Clobetasol propionate_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clobetasol propionate perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

169 genes differentially expressed following the Clobetasol propionate_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NKD1 naked cuticle homolog 1 (Drosophila) 0.163591
NALF1 NALCN channel auxiliary factor 1 0.121108
SLIT2 slit homolog 2 (Drosophila) 0.117498
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.110225
NCOR1 nuclear receptor corepressor 1 0.106843
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D 0.105253
MT2A metallothionein 2A 0.0975957
B2M beta-2-microglobulin 0.0967501
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0959366
RBM39 RNA binding motif protein 39 0.0919387
JMJD1C jumonji domain containing 1C 0.091291
CD46 CD46 molecule, complement regulatory protein 0.0884059
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0817287
FN1 fibronectin 1 0.0796307
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0779257
TRIO trio Rho guanine nucleotide exchange factor 0.0729028
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0719996
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0718727
MSI2 musashi RNA-binding protein 2 0.0702407
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0683916
SYT1 synaptotagmin I 0.0667813
ARHGAP32 Rho GTPase activating protein 32 0.0655334
PDE4D phosphodiesterase 4D, cAMP-specific 0.0652119
KTN1 kinectin 1 (kinesin receptor) 0.0642594
ANKRD11 ankyrin repeat domain 11 0.0623455
RORA RAR-related orphan receptor A 0.0605297
ENO1 enolase 1, (alpha) 0.0603829
AFDN afadin, adherens junction formation factor 0.0584713
FMN1 formin 1 0.0578697
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0563817
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0552571
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0533025
RAP1B RAP1B, member of RAS oncogene family 0.0525433
PRRC2C proline-rich coiled-coil 2C 0.0521909
NEBL nebulette 0.0508997
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0502783
ZFAND3 zinc finger, AN1-type domain 3 0.0497594
TXNRD1 thioredoxin reductase 1 0.0495116
PUM2 pumilio RNA-binding family member 2 0.0492729
SMYD3 SET and MYND domain containing 3 0.0484916
ZMYND8 zinc finger, MYND-type containing 8 0.0478861
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0469433
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0446906
CELF1 CUGBP, Elav-like family member 1 0.0406478
DSCAM Down syndrome cell adhesion molecule 0.0389527
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0378436
ELL2 elongation factor, RNA polymerase II, 2 0.0357199
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0356244
SLC38A1 solute carrier family 38, member 1 0.0348947
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0347739
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0337467
AKAP12 A kinase (PRKA) anchor protein 12 0.033265
FNIP1 folliculin interacting protein 1 0.0315165
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0313291
ANKRD12 ankyrin repeat domain 12 0.030723
ARHGAP26 Rho GTPase activating protein 26 0.0302779
MAML2 mastermind-like 2 (Drosophila) 0.0302449
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0298786
PRKCA protein kinase C, alpha 0.0294983
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0291622
SYAP1 synapse associated protein 1 0.0289141
NAMPT nicotinamide phosphoribosyltransferase 0.0271618
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0249817
SH3D19 SH3 domain containing 19 0.0247922
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0221935
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0220895
RAB7A RAB7A, member RAS oncogene family 0.0181874
FBXO11 F-box protein 11 0.0178016
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0172349
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.010916
MYH9 myosin, heavy chain 9, non-muscle 0.0102488
KDM3A lysine (K)-specific demethylase 3A 0.0100668
GOLGA4 golgin A4 0.00935349
CNOT4 CCR4-NOT transcription complex, subunit 4 0.00886944
MAP4 microtubule-associated protein 4 0.00814452
TTC3 tetratricopeptide repeat domain 3 0.00754534
FNDC3B fibronectin type III domain containing 3B 0.00693399
KMT2E lysine (K)-specific methyltransferase 2E 0.00508444
MED13L mediator complex subunit 13-like 0.00344163
SRPK2 SRSF protein kinase 2 0.00333385
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.00250282
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.00206643
EEF2 eukaryotic translation elongation factor 2 0.00164685

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.560748
PTMA prothymosin, alpha -0.166154
VIM vimentin -0.160359
MYO1E myosin IE -0.12115
ZBTB20 zinc finger and BTB domain containing 20 -0.115989
NDRG1 N-myc downstream regulated 1 -0.112464
UBC ubiquitin C -0.11174
LDHA lactate dehydrogenase A -0.110635
TMSB10 thymosin beta 10 -0.107534
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.1054
ANXA2 annexin A2 -0.0997091
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0940797
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0840578
RPL31 ribosomal protein L31 -0.0755409
ALCAM activated leukocyte cell adhesion molecule -0.0755401
TPT1 tumor protein, translationally-controlled 1 -0.0748326
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0695484
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0684592
RPS13 ribosomal protein S13 -0.0660848
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0645712
LAMA4 laminin, alpha 4 -0.0638527
RPL23 ribosomal protein L23 -0.0637985
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0616761
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0613479
CANX calnexin -0.0601638
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0594693
RNF213 ring finger protein 213 -0.059189
PARD3 par-3 family cell polarity regulator -0.0559159
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0534433
RLF rearranged L-myc fusion -0.0500589
SRRM2 serine/arginine repetitive matrix 2 -0.0489989
RPL15 ribosomal protein L15 -0.0486359
RPS3 ribosomal protein S3 -0.0468966
HMGA2 high mobility group AT-hook 2 -0.0467771
FLNB filamin B, beta -0.0465064
ACTN4 actinin, alpha 4 -0.0444292
ACTG1 actin gamma 1 -0.0403588
RAD51B RAD51 paralog B -0.0384047
RPS6 ribosomal protein S6 -0.0352865
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0327251
EGR1 early growth response 1 -0.0322033
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0311081
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0304129
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0303407
EIF1 eukaryotic translation initiation factor 1 -0.0300855
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0297683
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0278342
RTN4 reticulon 4 -0.0254464
GPHN gephyrin -0.0246358
RPL37A ribosomal protein L37a -0.0245038
SMAD3 SMAD family member 3 -0.0222477
TPI1 triosephosphate isomerase 1 -0.0220732
RPS27A ribosomal protein S27a -0.0216572
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0216081
MYO6 myosin VI -0.0213342
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0212772
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0207129
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0197736
WAC WW domain containing adaptor with coiled-coil -0.0192174
ASPH aspartate beta-hydroxylase -0.0182851
FHIT fragile histidine triad -0.0182772
NUP58 nucleoporin 58 -0.0175301
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) -0.0169969
ADAM10 ADAM metallopeptidase domain 10 -0.0166071
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0159314
RPS8 ribosomal protein S8 -0.0149489
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 -0.0148757
GPC6 glypican 6 -0.0134026
RPS19 ribosomal protein S19 -0.0130393
PTK2 protein tyrosine kinase 2 -0.0122456
CCNI cyclin I -0.0121116
MACF1 microtubule-actin crosslinking factor 1 -0.0120375
PGK1 phosphoglycerate kinase 1 -0.0113355
GLS2 glutaminase 2 (liver, mitochondrial) -0.0113172
MYOF myoferlin -0.0107506
DST dystonin -0.0103304
ELOF1 elongation factor 1 homolog (S. cerevisiae) -0.00721945
ZNF292 zinc finger protein 292 -0.00636572
GSK3B glycogen synthase kinase 3 beta -0.00611597
ADAM9 ADAM metallopeptidase domain 9 -0.00541582
SETD5 SET domain containing 5 -0.00540411
PKM pyruvate kinase, muscle -0.0051711
COG5 component of oligomeric golgi complex 5 -0.0036291
ERRFI1 ERBB receptor feedback inhibitor 1 -0.00319433
ARID1B AT rich interactive domain 1B (SWI1-like) -0.00315045
EFNA5 ephrin-A5 -0.00256538