Clobetasol propionate_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clobetasol propionate perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clobetasol propionate_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.122898
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0773861
CD109 CD109 molecule 0.0550912
MT2A metallothionein 2A 0.0515567
FNDC3B fibronectin type III domain containing 3B 0.048326
HMGA2 high mobility group AT-hook 2 0.0462873
MT1E metallothionein 1E 0.0444633
MT1X metallothionein 1X 0.0441939
FKBP5 FK506 binding protein 5 0.041281
MYOF myoferlin 0.0326244
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.030502
IRS2 insulin receptor substrate 2 0.0284955
CAST calpastatin 0.0274327
ANKRD28 ankyrin repeat domain 28 0.0256504
HIPK2 homeodomain interacting protein kinase 2 0.024902
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0237743
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0228972
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0222595
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0200153
PLIN2 perilipin 2 0.0198851
LPP LIM domain containing preferred translocation partner in lipoma 0.0192515
BCL6 B-cell CLL/lymphoma 6 0.0192031
CAV1 caveolin 1, caveolae protein, 22kDa 0.0181683
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0178576
AKAP13 A kinase (PRKA) anchor protein 13 0.0177878
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0171857
MSN moesin 0.01689
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0162809
MAN2A1 mannosidase, alpha, class 2A, member 1 0.0159818
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.015718
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma 0.0154793
SSBP2 single-stranded DNA binding protein 2 0.0149251
HELZ helicase with zinc finger 0.0135662
TMX4 thioredoxin-related transmembrane protein 4 0.0135611
ZMYND8 zinc finger, MYND-type containing 8 0.0134228
ADGRB3 adhesion G protein-coupled receptor B3 0.0133432
RASAL2 RAS protein activator like 2 0.0131833
MYO1B myosin IB 0.0131276
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0130966
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0129129
BNC2 basonuclin 2 0.0125846
TXNIP thioredoxin interacting protein 0.012477
RYBP RING1 and YY1 binding protein 0.0124613
UGP2 UDP-glucose pyrophosphorylase 2 0.012339
RPL7 ribosomal protein L7 0.0120353
RPS18 ribosomal protein S18 0.0120215
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0118361
NUP58 nucleoporin 58 0.0116976
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0116104
BDNF brain-derived neurotrophic factor 0.0116043
CDK19 cyclin-dependent kinase 19 0.0115604
LDHA lactate dehydrogenase A 0.0113878
FAT4 FAT atypical cadherin 4 0.0112998
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.0112693
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.011254
YBX1 Y box binding protein 1 0.0112286
HIPK3 homeodomain interacting protein kinase 3 0.0111731
ZNF292 zinc finger protein 292 0.0111669
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0108391
TRAM1 translocation associated membrane protein 1 0.0106997
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0106401
AGTPBP1 ATP/GTP binding protein 1 0.0106222
TSC22D3 TSC22 domain family, member 3 0.0105263
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0104657
TSC22D2 TSC22 domain family, member 2 0.0102518
SCAF4 SR-related CTD-associated factor 4 0.0102031
PPME1 protein phosphatase methylesterase 1 0.0101016
RPL3 ribosomal protein L3 0.0100058
NCKAP1 NCK-associated protein 1 0.00998942
EGLN1 egl-9 family hypoxia-inducible factor 1 0.00978844
NNMT nicotinamide N-methyltransferase 0.00978509
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.00957434
SOD2 superoxide dismutase 2, mitochondrial 0.00941081
RPL21 ribosomal protein L21 0.00937603
STK17B serine/threonine kinase 17b 0.00937165
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.00931276
FLNA filamin A, alpha 0.00929005
IL1R1 interleukin 1 receptor, type I 0.00921194
TMEM123 transmembrane protein 123 0.00918483
CLIC4 chloride intracellular channel 4 0.0091653
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 0.00912914
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0090272
KLF9 Kruppel-like factor 9 0.00901792
ZEB2 zinc finger E-box binding homeobox 2 0.00901246
COL12A1 collagen, type XII, alpha 1 0.00861857
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.00861538
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.00854461
FLRT2 fibronectin leucine rich transmembrane protein 2 0.0084991
CNOT1 CCR4-NOT transcription complex, subunit 1 0.00841378
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 0.0082223
RBM39 RNA binding motif protein 39 0.00815382
BCAR3 breast cancer anti-estrogen resistance 3 0.00807473
ARMC8 armadillo repeat containing 8 0.00805793
RARB retinoic acid receptor, beta 0.00798604
PRPF8 pre-mRNA processing factor 8 0.00797638
YBX3 Y box binding protein 3 0.0079746
NUP98 nucleoporin 98kDa 0.00793275
PER1 period circadian clock 1 0.00791642
BCL9L B-cell CLL/lymphoma 9-like 0.00790676
TSC22D1 TSC22 domain family, member 1 0.00789133

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.300952
EXT1 exostosin glycosyltransferase 1 -0.235511
LSAMP limbic system-associated membrane protein -0.16406
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.145095
TPT1 tumor protein, translationally-controlled 1 -0.126257
RPS6 ribosomal protein S6 -0.119564
DTNA dystrobrevin, alpha -0.100406
SAMD3 sterile alpha motif domain containing 3 -0.0954955
PRKG1 protein kinase, cGMP-dependent, type I -0.091331
KIAA1217 KIAA1217 -0.0839683
PHACTR1 phosphatase and actin regulator 1 -0.0838705
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0821804
ASPH aspartate beta-hydroxylase -0.0781432
PBX3 pre-B-cell leukemia homeobox 3 -0.0765079
SDCCAG8 serologically defined colon cancer antigen 8 -0.0733
TMSB10 thymosin beta 10 -0.0721998
KIAA1549L KIAA1549-like -0.0712618
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0707208
MYO10 myosin X -0.0686501
NTM neurotrimin -0.067715
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0657352
CDH13 cadherin 13 -0.0655349
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0644297
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0641092
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0627213
TRIO trio Rho guanine nucleotide exchange factor -0.0610463
HDAC9 histone deacetylase 9 -0.0609226
NAP1L1 nucleosome assembly protein 1-like 1 -0.0606704
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.05979
DSCAM Down syndrome cell adhesion molecule -0.0589606
RPL37A ribosomal protein L37a -0.0573799
C2CD2 C2 calcium-dependent domain containing 2 -0.0553321
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0551974
RPLP1 ribosomal protein, large, P1 -0.0545864
CD44 CD44 molecule (Indian blood group) -0.0542798
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0540488
JMJD1C jumonji domain containing 1C -0.0535307
RPL35A ribosomal protein L35a -0.0520581
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0512218
CALD1 caldesmon 1 -0.0510195
DOCK4 dedicator of cytokinesis 4 -0.0507258
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.05014
RUNX1 runt-related transcription factor 1 -0.0501168
TM4SF1 transmembrane 4 L six family member 1 -0.0482296
ENKUR enkurin, TRPC channel interacting protein -0.0479812
LIMCH1 LIM and calponin homology domains 1 -0.0479595
NAV3 neuron navigator 3 -0.0478158
RPS3 ribosomal protein S3 -0.0475436
NALF1 NALCN channel auxiliary factor 1 -0.0473499
ACTG1 actin gamma 1 -0.0465483
MACF1 microtubule-actin crosslinking factor 1 -0.0463796
PTMA prothymosin, alpha -0.0459749
ANTXR2 anthrax toxin receptor 2 -0.0454108
RPL31 ribosomal protein L31 -0.0441729
RPS12 ribosomal protein S12 -0.0432197
CFAP251 cilia and flagella associated protein 251 -0.0429615
FTL ferritin, light polypeptide -0.0400023
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0394539
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0391507
CSTB cystatin B (stefin B) -0.0385376
RPS27A ribosomal protein S27a -0.0382771
CDK6 cyclin-dependent kinase 6 -0.0382245
RPS8 ribosomal protein S8 -0.0381926
PTK2 protein tyrosine kinase 2 -0.0379095
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0373793
DST dystonin -0.0368309
ITGA6 integrin, alpha 6 -0.0361017
ADAM19 ADAM metallopeptidase domain 19 -0.0356952
ESM1 endothelial cell-specific molecule 1 -0.0356087
WSB1 WD repeat and SOCS box containing 1 -0.035201
RPS19 ribosomal protein S19 -0.0351212
GNAS GNAS complex locus -0.0343185
ZEB1 zinc finger E-box binding homeobox 1 -0.034125
GPC6 glypican 6 -0.0341065
CAVIN1 caveolae associated protein 1 -0.0340424
EIF1 eukaryotic translation initiation factor 1 -0.033751
YES1 YES proto-oncogene 1, Src family tyrosine kinase -0.0336462
MSR1 macrophage scavenger receptor 1 -0.0333125
SASH1 SAM and SH3 domain containing 1 -0.0332882
TPM4 tropomyosin 4 -0.0332631
RPLP2 ribosomal protein, large, P2 -0.0330946
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0330398
RPL38 ribosomal protein L38 -0.0328177
TNNC1 troponin C type 1 (slow) -0.0327528
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0325554
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0320455
RPL23 ribosomal protein L23 -0.0315598
BMAL2 basic helix-loop-helix ARNT like 2 -0.0315412
RPS24 ribosomal protein S24 -0.0304107
PGK1 phosphoglycerate kinase 1 -0.0303416
RPS13 ribosomal protein S13 -0.0301754
HAS2 hyaluronan synthase 2 -0.0299625
LIMA1 LIM domain and actin binding 1 -0.0297639
PTPRK protein tyrosine phosphatase, receptor type, K -0.0287609
AKAP12 A kinase (PRKA) anchor protein 12 -0.0287345
NSD2 nuclear receptor binding SET domain protein 2 -0.028432
USP34 ubiquitin specific peptidase 34 -0.0284121
MMP12 matrix metallopeptidase 12 -0.0281879
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0281506
CDK17 cyclin-dependent kinase 17 -0.027885