Clobetasol propionate_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clobetasol propionate perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clobetasol propionate_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.240527
FAT1 FAT atypical cadherin 1 0.0612797
CALR calreticulin 0.0520159
MYO1E myosin IE 0.0407545
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0403688
MBNL2 muscleblind-like splicing regulator 2 0.0370812
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0370282
PDIA3 protein disulfide isomerase family A, member 3 0.0369646
BTBD9 BTB (POZ) domain containing 9 0.035047
GOLGA4 golgin A4 0.031972
GOLGB1 golgin B1 0.0313521
EXT1 exostosin glycosyltransferase 1 0.0309567
MACF1 microtubule-actin crosslinking factor 1 0.0303153
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0296732
CANX calnexin 0.0292518
ZSWIM6 zinc finger, SWIM-type containing 6 0.0289833
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0285097
HDLBP high density lipoprotein binding protein 0.0284552
CEMIP2 cell migration inducing hyaluronidase 2 0.0283908
PDIA4 protein disulfide isomerase family A, member 4 0.0283387
PTEN phosphatase and tensin homolog 0.0280001
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0254732
TTC3 tetratricopeptide repeat domain 3 0.0246882
ERRFI1 ERBB receptor feedback inhibitor 1 0.0242921
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0232818
SEC31A SEC31 homolog A (S. cerevisiae) 0.0229014
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0218031
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.021596
AKAP9 A kinase (PRKA) anchor protein 9 0.0215884
RPL7 ribosomal protein L7 0.0212488
AGR2 anterior gradient 2 0.0210956
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0208464
EGFR epidermal growth factor receptor 0.020734
MRPS6 mitochondrial ribosomal protein S6 0.0205522
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0203598
VEGFA vascular endothelial growth factor A 0.0200119
KLF5 Kruppel-like factor 5 (intestinal) 0.019892
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0193253
AHNAK AHNAK nucleoprotein 0.0191508
LMO7 LIM domain 7 0.0190369
USO1 USO1 vesicle transport factor 0.0189527
HSPA8 heat shock 70kDa protein 8 0.0187232
SAMD4A sterile alpha motif domain containing 4A 0.0185707
ESYT2 extended synaptotagmin-like protein 2 0.0185115
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0184506
HYOU1 hypoxia up-regulated 1 0.0176975
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.017055
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0170536
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0169895
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0169891
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0168377
PPIB peptidylprolyl isomerase B (cyclophilin B) 0.0167011
BACE2 beta-site APP-cleaving enzyme 2 0.0165436
PTPRB protein tyrosine phosphatase, receptor type, B 0.0163913
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0160773
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 0.0160006
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0159321
NUCB2 nucleobindin 2 0.0159034
FNDC3B fibronectin type III domain containing 3B 0.0157371
CLIP2 CAP-GLY domain containing linker protein 2 0.0155666
INTS6 integrator complex subunit 6 0.015527
TMED2 transmembrane emp24 domain trafficking protein 2 0.0155101
SEC24D SEC24 family member D 0.0154013
MT2A metallothionein 2A 0.0152745
GCLC glutamate-cysteine ligase, catalytic subunit 0.015188
TMF1 TATA element modulatory factor 1 0.0150266
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0150067
LPP LIM domain containing preferred translocation partner in lipoma 0.0145816
PGM3 phosphoglucomutase 3 0.0144025
CDK13 cyclin-dependent kinase 13 0.0143733
PNPLA8 patatin-like phospholipase domain containing 8 0.0142942
SPTY2D1 SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) 0.0142774
TMCO3 transmembrane and coiled-coil domains 3 0.0142093
GOLGA2 golgin A2 0.0141479
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 0.0139523
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0139426
COG6 component of oligomeric golgi complex 6 0.0138818
PMM2 phosphomannomutase 2 0.0138642
UNC13B unc-13 homolog B (C. elegans) 0.0138206
POF1B premature ovarian failure, 1B 0.0138019
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.0137075
TPM4 tropomyosin 4 0.0136899
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0135714
RPS18 ribosomal protein S18 0.013562
KLHL29 kelch-like family member 29 0.0134947
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0134943
AHI1 Abelson helper integration site 1 0.0134911
HM13 histocompatibility (minor) 13 0.0133916
LARP1B La ribonucleoprotein domain family, member 1B 0.0133816
CADPS2 Ca++-dependent secretion activator 2 0.0132803
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0132348
SETX senataxin 0.0131117
ZCCHC7 zinc finger, CCHC domain containing 7 0.0131065
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0129898
ABHD3 abhydrolase domain containing 3 0.0129683
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0128515
SVIL supervillin 0.0125621
SLC10A7 solute carrier family 10, member 7 0.012555
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0124268
FAM114A1 family with sequence similarity 114, member A1 0.0124129

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.225291
TPT1 tumor protein, translationally-controlled 1 -0.169692
TMSB10 thymosin beta 10 -0.139941
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.132015
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0982057
RPS6 ribosomal protein S6 -0.0869994
NPSR1 neuropeptide S receptor 1 -0.0834656
ALCAM activated leukocyte cell adhesion molecule -0.0703321
S100A6 S100 calcium binding protein A6 -0.0693719
ACTG1 actin gamma 1 -0.0678407
ITGA6 integrin, alpha 6 -0.0655315
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0640782
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0640238
RPS24 ribosomal protein S24 -0.0633755
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0581899
KRT18 keratin 18, type I -0.0571471
EPCAM epithelial cell adhesion molecule -0.0561087
NALF1 NALCN channel auxiliary factor 1 -0.0557478
RPLP0 ribosomal protein, large, P0 -0.0530641
RPL34 ribosomal protein L34 -0.0518895
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0513352
LOC102724023 ES1 protein homolog, mitochondrial -0.0498319
EZR ezrin -0.0490981
LAMA4 laminin, alpha 4 -0.0454383
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0444799
MUC6 mucin 6, oligomeric mucus/gel-forming -0.0440637
KRT8 keratin 8, type II -0.0436032
IER3 immediate early response 3 -0.0432292
ANXA2 annexin A2 -0.0431461
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0424623
RPL9 ribosomal protein L9 -0.0419307
RPL35A ribosomal protein L35a -0.0418232
ACTN4 actinin, alpha 4 -0.0415776
RPLP2 ribosomal protein, large, P2 -0.0410204
RPS8 ribosomal protein S8 -0.0408155
TPI1 triosephosphate isomerase 1 -0.0397015
EREG epiregulin -0.0392931
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0392804
AREG amphiregulin -0.0384354
TNS4 tensin 4 -0.0380093
MYL12B myosin, light chain 12B, regulatory -0.0378193
POTEF POTE ankyrin domain family, member F -0.0376843
RPL37A ribosomal protein L37a -0.0373857
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0371819
HMGB1 high mobility group box 1 -0.0370238
GPHN gephyrin -0.0369037
FHIT fragile histidine triad -0.0367845
GNAS GNAS complex locus -0.0365645
CEMIP cell migration inducing protein, hyaluronan binding -0.0361159
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0353761
PERP PERP, TP53 apoptosis effector -0.035065
ZFP36L2 ZFP36 ring finger protein-like 2 -0.0339939
GREB1L growth regulation by estrogen in breast cancer-like -0.0331372
CD2AP CD2-associated protein -0.0327435
RPL19 ribosomal protein L19 -0.032638
LMNA lamin A/C -0.0325661
RPS21 ribosomal protein S21 -0.0323589
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0321314
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0320611
PRSS3 protease, serine, 3 -0.0312123
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0311257
RPS3 ribosomal protein S3 -0.0308014
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0305414
H1-0 H1.0 linker histone -0.0304741
KRT19 keratin 19, type I -0.0304724
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0301502
HMGA1 high mobility group AT-hook 1 -0.0300372
NAP1L1 nucleosome assembly protein 1-like 1 -0.0300283
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.029991
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0299664
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0299431
CCND1 cyclin D1 -0.029895
ANKRD11 ankyrin repeat domain 11 -0.0296029
PFN1 profilin 1 -0.0295431
GSTP1 glutathione S-transferase pi 1 -0.0293088
FERMT1 fermitin family member 1 -0.0292953
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0292098
KLK10 kallikrein-related peptidase 10 -0.028941
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0288353
SOX9 SRY (sex determining region Y)-box 9 -0.0283487
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0281345
RPL8 ribosomal protein L8 -0.0275881
MED13L mediator complex subunit 13-like -0.0274771
PLAUR plasminogen activator, urokinase receptor -0.0273816
RPL36A ribosomal protein L36a -0.0272944
RPL11 ribosomal protein L11 -0.0272722
CALB1 calbindin 1, 28kDa -0.027224
CBX3 chromobox homolog 3 -0.0265797
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0264995
FNBP1L formin binding protein 1-like -0.0264819
S100A10 S100 calcium binding protein A10 -0.0264534
RPS19 ribosomal protein S19 -0.0264383
GCC2 GRIP and coiled-coil domain containing 2 -0.0263935
FOXP1 forkhead box P1 -0.0263591
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0263013
KLF3 Kruppel-like factor 3 (basic) -0.0262537
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0261788
RPL26 ribosomal protein L26 -0.0260221
RBM25 RNA binding motif protein 25 -0.0259185
RPL5 ribosomal protein L5 -0.0257479