Clobetasol propionate_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clobetasol propionate perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Clobetasol propionate_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
S100P S100 calcium binding protein P 0.201783
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.143521
PDE4D phosphodiesterase 4D, cAMP-specific 0.139884
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0990551
MAP2K1 mitogen-activated protein kinase kinase 1 0.0989272
EGFR epidermal growth factor receptor 0.0922289
AHNAK AHNAK nucleoprotein 0.0883433
CAV1 caveolin 1, caveolae protein, 22kDa 0.0874032
CES1 carboxylesterase 1 0.0844527
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0800852
MT2A metallothionein 2A 0.0730745
FRY furry homolog (Drosophila) 0.0581966
MAML3 mastermind-like 3 (Drosophila) 0.0577285
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0551476
FGD4 FYVE, RhoGEF and PH domain containing 4 0.054013
EFNA5 ephrin-A5 0.0527182
TOP1 topoisomerase (DNA) I 0.0521188
AKAP13 A kinase (PRKA) anchor protein 13 0.051535
IRS2 insulin receptor substrate 2 0.0509753
MGST1 microsomal glutathione S-transferase 1 0.0499415
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0483301
TES testin LIM domain protein 0.0482737
BIRC3 baculoviral IAP repeat containing 3 0.0473873
ATP11A ATPase, class VI, type 11A 0.0452679
DSPP dentin sialophosphoprotein 0.0446699
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0429209
PLEC plectin 0.04277
ESYT2 extended synaptotagmin-like protein 2 0.0426564
MCTP1 multiple C2 domains, transmembrane 1 0.0424455
DNER delta/notch-like EGF repeat containing 0.0409919
FKBP5 FK506 binding protein 5 0.0409764
CD109 CD109 molecule 0.0394516
DYNC2I1 dynein 2 intermediate chain 1 0.0387008
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0382432
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0379186
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0367253
NEBL nebulette 0.0362139
SCEL sciellin 0.0360723
SMYD3 SET and MYND domain containing 3 0.0351136
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 0.0346026
SLC26A2 solute carrier family 26 (anion exchanger), member 2 0.0344669
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0324742
MCL1 myeloid cell leukemia 1 0.0319693
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0318115
LRP12 low density lipoprotein receptor-related protein 12 0.0315475
ANKRD11 ankyrin repeat domain 11 0.0302834
SCNN1G sodium channel, non voltage gated 1 gamma subunit 0.0300563
SOS1 son of sevenless homolog 1 (Drosophila) 0.0298842
SUMF1 sulfatase modifying factor 1 0.0297323
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0293449
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0292512
MLKL mixed lineage kinase domain-like 0.0289708
MKI67 marker of proliferation Ki-67 0.0278132
VCL vinculin 0.0263119
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0260856
FOXP1 forkhead box P1 0.0260034
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0253764
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0253579
HOMER2 homer scaffolding protein 2 0.0249093
FAT1 FAT atypical cadherin 1 0.0245093
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0244676
CAPRIN2 caprin family member 2 0.024458
IGF1R insulin-like growth factor 1 receptor 0.0242893
CMIP c-Maf inducing protein 0.0240569
YAP1 Yes-associated protein 1 0.0236886
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 0.0236011
TRIP12 thyroid hormone receptor interactor 12 0.0235547
ATF6 activating transcription factor 6 0.0233705
HYOU1 hypoxia up-regulated 1 0.0231713
CCSER1 coiled-coil serine-rich protein 1 0.0230161
TJP1 tight junction protein 1 0.022722
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0223599
CLMN calmin (calponin-like, transmembrane) 0.0223171
DOCK5 dedicator of cytokinesis 5 0.0217771
ZFP36L1 ZFP36 ring finger protein-like 1 0.0214441
ANKRD17 ankyrin repeat domain 17 0.0214015
RAD51B RAD51 paralog B 0.0212048
STK24 serine/threonine kinase 24 0.0212019
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0211439
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like 0.0208361
MACF1 microtubule-actin crosslinking factor 1 0.0202445
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.020235
SKI SKI proto-oncogene 0.020221
PYGL phosphorylase, glycogen, liver 0.020007
ARHGAP32 Rho GTPase activating protein 32 0.0197821
SFPQ splicing factor proline/glutamine-rich 0.0197711
GCLC glutamate-cysteine ligase, catalytic subunit 0.0197251
MPRIP myosin phosphatase Rho interacting protein 0.0194879
MOSMO modulator of smoothened 0.0194495
SGPP2 sphingosine-1-phosphate phosphatase 2 0.0191932
GOLGB1 golgin B1 0.0189329
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0189001
FAF1 Fas (TNFRSF6) associated factor 1 0.0186316
SPDYA speedy/RINGO cell cycle regulator family member A 0.0186137
MT1X metallothionein 1X 0.018558
THSD4 thrombospondin, type I, domain containing 4 0.0184568
SETX senataxin 0.018309
POLGARF POLG alternative reading frame 0.0181947
ZC3H12C zinc finger CCCH-type containing 12C 0.0180486
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0179337

decreased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.364319
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.328535
NDRG1 N-myc downstream regulated 1 -0.151082
TXNRD1 thioredoxin reductase 1 -0.142201
ASPH aspartate beta-hydroxylase -0.116824
TMSB10 thymosin beta 10 -0.116545
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0812421
FTL ferritin, light polypeptide -0.0806324
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0795557
PTMA prothymosin, alpha -0.079514
LAMC2 laminin, gamma 2 -0.0776271
PKM pyruvate kinase, muscle -0.0755009
TPT1 tumor protein, translationally-controlled 1 -0.0731686
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0726741
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0712501
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0695294
STC1 stanniocalcin 1 -0.0690413
ACTG1 actin gamma 1 -0.0651147
LRP1B low density lipoprotein receptor-related protein 1B -0.0648102
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0632656
LOC112694756 uncharaterized LOC112694756 -0.0610426
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0590494
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0567257
IGFBP3 insulin-like growth factor binding protein 3 -0.0560392
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0515456
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0514042
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0496449
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0475185
EGR1 early growth response 1 -0.0469411
SEC61G Sec61 gamma subunit -0.0447569
B2M beta-2-microglobulin -0.0430081
KMT2E lysine (K)-specific methyltransferase 2E -0.0402395
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0398599
BTG1 B-cell translocation gene 1, anti-proliferative -0.0392124
SLC38A1 solute carrier family 38, member 1 -0.0392021
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0388551
RPLP1 ribosomal protein, large, P1 -0.0379774
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0374521
ABLIM1 actin binding LIM protein 1 -0.0360883
PDE8A phosphodiesterase 8A -0.0357971
FNDC3B fibronectin type III domain containing 3B -0.035509
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0353684
RPL35A ribosomal protein L35a -0.0344576
HMGA1 high mobility group AT-hook 1 -0.0343889
ARRDC3 arrestin domain containing 3 -0.0343137
IER3 immediate early response 3 -0.0339573
RAB27B RAB27B, member RAS oncogene family -0.0338328
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0336954
DSCAM Down syndrome cell adhesion molecule -0.0331599
IGFBP5 insulin-like growth factor binding protein 5 -0.0325847
S100A10 S100 calcium binding protein A10 -0.0322961
MAP7 microtubule-associated protein 7 -0.0319516
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0315851
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0314767
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0312384
NGLY1 N-glycanase 1 -0.0307374
GRB10 growth factor receptor-bound protein 10 -0.0301053
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0300567
LAMB3 laminin, beta 3 -0.0298169
EIF1 eukaryotic translation initiation factor 1 -0.0297195
ANKRD12 ankyrin repeat domain 12 -0.0293645
RPS8 ribosomal protein S8 -0.0292877
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.0291223
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -0.0286783
PTPRM protein tyrosine phosphatase, receptor type, M -0.0285854
SMAD3 SMAD family member 3 -0.0273984
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0268517
CDCP1 CUB domain containing protein 1 -0.0268031
EYA2 EYA transcriptional coactivator and phosphatase 2 -0.0266854
RPS3 ribosomal protein S3 -0.0266443
FAM13A family with sequence similarity 13, member A -0.0266181
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0266074
GNAS GNAS complex locus -0.0262093
C15ORF48 chromosome 15 open reading frame 48 -0.0261123
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0260157
KRT18 keratin 18, type I -0.0258362
HLA-B major histocompatibility complex, class I, B -0.0254854
SQSTM1 sequestosome 1 -0.0253771
CPE carboxypeptidase E -0.0251209
ENO1 enolase 1, (alpha) -0.0250744
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0248048
RPS24 ribosomal protein S24 -0.02449
RPL37A ribosomal protein L37a -0.0243169
AREG amphiregulin -0.0243033
HILPDA hypoxia inducible lipid droplet-associated -0.0239344
IFI6 interferon, alpha-inducible protein 6 -0.0238778
S100A6 S100 calcium binding protein A6 -0.0237647
KRT7 keratin 7, type II -0.0236498
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0233422
PARD3 par-3 family cell polarity regulator -0.0233034
RPS25 ribosomal protein S25 -0.0229664
RPL34 ribosomal protein L34 -0.0227416
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0226752
HBP1 HMG-box transcription factor 1 -0.0224247
ZMYND8 zinc finger, MYND-type containing 8 -0.0222546
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0222456
H1-0 H1.0 linker histone -0.0221999
CEMIP cell migration inducing protein, hyaluronan binding -0.0219883
RPS6 ribosomal protein S6 -0.0219774
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0218418