Clobetasol propionate_PANC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clobetasol propionate perturbation in PANC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clobetasol propionate_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VCL vinculin 0.137938
ERRFI1 ERBB receptor feedback inhibitor 1 0.0977481
EGFR epidermal growth factor receptor 0.0963576
AHNAK AHNAK nucleoprotein 0.0828199
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0757172
CARD18 caspase recruitment domain family, member 18 0.0686877
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 0.061367
SLC35F3 solute carrier family 35, member F3 0.0579832
UTRN utrophin 0.057266
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0565388
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0508583
MED13L mediator complex subunit 13-like 0.0497198
DST dystonin 0.0484763
FKBP5 FK506 binding protein 5 0.0480874
EPAS1 endothelial PAS domain protein 1 0.0473357
ZNF780B zinc finger protein 780B 0.0472133
HMGA2 high mobility group AT-hook 2 0.0460051
AKAP13 A kinase (PRKA) anchor protein 13 0.0457665
EFNA5 ephrin-A5 0.0408673
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.0398921
THSD4 thrombospondin, type I, domain containing 4 0.0386103
SDK1 sidekick cell adhesion molecule 1 0.0381658
LPP LIM domain containing preferred translocation partner in lipoma 0.0339845
VMP1 vacuole membrane protein 1 0.0335395
DNAH5 dynein, axonemal, heavy chain 5 0.0333776
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0330116
ADGRG6 adhesion G protein-coupled receptor G6 0.0319134
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0315489
RASAL2 RAS protein activator like 2 0.0314381
ANXA2 annexin A2 0.031277
SBF2 SET binding factor 2 0.0312344
SLC38A2 solute carrier family 38, member 2 0.0309263
ARHGAP26 Rho GTPase activating protein 26 0.0297233
RABGAP1L RAB GTPase activating protein 1-like 0.0294834
LDLRAD3 low density lipoprotein receptor class A domain containing 3 0.0288086
PHF14 PHD finger protein 14 0.0269824
SMYD3 SET and MYND domain containing 3 0.0269803
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0269039
SEC14L1 SEC14-like 1 (S. cerevisiae) 0.0268244
BCL2L1 BCL2-like 1 0.0263602
SPIDR scaffolding protein involved in DNA repair 0.0261239
MSRB3 methionine sulfoxide reductase B3 0.0257304
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0253164
TMEM135 transmembrane protein 135 0.0251053
EXOC4 exocyst complex component 4 0.0250948
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0247279
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0247233
UBASH3B ubiquitin associated and SH3 domain containing B 0.0246238
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0242732
ZNF644 zinc finger protein 644 0.0240217
ZBTB20 zinc finger and BTB domain containing 20 0.0238987
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit 0.0234521
RUSC2 RUN and SH3 domain containing 2 0.022206
ARHGAP29 Rho GTPase activating protein 29 0.021447
OSMR oncostatin M receptor 0.0213394
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.020792
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0201369
MBNL1 muscleblind-like splicing regulator 1 0.0199467
HDAC8 histone deacetylase 8 0.0199237
PLCE1 phospholipase C, epsilon 1 0.0194753
AKT2 v-akt murine thymoma viral oncogene homolog 2 0.0193791
METTL15 methyltransferase like 15 0.0193348
SOD2 superoxide dismutase 2, mitochondrial 0.0193082
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0192894
EHBP1 EH domain binding protein 1 0.0192183
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0192048
ARB2A ARB2 cotranscriptional regulator A 0.0190186
FAF1 Fas (TNFRSF6) associated factor 1 0.018905
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.0188747
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0188657
TTC17 tetratricopeptide repeat domain 17 0.0182047
ACACA acetyl-CoA carboxylase alpha 0.0178859
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0178462
NFIA nuclear factor I/A 0.0177762
ELL2 elongation factor, RNA polymerase II, 2 0.0177487
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 0.0177115
ZC3H12B zinc finger CCCH-type containing 12B 0.0175931
NCOA7 nuclear receptor coactivator 7 0.0174961
MOSMO modulator of smoothened 0.0173985
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.017395
WDR27 WD repeat domain 27 0.0173227
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0171956
SLC39A11 solute carrier family 39, member 11 0.0171347
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0171159
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0170614
DNHD1 dynein heavy chain domain 1 0.0166018
ATM ATM serine/threonine kinase 0.0164875
IL6ST interleukin 6 signal transducer 0.0164343
FAM135A family with sequence similarity 135, member A 0.0163814
ADIPOR2 adiponectin receptor 2 0.0163766
PRIM2 primase, DNA, polypeptide 2 (58kDa) 0.0162906
NFE2L2 nuclear factor, erythroid 2-like 2 0.0162474
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.016161
TBC1D5 TBC1 domain family, member 5 0.0161006
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0160245
CAMKMT calmodulin-lysine N-methyltransferase 0.0159134
TOP1 topoisomerase (DNA) I 0.0158583
TMEM41B transmembrane protein 41B 0.0158011
ATP9B ATPase, class II, type 9B 0.0157274
DPY19L1 dpy-19-like 1 (C. elegans) 0.0156994

decreased expression

Symbol Name Standardized Value
RPS16 ribosomal protein S16 -0.310848
VIM vimentin -0.271163
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.223284
PTMA prothymosin, alpha -0.214854
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.163114
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.120405
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.116604
FBL fibrillarin -0.0934318
FTL ferritin, light polypeptide -0.09191
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0903835
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0862499
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0754911
RPLP2 ribosomal protein, large, P2 -0.0750009
RPL35A ribosomal protein L35a -0.0736256
RPLP1 ribosomal protein, large, P1 -0.0693262
RPS12 ribosomal protein S12 -0.0650858
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0640254
RPS8 ribosomal protein S8 -0.0629771
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0608718
RPL37A ribosomal protein L37a -0.055281
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0548653
TM4SF1 transmembrane 4 L six family member 1 -0.0548638
RPS2 ribosomal protein S2 -0.0545616
SPAG9 sperm associated antigen 9 -0.0538113
RPS3 ribosomal protein S3 -0.0501248
NAV2 neuron navigator 2 -0.0482188
SQSTM1 sequestosome 1 -0.0479082
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0475717
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0458708
GOLGA4 golgin A4 -0.0456349
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0451473
HMGA1 high mobility group AT-hook 1 -0.0449327
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0446426
SEPTIN7 septin 7 -0.0446365
NAP1L1 nucleosome assembly protein 1-like 1 -0.0445124
RPS6 ribosomal protein S6 -0.0436325
TPT1 tumor protein, translationally-controlled 1 -0.0428225
PKM pyruvate kinase, muscle -0.0414016
SMAD3 SMAD family member 3 -0.0399316
PDIA3 protein disulfide isomerase family A, member 3 -0.0397064
EIF1 eukaryotic translation initiation factor 1 -0.0393045
RPS27A ribosomal protein S27a -0.0384428
RPLP0 ribosomal protein, large, P0 -0.0384261
FOSL1 FOS-like antigen 1 -0.0366857
ICAM1 intercellular adhesion molecule 1 -0.036175
KTN1 kinectin 1 (kinesin receptor) -0.036094
WWTR1 WW domain containing transcription regulator 1 -0.0355282
ACTG1 actin gamma 1 -0.0352188
GNAS GNAS complex locus -0.0346727
CENPF centromere protein F, 350/400kDa -0.0341557
GRK5 G protein-coupled receptor kinase 5 -0.0339611
S100A6 S100 calcium binding protein A6 -0.0338703
CTSD cathepsin D -0.0337694
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0335589
RPS13 ribosomal protein S13 -0.0332775
RPL11 ribosomal protein L11 -0.0331266
TMSB10 thymosin beta 10 -0.0329661
SNX14 sorting nexin 14 -0.0329407
ADM adrenomedullin -0.0327969
RPS17 ribosomal protein S17 -0.0327229
CTBP2 C-terminal binding protein 2 -0.032677
PFN1 profilin 1 -0.032631
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 -0.0326275
UPP1 uridine phosphorylase 1 -0.0323969
RACK1 receptor for activated C kinase 1 -0.0322776
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0317077
DDIT4 DNA-damage-inducible transcript 4 -0.0316335
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 -0.0314366
SEPTIN9 septin 9 -0.03125
LOC112694756 uncharaterized LOC112694756 -0.0310653
YBX1 Y box binding protein 1 -0.0308605
KDM2A lysine (K)-specific demethylase 2A -0.0307122
FMNL2 formin-like 2 -0.0302735
RPS25 ribosomal protein S25 -0.0301585
B2M beta-2-microglobulin -0.0297713
RPL30 ribosomal protein L30 -0.0297064
RPS24 ribosomal protein S24 -0.0295299
RPL36A ribosomal protein L36a -0.0293553
RPL37 ribosomal protein L37 -0.029183
KPNB1 karyopherin (importin) beta 1 -0.029102
EIF3K eukaryotic translation initiation factor 3, subunit K -0.0287764
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0285597
RPL38 ribosomal protein L38 -0.0283872
CDCP1 CUB domain containing protein 1 -0.0283057
APLP2 amyloid beta (A4) precursor-like protein 2 -0.028276
RPL9 ribosomal protein L9 -0.0275374
MYO10 myosin X -0.0274521
RPL28 ribosomal protein L28 -0.0272239
HSPG2 heparan sulfate proteoglycan 2 -0.0271558
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0270075
WSB1 WD repeat and SOCS box containing 1 -0.0268412
COL18A1 collagen, type XVIII, alpha 1 -0.0268264
HMGB1 high mobility group box 1 -0.0266253
SYNJ2 synaptojanin 2 -0.0266192
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0265707
VEGFA vascular endothelial growth factor A -0.0264699
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0264449
RPS19 ribosomal protein S19 -0.0264015
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0263151
SET SET nuclear proto-oncogene -0.0260789