Clobetasol propionate_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clobetasol propionate perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clobetasol propionate_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0547968
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0527629
PON2 paraoxonase 2 0.047837
EEF2 eukaryotic translation elongation factor 2 0.0293392
INTS6 integrator complex subunit 6 0.0271593
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0228017
RPL7 ribosomal protein L7 0.0210693
LRRC23 leucine rich repeat containing 23 0.0203171
THSD4 thrombospondin, type I, domain containing 4 0.0197236
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough 0.0191638
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 0.0185747
MLEC malectin 0.0177227
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0171828
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0167673
RPL23 ribosomal protein L23 0.0165752
FTH1 ferritin, heavy polypeptide 1 0.0159352
CATSPERB catsper channel auxiliary subunit beta 0.0158603
EEF1G eukaryotic translation elongation factor 1 gamma 0.0152659
MT2A metallothionein 2A 0.015229
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0138989
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0137106
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0132827
RPL35A ribosomal protein L35a 0.0132037
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.012969
PCBP2 poly(rC) binding protein 2 0.0127815
ZBTB16 zinc finger and BTB domain containing 16 0.0126605
PER1 period circadian clock 1 0.0125371
CEMIP2 cell migration inducing hyaluronidase 2 0.0125182
CCND3 cyclin D3 0.0125097
GCLC glutamate-cysteine ligase, catalytic subunit 0.0124945
RPLP0 ribosomal protein, large, P0 0.0123734
NABP1 nucleic acid binding protein 1 0.0118996
ERRFI1 ERBB receptor feedback inhibitor 1 0.0117629
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0115857
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0115163
BIRC3 baculoviral IAP repeat containing 3 0.0108855
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0108172
ABLIM2 actin binding LIM protein family, member 2 0.010698
ATF6 activating transcription factor 6 0.010648
EGR1 early growth response 1 0.0103952
SPDYA speedy/RINGO cell cycle regulator family member A 0.0102398
CEMIP cell migration inducing protein, hyaluronan binding 0.0101938
ARF4 ADP-ribosylation factor 4 0.0101354
PDE9A phosphodiesterase 9A 0.0100785
APLP2 amyloid beta (A4) precursor-like protein 2 0.00976098
MARCHF3 membrane associated ring-CH-type finger 3 0.00972231
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.00964836
POTEF POTE ankyrin domain family, member F 0.00957191
C19ORF38 chromosome 19 open reading frame 38 0.00949668
TOP1 topoisomerase (DNA) I 0.00938342
THBS1 thrombospondin 1 0.00894236
STIM2 stromal interaction molecule 2 0.00890176
BZW2 basic leucine zipper and W2 domains 2 0.00851407
FAM222A family with sequence similarity 222, member A 0.00831209
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.00812137
ASS1 argininosuccinate synthase 1 0.00802923
RCC1 regulator of chromosome condensation 1 0.00793464
MCL1 myeloid cell leukemia 1 0.00781067
LARP1B La ribonucleoprotein domain family, member 1B 0.00777271
HYOU1 hypoxia up-regulated 1 0.00774741
MLIP muscular LMNA-interacting protein 0.00773231
RPL21 ribosomal protein L21 0.00771532
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.00761832
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.00756214
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.00744946
GNPDA1 glucosamine-6-phosphate deaminase 1 0.00724411
MSH4 mutS homolog 4 0.0072016
EVA1C eva-1 homolog C (C. elegans) 0.00719692
IGFBP3 insulin-like growth factor binding protein 3 0.0069866
GDA guanine deaminase 0.00695064
MAOA monoamine oxidase A 0.00689473
C6ORF62 chromosome 6 open reading frame 62 0.00688775
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.00683716
DKK1 dickkopf WNT signaling pathway inhibitor 1 0.00674838
TEX14 testis expressed 14 0.00668942
ADM adrenomedullin 0.0066874
FTL ferritin, light polypeptide 0.00662805
MUC12 mucin 12, cell surface associated 0.00662237
TRAM1 translocation associated membrane protein 1 0.00661829
DDIT4 DNA-damage-inducible transcript 4 0.0066119
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 0.00658546
AKAP12 A kinase (PRKA) anchor protein 12 0.00656055
BCL6 B-cell CLL/lymphoma 6 0.00650419
FGF18 fibroblast growth factor 18 0.00646815
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.00630349
TMCO3 transmembrane and coiled-coil domains 3 0.00624758
PLSCR2 phospholipid scramblase 2 0.00618175
FKBP5 FK506 binding protein 5 0.00615342
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1 0.00608187
POU2F2 POU class 2 homeobox 2 0.00602186
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.00599502
MBD6 methyl-CpG binding domain protein 6 0.00592953
FAM120A family with sequence similarity 120A 0.00592583
TRIM72 tripartite motif containing 72, E3 ubiquitin protein ligase 0.00592462
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 0.00581924
CMBL carboxymethylenebutenolidase homolog (Pseudomonas) 0.00576672
KLF9 Kruppel-like factor 9 0.00576202
SCNN1G sodium channel, non voltage gated 1 gamma subunit 0.00566802
CLDN7 claudin 7 0.00565665
FAM53C family with sequence similarity 53, member C 0.00563156

decreased expression

Symbol Name Standardized Value
PTPRR protein tyrosine phosphatase, receptor type, R -0.133337
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.130437
TPT1 tumor protein, translationally-controlled 1 -0.129467
PDE4D phosphodiesterase 4D, cAMP-specific -0.124667
LMO7 LIM domain 7 -0.0967033
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0965305
DSPP dentin sialophosphoprotein -0.0898872
KCNK1 potassium channel, two pore domain subfamily K, member 1 -0.0856833
FLNB filamin B, beta -0.0849608
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0846377
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 -0.0806393
RPS2 ribosomal protein S2 -0.0802812
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0788964
EZR ezrin -0.0759725
FRMD5 FERM domain containing 5 -0.0728642
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0721823
MUC13 mucin 13, cell surface associated -0.0720812
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0714543
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0710717
MSI2 musashi RNA-binding protein 2 -0.0705443
PRSS3 protease, serine, 3 -0.0686211
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0677053
ITPRID2 ITPR interacting domain containing 2 -0.0643955
LAMB3 laminin, beta 3 -0.0642092
RIGI RNA sensor RIG-I -0.0635903
DSG3 desmoglein 3 -0.0613712
PTMA prothymosin, alpha -0.0597566
MX1 MX dynamin-like GTPase 1 -0.0586037
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -0.0585329
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0580155
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0578681
UBE2H ubiquitin-conjugating enzyme E2H -0.0578356
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.057541
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0567551
LAMA4 laminin, alpha 4 -0.0558252
FOXO1 forkhead box O1 -0.0544162
ACTN4 actinin, alpha 4 -0.0519584
RNF213 ring finger protein 213 -0.051793
SERINC5 serine incorporator 5 -0.0517044
CALB1 calbindin 1, 28kDa -0.0510657
MYO5B myosin VB -0.0501125
DSG2 desmoglein 2 -0.0495413
KLF5 Kruppel-like factor 5 (intestinal) -0.0495296
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0489583
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0481032
RRBP1 ribosome binding protein 1 -0.0480333
JMJD1C jumonji domain containing 1C -0.0480038
VCL vinculin -0.0475239
KRT8 keratin 8, type II -0.0474423
TSPAN8 tetraspanin 8 -0.0473851
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0470073
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0468378
RAP1B RAP1B, member of RAS oncogene family -0.0467987
FERMT1 fermitin family member 1 -0.0463739
TXNRD1 thioredoxin reductase 1 -0.0452336
RPL4 ribosomal protein L4 -0.0450231
EXT1 exostosin glycosyltransferase 1 -0.0442977
RPLP1 ribosomal protein, large, P1 -0.0441038
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 -0.0439771
PRELID2 PRELI domain containing 2 -0.0436127
PRRC2C proline-rich coiled-coil 2C -0.0434006
TCF12 transcription factor 12 -0.0425809
PATJ PATJ crumbs cell polarity complex component -0.0424026
MYO1E myosin IE -0.042246
WWC1 WW and C2 domain containing 1 -0.0415375
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0414983
KMT2C lysine (K)-specific methyltransferase 2C -0.0408861
KRT18 keratin 18, type I -0.0407163
PLAUR plasminogen activator, urokinase receptor -0.0405974
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0402761
SP100 SP100 nuclear antigen -0.0397945
P3H2 prolyl 3-hydroxylase 2 -0.0394969
AOPEP aminopeptidase O (putative) -0.0394457
F3 coagulation factor III (thromboplastin, tissue factor) -0.0390516
ABHD17C abhydrolase domain containing 17C -0.0389982
XAF1 XIAP associated factor 1 -0.0387175
ANXA11 annexin A11 -0.0386701
TRIM2 tripartite motif containing 2 -0.0386297
LAMC2 laminin, gamma 2 -0.0384412
AKAP13 A kinase (PRKA) anchor protein 13 -0.0382654
IFI6 interferon, alpha-inducible protein 6 -0.0382463
TJP1 tight junction protein 1 -0.0382017
TAS2R14 taste receptor, type 2, member 14 -0.0380085
SLTM SAFB-like, transcription modulator -0.0379596
RBM25 RNA binding motif protein 25 -0.037898
NT5C2 5'-nucleotidase, cytosolic II -0.037757
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0372429
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0371755
RPS24 ribosomal protein S24 -0.0368344
NAP1L1 nucleosome assembly protein 1-like 1 -0.0367197
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.036604
CTNND1 catenin (cadherin-associated protein), delta 1 -0.036456
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.036433
SPATS2L spermatogenesis associated, serine-rich 2-like -0.036022
COBL cordon-bleu WH2 repeat protein -0.0358118
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0357805
CLIC5 chloride intracellular channel 5 -0.0356284
CD2AP CD2-associated protein -0.0356141
ALCAM activated leukocyte cell adhesion molecule -0.0355399
NF1 neurofibromin 1 -0.0352332