0283685
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0283243
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.027008
ATP13A3 ATPase type 13A3 0.0267513
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0264263
PTX3 pentraxin 3, long 0.0260232
LPP LIM domain containing preferred translocation partner in lipoma 0.0251475
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0250005
BCL2L1 BCL2-like 1 0.0234742
MMP12 matrix metallopeptidase 12 0.0232628
AGTPBP1 ATP/GTP binding protein 1 0.0231978
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.0224644
ADARB1 adenosine deaminase, RNA-specific, B1 0.0220424
RUNX2 runt-related transcription factor 2 0.021696
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0216261
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0215403
PHACTR1 phosphatase and actin regulator 1 0.0214026
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 0.0213863
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0213283
PLCB4 phospholipase C, beta 4 0.0213267
NCOA3 nuclear receptor coactivator 3 0.0209038
IL6ST interleukin 6 signal transducer 0.0206919
DIAPH3 diaphanous-related formin 3 0.0206718
MYH9 myosin, heavy chain 9, non-muscle 0.0206483
SENP5 SUMO1/sentrin specific peptidase 5 0.0205637
YEATS2 YEATS domain containing 2 0.0203332
RBM39 RNA binding motif protein 39 0.0201219
AKAP13 A kinase (PRKA) anchor protein 13 0.0200514
HIPK2 homeodomain interacting protein kinase 2 0.0198512
FTH1 ferritin, heavy polypeptide 1 0.0197831
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0196275
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0195651
LARP4B La ribonucleoprotein domain family, member 4B 0.0195218
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0194046
ABLIM3 actin binding LIM protein family, member 3 0.0192889
PTK2 protein tyrosine kinase 2 0.0192108
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0190412
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0188398
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0188201
FNDC3A fibronectin type III domain containing 3A 0.0187983
NUP153 nucleoporin 153kDa 0.0185903
MARCHF6 membrane associated ring-CH-type finger 6 0.01853
VGLL3 vestigial-like family member 3 0.0184497
ZNF804A zinc finger protein 804A 0.0183608
SAA2 serum amyloid A2 0.0183599
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0183479
AGFG1 ArfGAP with FG repeats 1 0.0182949
DIAPH2 diaphanous-related formin 2 0.01826
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.018139
ELOVL5 ELOVL fatty acid elongase 5 0.0180863
NUP98 nucleoporin 98kDa 0.018059
TAS2R14 taste receptor, type 2, member 14 0.0179194
LOX lysyl oxidase 0.0178459
OSMR oncostatin M receptor 0.0177627
MBNL1 muscleblind-like splicing regulator 1 0.0176975
AUH AU RNA binding protein/enoyl-CoA hydratase 0.0173956
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0173395
LDLRAD3 low density lipoprotein receptor class A domain containing 3 0.0173381
SMYD3 SET and MYND domain containing 3 0.0173334
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0172732
TRIO trio Rho guanine nucleotide exchange factor 0.0172327
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0172166
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0170475
GLS2 glutaminase 2 (liver, mitochondrial) 0.0168232
FNIP1 folliculin interacting protein 1 0.0167007
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0166394
VCL vinculin 0.0164228
CARD16 caspase recruitment domain family, member 16 0.0163803
FKBP5 FK506 binding protein 5 0.0163721
BIRC6 baculoviral IAP repeat containing 6 0.0163269
CDK13 cyclin-dependent kinase 13 0.0163131
EXOC4 exocyst complex component 4 0.0162255
NDUFAF6 NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 0.0162114
NEBL nebulette 0.016175
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0161528
UBQLN1 ubiquilin 1 0.016057
SBF2 SET binding factor 2 0.0160392

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.30448
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.215013
HLA-B major histocompatibility complex, class I, B -0.202313
NDRG1 N-myc downstream regulated 1 -0.109369
MT2A metallothionein 2A -0.0901731
CD44 CD44 molecule (Indian blood group) -0.0821399
B2M beta-2-microglobulin -0.0818276
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0700595
UGCG UDP-glucose ceramide glucosyltransferase -0.0689592
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0648733
RPS6 ribosomal protein S6 -0.0644531
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0630508
POTEF POTE ankyrin domain family, member F -0.0583766
IGFBP3 insulin-like growth factor binding protein 3 -0.0567469
TMSB10 thymosin beta 10 -0.0551383
PTMA prothymosin, alpha -0.0549937
RPLP2 ribosomal protein, large, P2 -0.0549835
DEK DEK proto-oncogene -0.0549474
MAP1B microtubule-associated protein 1B -0.0540353
F3 coagulation factor III (thromboplastin, tissue factor) -0.0538871
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0525008
VIM vimentin -0.0524211
FOSL1 FOS-like antigen 1 -0.0459114
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0458096
TPT1 tumor protein, translationally-controlled 1 -0.0442715
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0442369
DLG1 discs, large homolog 1 (Drosophila) -0.0429977
PFN1 profilin 1 -0.0421638
RPL35A ribosomal protein L35a -0.0392132
EIF1 eukaryotic translation initiation factor 1 -0.0391239
ENO1 enolase 1, (alpha) -0.0388643
LOC112694756 uncharaterized LOC112694756 -0.0379525
SQSTM1 sequestosome 1 -0.0379235
IFITM3 interferon induced transmembrane protein 3 -0.0360283
IFI6 interferon, alpha-inducible protein 6 -0.0358169
ACTG1 actin gamma 1 -0.0341327
CTSD cathepsin D -0.0340994
RPS8 ribosomal protein S8 -0.0340538
HLA-A major histocompatibility complex, class I, A -0.0339366
RPS19 ribosomal protein S19 -0.0336674
TXNRD1 thioredoxin reductase 1 -0.0327339
GNAS GNAS complex locus -0.0319202
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0319067
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0313466
RPLP1 ribosomal protein, large, P1 -0.0313089
JUN jun proto-oncogene -0.0306144
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0302711
KPNB1 karyopherin (importin) beta 1 -0.030133
RPL37 ribosomal protein L37 -0.0292226
TPI1 triosephosphate isomerase 1 -0.0289567
RPS3 ribosomal protein S3 -0.0285825
EGR1 early growth response 1 -0.0281945
KTN1 kinectin 1 (kinesin receptor) -0.0276424
PKM pyruvate kinase, muscle -0.0274214
TUBB4B tubulin, beta 4B class IVb -0.0272684
NAMPT nicotinamide phosphoribosyltransferase -0.0263805
RPL28 ribosomal protein L28 -0.0263169
ANXA1 annexin A1 -0.0261633
NPPB natriuretic peptide B -0.0261135
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0259899
HMGB1 high mobility group box 1 -0.0259393
RPL11 ribosomal protein L11 -0.0259042
TMSB4X thymosin beta 4, X-linked -0.0258782
SLC12A8 solute carrier family 12, member 8 -0.0255316
SRRM2 serine/arginine repetitive matrix 2 -0.0254528
S100A6 S100 calcium binding protein A6 -0.0253913
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0253028
IER3 immediate early response 3 -0.0252059
RPL8 ribosomal protein L8 -0.0251113
RPL23 ribosomal protein L23 -0.024898
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0245541
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.024342
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0241657
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0241244
RPS13 ribosomal protein S13 -0.0239565
LMNA lamin A/C -0.0234149
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0232323
LOC102724023 ES1 protein homolog, mitochondrial -0.0231612
HMGA1 high mobility group AT-hook 1 -0.0231409
RBM25 RNA binding motif protein 25 -0.0229218
HLA-E major histocompatibility complex, class I, E -0.0228638
CCND1 cyclin D1 -0.0225076
RPL7A ribosomal protein L7a -0.0223869
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0221305
RND3 Rho family GTPase 3 -0.0218834
RPL5 ribosomal protein L5 -0.0216336
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0214882
S100A11 S100 calcium binding protein A11 -0.0212708
POMP proteasome maturation protein -0.0209966
SEPTIN7 septin 7 -0.0208949
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0207015
NAP1L1 nucleosome assembly protein 1-like 1 -0.0206235
RPL35 ribosomal protein L35 -0.0204594
RPL37A ribosomal protein L37a -0.0203186
RPS27 ribosomal protein S27 -0.0203111
RPL19 ribosomal protein L19 -0.0203022
RPL12 ribosomal protein L12 -0.0202312
RPS12 ribosomal protein S12 -0.019713
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0195852
S100A10 S100 calcium binding protein A10 -0.0194133